CN105037465B - 一种从百里香属植物中得到的灯盏乙素 - Google Patents
一种从百里香属植物中得到的灯盏乙素 Download PDFInfo
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- CN105037465B CN105037465B CN201510413140.6A CN201510413140A CN105037465B CN 105037465 B CN105037465 B CN 105037465B CN 201510413140 A CN201510413140 A CN 201510413140A CN 105037465 B CN105037465 B CN 105037465B
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- scutellarin
- extract
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- thyme
- medicinal extract
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- DJSISFGPUUYILV-UHFFFAOYSA-N UNPD161792 Natural products O1C(C(O)=O)C(O)C(O)C(O)C1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 DJSISFGPUUYILV-UHFFFAOYSA-N 0.000 title claims abstract description 175
- DJSISFGPUUYILV-ZFORQUDYSA-N scutellarin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC(O)=CC=1)O2 DJSISFGPUUYILV-ZFORQUDYSA-N 0.000 title claims abstract description 175
- NPLTVGMLNDMOQE-UHFFFAOYSA-N carthamidin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=C(O)C(O)=C2C(=O)C1 NPLTVGMLNDMOQE-UHFFFAOYSA-N 0.000 title claims abstract description 172
- 229930190376 scutellarin Natural products 0.000 title claims abstract description 172
- 210000001541 thymus gland Anatomy 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 110
- 241000246358 Thymus Species 0.000 claims abstract description 37
- 235000007303 Thymus vulgaris Nutrition 0.000 claims abstract description 34
- 239000001585 thymus vulgaris Substances 0.000 claims abstract description 34
- 239000011347 resin Substances 0.000 claims abstract description 30
- 229920005989 resin Polymers 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 27
- 241000196324 Embryophyta Species 0.000 claims abstract description 24
- 241000207923 Lamiaceae Species 0.000 claims abstract description 10
- 238000000638 solvent extraction Methods 0.000 claims abstract description 8
- 238000001953 recrystallisation Methods 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 102
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 65
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 60
- 235000019441 ethanol Nutrition 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 36
- 239000003480 eluent Substances 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 25
- 239000000287 crude extract Substances 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 19
- 238000004090 dissolution Methods 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 18
- 239000006210 lotion Substances 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 18
- 238000009825 accumulation Methods 0.000 claims description 14
- 238000002386 leaching Methods 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 9
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims 6
- 239000001913 cellulose Substances 0.000 claims 6
- 125000005909 ethyl alcohol group Chemical group 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 239000002994 raw material Substances 0.000 abstract description 7
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 3
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 2
- 206010000891 acute myocardial infarction Diseases 0.000 abstract description 2
- 208000029078 coronary artery disease Diseases 0.000 abstract description 2
- 230000000302 ischemic effect Effects 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 17
- 230000002745 absorbent Effects 0.000 description 12
- 239000002250 absorbent Substances 0.000 description 12
- 239000007791 liquid phase Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 238000002137 ultrasound extraction Methods 0.000 description 4
- 239000006071 cream Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 241000329467 Thymus quinquecostatus Species 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 231100000614 poison Toxicity 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 206010010970 Cor pulmonale chronic Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241001518156 Thymus altaicus Species 0.000 description 1
- 241001403982 Thymus quinquecostatus var. przewalskii Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (37)
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CN201510413140.6A CN105037465B (zh) | 2015-07-14 | 2015-07-14 | 一种从百里香属植物中得到的灯盏乙素 |
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CN201510413140.6A CN105037465B (zh) | 2015-07-14 | 2015-07-14 | 一种从百里香属植物中得到的灯盏乙素 |
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CN105037465A CN105037465A (zh) | 2015-11-11 |
CN105037465B true CN105037465B (zh) | 2018-08-21 |
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CN107648248A (zh) * | 2017-09-18 | 2018-02-02 | 暨南大学 | 灯盏花乙素在制备治疗nlrp3相关疾病药物中的应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101497637B (zh) * | 2009-03-19 | 2011-07-27 | 云南植物药业有限公司 | 从灯盏花中提取高纯度灯盏花乙素的方法 |
CN101580527B (zh) * | 2009-04-29 | 2011-08-10 | 南开大学 | 灯盏花提取物中灯盏花乙素的吸附树脂法分离工艺 |
WO2013131270A1 (zh) * | 2012-03-08 | 2013-09-12 | Liu Li | 灯盏花乙素水合物及其制备方法和用途 |
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Inventor after: Conversion plum Inventor after: Wang Yanli Inventor after: Tian Yuxin Inventor after: Wang Xiaohong Inventor after: Xie Meng Inventor after: Liu Zizhen Inventor before: Conversion plum Inventor before: Tian Yuxin Inventor before: Wang Xiaohong Inventor before: Xie Meng Inventor before: Liu Zizhen |
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Effective date of registration: 20210121 Address after: 243000 floor 1-2, No.8 factory building, Jinpu Industrial Park, zhengpugang New District, Maanshan City, Anhui Province Patentee after: Anhui Shuanghui Biotechnology Co.,Ltd. Patentee after: Conversion plum Address before: 100102 No. 6 South Central Road, Chaoyang District, Beijing, China Patentee before: Conversion plum |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Scutellarin obtained from thyme Effective date of registration: 20220624 Granted publication date: 20180821 Pledgee: Ma'anshan branch of Bank of China Ltd. Pledgor: Anhui Shuanghui Biotechnology Co.,Ltd. Registration number: Y2022980008849 |
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