CN105008523B - iNOS抑制剂用于增加培养物中病毒产率的用途 - Google Patents

iNOS抑制剂用于增加培养物中病毒产率的用途 Download PDF

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CN105008523B
CN105008523B CN201480012376.2A CN201480012376A CN105008523B CN 105008523 B CN105008523 B CN 105008523B CN 201480012376 A CN201480012376 A CN 201480012376A CN 105008523 B CN105008523 B CN 105008523B
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hsv
ata
virus
cells
aav
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CN105008523A (zh
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P·佩汉
J·阿丁格
A·斯卡里亚
S·沃兹沃思
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Genzyme Corp
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Genzyme Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16651—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201480012376.2A 2013-01-08 2014-01-07 iNOS抑制剂用于增加培养物中病毒产率的用途 Active CN105008523B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750175P 2013-01-08 2013-01-08
US61/750,175 2013-01-08
PCT/US2014/010553 WO2014110053A1 (en) 2013-01-08 2014-01-07 Use of inos inhibitors to increase viral yield in culture

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Publication Number Publication Date
CN105008523A CN105008523A (zh) 2015-10-28
CN105008523B true CN105008523B (zh) 2020-03-27

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US (2) US11299715B2 (https=)
EP (3) EP2943567B1 (https=)
JP (2) JP6534933B2 (https=)
KR (1) KR102307279B1 (https=)
CN (1) CN105008523B (https=)
AR (1) AR094389A1 (https=)
AU (1) AU2014205604B2 (https=)
BR (2) BR112015016328B1 (https=)
CA (1) CA2897444A1 (https=)
DK (1) DK2943567T3 (https=)
ES (1) ES2651763T3 (https=)
HK (1) HK1249544A1 (https=)
HU (1) HUE037482T2 (https=)
IL (1) IL239824B (https=)
MX (2) MX360470B (https=)
NO (1) NO3050055T3 (https=)
RU (1) RU2676733C2 (https=)
SG (3) SG10201806715TA (https=)
TW (1) TWI608102B (https=)
WO (1) WO2014110053A1 (https=)

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SG11201703148TA (en) 2014-11-05 2017-05-30 Voyager Therapeutics Inc Aadc polynucleotides for the treatment of parkinson's disease
CN119876138A (zh) 2014-11-14 2025-04-25 沃雅戈治疗公司 调节性多核苷酸
CA3193811A1 (en) 2014-11-14 2016-05-19 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
HK1245326A1 (zh) 2014-12-12 2018-08-24 Voyager Therapeutics, Inc. 用於生产scaav的组合物和方法
PL3436593T3 (pl) 2016-03-28 2023-03-27 Ultragenyx Pharmaceutical Inc. Sposoby inaktywacji termicznej adenowirusów
CA3024448C (en) 2016-05-18 2025-09-09 Voyager Therapeutics, Inc. MODULATING POLYNUCLEOTIDES
ES3012649T3 (en) 2016-10-14 2025-04-09 Ultragenyx Pharmaceutical Inc Use of tonicifying agents to enhance recombinant adeno-associated virus yield
JP7142643B2 (ja) 2017-03-22 2022-09-27 ウルトラジェニックス ファーマシューティカル インコーポレイテッド Ｈｄａｃ阻害剤またはｒｅｐタンパク質を伴う細胞培養方法
JP7218303B2 (ja) 2017-05-09 2023-02-06 ウルトラジェニックス ファーマシューティカル インコーポレイテッド トランスフェクション試薬を生成するための拡大可能な方法
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
SG11202011296VA (en) 2018-05-15 2020-12-30 Voyager Therapeutics Inc Compositions and methods for the treatment of parkinson's disease
CN110835622B (zh) * 2018-08-16 2021-04-27 上海药明生物技术有限公司 用于调节哺乳动物细胞乳酸代谢的培养基及其应用
US12281321B2 (en) 2018-09-28 2025-04-22 Voyager Therapeutics, Inc. Frataxin expression constructs having engineered promoters and methods of use thereof
BR112022018658A2 (pt) 2020-03-16 2022-12-20 Ultragenyx Pharmaceutical Inc Métodos para potencializar o rendimento de vírus adenoassociado recombinante
WO2023157976A1 (ja) * 2022-02-21 2023-08-24 学校法人日本医科大学 ウイルスベクター生産性増強剤及びウイルスベクターの製造方法

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CN101784532A (zh) * 2007-06-29 2010-07-21 韩国化学研究院 新的hiv逆转录酶抑制剂

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Aurintricarboxylic Acid Inhibits the Early Stage of Vaccinia Virus Replication by Targeting both Cellular and Viral Factors;Chad Myskiw等;《JOURNAL OF VIROLOGY》;20070331;第81卷(第6期);第3028页 FIG.1 D及其附图解释 *
Chad Myskiw等.Aurintricarboxylic Acid Inhibits the Early Stage of Vaccinia Virus Replication by Targeting both Cellular and Viral Factors.《JOURNAL OF VIROLOGY》.2007,第81卷(第6期),第3028页 FIG.1 D及其附图解释. *
Herpes simplex virus type 1 infection and glucocorticoid treatment regulate viral yield, glucocorticoid receptor and NF-кB levels;A C Erlandsson等;《Journal of Endocrinology》;20021031;第175卷(第1期);第168页左栏倒数1-2段，图1 *
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EP2943567A1 (en) 2015-11-18
IL239824A0 (en) 2015-08-31
ES2651763T3 (es) 2018-01-29
RU2015133205A (ru) 2017-02-14
US20150353899A1 (en) 2015-12-10
CA2897444A1 (en) 2014-07-17
MX378877B (es) 2025-03-10
SG10201806715TA (en) 2018-09-27
HK1214840A1 (en) 2016-08-05
KR102307279B1 (ko) 2021-09-29
EP3266866B1 (en) 2019-03-06
AU2014205604A1 (en) 2015-08-13
HUE037482T2 (hu) 2018-08-28
EP3521420A1 (en) 2019-08-07
BR112015016328B1 (pt) 2023-04-18
NO3050055T3 (https=) 2018-02-10
TWI608102B (zh) 2017-12-11
EP2943567B1 (en) 2017-09-13
JP6837094B2 (ja) 2021-03-03
RU2018144779A3 (https=) 2022-03-02
US11299715B2 (en) 2022-04-12
AU2014205604B2 (en) 2020-01-02
MX360470B (es) 2018-11-05
SG11201505333PA (en) 2015-08-28
DK2943567T3 (en) 2018-01-02
KR20150103275A (ko) 2015-09-09
BR112015016328A2 (https=) 2017-09-05
US20220340883A1 (en) 2022-10-27
JP2019187420A (ja) 2019-10-31
MX2015008861A (es) 2016-04-13
HK1249544A1 (en) 2018-11-02
RU2676733C2 (ru) 2019-01-10
SG10201913130PA (en) 2020-03-30
AR094389A1 (es) 2015-07-29
CN105008523A (zh) 2015-10-28
RU2018144779A (ru) 2019-01-29
WO2014110053A1 (en) 2014-07-17
IL239824B (en) 2019-03-31
EP3266866A1 (en) 2018-01-10
JP2016504913A (ja) 2016-02-18
TW201446965A (zh) 2014-12-16
JP6534933B2 (ja) 2019-06-26
BR122020002822B1 (pt) 2023-04-18

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