CN104955453A - Lfa-1抑制剂制剂 - Google Patents
Lfa-1抑制剂制剂 Download PDFInfo
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- CN104955453A CN104955453A CN201380071760.5A CN201380071760A CN104955453A CN 104955453 A CN104955453 A CN 104955453A CN 201380071760 A CN201380071760 A CN 201380071760A CN 104955453 A CN104955453 A CN 104955453A
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019795 sodium metasilicate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960005559 sulforaphane Drugs 0.000 description 1
- 235000015487 sulforaphane Nutrition 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-M undecanoate Chemical compound CCCCCCCCCCC([O-])=O ZDPHROOEEOARMN-UHFFFAOYSA-M 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (59)
Applications Claiming Priority (5)
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US201261739609P | 2012-12-19 | 2012-12-19 | |
US61/739,609 | 2012-12-19 | ||
US201361758147P | 2013-01-29 | 2013-01-29 | |
US61/758,147 | 2013-01-29 | ||
PCT/US2013/076041 WO2014100135A1 (en) | 2012-12-19 | 2013-12-18 | Lfa-1 inhibitor formulations |
Publications (2)
Publication Number | Publication Date |
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CN104955453A true CN104955453A (zh) | 2015-09-30 |
CN104955453B CN104955453B (zh) | 2018-09-18 |
Family
ID=50979140
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CN201380071760.5A Active CN104955453B (zh) | 2012-12-19 | 2013-12-18 | Lfa-1抑制剂制剂 |
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EP (2) | EP2934510B1 (zh) |
JP (1) | JP6373867B2 (zh) |
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CN (1) | CN104955453B (zh) |
AU (1) | AU2013361579B2 (zh) |
BR (1) | BR112015014367B1 (zh) |
CA (1) | CA2894170C (zh) |
DK (1) | DK2934510T3 (zh) |
EA (2) | EA028008B1 (zh) |
ES (1) | ES2846724T3 (zh) |
HK (2) | HK1214536A1 (zh) |
HU (1) | HUE052299T2 (zh) |
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MX (2) | MX368876B (zh) |
NZ (1) | NZ708821A (zh) |
PL (1) | PL2934510T3 (zh) |
PT (1) | PT2934510T (zh) |
SI (1) | SI2934510T1 (zh) |
WO (1) | WO2014100135A1 (zh) |
ZA (2) | ZA201504404B (zh) |
Cited By (2)
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---|---|---|---|---|
CN106995439A (zh) * | 2016-01-26 | 2017-08-01 | 镇江圣安医药有限公司 | 氘取代3‑(甲磺酰基)‑l‑苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
CN114025759A (zh) * | 2019-04-18 | 2022-02-08 | 阿祖拉眼科有限公司 | 用于治疗眼病的化合物和方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019171260A1 (en) * | 2018-03-09 | 2019-09-12 | Mankind Pharma Ltd. | Pharmaceutical composition of lifitegrast |
EP3842032A1 (en) | 2019-12-24 | 2021-06-30 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | A pharmaceutical formulation |
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RU2149611C1 (ru) * | 1998-04-06 | 2000-05-27 | Московская медицинская академия им. И.М. Сеченова | Капли для лечения воспалительных заболеваний глаз (варианты) |
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-
2013
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- 2013-12-18 MX MX2015007540A patent/MX368876B/es active IP Right Grant
- 2013-12-18 US US14/650,955 patent/US11058677B2/en active Active
- 2013-12-18 PL PL13865757T patent/PL2934510T3/pl unknown
- 2013-12-18 AU AU2013361579A patent/AU2013361579B2/en active Active
- 2013-12-18 WO PCT/US2013/076041 patent/WO2014100135A1/en active Application Filing
- 2013-12-18 HU HUE13865757A patent/HUE052299T2/hu unknown
- 2013-12-18 SI SI201331833T patent/SI2934510T1/sl unknown
- 2013-12-18 EP EP13865757.2A patent/EP2934510B1/en active Active
- 2013-12-18 ES ES13865757T patent/ES2846724T3/es active Active
- 2013-12-18 EP EP20204080.4A patent/EP3827823A1/en not_active Withdrawn
- 2013-12-18 EA EA201591180A patent/EA028008B1/ru unknown
- 2013-12-18 JP JP2015549612A patent/JP6373867B2/ja active Active
- 2013-12-18 BR BR112015014367-9A patent/BR112015014367B1/pt active IP Right Grant
- 2013-12-18 PT PT138657572T patent/PT2934510T/pt unknown
- 2013-12-18 EA EA201791321A patent/EA201791321A1/ru unknown
- 2013-12-18 CN CN201380071760.5A patent/CN104955453B/zh active Active
- 2013-12-18 KR KR1020157019352A patent/KR101891144B1/ko active IP Right Grant
- 2013-12-18 DK DK13865757.2T patent/DK2934510T3/da active
- 2013-12-18 NZ NZ708821A patent/NZ708821A/en unknown
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2015
- 2015-06-12 MX MX2019012375A patent/MX2019012375A/es unknown
- 2015-06-18 ZA ZA2015/04404A patent/ZA201504404B/en unknown
- 2015-06-18 IL IL239490A patent/IL239490B/en active IP Right Grant
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2016
- 2016-03-08 HK HK16102642.0A patent/HK1214536A1/zh unknown
- 2016-03-15 HK HK16102972.0A patent/HK1214963A1/zh unknown
- 2016-11-22 ZA ZA2016/08069A patent/ZA201608069B/en unknown
-
2021
- 2021-06-09 US US17/342,631 patent/US20220000859A1/en not_active Abandoned
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US20060073172A1 (en) * | 2004-10-01 | 2006-04-06 | Schneider L W | Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure |
US20090298869A1 (en) * | 2008-04-15 | 2009-12-03 | John Burnier | Crystalline pharmaceutical and methods of preparation and use thereof |
WO2012100109A2 (en) * | 2011-01-20 | 2012-07-26 | Advanced Vision Research, Inc. | Therapeutic eye drop comprising doxycycline and a stabilizer |
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CN106995439A (zh) * | 2016-01-26 | 2017-08-01 | 镇江圣安医药有限公司 | 氘取代3‑(甲磺酰基)‑l‑苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
CN106995439B (zh) * | 2016-01-26 | 2019-09-20 | 镇江圣安医药有限公司 | 氘取代3-(甲磺酰基)-l-苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
CN114025759A (zh) * | 2019-04-18 | 2022-02-08 | 阿祖拉眼科有限公司 | 用于治疗眼病的化合物和方法 |
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