CN104945318A - 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 - Google Patents
羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 Download PDFInfo
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- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
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- 230000032258 transport Effects 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
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- 125000005591 trimellitate group Chemical group 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US35043110P | 2010-06-01 | 2010-06-01 | |
| US61/350,431 | 2010-06-01 | ||
| CN2011800377765A CN103038216A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
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| CN2011800377765A Division CN103038216A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
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|---|---|
| CN104945318A true CN104945318A (zh) | 2015-09-30 |
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| CN201510258042.XA Pending CN104945318A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
| CN2011800377765A Pending CN103038216A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
| CN201510258095.1A Pending CN104926722A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011800377765A Pending CN103038216A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
| CN201510258095.1A Pending CN104926722A (zh) | 2010-06-01 | 2011-06-01 | 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8334307B2 (https=) |
| EP (1) | EP2576513A1 (https=) |
| JP (1) | JP5844354B2 (https=) |
| CN (3) | CN104945318A (https=) |
| AU (1) | AU2011261499B2 (https=) |
| CA (1) | CA2801001A1 (https=) |
| MX (1) | MX2012013879A (https=) |
| WO (1) | WO2011153197A1 (https=) |
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| US20170277149A1 (en) * | 2013-10-22 | 2017-09-28 | Lite-On Technology Corporation | Control device with automatic adjustment |
| US9527815B2 (en) | 2014-06-18 | 2016-12-27 | Biotheryx, Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases |
| DK3217980T3 (da) * | 2014-11-11 | 2020-12-07 | Univ Kansas | Ciclopirox, ciclopirox-olamin, eller et ciclopirox-prodrug til anvendelse i behandlingen af blærekræft |
| GB201420348D0 (en) * | 2014-11-17 | 2014-12-31 | Univ Northumbria Newcastle | Compounds for treating neurodegenerative diseases |
| AU2020256166A1 (en) | 2019-04-02 | 2021-10-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
| CN110354121B (zh) * | 2019-07-08 | 2023-05-02 | 温州医科大学 | 环吡酮胺在制备治疗肿瘤药物中的应用和包含环吡酮胺的组合药物及用途 |
| CN113603640A (zh) * | 2021-08-06 | 2021-11-05 | 成都化润药业有限公司 | 一种羟吡酮乙胺盐的合成方法 |
| CN113588852A (zh) * | 2021-08-16 | 2021-11-02 | 浙江鼎泰药业股份有限公司 | 一种高活性透皮贴膏中挥发性成分含量的测定方法 |
| KR102800868B1 (ko) * | 2021-12-31 | 2025-04-29 | 주식회사 삼양케이씨아이 | 치환된 1-하이드록시-2-피리돈 화합물의 신규한 제조 방법 |
| WO2025214612A1 (en) | 2023-04-14 | 2025-10-16 | Syngenta Crop Protection Ag | Pesticidally-active 2,2-dihalocyclopropyl compounds |
| WO2025261608A1 (en) | 2023-06-29 | 2025-12-26 | Syngenta Crop Protection Ag | Pesticidally-active 2,2-dihalocyclopropyl compounds |
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| CN1889952A (zh) * | 2003-12-19 | 2007-01-03 | 诺瓦提斯公司 | (a)N－{5－[4－(4－甲基－(哌嗪－1－基)－甲基)－苯甲酰胺基]－2－甲基苯基}－4－(3－吡啶基)－2－嘧啶－胺和( b )至少一种羟丁赖氨酸形成抑制剂的组合产品及其用途 |
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2011
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- 2011-06-01 CN CN201510258042.XA patent/CN104945318A/zh active Pending
- 2011-06-01 JP JP2013513287A patent/JP5844354B2/ja not_active Expired - Fee Related
- 2011-06-01 CN CN2011800377765A patent/CN103038216A/zh active Pending
- 2011-06-01 CN CN201510258095.1A patent/CN104926722A/zh active Pending
- 2011-06-01 CA CA2801001A patent/CA2801001A1/en not_active Abandoned
- 2011-06-01 AU AU2011261499A patent/AU2011261499B2/en not_active Ceased
- 2011-06-01 EP EP11731574.7A patent/EP2576513A1/en not_active Withdrawn
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| AU2011261499A1 (en) | 2013-01-10 |
| US20120022115A1 (en) | 2012-01-26 |
| CN103038216A (zh) | 2013-04-10 |
| AU2011261499B2 (en) | 2015-07-16 |
| EP2576513A1 (en) | 2013-04-10 |
| MX2012013879A (es) | 2013-04-03 |
| JP2013528619A (ja) | 2013-07-11 |
| US9273005B2 (en) | 2016-03-01 |
| CA2801001A1 (en) | 2011-12-08 |
| US20130072526A1 (en) | 2013-03-21 |
| CN104926722A (zh) | 2015-09-23 |
| WO2011153197A1 (en) | 2011-12-08 |
| JP5844354B2 (ja) | 2016-01-13 |
| US8334307B2 (en) | 2012-12-18 |
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