CN104936592A - 一种注射用hpph冻干粉针制剂及其制备方法 - Google Patents

一种注射用hpph冻干粉针制剂及其制备方法 Download PDF

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Publication number
CN104936592A
CN104936592A CN201480005064.9A CN201480005064A CN104936592A CN 104936592 A CN104936592 A CN 104936592A CN 201480005064 A CN201480005064 A CN 201480005064A CN 104936592 A CN104936592 A CN 104936592A
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hpph
injection
freeze
cosolvent
solubilizer
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CN104936592B (zh
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冯春荣
张环伟
王剑桥
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ZHEJIANG HAIZHENG PHARMACEUTICAL CO Ltd
Shanghai Aryl Pharmtech Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种注射用HPPH冻干粉针制剂及其制备方法。该冻干粉针制剂含有HPPH、助溶剂、增溶剂、赋形剂、pH调节剂。所述的HPPH冻干粉针制剂疏松，复溶性好，水分低，稳定性好。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201480005064.9A 2013-02-05 2014-01-21 一种注射用hpph冻干粉针制剂及其制备方法 Active CN104936592B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480005064.9A CN104936592B (zh) 2013-02-05 2014-01-21 一种注射用hpph冻干粉针制剂及其制备方法

Applications Claiming Priority (4)

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CN201310046627.6A CN103961323B (zh) 2013-02-05 2013-02-05 一种注射用hpph冻干粉针制剂及其制备方法
CN2013100466276 2013-02-05
PCT/CN2014/070974 WO2014121691A1 (zh) 2013-02-05 2014-01-21 一种注射用hpph冻干粉针制剂及其制备方法
CN201480005064.9A CN104936592B (zh) 2013-02-05 2014-01-21 一种注射用hpph冻干粉针制剂及其制备方法

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CN104936592A true CN104936592A (zh) 2015-09-23
CN104936592B CN104936592B (zh) 2018-05-11

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US (1) US9717795B2 (zh)
EP (1) EP2954898B1 (zh)
JP (1) JP6235614B2 (zh)
KR (1) KR101804206B1 (zh)
CN (2) CN103961323B (zh)
CA (1) CA2900120C (zh)
HK (1) HK1211871A1 (zh)
WO (1) WO2014121691A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104306326B (zh) * 2014-09-25 2016-10-05 江苏红豆杉药业有限公司 含有hpph的水性药物组合物和注射液
CN108586468B (zh) * 2018-01-10 2020-06-23 浙江海正药业股份有限公司 一种hpph的纯化方法
CN113577034A (zh) * 2021-08-30 2021-11-02 苏州素仕生物科技有限公司 一种兽用促黄体素释放激素a3冻干粉针剂及制备方法
KR20230126654A (ko) * 2022-02-23 2023-08-30 주식회사 엘지화학 이소옥사졸린 유도체를 포함하는 주사용 제제 및 이의 제조방법

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JPH0331283A (ja) * 1989-06-14 1991-02-12 Quadra Logic Technol Inc 安定な凍結乾燥したポリヘマトポルフイリンエーテル／エステル組成物
WO2003028628A2 (en) * 2001-10-03 2003-04-10 Miravant Pharmaceuticals, Inc. Photosensitizing carbamate derivatives
CN101219137A (zh) * 2007-01-09 2008-07-16 健康研究有限公司 使用光动力疗法对食道高度发育异常的治疗

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Publication number Priority date Publication date Assignee Title
CA2490692A1 (en) * 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7364754B2 (en) * 2003-01-24 2008-04-29 Research Foundation Of The State University Of New York Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same
US20100056983A1 (en) * 2007-09-27 2010-03-04 Health Research, Inc. Treatment of cancer using photodynamic therapy

Patent Citations (3)

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JPH0331283A (ja) * 1989-06-14 1991-02-12 Quadra Logic Technol Inc 安定な凍結乾燥したポリヘマトポルフイリンエーテル／エステル組成物
WO2003028628A2 (en) * 2001-10-03 2003-04-10 Miravant Pharmaceuticals, Inc. Photosensitizing carbamate derivatives
CN101219137A (zh) * 2007-01-09 2008-07-16 健康研究有限公司 使用光动力疗法对食道高度发育异常的治疗

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DENGPAN WU等: "Efficacy of 2‑(1‑hexyloxyethyl)‑2‑devinyl pyropheophorbide‑a in photodynamic therapy of human esophageal squamous cancer cells", 《ONCOLOGY LETTERS》 *

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Publication number Publication date
US9717795B2 (en) 2017-08-01
HK1211871A1 (zh) 2016-06-03
JP2016506936A (ja) 2016-03-07
CA2900120C (en) 2018-07-03
WO2014121691A1 (zh) 2014-08-14
EP2954898A4 (en) 2016-08-03
CN103961323A (zh) 2014-08-06
JP6235614B2 (ja) 2017-11-22
CN104936592B (zh) 2018-05-11
CN103961323B (zh) 2017-10-17
KR20150113184A (ko) 2015-10-07
EP2954898B1 (en) 2019-04-24
KR101804206B1 (ko) 2017-12-04
CA2900120A1 (en) 2014-08-14
EP2954898A1 (en) 2015-12-16
US20150366965A1 (en) 2015-12-24

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Effective date of registration: 20191113

Address after: 201600 building 3, No. 301, Minqiang Road, Songjiang District, Shanghai

Co-patentee after: Zhejiang Haizheng Pharmaceutical Co., Ltd.

Patentee after: Shanghai Angrui Pharmaceutical Technology Co., Ltd

Address before: Jiaojiang District of Taizhou City, Zhejiang province 318000 road outside No. 46

Patentee before: Zhejiang Haizheng Pharmaceutical Co., Ltd.