CN104906127B - 一种有效碘含量稳定性增强的聚维酮碘复方制剂及其制备方法 - Google Patents
一种有效碘含量稳定性增强的聚维酮碘复方制剂及其制备方法 Download PDFInfo
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- CN104906127B CN104906127B CN201510296806.4A CN201510296806A CN104906127B CN 104906127 B CN104906127 B CN 104906127B CN 201510296806 A CN201510296806 A CN 201510296806A CN 104906127 B CN104906127 B CN 104906127B
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- China
- Prior art keywords
- pvp
- available iodine
- iodine content
- compound preparation
- content stability
- Prior art date
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 53
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 53
- 239000011630 iodine Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 53
- -1 PVP-I compound Chemical class 0.000 title claims abstract description 31
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 63
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 25
- 238000003756 stirring Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 14
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 208000010195 Onychomycosis Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical compound OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003918 potentiometric titration Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000005882 tinea unguium Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
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CN201510296806.4A CN104906127B (zh) | 2015-06-03 | 2015-06-03 | 一种有效碘含量稳定性增强的聚维酮碘复方制剂及其制备方法 |
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CN201510296806.4A CN104906127B (zh) | 2015-06-03 | 2015-06-03 | 一种有效碘含量稳定性增强的聚维酮碘复方制剂及其制备方法 |
Publications (2)
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CN104906127A CN104906127A (zh) | 2015-09-16 |
CN104906127B true CN104906127B (zh) | 2017-11-14 |
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CN201510296806.4A Active CN104906127B (zh) | 2015-06-03 | 2015-06-03 | 一种有效碘含量稳定性增强的聚维酮碘复方制剂及其制备方法 |
Country Status (1)
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Families Citing this family (1)
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CN112315974B (zh) * | 2020-11-16 | 2023-05-16 | 乐泰药业有限公司 | 一种稳定性增强的聚维酮碘溶液及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0940563A (ja) * | 1995-07-28 | 1997-02-10 | Nippon Kayaku Co Ltd | 褥瘡・皮膚潰瘍治療組成物 |
CN101229188A (zh) * | 2008-02-01 | 2008-07-30 | 郎伟君 | 一种治疗甲癣的外用药物 |
CN102335197A (zh) * | 2010-07-23 | 2012-02-01 | 北京施耐克生物制药有限公司 | 一种用于杀灭病毒的皮肤粘膜消毒剂 |
CN102550601A (zh) * | 2010-12-22 | 2012-07-11 | 昆明振华制药厂有限公司 | 一种碘伏消毒液及其制备方法 |
CN103548873A (zh) * | 2013-11-12 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | 一种医用手套专用灭菌溶液及其制备方法 |
-
2015
- 2015-06-03 CN CN201510296806.4A patent/CN104906127B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0940563A (ja) * | 1995-07-28 | 1997-02-10 | Nippon Kayaku Co Ltd | 褥瘡・皮膚潰瘍治療組成物 |
CN101229188A (zh) * | 2008-02-01 | 2008-07-30 | 郎伟君 | 一种治疗甲癣的外用药物 |
CN102335197A (zh) * | 2010-07-23 | 2012-02-01 | 北京施耐克生物制药有限公司 | 一种用于杀灭病毒的皮肤粘膜消毒剂 |
CN102550601A (zh) * | 2010-12-22 | 2012-07-11 | 昆明振华制药厂有限公司 | 一种碘伏消毒液及其制备方法 |
CN103548873A (zh) * | 2013-11-12 | 2014-02-05 | 镇江苏惠乳胶制品有限公司 | 一种医用手套专用灭菌溶液及其制备方法 |
Non-Patent Citations (1)
Title |
---|
聚维酮碘溶液稳定性的研究;郎轶咏 等;《中国医院药学杂志》;20080930;第28卷(第17期);第1523页右栏第1段-1525页左栏第3段 * |
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Effective date of registration: 20171009 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Applicant after: HARBIN KUAIHAO PHARMACEUTICAL CO.,LTD. Address before: 150025 Beijing Road, Limin economic and Technological Development Zone, Heilongjiang, Harbin Applicant before: LOCTITE HARBIN PHARMACEUTICAL Co.,Ltd. |
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Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20200730 Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Co-patentee after: Heilongjiang Letai Pharmaceutical Co.,Ltd. Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: Letai Pharmaceutical Co.,Ltd. |
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TR01 | Transfer of patent right | ||
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Address after: 150025 Zhuhai Road, Limin development area, Hulan District, Harbin, Heilongjiang, China Patentee after: Letai Pharmaceutical Co.,Ltd. Patentee after: Loctite Pharmaceutical (Lanxi) Co.,Ltd. Address before: 150025 Zhuhai Road, Limin development area, Hulan District, Harbin, Heilongjiang, China Patentee before: Letai Pharmaceutical Co.,Ltd. Patentee before: Heilongjiang Letai Pharmaceutical Co.,Ltd. |
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