CN104884076A - 利用了hmgb1片段的新型心肌梗塞的治疗方法 - Google Patents
利用了hmgb1片段的新型心肌梗塞的治疗方法 Download PDFInfo
- Publication number
- CN104884076A CN104884076A CN201380067948.2A CN201380067948A CN104884076A CN 104884076 A CN104884076 A CN 104884076A CN 201380067948 A CN201380067948 A CN 201380067948A CN 104884076 A CN104884076 A CN 104884076A
- Authority
- CN
- China
- Prior art keywords
- cell
- marrow
- hmgb1
- peptide
- positive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Abstract
Description
Claims (3)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012-235785 | 2012-10-25 | ||
JP2012235785 | 2012-10-25 | ||
PCT/JP2013/078758 WO2014065347A1 (ja) | 2012-10-25 | 2013-10-24 | Hmgb1断片を利用した新規心筋梗塞の治療法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104884076A true CN104884076A (zh) | 2015-09-02 |
CN104884076B CN104884076B (zh) | 2017-10-03 |
Family
ID=50544720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380067948.2A Active CN104884076B (zh) | 2012-10-25 | 2013-10-24 | 利用了hmgb1片段的心肌梗塞的治疗方法 |
Country Status (17)
Country | Link |
---|---|
US (1) | US9623078B2 (zh) |
EP (1) | EP2913058B1 (zh) |
JP (1) | JP6253589B2 (zh) |
KR (1) | KR102146815B1 (zh) |
CN (1) | CN104884076B (zh) |
AU (1) | AU2013335684B2 (zh) |
BR (1) | BR112015009037A2 (zh) |
CA (1) | CA2889275C (zh) |
DK (1) | DK2913058T3 (zh) |
ES (1) | ES2660420T3 (zh) |
HK (2) | HK1211488A1 (zh) |
MX (1) | MX361259B (zh) |
PL (1) | PL2913058T3 (zh) |
RU (1) | RU2647467C2 (zh) |
SG (1) | SG11201503236RA (zh) |
TR (1) | TR201802122T4 (zh) |
WO (1) | WO2014065347A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110494154A (zh) * | 2017-01-27 | 2019-11-22 | 斯特姆里姆有限公司 | 心肌病、陈旧性心肌梗塞及慢性心力衰竭的治疗剂 |
CN110612307A (zh) * | 2017-04-25 | 2019-12-24 | 盐野义制药株式会社 | 用于诱导组织再生的肽及其应用 |
CN113194978A (zh) * | 2018-10-05 | 2021-07-30 | 斯特姆里姆有限公司 | 具有间充质干细胞的动员活性的肽 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20160070169A (ko) | 2008-04-30 | 2016-06-17 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
CA2778759A1 (en) | 2009-10-28 | 2011-05-05 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
CA2834255C (en) | 2011-04-26 | 2021-11-02 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
TR201807769T4 (tr) | 2012-10-25 | 2018-06-21 | Genomix Co Ltd | HMGB1 fragmanı kullanılarak spinal kord yaralanmasının tedavi edilmesine yönelik yeni yöntem. |
BR112019020294A2 (pt) | 2017-04-07 | 2020-05-12 | StemRIM Inc. | Medicamento terapêutico para doença fibrótica |
EP3718561A4 (en) * | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapy for inflammatory bowel disease |
WO2019156137A1 (ja) | 2018-02-08 | 2019-08-15 | 株式会社ステムリム | 乾癬の治療薬 |
CN113423466A (zh) | 2018-10-25 | 2021-09-21 | 国立大学法人大阪大学 | 软骨病症的治疗剂 |
JP2023512392A (ja) | 2019-11-12 | 2023-03-27 | オックスフォード ユニバーシティ イノベーション リミテッド | 組織再生の促進に有用なhmgb1に関連するポリペプチド、それを含む組成物、及びその使用 |
RU2718912C1 (ru) * | 2019-12-24 | 2020-04-15 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт общей патологии и физиологии" (ФГБНУ "НИИОПП") | Способ лечения и профилактики инфаркта миокарда с патологией легких |
US20230173027A1 (en) | 2020-04-20 | 2023-06-08 | Shionogi & Co., Ltd. | Formulation containing hmgb1 partial peptide |
WO2022243932A1 (en) | 2021-05-19 | 2022-11-24 | Oxford University Innovation Limited | Polypeptides related to hmgb1 useful for promoting tissue regeneration, compositions comprising same, and uses thereof |
WO2024005133A1 (ja) * | 2022-06-30 | 2024-01-04 | 国立大学法人大阪大学 | 半月板の治療薬 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3018313B2 (ja) * | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
CN1516739A (zh) * | 2001-05-15 | 2004-07-28 | ����������̫���о�ѧԺ | 利用hmg片段作为抗炎症试剂 |
CN1671742A (zh) * | 2002-07-03 | 2005-09-21 | 塔博尔山圣拉弗尔基金中心 | Hmgb1在治疗组织损伤和/或促进组织修复中的用途 |
WO2007130725A2 (en) * | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
CN102443064A (zh) * | 2011-11-03 | 2012-05-09 | 刘誉 | 一种基于凝血酶活性的双靶向作用的嵌合多肽及其应用 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5238680B2 (zh) | 1972-12-27 | 1977-09-30 | ||
US5658894A (en) | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
US5661127A (en) * | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
AU778386B2 (en) | 1999-07-28 | 2004-12-02 | Board Of Trustees Of The Leland Stanford Junior University | Nicotine receptor agonists in stem cell and progenitor cell recruitment |
EP1114862A3 (de) | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen |
JP2004500095A (ja) | 2000-02-24 | 2004-01-08 | エクサイト セラピーズ, インコーポレイテッド | 細胞の同時の刺激および濃縮 |
JP3421741B2 (ja) | 2000-05-18 | 2003-06-30 | 筑波大学長 | 人工骨髄、血球細胞の増殖方法 |
ITMI20010562A1 (it) | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
EP1390058A2 (en) | 2001-04-30 | 2004-02-25 | Switch Biotech Aktiengesellschaft | Mrp8/mrp14 heterodimer, or its individual components in combination, for treating and/or preventing skin diseases, wounds and/or wound-healing disturbances |
DE10121254A1 (de) | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | MRP8/MRP14 Heterodimers oder seiner Einzelkomponenten alleine oder in Kombination zur Behandlung und/oder Prävention von Hauterkrankungen, Wunden und/oder Wundheilungsstörungen, die durch eine verringerte Menge an MRP8/MRP14 Heterodimeren gekennzeichnet sind |
US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
CN100484569C (zh) | 2001-11-19 | 2009-05-06 | 协和发酵工业株式会社 | 将多潜能干细胞从组织中流通到外周血的药物 |
EP1572071B1 (en) | 2001-12-07 | 2018-10-03 | Cytori Therapeutics, Inc. | Methods for preparing fresh adipose tissue-derived cells and uses in treating patients |
EP1519749B1 (en) | 2002-07-05 | 2009-04-08 | Universite Laval | Chemotactic factor inhibitor for inhibiting inflammatory reactions |
GB0226251D0 (en) | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
NZ540067A (en) | 2002-11-20 | 2007-05-31 | Critical Therapeutics Inc | A purified preparation of antibodies that specifically bind to a high mobility group box protein (HMGB) B box but do not specifically to non-B box epitopes of HMGB |
WO2004061456A2 (de) | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Verwendungen von hmgb, hmgn, hmga proteinen |
WO2004075855A2 (en) | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
WO2004084928A1 (en) | 2003-03-28 | 2004-10-07 | UNIVERSITé LAVAL | S100 protein as neutrophil activator for alleviating neutropenia in cancer treatment |
US20050014255A1 (en) | 2003-05-29 | 2005-01-20 | Board Of Regents, The University Of Texas System | Stem cells for clinical and commercial uses |
WO2005025604A2 (en) | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Use of hmgb and hmgb fragments to decrease specific immune response |
ITRM20040058A1 (it) | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
US20090062187A1 (en) | 2004-07-20 | 2009-03-05 | Marco Bianchi | Use of Hmgb1 for Wound Healing |
MX2007001155A (es) | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
BRPI0514835A (pt) | 2004-09-03 | 2008-06-24 | Creabilis Therapeutics Spa | variante de polipetìdeo de box de domìnio de ligação por alta afinidade de hmbg1 humano e/ou não humano ou de fragmento biologicamente ativo de box-a de hmgb1, molécula de ácido nucléico, uso, composição farmacêutica e dispositivo médico |
KR100593397B1 (ko) | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 p 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
WO2006047820A1 (en) | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Use of calgranulin a and b in the promotion and inhibition of mineralized tissue formation |
ITRM20050032A1 (it) | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
WO2006080434A1 (ja) | 2005-01-27 | 2006-08-03 | Japan Health Sciences Foundation | 間葉系幹細胞を含む細胞シート |
DK1893253T3 (da) | 2005-03-23 | 2010-08-16 | Biosafe Sa | Integreret system til opsamling, forarbejdning og transplantation af celledelmængder, omfattende voksenstamceller til regenerativ medicin |
WO2006114805A2 (en) | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
WO2007015546A1 (ja) | 2005-08-04 | 2007-02-08 | Genomix Co., Ltd | 間葉系幹細胞誘導剤及び組織再生促進剤並びに間葉系幹細胞の調製方法 |
WO2007031100A1 (en) | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
JP4982739B2 (ja) | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | ポリグルタミン病の予防・治療剤 |
US8496931B2 (en) | 2006-08-11 | 2013-07-30 | Medarex, Inc. | Monoclonal antibodies against stromal derived factor-1 (SDF-1) |
CN101374538A (zh) | 2006-10-30 | 2009-02-25 | 吉诺米克斯股份有限公司 | 损伤组织的功能再生促进药物 |
KR20160070169A (ko) | 2008-04-30 | 2016-06-17 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
AU2009240885A1 (en) | 2008-04-30 | 2009-11-05 | Genomix Co., Ltd. | Pharmaceutical agent for promoting the functional regeneration of damaged tissue |
RU2519714C2 (ru) | 2008-04-30 | 2014-06-20 | Дженомикс Ко., Лтд. | Средство для вовлечения происходящей из костного мозга плюрипотентной стволовой клетки в периферический кровоток |
WO2011046570A1 (en) | 2009-10-16 | 2011-04-21 | The University Of Medicine And Dentistry Of New Jersey | Method for treating chronic nerve tissue injury using a cell therapy strategy |
CA2778759A1 (en) | 2009-10-28 | 2011-05-05 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
CA2834255C (en) * | 2011-04-26 | 2021-11-02 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
TR201807769T4 (tr) | 2012-10-25 | 2018-06-21 | Genomix Co Ltd | HMGB1 fragmanı kullanılarak spinal kord yaralanmasının tedavi edilmesine yönelik yeni yöntem. |
-
2013
- 2013-10-24 AU AU2013335684A patent/AU2013335684B2/en active Active
- 2013-10-24 WO PCT/JP2013/078758 patent/WO2014065347A1/ja active Application Filing
- 2013-10-24 CA CA2889275A patent/CA2889275C/en active Active
- 2013-10-24 DK DK13849289.7T patent/DK2913058T3/en active
- 2013-10-24 ES ES13849289.7T patent/ES2660420T3/es active Active
- 2013-10-24 BR BR112015009037A patent/BR112015009037A2/pt not_active Application Discontinuation
- 2013-10-24 PL PL13849289T patent/PL2913058T3/pl unknown
- 2013-10-24 TR TR2018/02122T patent/TR201802122T4/tr unknown
- 2013-10-24 MX MX2015005252A patent/MX361259B/es active IP Right Grant
- 2013-10-24 JP JP2014543334A patent/JP6253589B2/ja active Active
- 2013-10-24 RU RU2015119517A patent/RU2647467C2/ru active
- 2013-10-24 CN CN201380067948.2A patent/CN104884076B/zh active Active
- 2013-10-24 SG SG11201503236RA patent/SG11201503236RA/en unknown
- 2013-10-24 US US14/436,906 patent/US9623078B2/en active Active
- 2013-10-24 KR KR1020157013590A patent/KR102146815B1/ko active IP Right Grant
- 2013-10-24 EP EP13849289.7A patent/EP2913058B1/en active Active
-
2015
- 2015-12-17 HK HK15112430.6A patent/HK1211488A1/zh unknown
-
2016
- 2016-01-25 HK HK16100782.4A patent/HK1212887A1/zh unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3018313B2 (ja) * | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
EP0791601B1 (en) * | 1996-02-23 | 2005-04-27 | Snow Brand Milk Products Co., Ltd. | An agent promoting bone formation and inhibiting bone resorption |
CN1516739A (zh) * | 2001-05-15 | 2004-07-28 | ����������̫���о�ѧԺ | 利用hmg片段作为抗炎症试剂 |
CN1671742A (zh) * | 2002-07-03 | 2005-09-21 | 塔博尔山圣拉弗尔基金中心 | Hmgb1在治疗组织损伤和/或促进组织修复中的用途 |
WO2007130725A2 (en) * | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
CN102443064A (zh) * | 2011-11-03 | 2012-05-09 | 刘誉 | 一种基于凝血酶活性的双靶向作用的嵌合多肽及其应用 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110494154A (zh) * | 2017-01-27 | 2019-11-22 | 斯特姆里姆有限公司 | 心肌病、陈旧性心肌梗塞及慢性心力衰竭的治疗剂 |
CN110494154B (zh) * | 2017-01-27 | 2023-09-29 | 斯特姆里姆有限公司 | 心肌病、陈旧性心肌梗塞及慢性心力衰竭的治疗剂 |
US11969459B2 (en) | 2017-01-27 | 2024-04-30 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
CN110612307A (zh) * | 2017-04-25 | 2019-12-24 | 盐野义制药株式会社 | 用于诱导组织再生的肽及其应用 |
CN110612307B (zh) * | 2017-04-25 | 2023-02-14 | 盐野义制药株式会社 | 用于诱导组织再生的肽及其应用 |
CN113194978A (zh) * | 2018-10-05 | 2021-07-30 | 斯特姆里姆有限公司 | 具有间充质干细胞的动员活性的肽 |
CN113194978B (zh) * | 2018-10-05 | 2024-03-08 | 斯特姆里姆有限公司 | 具有间充质干细胞的动员活性的肽 |
Also Published As
Publication number | Publication date |
---|---|
EP2913058B1 (en) | 2017-12-20 |
MX361259B (es) | 2018-11-30 |
KR20150103660A (ko) | 2015-09-11 |
DK2913058T3 (en) | 2018-02-19 |
HK1212887A1 (zh) | 2016-06-24 |
AU2013335684A1 (en) | 2015-05-14 |
EP2913058A4 (en) | 2016-04-13 |
RU2015119517A (ru) | 2016-12-20 |
SG11201503236RA (en) | 2015-06-29 |
JPWO2014065347A1 (ja) | 2016-09-08 |
CA2889275C (en) | 2021-06-15 |
TR201802122T4 (tr) | 2018-03-21 |
MX2015005252A (es) | 2015-10-29 |
US20150273017A1 (en) | 2015-10-01 |
EP2913058A1 (en) | 2015-09-02 |
PL2913058T3 (pl) | 2018-04-30 |
RU2647467C2 (ru) | 2018-03-15 |
US9623078B2 (en) | 2017-04-18 |
ES2660420T3 (es) | 2018-03-22 |
WO2014065347A1 (ja) | 2014-05-01 |
CA2889275A1 (en) | 2014-05-01 |
BR112015009037A2 (pt) | 2017-11-14 |
CN104884076B (zh) | 2017-10-03 |
AU2013335684B2 (en) | 2017-06-29 |
HK1211488A1 (zh) | 2016-05-27 |
KR102146815B1 (ko) | 2020-08-21 |
JP6253589B2 (ja) | 2017-12-27 |
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