CN104799002A - Feed additive for treating goat urolithiasis and preparation method thereof - Google Patents
Feed additive for treating goat urolithiasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a feed additive for treating goat urolithiasis and a preparation method thereof. The feed additive comprises the following raw medicinal materials: moupin dutchmanspipe stem or root, lacmus, desmodium styracifolium, ficus tikoua, juncus effuses, cucumber stem, muskroot-like semiaquilegia root, common aeschynomene stem-xylem, sinosenecio oldhamianus, medical stone, common triumfetta root, otolithum sciaenae, bighead atractylodes rhizome, argy wormwood fruit, placenta hominis, syngnathus schlegeli, liquorice, rhizoma polygonati, whiteflower cacalia seed and ulva lactuca. The feed additive has the beneficial effects that the feed additive disclosed by the invention has the main effects of clearing away heat and removing dampness, relieving stranguria by diuresis, strengthening spleen and warming kidney and tonifying Yang and removing calculi, has the auxiliary effects of invigorating spleen and replenishing qi and dispersing blood stasis and removing calculi and has the advantages of good treatment effect, a good curative effect, no toxic or side effects, difficulty in relapse and the like.
Description
Technical field
The present invention relates to livestock and poultry animal feed addictive, be particularly a kind ofly used for the treatment of feed addictive of goat uriasis and preparation method thereof.
Background technology
Goat uriasis, refers to that saline crystallization in urinary tract condenses into not of uniform size, quantity coagulation not etc., stimulates urinary tract mucous membrane and the hemorrhagic inflammation that causes and ureteral obstruction disease.Clinically with stomachache, urination disorder and blood urine are feature.This disease mainly betides he-goat.
The origin cause of formation of urinary calculi generally believes it is result with the general disorder of mineral metabolism under urinary organ pathological state, and relevant with following factors.1. the feed of high calcium, low-phosphorous and Silicon-rich, rich phosphorus: the feed that Long-term Feeding high calcium is low-phosphorous and drinking-water, can promote that urinary calculi is formed.The Liaoning Cashmere Goat of Long-term Feeding soya-bean cake, very easily forms ceramuria calculus.2. drinking-water lacks: the formation of urinary calculi is dewatered relevant with body.Therefore, subimbition is the key factor that urinary calculi is formed, and as heat, subimbition, dehydration in various degree appears in body, salt density in urine is increased, impels the formation of urinary calculi.3. VAD: VAD can cause urothelium to organize angling, promotes that urinary calculi is formed.4. infective agent.When kidney and urinary tract infections inflammation, inflammatory products, the epithelial cell come off and accumulation of bacteria, can become the core substance that urinary calculi is formed.5. other factors.Hyperparathyroidism, the retention of long term periodicities urine, widely applies sulfa drugs etc. all can promote the formation of urinary calculi.
The main manifestations suffering from uriasis goat is: ill domestic animal dysuria, posture of again and again urinating, fork leg, hogback, and contracting abdomen lifts tail, and vaginal orifice is twitched, and exerts duty, whinnies, wire or put drop-wise discharge and be mixed with the red urine that pus and blood clotting determine.When calculus blocks urinary tract, the urine stream that ill domestic animal is discharged attenuates or anuria is discharged and the retention of urine occurs.Because obstructive position is different with degree of congestion, its clinical symptoms also have different.When calculus is positioned at renal plevis, many in pyelitis symptom, there is blood urine.During severe obstruction, have nephredema, ill domestic animal pain over renal region, fortune step is strong arrests, and gait is nervous.When calculus travels to ureter and occurs to block, ill domestic animal stomachache is violent.Palpation in rectum, the ureter of the tangible nearly kidney end to its blockage is significantly nervous and expand.During vesical calculus, can occur painful frequent micturition, ill domestic animal groan when urinating, stomach wall shrinks.Urethral calculus, when urethra incomplete obstruction, urinate misery and urination time of ill domestic animal extends, and urine be drop-wise or wire outflow, sometimes has blood urine.When urethra gets clogged completely, then occur renal shutdown or kidney stomachache phenomenon, sick sheep lifts tail again and again, makes micturition repeatly but anuria discharge.Urinary tract is visited to examine and can be touched position, urinary calculi place, and the outside palpation of urethra, ill domestic animal has pain.In rectum during palpation, in bladder, urine is full of, and volume increases.If long-term renal shutdown, uremia can be caused or cystorrhexis occurs.When calculus does not cause stimulation and blocking action, often do not manifest any clinical symptoms.
At present, several mode below the many employings for the treatment of goat uriasis: physical treatment, drug therapy and operative treatment, physical treatment many employings water rinses, catheter is sterilized, and embrocates lubricant, slowly inserts urethra or bladder, inject sterilised liq, repeatedly rinse, but be only applicable to Powdered or grains of sand shape urinary calculi, and index is not effected a permanent cure; Drug therapy Chinese medicine many employings Paishi Tang, Western medicine many employings urethra muscle relaxant, but result for the treatment of is unsatisfactory; Operative treatment: be used for the ill goat that urinary calculi is blocked in bladder or urethra, but there is infection hidden danger in operative treatment, and treatment is inconvenient.
Summary of the invention
For prior art Problems existing, the invention provides a kind of feed addictive being used for the treatment of goat uriasis, based on removing damp-heat, promoting diuresis for stranguria, invigorate the spleen and warm the kidney, establishing-Yang fossil, to invigorate the spleen and benefit qi, stagnation resolvation row Shi Weifu, treatment goat uriasis has that result for the treatment of is good, curative effect is short, has no side effect, the not easily advantage such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of feed addictive being used for the treatment of goat uriasis, described feed addictive comprises following raw medicinal material: Huaihe River is logical, reindeer moss, Desmodium styracifolium, digua fig stem and leaf, rush, cucumber stem, radix semiaquilegiae, common aeschynomene stem-xylem, Pu Konjac, medical stone, common triumfetta root, Yellow Croaker Ear-stone, the bighead atractylodes rhizome, Ai Shi, dried human placenta, sea otter, Radix Glycyrrhizae, sealwort, whiteflower cacalia seed and sea lettuce.
Described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 20-34 weight portion, reindeer moss 15-28 weight portion, Desmodium styracifolium 13-25 weight portion, digua fig stem and leaf 10-18 weight portion, rush 20-34 weight portion, cucumber stem 17-30 weight portion, radix semiaquilegiae 13-24 weight portion, common aeschynomene stem-xylem 11-18 weight portion, Pu Konjac 12-20 weight portion, medical stone 18-32 weight portion, common triumfetta root 15-31 weight portion, Yellow Croaker Ear-stone 16-30 weight portion, bighead atractylodes rhizome 8-15 weight portion, end real 10-18 weight portion, dried human placenta 10-20 weight portion, sea otter 11-19 weight portion, Radix Glycyrrhizae 15-30 weight portion, sealwort 13-25 weight portion, whiteflower cacalia seed 11-15 weight portion and sea lettuce 10-19 weight portion.
Described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion and sea lettuce 14 weight portion.
Described feed addictive also comprises safflower, amaranth reality, tawny daylily and glossy ganoderma.
Described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 20-34 weight portion, reindeer moss 15-28 weight portion, Desmodium styracifolium 13-25 weight portion, digua fig stem and leaf 10-18 weight portion, rush 20-34 weight portion, cucumber stem 17-30 weight portion, radix semiaquilegiae 13-24 weight portion, common aeschynomene stem-xylem 11-18 weight portion, Pu Konjac 12-20 weight portion, medical stone 18-32 weight portion, common triumfetta root 15-31 weight portion, Yellow Croaker Ear-stone 16-30 weight portion, bighead atractylodes rhizome 8-15 weight portion, end real 10-18 weight portion, dried human placenta 10-20 weight portion, sea otter 11-19 weight portion, Radix Glycyrrhizae 15-30 weight portion, sealwort 13-25 weight portion, whiteflower cacalia seed 11-15 weight portion, sea lettuce 10-19 weight portion, safflower 15-30 weight portion, the real 18-25 weight portion of amaranth, tawny daylily 10-20 weight portion and glossy ganoderma 15-30 weight portion.
Described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion, sea lettuce 14 weight portion, safflower 23 weight portion, real 21 weight portions of amaranth, tawny daylily 15 weight portion and glossy ganoderma 23 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the feed addictive of goat uriasis, its preparation method comprises:
The first step, mixes described raw medicinal material in proportion, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filter residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, reduced pressure concentration, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, mixes and obtains powder.
The invention has the beneficial effects as follows: feed addictive of the present invention is based on removing damp-heat, promoting diuresis for stranguria, invigorate the spleen and warm the kidney, establishing-Yang fossil, to invigorate the spleen and benefit qi, stagnation resolvation row Shi Weifu, treatment goat uriasis has that result for the treatment of is good, curative effect is short, has no side effect, the not easily advantage such as recurrence.
Detailed description of the invention
The invention provides a kind of feed addictive being used for the treatment of goat uriasis, comprise following raw medicinal material: Huaihe River is logical, reindeer moss, Desmodium styracifolium, digua fig stem and leaf, rush, cucumber stem, radix semiaquilegiae, common aeschynomene stem-xylem, Pu Konjac, medical stone, common triumfetta root, Yellow Croaker Ear-stone, the bighead atractylodes rhizome, Ai Shi, dried human placenta, sea otter, Radix Glycyrrhizae, sealwort, whiteflower cacalia seed and sea lettuce.Wherein, Huaihe River is logical, reindeer moss, Desmodium styracifolium removing damp-heat, rush, cucumber stem, radix semiaquilegiae promoting diuresis for stranguria, and medical stone, common triumfetta root, Yellow Croaker Ear-stone diuresis fossil are monarch drug in a prescription; Digua fig stem and leaf, whiteflower cacalia seed heat-clearing, dampness removing, invigorate blood circulation, detoxify, common aeschynomene stem-xylem, Pu Konjac heat-clearing, dampness removing, treating stranguria, be ministerial drug, the bighead atractylodes rhizome, Ai Shi, dried human placenta, sea otter warming kidney to invigorate yang, Radix Glycyrrhizae, sealwort are invigorated the spleen and benefited qi, and whiteflower cacalia seed, sea lettuce stagnation resolvation row stone are all ministerial drug, Radix Glycyrrhizae Qi-benefiting and heart-nourishing, coordinating the drug actions of a prescription is adjuvant, and full side organically combines, complement each other, play the effect of removing damp-heat, promoting diuresis for stranguria, diuresis fossil altogether, clinical effectiveness is good, is worthy of further application.Preferably, can also comprise that safflower, amaranth are real, tawny daylily and glossy ganoderma, safflower is promoting blood circulation and removing blood stasis, the real smoothening secretion of amaranth, the cooling blood and hemostasis of tawny daylily reducing fever and causing diuresis, and, reindeer moss logical with Huaihe River, Desmodium styracifolium are monarch drug in a prescription altogether, and glossy ganoderma invigorating qi for tranquilization is adjuvant with Radix Glycyrrhizae altogether.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Huaihe River leads to: bitter, cold.Function cures mainly: clearing heat and promoting diuresis, and row is breast under water, apocenosis pain relieving.For difficult urination, oedema, urinary tract infections, Trichomonas vaginalis, rheumatic arthritis, eczema, nettle rash, carbuncle swells.
Reindeer moss: salty, cold.Function cures mainly: removing damp-heat, analgesia, cooling blood and hemostasis.Cure mainly knife wound, rheumatalgia, hemoptysis, headache, antimigraine.
Desmodium styracifolium: sweet, light, cool.Return liver, kidney, urinary bladder channel.Function cures mainly: removing damp-heat, inducing diuresis for treating strangurtia.Drench for heat, sand drenches, urolithiasis, difficulty and pain in micturition, oedema oliguria, and jaundice urine is red, lithangiuria.
Digua fig stem and leaf: bitter; Cold in nature.Function cures mainly: clearing heat and promoting diuresis; Promoting blood circulation and removing obstruction in channels; Removing toxicity for detumescence.Main cough with lung heat; Dysentery; Oedema; Yellow subcutaneous ulcer; Children's indigestion; Rheumatalgia pain; Through closing; Under band; Traumatic injury; Hemorrhoid hemorrhage; Nameless sores or boils
Rush: sweet, light, is slightly cold.The thoughts of returning home, lung, small intestinl channel.Function cures mainly: clearing away the heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphthae.
Cucumber stem: bitter; Cool in nature.The thoughts of returning home; Lung.Function cures mainly: heat-clearing; Reduce phlegm; Dampness removing; Removing toxic substances.Main phlegm-heat cough; Epilepsy; Damp-heat dysentery; Multiple abscess with damp phlegm; Sore and toxic; High blood pressure.
Radix semiaquilegiae: sweet, bitter, cold.Return liver, stomach warp.Function cures mainly: clearing heat and detoxicating, dispersing swelling and dissipating binds.To swell furunculosis for carbuncle, acute mastitis, scrofula, venomous snake bite.
Common aeschynomene stem-xylem: light, micro-hardship; Cool; Flat.Return liver; Urinary bladder channel.Function cures mainly: heat-clearing, diuresis, logical breast, improving eyesight.Main heat is drenched, difficult urination, oedema, alactation, yctalopia.
Pu Konjac: another name: cattail pollen root (" galactopoiesis collection proved recipe "), Pu bamboo shoot (" daily book on Chinese herbal medicine "), Pu root (" edible wild herbs spectrum "), rush bag grass roots (" Chinese herbal medicine is commonly used in Shanghai ").Source: be Typhaceae plant
typha angustataor it belongs to various plants together
with the rhizome of the tender stem of part.Spring excavates.Sweet, cool.Function cures mainly: clearing heat and cooling blood, inducing diuresis for removing edema.Control pregnant woman Lao Re, vaginal bleeding with fetal movement, quench one's thirst, aphtha, hot dysentery, gonorrhoea, leukorrhea, oedema, scrofula.
Medical stone: sweet; Temperature; Nontoxic.Return liver; Stomach; Kidney channel.Function cures mainly: detoxicating and resolving a mass; Remove necrosis and promote granulation; Except cold clearing damp; Benefit liver and strengthening stomach; Promoting blood circulation and removing blood stasis; Diuresis fossil; Promote longevity.Main ulcer carbuncle on the back; Acne; Eczema; Beriberi; Prickly heat; Finger is chapped; Chloasma; Toothache; Canker sore; Arthralgia due to wind-dampness; Lumbago; Chronic hepatitis; Gastritis; Dysentery; Diabetes; Neurasthenia; Wound is red and swollen; Hypertension; Senile vascular sclerosis; Tumour; Lithangiuria.
Common triumfetta root: bitter, cold.Function cures mainly: diuresis fossil.Control urolithiasis, cold anemopyretic illness that has not attacked the vital organs of the human body.
Yellow Croaker Ear-stone: sweet, salty, cold.Function cures mainly: diuresis, row's stone.For lithangiuria, difficult urination, separates wild gill fungus poison.Otitis media suppurative and rhinitis are controlled in external application.
The bighead atractylodes rhizome: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, and hidroschesis is antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.Rhizoma Atractylodis Macrocephalae invigorating the spleen, and stomach, antiabortive.Few for insufficiency of the spleen food, loose stool of having loose bowels, fetal irritability.
Ai Shi: bitter; Pungent; Warm in nature.Function cures mainly: warming kidney to invigorate yang.The main soreness of waist of suffering from a deficiency of the kidney; Cold in the deficiency of yang.
Dried human placenta: sweet, salty, temperature.The thoughts of returning home, lung, kidney channel.Function cures mainly: warm kidney mends essence, nourishing qi and blood.Thin thin for consumptive disease, hectic fever due to yin night sweat, cough and asthma, food weak breath is short, impotence and seminal emission, infertile few breast.
Sea otter: sweet, temperature.Return liver, kidney channel.Function cures mainly: warming kidney to invigorate yang, mass dissipating and swelling eliminating.For impotence and seminal emission, a lump in the abdomen causing distension and pain, scrofula subcutaneous nodule, injury from falling down; Control carbuncle outward to swell furunculosis.
Radix Glycyrrhizae: sweet, flat.The thoughts of returning home, lung, spleen, stomach warp.Function cures mainly: invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Sealwort: sweet is flat.Return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.For weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, and deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, interior heat is quenched one's thirst.
Whiteflower cacalia seed: bitter; Cool cold.The thoughts of returning home; Spleen; Kidney channel.Function cures mainly: clearing away heat and eliminating dampeness, blood stasis removing analgesic.Main anemopyretic cold, dysentery stranguria with turbid discharge, hiccup, carbuncle swells, sore tinea, traumatic injury, venomous snake bite
Sea lettuce: sweet; Salty; Cold; Flat.Enter kidney channel.Function cures mainly: inducing diuresis for removing edema; Softening and eliminating sputum; Clearing heat and detoxicating.Main oedema; Enlarged lymph nodes of neck; Goiter and tumor; Hypertension; Laryngitis; Sore furuncle; Acute and chronic enterogastritis; Infantile malnutrition due to digestive disturbances or intestinalparasites disease
Safflower: enter the heart, Liver Channel.Function cures mainly: promoting blood circulation and removing blood stasis, loose Yu Kaijie.Control troubled thoughts pent-up, chest diaphragm ruffian is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women is through closing, and postpartum blood stasis is suffered from abdominal pain, tumbling and swelling.
Amaranth is real: sweet; Cold in nature.Return liver; Large intestine; Wing takes off warp.Function cures mainly: clear liver and improve vision; Smoothening secretion.Main glaucoma ocular; Poor vision; Gonorrhoea blood urine; Two are not just
Tawny daylily: sweet is cool.Function cures mainly: reducing fever and causing diuresis, cooling blood and hemostasis.For mumps, jaundice, cystitis, hematuria, difficult urination, agalactosis, irregular menstruation, bleeding from five sense organs or subcutaneous tissue, has blood in stool.Mastitis is controlled in external application.
Glossy ganoderma: sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Function cures mainly: invigorating qi for tranquilization, relieving cough and asthma.For dizzy egersis, palpitation, consumptive disease is coughed and is breathed heavily.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
Embodiments provide one and be used for the treatment of goat uriasis Chinese medicine composition, it is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion and sea lettuce 14 weight portion.
Preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly diacolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the lotion of 1.07, spraying dry, the EAT 165 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes particle, in 45 DEG C of dryings, obtains granule.
Embodiment 2 powder
Embodiments provide one and be used for the treatment of goat uriasis feed addictive, it is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion, sea lettuce 14 weight portion, safflower 23 weight portion, real 21 weight portions of amaranth, tawny daylily 15 weight portion and glossy ganoderma 23 weight portion.
Preparation method is:
The first step, mixes described raw medicinal material in proportion, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 9 hours, with slow fire boiling, decocting time is 4 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;
3rd step, filters second step the filter residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second filtrate, and the quality of the water added is 3 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, reduced pressure concentration, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, mixes and obtains powder.
Embodiment 3 injection
Embodiments provide one and be used for the treatment of goat uriasis Chinese medicine composition, it is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 34 weight portions, reindeer moss 28 weight portion, Desmodium styracifolium 25 weight portion, digua fig stem and leaf 10 weight portion, rush 20 weight portion, cucumber stem 30 weight portion, radix semiaquilegiae 13 weight portion, common aeschynomene stem-xylem 11 weight portion, Pu Konjac 20 weight portion, medical stone 18 weight portion, common triumfetta root 31 weight portion, Yellow Croaker Ear-stone 16 weight portion, the bighead atractylodes rhizome 8 weight portion, real 10 weight portions of Chinese mugwort, dried human placenta 20 weight portion, sea otter 19 weight portion, Radix Glycyrrhizae 15 weight portion, sealwort 25 weight portion, whiteflower cacalia seed 15 weight portion, sea lettuce 19 weight portion, safflower 15 weight portion, real 25 weight portions of amaranth, tawny daylily 10 weight portion and glossy ganoderma 30 weight portion.
Its preparation method is:
The first step, described raw medicinal material is mixed in proportion, put into micronizer and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains ethanolic solution, ethanolic solution is left standstill 30 hours under the condition of 8 DEG C, adopt percolation with the speed of 1ml per minute slowly diacolation, collect percolate, concentrated and dry, and put into micronizer pulverizing 50 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 2g that second step obtains, adds sodium chloride 100g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.23 μm of filtering with microporous membrane; Packing embedding, every bottle of 250ml, sterilizing.
Toxicity test
With the powder of the embodiment of the present invention 2 for object, give dispensing in white mouse large intestine, observe 7 for 150 times of dog consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other bad reaction.Toxicity test proves, the not toxic effect of this medicine and bad reaction, clinical practice is safe and reliable.
The powder of the embodiment of the present invention 2 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mouse, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of medicine of the present invention to mouse all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Contrast test
Shandong animal husbandry plant, in November, 2013 goes wrong due to the feed for goat bought, and causes the urinary calculus symptom that 540 he-goats nearly all occur in various degree, there is dysuria in ill goat, frequent posture of urinating, fork leg, hogback, contracting abdomen, lift tail, vaginal orifice is twitched, and exerts duty, whinny, serious wire or the some drop-wise of have also appeared discharges the red urine being mixed with pus and blood clotting and determining.Palpation in rectum, tangible to stone location, in bladder, urine is full of, and volume increases, and changes conventional feed immediately after there is symptom, eliminates problem feed.
Choose 400 ill he-goats of making a definite diagnosis (getting rid of ill very serious individually, the ill goat of complete obstructive urinary calculus), at random 400 ill goats are divided into four experimental group, are respectively embodiment group 1, embodiment group 2, embodiment group 3 and control group.Wherein, embodiment group 1 uses the embodiment of the present invention 1 granule to treat, every day three times, presses 0.2g/kg(body weight for every at every turn), be dissolved in drinking water or be mixed in daily ration, continuously treatment 1-3 days; Embodiment group 2 uses the powder of the embodiment of the present invention 2 to treat, and every day three times, is mixed in feed according to the weight ratio of 5:100 at every turn, continuously treatment 1-3 days; Embodiment group 3 uses the powder needle injection of the embodiment of the present invention 3 to treat, hypodermic injection once a day, each 0.02g/kg(body weight), continuously treatment 1-3 days, observes treatment results, as shown in Table 1 and Table 2.Wherein, the symptoms such as ill goat dysuria all disappear, and mental status, appetite are completely normally recovery from illness, and ill goat urinates than smoothly, but still to there is the situation of slightly suppressing urine be effective, and symptom is invalid without any alleviating.
Table 1 each experimental group treatment results table of comparisons only
As can be seen from the data of table 1, use the drug therapy goat uriasis of embodiment of the present invention 1-3 have effective, the advantage such as have no side effect.Follow up a case by regular visits to the goat that half a year, embodiment group 1-3 fully recovered and do not occur rebound phenomenon.
The each experimental group recovery from illness of table 2 and the table of comparisons of time are only (%)
As can be seen from the data of table 2, use the advantage that the drug therapy goat uriasis tool curative effect of embodiment of the present invention 1-3 is fast.
Model case
The individual raiser of certain goat, in March, 2014, shout when having 20 to occur urinating in 23 he-goats raised, the symptom of pain uneasiness, and urinate in dripping shape, from continuing about 5 days, inquiry of coming is examined, after inspection, find that most ill he-goat is above the s sigmoid portion or glans penis of yin channel, there is calculus, but do not block completely, choose wherein 10 ill goats, the powder of the embodiment of the present invention 2 is used to treat, every day three times, be mixed in feed according to the weight ratio of 5:100 at every turn, continuous treatment 1-3 days, treatment first day 5 goat symptoms are clearly better, continual cure two days, 10 goats are all fully recovered.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. be used for the treatment of the feed addictive of goat uriasis, it is characterized in that, described feed addictive comprises following raw medicinal material: Huaihe River is logical, reindeer moss, Desmodium styracifolium, digua fig stem and leaf, rush, cucumber stem, radix semiaquilegiae, common aeschynomene stem-xylem, Pu Konjac, medical stone, common triumfetta root, Yellow Croaker Ear-stone, the bighead atractylodes rhizome, Ai Shi, dried human placenta, sea otter, Radix Glycyrrhizae, sealwort, whiteflower cacalia seed and sea lettuce.
2. the feed addictive being used for the treatment of goat uriasis according to claim 1, it is characterized in that, described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 20-34 weight portion, reindeer moss 15-28 weight portion, Desmodium styracifolium 13-25 weight portion, digua fig stem and leaf 10-18 weight portion, rush 20-34 weight portion, cucumber stem 17-30 weight portion, radix semiaquilegiae 13-24 weight portion, common aeschynomene stem-xylem 11-18 weight portion, Pu Konjac 12-20 weight portion, medical stone 18-32 weight portion, common triumfetta root 15-31 weight portion, Yellow Croaker Ear-stone 16-30 weight portion, bighead atractylodes rhizome 8-15 weight portion, end real 10-18 weight portion, dried human placenta 10-20 weight portion, sea otter 11-19 weight portion, Radix Glycyrrhizae 15-30 weight portion, sealwort 13-25 weight portion, whiteflower cacalia seed 11-15 weight portion and sea lettuce 10-19 weight portion.
3. the feed addictive being used for the treatment of goat uriasis according to claim 1 and 2, it is characterized in that, described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion and sea lettuce 14 weight portion.
4. the feed addictive being used for the treatment of goat uriasis according to any one of claim 1-3, is characterized in that, described feed addictive also comprises safflower, amaranth reality, tawny daylily and glossy ganoderma.
5. the feed addictive being used for the treatment of goat uriasis according to any one of claim 1-4, it is characterized in that, described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 20-34 weight portion, reindeer moss 15-28 weight portion, Desmodium styracifolium 13-25 weight portion, digua fig stem and leaf 10-18 weight portion, rush 20-34 weight portion, cucumber stem 17-30 weight portion, radix semiaquilegiae 13-24 weight portion, common aeschynomene stem-xylem 11-18 weight portion, Pu Konjac 12-20 weight portion, medical stone 18-32 weight portion, common triumfetta root 15-31 weight portion, Yellow Croaker Ear-stone 16-30 weight portion, bighead atractylodes rhizome 8-15 weight portion, end real 10-18 weight portion, dried human placenta 10-20 weight portion, sea otter 11-19 weight portion, Radix Glycyrrhizae 15-30 weight portion, sealwort 13-25 weight portion, whiteflower cacalia seed 11-15 weight portion, sea lettuce 10-19 weight portion, safflower 15-30 weight portion, the real 18-25 weight portion of amaranth, tawny daylily 10-20 weight portion and glossy ganoderma 15-30 weight portion.
6. the feed addictive being used for the treatment of goat uriasis according to any one of claim 1-5, it is characterized in that, described feed addictive is made up of the raw medicinal material of following parts by weight: Huaihe River leads to 27 weight portions, reindeer moss 21 weight portion, Desmodium styracifolium 19 weight portion, digua fig stem and leaf 14 weight portion, rush 27 weight portion, cucumber stem 23 weight portion, radix semiaquilegiae 18 weight portion, common aeschynomene stem-xylem 15 weight portion, Pu Konjac 16 weight portion, medical stone 25 weight portion, common triumfetta root 23 weight portion, Yellow Croaker Ear-stone 23 weight portion, the bighead atractylodes rhizome 11 weight portion, real 14 weight portions of Chinese mugwort, dried human placenta 15 weight portion, sea otter 15 weight portion, Radix Glycyrrhizae 23 weight portion, sealwort 19 weight portion, whiteflower cacalia seed 13 weight portion, sea lettuce 14 weight portion, safflower 23 weight portion, real 21 weight portions of amaranth, tawny daylily 15 weight portion and glossy ganoderma 23 weight portion.
7. the preparation method being used for the treatment of the feed addictive of goat uriasis according to any one of claim 1-6, is characterized in that, described preparation method comprises the following steps:
The first step, mixes described raw medicinal material in proportion, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filter residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, reduced pressure concentration, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, mixes and obtains powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510249284.2A CN104799002A (en) | 2015-05-18 | 2015-05-18 | Feed additive for treating goat urolithiasis and preparation method thereof |
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| CN201510249284.2A CN104799002A (en) | 2015-05-18 | 2015-05-18 | Feed additive for treating goat urolithiasis and preparation method thereof |
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| CN117224637A (en) * | 2023-11-16 | 2023-12-15 | 北京生泰尔科技股份有限公司 | Traditional Chinese medicine composition for preventing sheep urinary stones |
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