CN104640969A - 细胞培养基的病毒过滤 - Google Patents

细胞培养基的病毒过滤 Download PDF

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Publication number
CN104640969A
CN104640969A CN201380032998.7A CN201380032998A CN104640969A CN 104640969 A CN104640969 A CN 104640969A CN 201380032998 A CN201380032998 A CN 201380032998A CN 104640969 A CN104640969 A CN 104640969A
Authority
CN
China
Prior art keywords
virus
filter
cell culture
filtration
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380032998.7A
Other languages
English (en)
Chinese (zh)
Inventor
W·蒙特
A·米特雷尔
M·赖特尔
M·哈斯拉赫尔
L·格里伯格
T·克赖尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hundred Deep Co
Hundred Deep LLC
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to CN201810569534.4A priority Critical patent/CN108795724A/zh
Publication of CN104640969A publication Critical patent/CN104640969A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
CN201380032998.7A 2012-06-21 2013-06-13 细胞培养基的病毒过滤 Pending CN104640969A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810569534.4A CN108795724A (zh) 2012-06-21 2013-06-13 细胞培养基的病毒过滤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
US61/662,814 2012-06-21
PCT/US2013/045663 WO2013192009A1 (en) 2012-06-21 2013-06-13 Virus filtration of cell culture media

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810569534.4A Division CN108795724A (zh) 2012-06-21 2013-06-13 细胞培养基的病毒过滤

Publications (1)

Publication Number Publication Date
CN104640969A true CN104640969A (zh) 2015-05-20

Family

ID=48672845

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380032998.7A Pending CN104640969A (zh) 2012-06-21 2013-06-13 细胞培养基的病毒过滤
CN201810569534.4A Pending CN108795724A (zh) 2012-06-21 2013-06-13 细胞培养基的病毒过滤

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810569534.4A Pending CN108795724A (zh) 2012-06-21 2013-06-13 细胞培养基的病毒过滤

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US (3) US9670456B2 (cg-RX-API-DMAC7.html)
EP (2) EP2732020B1 (cg-RX-API-DMAC7.html)
JP (3) JP6220392B2 (cg-RX-API-DMAC7.html)
KR (2) KR102008048B1 (cg-RX-API-DMAC7.html)
CN (2) CN104640969A (cg-RX-API-DMAC7.html)
AR (1) AR092847A1 (cg-RX-API-DMAC7.html)
AU (2) AU2013277532B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014031842B1 (cg-RX-API-DMAC7.html)
CA (1) CA2876473C (cg-RX-API-DMAC7.html)
CO (1) CO7151484A2 (cg-RX-API-DMAC7.html)
DK (2) DK3103861T3 (cg-RX-API-DMAC7.html)
EA (2) EA033006B1 (cg-RX-API-DMAC7.html)
ES (2) ES2601429T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20161435T1 (cg-RX-API-DMAC7.html)
HU (1) HUE031601T2 (cg-RX-API-DMAC7.html)
IL (2) IL236073B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN10441A (cg-RX-API-DMAC7.html)
MX (2) MX386767B (cg-RX-API-DMAC7.html)
MY (2) MY195362A (cg-RX-API-DMAC7.html)
NZ (1) NZ629083A (cg-RX-API-DMAC7.html)
PL (2) PL2732020T3 (cg-RX-API-DMAC7.html)
PT (2) PT3103861T (cg-RX-API-DMAC7.html)
SG (2) SG11201408490PA (cg-RX-API-DMAC7.html)
SI (1) SI2732020T1 (cg-RX-API-DMAC7.html)
TW (2) TWI698522B (cg-RX-API-DMAC7.html)
WO (1) WO2013192009A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201409253B (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110225790A (zh) * 2016-12-09 2019-09-10 龙沙有限公司 减少药物中病毒滴度的方法
CN113784779A (zh) * 2019-03-11 2021-12-10 建新公司 切向病毒过滤

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BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
US20180072769A1 (en) * 2015-03-23 2018-03-15 Alexion Pharmaceuticals, Inc. Virus filtration
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
US12157877B2 (en) * 2016-04-15 2024-12-03 Boehringer Ingelheim International Gmbh Cell retention device and method
MX2020000228A (es) * 2017-07-06 2020-08-10 Regeneron Pharma Proceso de cultivo celular para producir una glicoproteina.
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CA3135611A1 (en) * 2019-04-03 2020-10-08 Genzyme Corporation Continuous production of recombinant proteins
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
US20230181796A1 (en) * 2020-05-14 2023-06-15 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
JP2023544163A (ja) * 2020-10-02 2023-10-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 連続的なウイルス捕捉濾過
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

Citations (5)

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US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
EP1457497A1 (en) * 2003-03-06 2004-09-15 Probitas Pharma, S.A. Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes
CN102482341A (zh) * 2009-08-20 2012-05-30 巴克斯特国际公司 纯化vwf以增加非-脂质包封的病毒的去除
CN102482660A (zh) * 2009-07-31 2012-05-30 巴克斯特保健股份有限公司 用于纯化重组adamts13和其它蛋白质的方法以及其组合物

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JPH0422874A (ja) * 1990-05-16 1992-01-27 Matsushita Electric Ind Co Ltd 波形表示装置
GB2352652A (en) 1999-08-06 2001-02-07 Fsm Technologies Ltd Pre-treating hollow fibre membranes for micro-organism detection
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
AU1811301A (en) 1999-12-02 2001-06-12 General Hospital Corporation, The Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6835311B2 (en) * 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
JP4874806B2 (ja) 2003-12-01 2012-02-15 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 液体因子ｖｉｉ組成物のウイルス濾過
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
EP1457497A1 (en) * 2003-03-06 2004-09-15 Probitas Pharma, S.A. Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes
CN102482660A (zh) * 2009-07-31 2012-05-30 巴克斯特保健股份有限公司 用于纯化重组adamts13和其它蛋白质的方法以及其组合物
CN102482341A (zh) * 2009-08-20 2012-05-30 巴克斯特国际公司 纯化vwf以增加非-脂质包封的病毒的去除

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110225790A (zh) * 2016-12-09 2019-09-10 龙沙有限公司 减少药物中病毒滴度的方法
CN113784779A (zh) * 2019-03-11 2021-12-10 建新公司 切向病毒过滤

Also Published As

Publication number Publication date
NZ629083A (en) 2016-11-25
MX2014015950A (es) 2015-07-17
JP2017184765A (ja) 2017-10-12
KR20150032709A (ko) 2015-03-27
JP2015529447A (ja) 2015-10-08
AU2013277532B2 (en) 2017-06-15
CN108795724A (zh) 2018-11-13
EP2732020B1 (en) 2016-08-10
US20170260498A1 (en) 2017-09-14
ZA201409253B (en) 2022-05-25
CA2876473C (en) 2021-05-11
IL236073A0 (en) 2015-01-29
PL2732020T3 (pl) 2017-06-30
CO7151484A2 (es) 2014-12-29
AR092847A1 (es) 2015-05-06
JP6220392B2 (ja) 2017-10-25
EP3103861A1 (en) 2016-12-14
SI2732020T1 (sl) 2017-03-31
AU2017228547A1 (en) 2017-10-05
IL263479B (en) 2020-08-31
US20130344535A1 (en) 2013-12-26
ES2601429T3 (es) 2017-02-15
HUE031601T2 (hu) 2017-07-28
SG10201701721TA (en) 2017-04-27
IL263479A (en) 2019-01-31
US9670456B2 (en) 2017-06-06
PT2732020T (pt) 2016-11-10
BR112014031842B1 (pt) 2020-09-15
AU2017228547B2 (en) 2019-02-21
MY173835A (en) 2020-02-24
MY195362A (en) 2023-01-16
EP3103861B1 (en) 2020-09-30
ES2829968T3 (es) 2021-06-02
TW201412986A (zh) 2014-04-01
JP2019022526A (ja) 2019-02-14
HK1198335A1 (zh) 2015-04-02
PL3103861T3 (pl) 2021-03-22
KR20190092618A (ko) 2019-08-07
US20200277565A1 (en) 2020-09-03
TWI609962B (zh) 2018-01-01
DK2732020T3 (en) 2016-11-28
JP6557706B2 (ja) 2019-08-07
SG11201408490PA (en) 2015-01-29
IN2014DN10441A (cg-RX-API-DMAC7.html) 2015-08-21
HK1231502A1 (en) 2017-12-22
EA201590059A1 (ru) 2015-04-30
CA2876473A1 (en) 2013-12-27
AU2013277532A1 (en) 2015-01-15
TWI698522B (zh) 2020-07-11
US11421202B2 (en) 2022-08-23
EP2732020A1 (en) 2014-05-21
TW201816105A (zh) 2018-05-01
MX386767B (es) 2025-03-19
DK3103861T3 (da) 2020-11-16
PT3103861T (pt) 2020-11-16
BR112014031842A2 (pt) 2017-08-22
IL236073B (en) 2019-01-31
HRP20161435T1 (hr) 2017-02-24
EA201990887A1 (ru) 2019-08-30
WO2013192009A1 (en) 2013-12-27
EA033006B1 (ru) 2019-08-30
KR102008048B1 (ko) 2019-08-06
MX347319B (es) 2017-04-21

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160811

Address after: Aupu, Switzerland

Applicant after: Hundred deep limited liability company

Applicant after: Hundred deep company

Address before: Illinois State

Applicant before: Baxter International Inc.

Applicant before: Bakst Helth Co., Ltd.

RJ01 Rejection of invention patent application after publication

Application publication date: 20150520

RJ01 Rejection of invention patent application after publication