CN104640844B - 4-氨基-5-氟-3-卤代-6-(取代的)吡啶-2-甲酸酯的制备方法 - Google Patents
4-氨基-5-氟-3-卤代-6-(取代的)吡啶-2-甲酸酯的制备方法 Download PDFInfo
- Publication number
- CN104640844B CN104640844B CN201380048518.6A CN201380048518A CN104640844B CN 104640844 B CN104640844 B CN 104640844B CN 201380048518 A CN201380048518 A CN 201380048518A CN 104640844 B CN104640844 B CN 104640844B
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- CN
- China
- Prior art keywords
- compound
- formula
- alkyl
- fluoride
- halogen
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)=C(C(NC)=CC(C(*=C)=C)=C)I Chemical compound CC(C)=C(C(NC)=CC(C(*=C)=C)=C)I 0.000 description 14
- FFOVLOULYZGVOE-UHFFFAOYSA-N CC(Nc1cc(C(OC)=O)nc(-c(ccc(Cl)c2C=O)c2F)c1F)=O Chemical compound CC(Nc1cc(C(OC)=O)nc(-c(ccc(Cl)c2C=O)c2F)c1F)=O FFOVLOULYZGVOE-UHFFFAOYSA-N 0.000 description 1
- KXTATMNUJYNBRT-UHFFFAOYSA-N CC(c(cc1N)nc(F)c1F)=[U] Chemical compound CC(c(cc1N)nc(F)c1F)=[U] KXTATMNUJYNBRT-UHFFFAOYSA-N 0.000 description 1
- GMVHISGLYFTQDW-UHFFFAOYSA-N CCC(c(cc1NC)ncc1F)=C Chemical compound CCC(c(cc1NC)ncc1F)=C GMVHISGLYFTQDW-UHFFFAOYSA-N 0.000 description 1
- CVYZJUXLXNJDEU-UHFFFAOYSA-N COC(c(c(Cl)c1N)nc(Br)c1F)=O Chemical compound COC(c(c(Cl)c1N)nc(Br)c1F)=O CVYZJUXLXNJDEU-UHFFFAOYSA-N 0.000 description 1
- ZAYTUZJMFVYJSU-UHFFFAOYSA-N COc(c(Cl)ccc1-c(nc(cc2Cl)C(O)=O)c2Cl)c1F Chemical compound COc(c(Cl)ccc1-c(nc(cc2Cl)C(O)=O)c2Cl)c1F ZAYTUZJMFVYJSU-UHFFFAOYSA-N 0.000 description 1
- ZHWBNBHTQZRIQD-UHFFFAOYSA-N COc(c(F)c(cc1)-c(nc(cc2Cl)C(Cl)=O)c2Cl)c1Cl Chemical compound COc(c(F)c(cc1)-c(nc(cc2Cl)C(Cl)=O)c2Cl)c1Cl ZHWBNBHTQZRIQD-UHFFFAOYSA-N 0.000 description 1
- DIOPSWLKJOYZAR-UHFFFAOYSA-N OC(C(N=C(C1Cl)c2ccccc2)=CC1Cl)=O Chemical compound OC(C(N=C(C1Cl)c2ccccc2)=CC1Cl)=O DIOPSWLKJOYZAR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675235P | 2012-07-24 | 2012-07-24 | |
| US61/675,235 | 2012-07-24 | ||
| PCT/US2013/051623 WO2014018502A1 (en) | 2012-07-24 | 2013-07-23 | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104640844A CN104640844A (zh) | 2015-05-20 |
| CN104640844B true CN104640844B (zh) | 2016-11-09 |
Family
ID=48901197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380048518.6A Active CN104640844B (zh) | 2012-07-24 | 2013-07-23 | 4-氨基-5-氟-3-卤代-6-(取代的)吡啶-2-甲酸酯的制备方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8871943B2 (enExample) |
| EP (1) | EP2877453B1 (enExample) |
| JP (1) | JP6046817B2 (enExample) |
| KR (1) | KR101946681B1 (enExample) |
| CN (1) | CN104640844B (enExample) |
| AR (1) | AR091856A1 (enExample) |
| AU (1) | AU2013293200B2 (enExample) |
| BR (1) | BR112015001615B8 (enExample) |
| CA (1) | CA2879530C (enExample) |
| CO (1) | CO7200265A2 (enExample) |
| IL (1) | IL236816A (enExample) |
| IN (1) | IN2015DN00821A (enExample) |
| MX (1) | MX351886B (enExample) |
| NZ (1) | NZ704103A (enExample) |
| PL (1) | PL2877453T3 (enExample) |
| RU (1) | RU2632203C2 (enExample) |
| TW (1) | TWI577663B (enExample) |
| UY (1) | UY34946A (enExample) |
| WO (1) | WO2014018502A1 (enExample) |
| ZA (1) | ZA201500701B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR092355A1 (es) * | 2012-07-24 | 2015-04-15 | Dow Agrosciences Llc | Fluoruros de fluoropicolinoilo y procesos para su preparacion |
| US8764316B1 (en) | 2013-05-23 | 2014-07-01 | Corning Cable Systems Llc | Fiber optic connector with vented ferrule holder |
| TW201609651A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程（一） |
| BR102014028164A2 (pt) * | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
| TW201609652A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程（三） |
| TWI726900B (zh) | 2015-08-04 | 2021-05-11 | 美商陶氏農業科學公司 | 用於氟化化合物之過程 |
| CA3012167A1 (en) * | 2016-01-22 | 2017-07-27 | Dow Agrosciences Llc | Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids |
| BR112018073348B8 (pt) * | 2016-05-19 | 2023-05-16 | Dow Agrosciences Llc | Métodos para preparar 6-aril-4-aminopicolinatos e 2-aril-6-aminopirimidina-4-carboxilatos por acoplamento direto de suzuki |
| EP3555049A4 (en) * | 2016-12-13 | 2020-04-29 | Dow AgroSciences LLC | Method of preparing benzy 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate |
| EP3853205A1 (en) * | 2018-09-19 | 2021-07-28 | Corteva Agriscience LLC | Preparation of halogen analogs of picloram |
| BR112022018508A2 (pt) * | 2020-03-18 | 2022-10-25 | Corteva Agriscience Llc | Síntese melhorada de 4-amino-6-(heterocíclico)picolinatos |
| CN114702440B (zh) * | 2022-04-26 | 2024-06-18 | 永农生物科学有限公司 | 一种氨氯吡啶酸的制备方法及制备的氨氯吡啶酸 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2520254B2 (ja) * | 1987-04-28 | 1996-07-31 | イハラケミカル工業株式会社 | ３，４，５−トリフルオロ安息香酸誘導体およびその製造方法 |
| US4847442A (en) * | 1988-07-18 | 1989-07-11 | Allied-Signal Inc. | Process for the preparation of difluorobenzenes |
| US6297197B1 (en) | 2000-01-14 | 2001-10-02 | Dow Agrosciences Llc | 4-aminopicolinates and their use as herbicides |
| AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
| AU2003238390A1 (en) * | 2002-06-04 | 2003-12-19 | Clariant Gmbh | Method for producing a compound containing fluorine via fluorine-halogen exchange by special polyamino phosphazene catalysts |
| UA82358C2 (uk) * | 2003-04-02 | 2008-04-10 | Дау Агросайенсиз Ллс | 6-алкіл або алкеніл-4-амінопіколінати гербіцидна композиція, спосіб боротьби з небажаною рослинністю |
| AR059010A1 (es) | 2006-01-13 | 2008-03-05 | Dow Agrosciences Llc | 6-( aril polisustituido )-4- aminopicolinatos y su uso como herbicidas |
| TWI529163B (zh) | 2011-01-25 | 2016-04-11 | 陶氏農業科學公司 | 用於製備４－胺基－５－氟－３－鹵素－６－（經取代之）吡啶甲酸酯的方法 |
| TWI537252B (zh) | 2011-01-25 | 2016-06-11 | 陶氏農業科學公司 | 用於製備４－胺基－５－氟－３－鹵素－６－（經取代之）吡啶甲酸酯的方法（一） |
-
2013
- 2013-07-22 AR ARP130102597A patent/AR091856A1/es active IP Right Grant
- 2013-07-23 EP EP13742581.5A patent/EP2877453B1/en active Active
- 2013-07-23 WO PCT/US2013/051623 patent/WO2014018502A1/en not_active Ceased
- 2013-07-23 RU RU2015106019A patent/RU2632203C2/ru active
- 2013-07-23 PL PL13742581T patent/PL2877453T3/pl unknown
- 2013-07-23 NZ NZ704103A patent/NZ704103A/en unknown
- 2013-07-23 CN CN201380048518.6A patent/CN104640844B/zh active Active
- 2013-07-23 CA CA2879530A patent/CA2879530C/en active Active
- 2013-07-23 TW TW102126266A patent/TWI577663B/zh active
- 2013-07-23 US US13/949,060 patent/US8871943B2/en active Active
- 2013-07-23 MX MX2015001141A patent/MX351886B/es active IP Right Grant
- 2013-07-23 BR BR112015001615A patent/BR112015001615B8/pt active IP Right Grant
- 2013-07-23 UY UY0001034946A patent/UY34946A/es active IP Right Grant
- 2013-07-23 KR KR1020157004099A patent/KR101946681B1/ko active Active
- 2013-07-23 AU AU2013293200A patent/AU2013293200B2/en active Active
- 2013-07-23 IN IN821DEN2015 patent/IN2015DN00821A/en unknown
- 2013-07-23 JP JP2015524380A patent/JP6046817B2/ja active Active
-
2015
- 2015-01-20 IL IL236816A patent/IL236816A/en active IP Right Grant
- 2015-01-30 ZA ZA2015/00701A patent/ZA201500701B/en unknown
- 2015-02-06 CO CO15024012A patent/CO7200265A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR091856A1 (es) | 2015-03-04 |
| BR112015001615B1 (pt) | 2019-10-22 |
| PL2877453T3 (pl) | 2017-08-31 |
| KR101946681B1 (ko) | 2019-02-11 |
| MX351886B (es) | 2017-11-01 |
| US20140031556A1 (en) | 2014-01-30 |
| EP2877453B1 (en) | 2016-07-06 |
| CO7200265A2 (es) | 2015-02-27 |
| CN104640844A (zh) | 2015-05-20 |
| CA2879530A1 (en) | 2014-01-30 |
| UY34946A (es) | 2014-02-28 |
| IL236816A (en) | 2016-11-30 |
| NZ704103A (en) | 2016-08-26 |
| BR112015001615A2 (pt) | 2017-07-04 |
| AU2013293200A1 (en) | 2015-02-19 |
| WO2014018502A1 (en) | 2014-01-30 |
| IN2015DN00821A (enExample) | 2015-06-12 |
| BR112015001615B8 (pt) | 2022-08-23 |
| EP2877453A1 (en) | 2015-06-03 |
| JP2015530367A (ja) | 2015-10-15 |
| US8871943B2 (en) | 2014-10-28 |
| JP6046817B2 (ja) | 2016-12-21 |
| TWI577663B (zh) | 2017-04-11 |
| RU2015106019A (ru) | 2016-09-10 |
| CA2879530C (en) | 2019-06-18 |
| HK1210613A1 (en) | 2016-04-29 |
| TW201406726A (zh) | 2014-02-16 |
| KR20150036673A (ko) | 2015-04-07 |
| RU2632203C2 (ru) | 2017-10-03 |
| MX2015001141A (es) | 2015-09-08 |
| AU2013293200B2 (en) | 2016-11-17 |
| ZA201500701B (en) | 2016-10-26 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Indiana, USA Patentee after: Kedihua Agricultural Technology Co.,Ltd. Address before: Indiana, USA Patentee before: DOW AGROSCIENCES LLC |