CN104602702B - 外膜囊泡 - Google Patents

外膜囊泡 Download PDF

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Publication number
CN104602702B
CN104602702B CN201380045396.5A CN201380045396A CN104602702B CN 104602702 B CN104602702 B CN 104602702B CN 201380045396 A CN201380045396 A CN 201380045396A CN 104602702 B CN104602702 B CN 104602702B
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Prior art keywords
omv
protein
heterologous protein
omvs
heterologous
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Expired - Fee Related
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CN201380045396.5A
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Chinese (zh)
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CN104602702A (zh
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G·格兰迪
伊 若斯 I·马格里特
E·恰洛特
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201380045396.5A 2012-09-18 2013-09-18 外膜囊泡 Expired - Fee Related CN104602702B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261702296P 2012-09-18 2012-09-18
US61/702,296 2012-09-18
US201361799311P 2013-03-15 2013-03-15
US61/799,311 2013-03-15
PCT/EP2013/069415 WO2014044728A1 (en) 2012-09-18 2013-09-18 Outer membrane vesicles

Publications (2)

Publication Number Publication Date
CN104602702A CN104602702A (zh) 2015-05-06
CN104602702B true CN104602702B (zh) 2021-08-27

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Family Applications (1)

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CN201380045396.5A Expired - Fee Related CN104602702B (zh) 2012-09-18 2013-09-18 外膜囊泡

Country Status (9)

Country Link
US (1) US9764027B2 (https=)
EP (3) EP2897635A1 (https=)
JP (1) JP6283674B2 (https=)
CN (1) CN104602702B (https=)
AU (1) AU2013320313B2 (https=)
CA (1) CA2882382A1 (https=)
MX (1) MX363529B (https=)
RU (1) RU2662970C2 (https=)
WO (1) WO2014044728A1 (https=)

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JP5814507B2 (ja) * 2006-09-07 2015-11-17 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
BE1022875B1 (fr) * 2014-03-26 2016-09-30 Glaxosmithkline Biologicals S.A. Compositions pour une immunisation contre staphylococcus aureus
WO2015155178A1 (en) * 2014-04-07 2015-10-15 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for producing outer membrane vesicles
BE1022553A1 (fr) * 2014-05-07 2016-05-31 Glaxosmithkline Biologicals Sa Mutants de spy0269
KR101742236B1 (ko) * 2014-10-29 2017-05-31 인하대학교 산학협력단 쯔쯔가무시병에 대한 면역 조성물 및 이의 제조방법
MX2017015404A (es) 2015-06-02 2018-05-22 De Staat Der Nederlanden Vert Door De Mini Van Vws Miniie Van Volksgezondheid Welzijn En Sport Visualizacion de superficie de antigenos en vesiculas de membrana externa gram-negativas.
CN105861402B (zh) * 2015-07-20 2020-02-14 中国医学科学院医学生物学研究所 将异源蛋白呈递于大肠杆菌外膜囊泡表面的新型疫苗形式
CN106866804B (zh) * 2015-12-11 2021-03-05 中国科学院植物研究所 一种与植物光合作用相关的cam01蛋白及其编码基因和应用
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
GB201607510D0 (en) * 2016-04-29 2016-06-15 Inst Of Food Res The Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (OMV) for delivery to the GI-tract
US12109259B2 (en) * 2016-09-02 2024-10-08 Glaxosmithkline Biologicals Sa Vaccines for Neisseria gonorrhoeae
SI3544637T1 (sl) * 2016-11-25 2021-02-26 Glaxosmithkline Biologicals S.A. Nativni OMV-antigen konjugati in njihova uporaba
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CA3063419A1 (en) * 2017-05-15 2018-11-22 University Of Maryland, Baltimore Live salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
GB201708277D0 (en) * 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
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CA3096849A1 (en) * 2018-04-10 2019-10-17 The Administrators Of The Tulane Educational Fund Burkholderia pseudomallei complex outer membrane vesicles as adjuvants
CN109554311B (zh) * 2018-12-18 2022-01-14 中国农业科学院兰州兽医研究所 一种鼠伤寒沙门氏菌外膜囊泡的提取方法
CN113727722A (zh) * 2019-02-22 2021-11-30 伊夫罗生物科学公司 细菌膜制剂
EP3960191A4 (en) * 2019-04-26 2023-01-04 MD Healthcare Inc. PROTEIN DERIVED FROM STREPTOCOCCUS PYOGENES BACTERIA AND ITS USE
CN110272910A (zh) * 2019-06-25 2019-09-24 四川农业大学 一种包括jev抗原基因的重组载体、重组菌株和递呈jev抗原的外膜囊泡及其应用
US20220378902A1 (en) * 2019-08-22 2022-12-01 Sichuan University Bacterial membrane vesicles, and separation and preparation system and method therefor
EP4090773A2 (en) 2020-01-17 2022-11-23 Université catholique de Louvain Genetically modified bacterium with altered envelop integrity and uses thereof
CA3168201A1 (en) * 2020-02-18 2021-08-26 Vaxcyte, Inc. Group a strep immunogenic compositions with polysaccharide-protein conjugates
WO2022026896A2 (en) * 2020-07-30 2022-02-03 Omvax, Inc. Sars-cov-2 receptor binding domain in native outer membrane vesicles
CN117065041B (zh) * 2023-04-04 2024-02-27 山东大学 一种包被载药脂质纳米粒的外膜囊泡及其制备方法和应用
CN119932075A (zh) * 2025-01-25 2025-05-06 四川大学 一种携带外源蛋白的重组单增李斯特菌膜囊泡及其制备方法和应用

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JP2015535812A (ja) 2015-12-17
CA2882382A1 (en) 2014-03-27
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JP6283674B2 (ja) 2018-02-21
MX363529B (es) 2019-03-27
AU2013320313B2 (en) 2018-07-12
US9764027B2 (en) 2017-09-19
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