CN104582705A - 白介素-1受体相关激酶(irak)抑制剂和其用途 - Google Patents
白介素-1受体相关激酶(irak)抑制剂和其用途 Download PDFInfo
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- CN104582705A CN104582705A CN201380013538.XA CN201380013538A CN104582705A CN 104582705 A CN104582705 A CN 104582705A CN 201380013538 A CN201380013538 A CN 201380013538A CN 104582705 A CN104582705 A CN 104582705A
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Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019001461A1 (zh) * | 2017-06-27 | 2019-01-03 | 南京明德新药研发股份有限公司 | Irak4抑制剂 |
| CN112437665A (zh) * | 2018-07-20 | 2021-03-02 | 默克专利有限公司 | 用于治疗及预防多发性硬化症的方法中的经取代氨基-嘧啶化合物 |
| CN114502158A (zh) * | 2019-06-28 | 2022-05-13 | 凯麦拉医疗公司 | Irak降解剂及其用途 |
| CN116669722A (zh) * | 2020-12-09 | 2023-08-29 | 凯麦拉医疗公司 | 白细胞介素-1受体相关激酶(irak)降解物及其用途 |
| CN118978528A (zh) * | 2024-08-02 | 2024-11-19 | 上海信诺维生物医药有限公司 | 一种irak4激酶抑制剂 |
| US12497402B2 (en) | 2021-02-15 | 2025-12-16 | Kymera Therapeutics, Inc. | IRAK4 degraders and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101580714B1 (ko) | 2010-06-03 | 2016-01-04 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(btk)의 억제제의 용도 |
| EP2595993B1 (en) | 2010-07-23 | 2018-04-18 | President and Fellows of Harvard College | Tricyclic proteasome activity enhancing compounds |
| US8703941B2 (en) | 2011-01-10 | 2014-04-22 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| TWI589579B (zh) | 2012-01-10 | 2017-07-01 | 林伯士艾瑞斯公司 | Irak抑制劑及其用途 |
| AU2013202373B2 (en) * | 2012-01-25 | 2016-04-14 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| JP2015504919A (ja) | 2012-01-25 | 2015-02-16 | プロテオステイシス セラピューティクス,インコーポレイテッド | プロテアソーム活性を調節する化合物 |
| HK1210732A1 (en) | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| HK1210696A1 (en) | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| BR112015001690A2 (pt) | 2012-07-24 | 2017-11-07 | Pharmacyclics Inc | mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk) |
| BR112015014034A2 (pt) * | 2013-01-10 | 2017-07-11 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| WO2014118229A1 (en) | 2013-02-01 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Substituted thienopyrimidines and pharmaceutical use thereof |
| SG11201507320QA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014194245A2 (en) * | 2013-05-31 | 2014-12-04 | Nimbus Iris, Inc. | Cdk8 inhibitors and uses thereof |
| WO2014194242A2 (en) * | 2013-05-31 | 2014-12-04 | Nimbus Iris, Inc. | Flt3 inhibitors and uses thereof |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| RU2016110852A (ru) * | 2013-09-27 | 2017-10-30 | Нимбус Айрис, Инк. | Ингибиторы irak и их применения |
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| CN112437665A (zh) * | 2018-07-20 | 2021-03-02 | 默克专利有限公司 | 用于治疗及预防多发性硬化症的方法中的经取代氨基-嘧啶化合物 |
| CN114502158A (zh) * | 2019-06-28 | 2022-05-13 | 凯麦拉医疗公司 | Irak降解剂及其用途 |
| CN116669722A (zh) * | 2020-12-09 | 2023-08-29 | 凯麦拉医疗公司 | 白细胞介素-1受体相关激酶(irak)降解物及其用途 |
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| CN118978528A (zh) * | 2024-08-02 | 2024-11-19 | 上海信诺维生物医药有限公司 | 一种irak4激酶抑制剂 |
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| BR112014017021A8 (pt) | 2017-07-04 |
| JP6126131B2 (ja) | 2017-05-10 |
| TWI589579B (zh) | 2017-07-01 |
| HK1209632A1 (en) | 2016-04-08 |
| US20160193216A1 (en) | 2016-07-07 |
| TW201333014A (zh) | 2013-08-16 |
| TW201728592A (zh) | 2017-08-16 |
| AU2017228639A1 (en) | 2017-10-26 |
| WO2013106535A1 (en) | 2013-07-18 |
| BR112014017021A2 (pt) | 2017-06-13 |
| EP2802330A1 (en) | 2014-11-19 |
| AU2013207972B2 (en) | 2017-06-15 |
| WO2013106535A9 (en) | 2014-09-04 |
| AU2013207972A1 (en) | 2014-07-31 |
| US20130231328A1 (en) | 2013-09-05 |
| JP2015503618A (ja) | 2015-02-02 |
| EP2802330A4 (en) | 2015-10-21 |
| CA2863259A1 (en) | 2013-07-18 |
| JP2017008110A (ja) | 2017-01-12 |
| US9212190B2 (en) | 2015-12-15 |
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