CN104524461A - 一种治疗心肌炎的药物组合物及其应用 - Google Patents
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Abstract
一种治疗心肌炎的药物组合物,主要由三七、赤芍、柏子仁、连翘、黄芪、胡荽、柳枝、白杨枝、桃枝、芦根、苍术、灯心草、红花、川芎、莪术、麦冬、郁金、薤白、桂枝、太子参、瓜萎、淡竹叶、天南星、炙甘草、合欢皮、五味子、丹参、川升麻、白薇、肉苁蓉、薄荷叶、银杏叶组成,具有益气养元、扶正祛邪、养心通脉之功效,能够双向调节免疫功能,有效控制各种心肌炎症状,保护心肌,促进心肌功能恢复,疗效显著,不仅作用时间长,疗程短,见效快,安全无毒副作用,而且具有防止病情发生、迁延及预防复发的作用。
Description
技术领域
本发明涉及一种药物组合物,具体涉及一种治疗心肌炎的药物组合物及其应用。
背景技术
心肌炎指心肌中有局限性或弥漫性的急性、亚急性或慢性的炎性病变。近年来病毒性心肌炎的相对发病率不断增加。病情轻重不同,表现差异很大,婴幼儿病情多较重,成年人多较轻,轻者可无明显病状,重者可并发严重心律失常,心功能不全甚至猝死。急性期或亚急性期心肌炎病的前驱症状,病人可有发热、疲乏、多汗、心慌、气急、心前区闷痛等。检查可见期前收缩、传导阻滞等心律失常,谷草转氨酶、肌酸磷酸激酶增高,血沉增快。心肌炎可原发于心肌,也可是全身性疾病的一部分。心肌炎临床症状:1.症状:疲乏、发热、胸闷、心悸、气短、头晕,严重者可出现心功能不全或心源性休克;2.体征:心率增快,与体温升高不成比例,心界扩大,杂音改变,心律失常。
心肌炎的分类有:病毒性心肌炎、小儿心肌炎、肥大性心肌炎、中毒性心肌炎、扩张性心肌炎、寄生虫性心肌炎、细菌感染性心肌炎。
病毒性心肌炎:发病原因可由多种病毒感染引起,其中以柯萨基病毒B最常见,水痘、EB病毒也可引起。据研究,约有5%病毒感染者感染后可累及心脏发生心肌炎。可为病毒感染后的直接侵袭心肌,也可为病毒感染后的自身免疫反应所致,前者以儿童多见,后者以青少年多见,春季是病毒性心肌炎的高发季节。其临床症状为病初有上呼吸道感染或肠道感染症状,7~10天后出现胸闷、心悸、极度乏力、易出汗等症状。此时,如做心电图,可能发现有早搏等心率失常和心肌损害表现。作血沉、心肌酶测定可能升高。2-4周后查柯萨基病毒抗体、抗心肌抗体可为阳性。
小儿心肌炎:小儿心肌炎患者,往往先出现感冒症状,如发烧、咳嗽、咽痛、流涕、全身不适、恶心呕吐、腹痛、腹泻,有些还有关节痛、肌肉痛。慢慢地这些症状逐渐好转或消失,而心脏异常的征象开始出现:心跳加快或明显减慢,或者出现停搏,不规则。宝宝的精神萎靡、脸色苍白、无力、多汗,食欲不振或反复出现恶心呕吐,上腹部疼痛;或诉说头痛、头晕、心悸、胸闷、心前区不适或疼痛。严重者还可见到脸面浮肿、不能平卧、气促等心脏功能不全的表现。有些宝宝会突然心跳变慢,每分钟只有20~30次,导致了急性脑缺血,引起抽风发作或意外发生,直接威胁到生命。
肥大性心肌炎:心肌细胞有了缺陷,心壁会变粗。在严重的情况下,肿大的心壁可能会阻碍血液流进及流出心脏。这种疾病就叫肥大性心肌病。其症状为患肥大性心肌炎的患者易出现疲乏、胸痛、气促及心悸等现象。
中毒性心肌炎:是指毒素或毒物所致的心肌炎症,除白喉、伤寒、菌痢等感染性疾病外毒素、内毒素对心肌损害外,某些生物毒素如蛇毒、毒蕈、河豚、乌头等,以及某些药物或化学物质如奎尼丁、奎宁、依米丁、锑剂、有机磷、有机汞、砷、一氧化碳、铅、阿酶素等,均可引起心肌损害产生中毒性心肌炎。中毒性心肌炎往往是全身中毒的一部分重要表现,病情危重或并发严重心功能不全和心律失常者死亡率高,及时、有效地抢救往往能够挽救病人生命。其症状体征为:1.心功能不全的症状,如心悸、气短、体和肺循环瘀血征象;2.心律失常的表现。
扩张性心肌炎:扩张性心肌炎心脏常增大,心脏扩张以双侧心室最明显,因而称扩张性心肌炎,心腔扩张较轻者,心室壁稍增厚,病变发展,扩张加重,心室壁相对变薄,心室壁厚度正常或稍增厚。由于心肌纤维化,心肌收缩无力,射血分值下降,半月瓣口可能出现功能狭窄,左右心室扩张,可致房室瓣口相对性关闭不全,血流反复冲击致房室瓣膜轻度增厚,心肌病变可扩及心内膜,以及心内局部压力的升高局部供血不足,可致心内膜斑状纤维性增厚,约60%的病例有附壁血栓形成。
寄生虫性心肌炎常见的有以下两种类型:1.弓形虫性心肌炎。此型心肌炎由鼠弓形虫感染而引起。人类主要因食入含有包囊的未煮熟肉类而感染。弓形虫进入人体后,经血流到达单核巨噬细胞系统及各种组织,并在细胞内繁殖。弓形虫侵入心肌细胞后很快繁殖,形成集合体,亦称假包囊。心肌细胞很快破裂,病原体进入周围组织。被破坏的心肌细胞周围有淋巴细胞、单核细胞浸润。愈复后有瘢痕形成。约半数患者因心力衰竭致死;2.Chagas心肌炎。此种心肌炎由原虫枯氏锥虫感染引起,流行于拉丁美洲各国。病情严重,死亡率高。可引起灶状或弥散性心肌坏死,周围有淋巴细胞、单核细胞浸润。心腔扩张,心室壁(主要在心尖区)变薄,常形成室壁瘤,伴有心腔内附壁血栓形成。
细菌性心肌炎:某些心肌炎可由细菌直接感染,或细菌产生的毒素对心肌的作用,或细菌产物所致的变态反应而引起:1.心肌脓肿常由化脓菌引起,如葡萄球菌、链球菌、肺炎双球菌、脑膜炎双球菌等。化脓菌来源于脓毒败血症时的转移性细菌菌落,或来自细菌性心内膜炎时的化脓性血栓栓子。肉眼观,心脏表面及切面可见多发性黄色小脓肿,周围有充血带。镜下,脓肿内心肌细胞坏死液化,脓腔内有大量脓细胞及数量不等的细菌集落。脓肿周围心肌有不同程度的变性、坏死,间质内有中性粒细胞及单核细胞浸润;2.白喉杆菌可产生外毒素,一方面可阻断心肌细胞核蛋白体的蛋白质合成,另一方面可阻断肉碱介导的长链脂肪酸运入线粒体,导致心肌细胞脂肪变性和坏死。镜下,可见灶状心肌变性坏死,心肌细胞出现嗜酸性变、肌浆凝聚、脂肪变性及肌浆溶解。病灶内可见淋巴细胞、单核细胞及少数中性粒细胞浸润。病灶多见于右心室壁,愈复后形成细网状小瘢痕。有的病例出现弥漫性心肌坏死,可导致心性猝死;3.在上呼吸道链球菌感染(急性咽峡炎、扁桃体炎)及猩红热时,可并发急性非风湿性心肌炎。其发病机制尚未明了,可能是由链球菌毒素引起。病变是间质性心肌炎。镜下,心肌间质结缔组织内及小血管周围有淋巴细胞、单核细胞浸润,心肌细胞有程度不等的变性、坏死。
对于心肌炎的治疗,目前还没有特异方法,主要是强调应卧床休息,以减轻心脏负担和组织损伤。对于心肌炎的治疗,主要是采用针灸、免疫抑制剂以及激素等,针灸主要是针对心律失常、心力衰竭、心源性休克的治疗,免疫抑制剂并没有获得一致公认的临床疗效,故不推荐常规应用,由于重症心肌炎伴有房室传导阻滞,心源性休克者等可以应用激素。
由于上述治疗的缺陷性,对于心肌炎的治疗往往得不到最好的治疗,使患者病情加重,最终延误了病情的治疗,由此我们急需一种有效的药物来帮助患者治愈心肌炎症。
发明内容
本发明针对现有技术中的不足之处,提供一种治疗心肌炎的药物组合物及其应用,该药物组合物所选药材配伍相宜,符合中医药和现代医药研究理论,并采用现代先进的医药制药技术制成,具有益气养元、扶正祛邪、养心通脉之功效,能够双向调节免疫功能,有效控制各种心肌炎症状,保护心肌,促进心肌功能恢复,疗效显著,不仅作用时间长,疗程短,见效快,安全无毒副作用,而且具有防止病情发生、迁延及预防复发的作用。
本发明的上述目的是通过下述技术方案来实现的:
一种治疗心肌炎的药物组合物,制成所述药物组合物的原料组成及重量份数为:三七7-13份,赤芍6-12份,柏子仁2-5份,连翘7-13份,黄芪13-19份,胡荽20-25份,柳枝28-36份,白杨枝10-18份,桃枝17-30份,芦根34-45份,苍术10-16份,灯心草2-5份,红花5-8份,川芎30-35份,莪术30-35份,麦冬11-16份,郁金11-18份,薤白20-25份,桂枝5-6份,太子参10-15份,瓜萎26-34份,淡竹叶12-18份,天南星20-25份,炙甘草3-4份,合欢皮3-9份,五味子4-7份,丹参10-12份,川升麻11-15份,白薇10-16份,肉苁蓉10-15份,薄荷叶3-7份,银杏叶10-18份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七13份,赤芍10份,柏子仁3份,连翘7份,黄芪19份,胡荽25份,柳枝36份,白杨枝18份,桃枝30份,芦根45份,苍术16份,灯心草2份,红花7份,川芎35份,莪术30份,麦冬16份,郁金13份,薤白25份,桂枝5份,太子参15份,瓜萎30份,淡竹叶16份,天南星23份,炙甘草3份,合欢皮9份,五味子7份,丹参12份,川升麻15份,白薇10份,肉苁蓉15份,薄荷叶7份,银杏叶10份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七11份,赤芍12份,柏子仁3.5份,连翘8份,黄芪17份,胡荽22份,柳枝32份,白杨枝16份,桃枝30份,芦根40份,苍术12份,灯心草3份,红花5份,川芎35份,莪术33份,麦冬16份,郁金13份,薤白20份,桂枝5份,太子参13份,瓜萎31份,淡竹叶16份,天南星23份,炙甘草3份,合欢皮3份,五味子5份,丹参10份,川升麻15份,白薇10份,肉苁蓉12份,薄荷叶3份,银杏叶10份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七9份,赤芍10份,柏子仁4.5份,连翘8.5份,黄芪15份,胡荽20份,柳枝28份,白杨枝11份,桃枝30份,芦根40份,苍术11份,灯心草3.5份,红花5.5份,川芎35份,莪术35份,麦冬12份,郁金11份,薤白20份,桂枝5份,太子参11份,瓜萎34份,淡竹叶18份,天南星23份,炙甘草3.5份,合欢皮3份,五味子5份,丹参10份,川升麻15份,白薇10份,肉苁蓉12份,薄荷叶3份,银杏叶12份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七15份,赤芍8份,柏子仁4份,连翘9份,黄芪19份,胡荽25份,柳枝30份,白杨枝10份,桃枝20份,芦根40份,苍术10份,灯心草3份,红花6份,川芎35份,莪术30份,麦冬11份,郁金13份,薤白20份,桂枝5份,太子参15份,瓜萎30份,淡竹叶12份,天南星20份,炙甘草3份,合欢皮8份,五味子5份,丹参10份,川升麻15份,白薇12份,肉苁蓉10份,薄荷叶7份,银杏叶18份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七11份,赤芍9份,柏子仁5份,连翘10份,黄芪18份,胡荽20份,柳枝32份,白杨枝12份,桃枝21份,芦根40份,苍术13份,灯心草3.5份,红花6份,川芎35份,莪术30份,麦冬11份,郁金13份,薤白22份,桂枝6份,太子参12份,瓜萎30份,淡竹叶12份,天南星20份,炙甘草3份,合欢皮9份,五味子4份,丹参11份,川升麻11份,白薇10份,肉苁蓉10份,薄荷叶5份,银杏叶18份。
进一步地,制成所述药物组合物的原料组成及重量份数为:三七10份,赤芍6份,柏子仁2份,连翘13份,黄芪13份,胡荽23份,柳枝31份,白杨枝11份,桃枝17份,芦根34份,苍术15份,灯心草5份,红花8份,川芎30份,莪术32份,麦冬15份,郁金18份,薤白22份,桂枝5份,太子参10份,瓜萎26份,淡竹叶15份,天南星25份,炙甘草4份,合欢皮8份,五味子5份,丹参12份,川升麻15份,白薇16份,肉苁蓉15份,薄荷叶7份,银杏叶12份。
本发明还涉及一种治疗心肌炎的药物组合物的制备方法,所述制备方法具体为以下步骤:
(1)按照所述的重量份数配比提取各中药原料药,然后共同细研成药末,备用;
(2)取步骤(1)中研磨的药末放置于砂锅中加水,水量为药末重量的4倍,然后用大火将水煮沸4-6min后,改小火煎熬,煎熬时搅拌药末,搅拌次数为2-3次,煎熬时间为30-45min,煎熬完成后滤去药渣,取药液。
或是一种治疗心肌炎的药物组合物的制备方法采用以下步骤:
(1)按照所述的重量份数配比提取各中药原料药加水煎煮2次,第一次2-2.5小时,第二次1.5小时,滤液合并再煎1小时,静置30小时,再次过滤,滤过,滤液浓缩至相对密度为1.05;
(2)将步骤(1)所得滤液加入乙醇,乙醇用量为滤液质量的1.5倍,充分混合均匀,静置冷藏25-30小时,滤过,滤液回收乙醇后,再继续浓缩至稠膏,至相对密度为1.40;
(3)取适量糖粉于60℃烘1-2小时,置于适宜容器内,加入步骤(2)中所得稠膏搅拌混匀,调制成软硬度为手捏成团,轻压则散的软材,软材过14目筛,制成湿颗粒;
(4)将步骤(3)制成的湿颗粒烘干干燥,干燥温度为80℃,冷却后密封待用。
本发明还涉及一种药物组合物的应用,所述药物组合物制成汤剂、丸剂、散剂、膏剂、丹剂、胶囊或颗粒剂。虽然在后面实施例中以汤剂、颗粒剂作为实施例,但是本领域技术人员可以预期的是将所述药物组合物制成、丸剂、散剂、膏剂、丹剂、胶囊等,都可以起到同样的治疗效果。
其中,各原料药的药理功效分别为:
三七:三七性甘味微苦,性温,归肝、胃经以根、根状茎入药。是名贵中药材,生用可止血化瘀、消肿止痛,具有良好的止血功效、显著的造血功能;能加强和改善冠脉微循环,三七入药历史悠久,作用奇特被历代医家视为药中之宝,故有“金不换”之说法。三七“味微甘而苦,颇似人参之味。”“凡杖扑伤损,瘀血淋漓者,随即嚼烂罨之即止,青肿者即消散。若受杖时,先服一、二钱,则血不冲心,杖后尤宜服之,产后服亦良。大抵此药气温,味甘微苦,及阳明、厥阴血分之药,故能治一切血病”。《本草求真》记载:“三七,世人仅知功能止血止痛。殊不知痛因血瘀而疼作,血因敷散而血止。三七气味苦温,能于血分化其血瘀。”三七能增加冠脉血流量,减慢心率,减少心肌耗氧量,增加心肌耐氧能力,改善微循环,解除平滑肌痉挛的作用。
赤芍:苦,微寒。归肝经。功能主治清热凉血,散瘀止痛。用于温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,症瘕腹痛,跌扑损伤,痈肿疮疡。赤芍能清血分实热,散瘀血留滞。本品功能与丹皮相近,故常与丹皮相须为用。但丹皮清热凉血的作用较佳,既能清血分实热,又能治阴虚发热;而赤芍只能用于血分实热,以活血散瘀见长。
柏子仁:味甘,性平。有养心安神,止汗,润肠的功效,用于虚烦失眠,心悸怔忡,阴虚盗汗,肠燥便秘。
连翘:味苦,性微寒。有清热解毒,消肿散结的功效,用于痈疽,风热感冒。温热入营,高热烦渴。
黄芪:味甘,性微温。有益气固表,敛汗固脱,利水消肿的功效,用于气虚乏力,中气下陷,血虚萎黄。
胡荽,辛、温,归肺、胃经,发汗透疹,消食下气,醒脾和中。
柳枝,苦、寒,归足阳明、厥阴经,祛风,利尿,止痛,消肿。治风湿痹痛。
白杨枝,苦、寒,归脾经,行气散结。
桃枝,苦、平,归心、肝、大肠经,利水,活血化瘀,通络,治心腹痛。
芦根,甘、寒,归肺、胃经,清热生津,除心烦。
苍术:性辛、味苦,温。归脾、胃、肝经。功能主治燥湿健脾,祛风散寒,明目。用于脘腹胀满,泄泻水肿,脚气痿躄,风湿痹痛,风寒感冒,夜盲。对心血管系统的影响显示,苍术对蟾蜍心脏有轻度抑制作用,对蟾蜍后肢血管有轻度扩张作用。苍术浸膏小剂量静脉注射,可使家兔血压轻度上升,大剂量则使血压下降。苍术燥湿健脾功效相关的药理作用为调整胃肠运动功能、抗溃疡、保肝。抑菌等。苍术主要有效成分是以β-桉叶醇及茅术醇为代表的挥发油。苍术对血糖的影响,抗缺氧、中枢抑制、抗肿瘤、促进骨骼钙化及对心血管系统的影响等作用,则是其药理作用的现代研究进展。
灯心草:味甘、淡,性微寒。有清心火,利小便的功效,用于心烦失眠。尿少涩痛,口舌生疮。
红花:味辛,性温。有活血通经,散瘀止痛的功效,用于经闭,恶露不行,疮疡肿痛。
川芎:入肝、脾、三焦三经。功用主治行气开郁,法风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。《纲目》载:"燥湿,止泻痢,行气开郁。"川芎嗪解除血管平滑肌(主动脉条)痉挛(肾上腺素、氯化钾引起)。还能扩张冠状血管,增加冠脉血流量。对抗垂体后叶素引起的心肌缺血缺氧。减轻结扎冠脉引起的心肌梗死病变程度。
莪术:辛、苦,温。归肝、脾经。破血行气止痛:本品功效与三棱相似,但温通力较大,可治疗血滞经闭腹痛、腹部包块、积聚。积散结:本品能行气消积止痛,用于饮食积滞、胸腹满闷作痛。破血祛瘀,妇女闭经,或痰湿淤血凝结而成的症瘕癖块。行气止痛:适于饮食失调,脘腹涨满疼痛之证。适当配伍,虚症、实症均可。
麦冬:味甘、微苦,性微寒。有养阴生津,润肺清心,用于肺燥干咳,虚劳咳嗽,心烦失眠,内热消渴。
郁金:味辛、苦,性寒。有行气化瘀,清心解郁,利胆退黄的功效,用于经闭痛经,胸腹胀痛。
薤白:主治胸痹心痛彻背;胸脘痞闷;咳喘痰多;脘腹疼痛;泄痢后重;白带;疮疖痈肿。离体兔心灌流实验结果表明薤白能使冠脉流量减少(但差异无显著性),然后出现心缩力的迅速衰减,有难于恢复的特点,因此该冠脉流量减少似非由心缩力抑制所致,而可能系药物直接作用冠脉使之收缩的结果;但实验结果不完全一致,在16次实验中,作用不明显或反而使冠脉流量增加者有7次。此外,薤白对心率有抑制作用,但程度不大(小于10%)。《本草求真》:薤,味辛则散,散则能使在上寒滞立消;味苦则降,降则能使在下寒滞立下;气温则散,散则能使在中寒滞立除;体滑则通,通则能使久痼寒滞立解。是以下痢可除,瘀血可散,喘急可止,水肿可敷,胸痹刺痛可愈,胎产可治,汤火及中恶卒死可救,实通气、滑窍、助阳佳品也。功用有类于韭,但韭则入血行气及补肾阳,此则专通寒滞及兼滑窍之为异耳。
桂枝辛、甘,温。归心、肺、膀胱经。散寒解表;温通经脉;通阳化气。发汗解肌,温通经脉,助阳化气,平冲降气。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。1.抗菌作用:桂枝醇提物在体外能抑制大肠杆菌、枯草杆菌及金黄色葡萄球菌,有效浓度为25mg/ml或以下;对白色葡萄球菌、志贺氏痢疾杆菌、伤寒和副伤寒甲杆菌、肺炎球菌、产气杆菌、变形杆菌、炭疽杆菌、肠炎沙门氏菌、霍乱弧菌等亦有抑制作用(平板挖洞法)2.抗病毒作用:用人胚肾原代单层上皮细胞组织培养,桂枝煎剂(1∶20)对流感亚洲甲型京科68-l株和孤儿病毒(ECHO11)有抑制作用。在鸡胚上,对流感病毒有抑制作用,以70%醇浸剂作用较好。
太子参:味甘、微苦,性平。有益气健脾,生津润肺的功效,用于脾虚体倦,食欲不振,病后虚弱。
瓜萎:味甘、微苦,性寒。有清热涤痰,宽胸散结,润燥滑肠的功效,用于肺热咳嗽,胸痹心痛,肺痈。
淡竹叶:味甘、淡,性寒。有清热除烦,利尿的功效,用于热病烦渴,小便赤涩淋痛,口舌生疮。
天南星:味苦、辛,性温。有燥湿化痰,祛风止痉,散结消肿的功效,用于顽痰咳嗽,风瘫眩晕,半身不遂。
炙甘草:味甘、性平。有补脾和胃,益气复脉的功效,用于脾胃虚弱,倦态乏力,心动悸,脉结代。
合欢皮:味甘,性平。有解郁安神,活血消肿的功效,用于心神不安,解郁失眠,肺痈疮肿,跌扑伤痛。
五味子:味酸、甘,性温。有收敛固涩,益气生津,补肾宁心的功效,用于久嗽虚咳,自汗,盗汗。
丹参:丹参苦,微寒。归心、肝经。祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠。用于胸肋胁痛,风湿痹痛,症瘕结块,疮疡肿痛,跌仆伤痛,月经不调,经闭痛经,产后瘀痛等。治疗胸肋疼痛、症瘕结块,以及月经不调、经闭经痛具有良效。盖丹参能破宿血,补新血,安生胎,落死胎,止崩中滞下,调经脉。丹参其化学成分主要分为2类:一为脂溶性丹参酮,一为水溶性丹参素等。不管是临床还是实验研究多数学者都肯定了丹参具有扩张冠状动脉,提高心肌抗缺氧能力,扩张外周血管,改善微循环,调节组织的修复与再生,抑制凝血激活纤溶,增强免疫力,抗菌等作用。尤其是其可以在心功能不良时,在不影响耗氧的情况下能改善心肌收缩力,减慢心率,使心功能明显改善,并可使血流加速,毛细血管床开放增多。
川升麻:具有热病口疮,壮热头痛,心神烦躁的功效。
白薇:具有清热凉血,利尿通淋,解毒疗疮。用于温邪伤营发热,阴虚发热,骨蒸劳热,产后血虚发热,热淋,血淋,痈疽肿毒的功效。
肉苁蓉:具有补肾阳,益精血,润肠通便。用于阳痿,不孕,腰膝酸软,筋骨无力,肠燥便秘的功效。
薄荷叶:薄荷味辛,性凉,具有兴奋大脑、促进血液循环、发汗,与消炎镇痛、止痒解毒和疏散风热。
银杏叶:敛肺,平喘,活血化瘀,止痛。用于肺虚咳喘,冠心病,心绞痛,心肌炎。
本发明与现有技术相比,具有以下有益效果:
1、本发明药物基于中医中药治疗心肌炎的原理,具有益气养元、扶正祛邪、养心通脉之功效,针对心肌炎辨证施治,属于标本兼治的组方,能够双向调节免疫功能,有效控制各种心肌炎症状,保护心肌,促进心肌功能恢复,对心肌炎有极好的治疗作用。
2、本发明中药制剂所选药材配伍相宜,符合中医药和现代医药研究理论,并采用现代先进的医药制药技术制成,作用时间长,疗程短,见效快,安全无毒副作用,而且具有防止病情发生、迁延及预防复发的作用。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合实施例对本发明的技术方案进行清楚、完整地描述。显然,所描述的实施例是本发明的一部分,而不是全部的实施例。基于所描述的本发明的实施例,本领域普通技术人员在无需创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
本发明的一种治疗心肌炎的药物组合物,取下列中药原料药:三七13克,赤芍10克,柏子仁3克,连翘7克,黄芪19克,胡荽25克,柳枝36克,白杨枝18克,桃枝30克,芦根45克,苍术16克,灯心草2克,红花7克,川芎35克,莪术30克,麦冬16克,郁金13克,薤白25克,桂枝5克,太子参15克,瓜萎30克,淡竹叶16克,天南星23克,炙甘草3克,合欢皮9克,五味子7克,丹参12克,川升麻15克,白薇10克,肉苁蓉15克,薄荷叶7克,银杏叶10克。
所述治疗心肌炎的药物组合物的制备方法具体为以下步骤:
(1)按上述配比提取各中药原料药,然后共同细研成药末,备用;
(2)取步骤(1)中研磨的药末放置于砂锅中加水,水量为药末重量的4倍,然后用大火将水煮沸4-6min后,改小火煎熬,煎熬时搅拌药末,搅拌次数为2-3次,煎熬时间为30-45min,煎熬完成后滤去药渣,取药液。
临床资料:
病例:2007年6月,何某,男性,55岁,春季感冒引发腮腺炎,心悸、胸闷、心前区不适或疼痛(活动后加重),烦躁、头昏、乏力、多梦,面色发青、气急、水肿、脉结代,心电图检查均出现ST-T改变,并出现Ⅰ~Ⅱ度房室传导阻滞。采用上述配方和制备方法制成的药液,每日服用三次,7天好转,30天后症状明显好转,经治疗2个月后心电图S-T段改变纠正常,心脏超声示左室收缩功能正常,继续服用50天巩固,停药后至今未复发。
实施例2:
本发明的一种治疗心肌炎的药物组合物,取下列中药原料药:三七11克,赤芍12克,柏子仁3.5克,连翘8克,黄芪17克,胡荽22克,柳枝32克,白杨枝16克,桃枝30克,芦根40克,苍术12克,灯心草3克,红花5克,川芎35克,莪术33克,麦冬16克,郁金13克,薤白20克,桂枝5克,太子参13克,瓜萎31克,淡竹叶16克,天南星23克,炙甘草3克,合欢皮3克,五味子5克,丹参10克,川升麻15克,白薇10克,肉苁蓉12克,薄荷叶3克,银杏叶10克。
所述治疗心肌炎的药物组合物的制备方法具体为以下步骤:
(1)按上述配比提取各中药原料药,然后共同细研成药末,备用;
(2)取步骤(1)中研磨的药末放置于砂锅中加水,水量为药末重量的5倍,然后用大火将水煮沸6-7min后,改小火煎熬,煎熬时搅拌药末,搅拌次数为2-3次,煎熬时间为30-45min,煎熬完成后滤去药渣,取药液。
临床资料:
病例:2009年1月,徐某,女,66岁,高烧、头昏、乏力、多梦,面色发青、气急、水肿、脉结代,听诊有心律失常,可闻及收缩期杂音。采用上述配方和制备方法制成的药液,14天改善,30天后症状明显好转,每日服用三次,经治疗3个月后心电图S-T段改变纠正常,心脏超声示左室收缩功能正常,继续服用50天巩固,停药后至今未复发随访至今未见复发。
实施例3:
本发明的一种治疗心肌炎的药物组合物,取下列中药原料药:三七9克,赤芍10克,柏子仁4.5克,连翘8.5克,黄芪15克,胡荽20克,柳枝28克,白杨枝11克,桃枝30克,芦根40克,苍术11克,灯心草3.5克,红花5.5克,川芎35克,莪术35克,麦冬12克,郁金11克,薤白20克,桂枝5克,太子参11克,瓜萎34克,淡竹叶18克,天南星23克,炙甘草3.5克,合欢皮3克,五味子5克,丹参10克,川升麻15克,白薇10克,肉苁蓉12克,薄荷叶3克,银杏叶12克。
所述治疗心肌炎的药物组合物的制备方法具体为以下步骤:
(1)按上述配比提取各中药原料药,然后共同细研成药末,备用;
(2)取步骤(1)中研磨的药末放置于砂锅中加水,水量为药末重量的5倍,然后用大火将水煮沸4min后,改小火煎熬,煎熬时搅拌药末,搅拌次数为2-3次,煎熬时间为30-45min,煎熬完成后滤去药渣,取药液。
临床资料:
病例:2011年11月,冯某,男,34岁,因流感高烧,心悸、胸闷、心前区不适或疼痛(活动后加重),烦躁、头昏、乏力,“病毒性心肌炎”。胸闷气短,口渴乏力,舌淡苔白,脉沉细。方采用上述配方和制备方法制成的药液,经过一个月的治疗,病情趋地稳定,但有轻微的心脏扩大、心动能减退、心律失常或心电图变化,经过6个月的治疗,患者痊愈,未遗留任何症状或体征。
实施例4:
本发明的一种治疗心肌炎的药物组合物,取下列中药原料药:三七15克,赤芍8克,柏子仁4克,连翘9克,黄芪19克,胡荽25克,柳枝30克,白杨枝10克,桃枝20克,芦根40克,苍术10克,灯心草3克,红花6克,川芎35克,莪术30克,麦冬11克,郁金13克,薤白20克,桂枝5克,太子参15克,瓜萎30克,淡竹叶12克,天南星20克,炙甘草3克,合欢皮8克,五味子5克,丹参10克,川升麻15克,白薇12克,肉苁蓉10克,薄荷叶7克,银杏叶18克。
上述药物组合物的制备方法,步骤是:
(1)按上述配比提取各中药原料药加水煎煮2次,第一次2.5小时,第二次1.5小时,滤液合并再煎1小时,静置30小时,再次过滤,滤过,滤液浓缩至相对密度为1.05;
(2)将步骤(1)所得滤液加入乙醇,乙醇用量为滤液质量的1.5倍,充分混合均匀,静置冷藏25小时,滤过,滤液回收乙醇后,再继续浓缩至稠膏,至相对密度为1.40;
(3)取适量糖粉于60℃烘1-2小时,置于适宜容器内,加入步骤(2)中所得稠膏搅拌混匀,调制成软硬度为手捏成团,轻压则散的软材,软材过14目筛,制成湿颗粒;
(4)将步骤(3)制成的湿颗粒烘干干燥,干燥温度为80℃,冷却后密封待用。
临床资料:
病例:陆某,男,41岁,症状:患者有扩张性心肌炎多年经常胸闷气短,心悸乏力,呼吸困难,腹胀,偶尔情绪激动或者有些劳累的时候都会引发这些症状。病龄:4.5年。来诊时间:2012年1月01日;服用本发明中药组合物制成的颗粒剂,每次取10克以开水冲泡,一日两次,于每日早晚饭后1小时服用。服用15天,胸闷气短症状缓解,服用20天,胸闷气短症状完全消失,呼吸困难好转;服用1个月,呼吸正常,腹胀消失;服用1个半月,心悸症状缓解,乏力症状消失;服用2个月,心悸症状消失,各项不良症状完全消失,病愈后又服用本发明中药组合颗粒剂巩固疗效10天,停药至今无复发。
实施例5:
本发明的一种治疗心肌炎的药物组合物,取下列中药原料药:三七11克,赤芍9克,柏子仁5克,连翘10克,黄芪18克,胡荽20克,柳枝32克,白杨枝12克,桃枝21克,芦根40克,苍术13克,灯心草3.5克,红花6克,川芎35克,莪术30克,麦冬11克,郁金13克,薤白22克,桂枝6克,太子参12克,瓜萎30克,淡竹叶12克,天南星20克,炙甘草3克,合欢皮9克,五味子4克,丹参11克,川升麻11克,白薇10克,肉苁蓉10克,薄荷叶5克,银杏叶18克。
上述药物组合物的制备方法,步骤是:
(1)按上述配比提取各中药原料药加水煎煮2次,第一次2.0小时,第二次1.5小时,滤液合并再煎1小时,静置30小时,再次过滤,滤过,滤液浓缩至相对密度为1.05;
(2)将步骤(1)所得滤液加入乙醇,乙醇用量为滤液质量的1.5倍,充分混合均匀,静置冷藏30小时,滤过,滤液回收乙醇后,再继续浓缩至稠膏,至相对密度为1.40;
(3)取适量糖粉于60℃烘1-2小时,置于适宜容器内,加入步骤(2)中所得稠膏搅拌混匀,调制成软硬度为手捏成团,轻压则散的软材,软材过14目筛,制成湿颗粒;
(4)将步骤(3)制成的湿颗粒烘干干燥,干燥温度为80℃,冷却后密封待用。
临床资料:
病例:谢XX,男,22岁,症状:患者去年春天因感冒后出现心慌气短,全身乏力,易出汗的症状,且活动后症状加重,去医院经诊断为病毒性心肌炎,住院治疗好转,但近一周因劳累复发,症状较以前明显严重,还出现了胸闷。病龄:2年半。来诊时间:2013年7月20日;服用本发明中药组合物制成的颗粒剂,每次取10克以开水冲泡,一日两次,于每日早晚饭后1小时服用。服用10天,胸闷症状减轻,;服用20天,胸闷症状完全消失,出汗症状缓解;服用1个月,出汗症状消失,心慌气短症状明显改善;服用1个半月,心慌气短症状消失,病愈。服用本发明中药组合颗粒剂期间无不良反应,停药至今无复发。
实施例6
一种治疗心肌炎的药物组合物,取下列中药原料药:三七10克,赤芍6克,柏子仁2克,连翘13克,黄芪13克,胡荽23克,柳枝31克,白杨枝11克,桃枝17克,芦根34克,苍术15克,灯心草5克,红花8克,川芎30克,莪术32克,麦冬15克,郁金18克,薤白22克,桂枝5克,太子参10克,瓜萎26克,淡竹叶15克,天南星25克,炙甘草4克,合欢皮8克,五味子5克,丹参12克,川升麻15克,白薇16克,肉苁蓉15克,薄荷叶7克,银杏叶12克。
分别按照实施例1中药液的制备方法和实施例4中颗粒剂的制备方法来制备该药物组合物。
临床资料:
为了验证本发明中药组合物的效果,2013年6月,在齐鲁医院多名心脏外科专家的指导下,我们随机抽取了150名患者进行了上述药物的实验,平均分为三组,每组50人,实验组1(服用药液)、实验组2(服用颗粒剂)及对照组,实验组1、2使用实施例6所得药物组合物,对照组服用其它治疗心肌炎的中药药物。
入选标准:经确诊为心肌炎患者,病龄2-5年,有心肌炎临床症状一项或多项。
疗效情况判定标准(以服用3个月的数据进行对比):1、治愈。服用药物3个月,不适症状完全消失;2、有效。服用药物3个月,不适症状减轻或部分消失;3、无效。服用药物3个月,不适症状无变化。
我们对实验数据进行了精确的统计和数理分析。具体实验结果如下表:
表1:三组临床疗效比较【例】
组别 | 病例数 | 治愈 | 有效 | 无效 | 总有效率 |
对照组 | 50 | 3 | 21 | 26 | 48% |
实验组1(服用药液) | 50 | 47 | 2 | 1 | 98% |
实验组2(服用颗粒剂) | 50 | 45 | 3 | 2 | 96% |
结果:经临床疗效比较,对照组总有效率为48%;实验组1、2总有效率分别为98%、96%,两组总有效率比较表明实验组疗效优于对照组。
综上所述,本发明中药组合物与其它治疗心肌炎的药物相比有效率高,总有效率在96%以上,比对照组有效率高40%,效果明显优于对照组,该发明的中药组合物造价低廉,普通百姓长期使用,也不会增加身体和金钱上的负担。临床实验中未出现一例副作用情况,安全性远高于治疗心肌炎的同类药物,且疗效显著,使用本发明中药组合物能够快速缓解疾病带来的心悸、眩晕症状,还能调理因病而致虚弱的身体,属于标本兼顾的组方,是目前治疗心肌炎较为理想安全的中药组合物。
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (10)
1.一种治疗心肌炎的药物组合物,其特征在于,制成所述药物组合物的原料组成及重量份数为:三七7-13份,赤芍6-12份,柏子仁2-5份,连翘7-13份,黄芪13-19份,胡荽20-25份,柳枝28-36份,白杨枝10-18份,桃枝17-30份,芦根34-45份,苍术10-16份,灯心草2-5份,红花5-8份,川芎30-35份,莪术30-35份,麦冬11-16份,郁金11-18份,薤白20-25份,桂枝5-6份,太子参10-15份,瓜萎26-34份,淡竹叶12-18份,天南星20-25份,炙甘草3-4份,合欢皮3-9份,五味子4-7份,丹参10-12份,川升麻11-15份,白薇10-16份,肉苁蓉10-15份,薄荷叶3-7份,银杏叶10-18份。
2.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七13份,赤芍10份,柏子仁3份,连翘7份,黄芪19份,胡荽25份,柳枝36份,白杨枝18份,桃枝30份,芦根45份,苍术16份,灯心草2份,红花7份,川芎35份,莪术30份,麦冬16份,郁金13份,薤白25份,桂枝5份,太子参15份,瓜萎30份,淡竹叶16份,天南星23份,炙甘草3份,合欢皮9份,五味子7份,丹参12份,川升麻15份,白薇10份,肉苁蓉15份,薄荷叶7份,银杏叶10份。
3.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七11份,赤芍12份,柏子仁3.5份,连翘8份,黄芪17份,胡荽22份,柳枝32份,白杨枝16份,桃枝30份,芦根40份,苍术12份,灯心草3份,红花5份,川芎35份,莪术33份,麦冬16份,郁金13份,薤白20份,桂枝5份,太子参13份,瓜萎31份,淡竹叶16份,天南星23份,炙甘草3份,合欢皮3份,五味子5份,丹参10份,川升麻15份,白薇10份,肉苁蓉12份,薄荷叶3份,银杏叶10份。
4.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七9份,赤芍10份,柏子仁4.5份,连翘8.5份,黄芪15份,胡荽20份,柳枝28份,白杨枝11份,桃枝30份,芦根40份,苍术11份,灯心草3.5份,红花5.5份,川芎35份,莪术35份,麦冬12份,郁金11份,薤白20份,桂枝5份,太子参11份,瓜萎34份,淡竹叶18份,天南星23份,炙甘草3.5份,合欢皮3份,五味子5份,丹参10份,川升麻15份,白薇10份,肉苁蓉12份,薄荷叶3份,银杏叶12份。
5.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七15份,赤芍8份,柏子仁4份,连翘9份,黄芪19份,胡荽25份,柳枝30份,白杨枝10份,桃枝20份,芦根40份,苍术10份,灯心草3份,红花6份,川芎35份,莪术30份,麦冬11份,郁金13份,薤白20份,桂枝5份,太子参15份,瓜萎30份,淡竹叶12份,天南星20份,炙甘草3份,合欢皮8份,五味子5份,丹参10份,川升麻15份,白薇12份,肉苁蓉10份,薄荷叶7份,银杏叶18份。
6.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七11份,赤芍9份,柏子仁5份,连翘10份,黄芪18份,胡荽20份,柳枝32份,白杨枝12份,桃枝21份,芦根40份,苍术13份,灯心草3.5份,红花6份,川芎35份,莪术30份,麦冬11份,郁金13份,薤白22份,桂枝6份,太子参12份,瓜萎30份,淡竹叶12份,天南星20份,炙甘草3份,合欢皮9份,五味子4份,丹参11份,川升麻11份,白薇10份,肉苁蓉10份,薄荷叶5份,银杏叶18份。
7.根据权利要求1所述的治疗心肌炎的药物组合物,其特征在于:制成所述药物组合物的原料组成及重量份数为:三七10份,赤芍6份,柏子仁2份,连翘13份,黄芪13份,胡荽23份,柳枝31份,白杨枝11份,桃枝17份,芦根34份,苍术15份,灯心草5份,红花8份,川芎30份,莪术32份,麦冬15份,郁金18份,薤白22份,桂枝5份,太子参10份,瓜萎26份,淡竹叶15份,天南星25份,炙甘草4份,合欢皮8份,五味子5份,丹参12份,川升麻15份,白薇16份,肉苁蓉15份,薄荷叶7份,银杏叶12份。
8.一种治疗心肌炎的药物组合物的制备方法,其特征在于,所述制备方法具体为以下步骤:
(1)按照权利要求1-7任一所述的重量份数配比提取各中药原料药,然后共同细研成药末,备用;
(2)取步骤(1)中研磨的药末放置于砂锅中加水,水量为药末重量的4倍,然后用大火将水煮沸4-6min后,改小火煎熬,煎熬时搅拌药末,搅拌次数为2-3次,煎熬时间为30-45min,煎熬完成后滤去药渣,取药液。
9.一种治疗心肌炎的药物组合物的制备方法,其特征在于,所述制备方法具体为以下步骤:
(1)按照权利要求1-7任一所述的重量份数配比提取各中药原料药加水煎煮2次,第一次2-2.5小时,第二次1.5小时,滤液合并再煎1小时,静置30小时,再次过滤,滤过,滤液浓缩至相对密度为1.05;
(2)将步骤(1)所得滤液加入乙醇,乙醇用量为滤液质量的1.5倍,充分混合均匀,静置冷藏25-30小时,滤过,滤液回收乙醇后,再继续浓缩至稠膏,至相对密度为1.40;
(3)取适量糖粉于60℃烘1-2小时,置于适宜容器内,加入步骤(2)中所得稠膏搅拌混匀,调制成软硬度为手捏成团,轻压则散的软材,软材过14目筛,制成湿颗粒;
(4)将步骤(3)制成的湿颗粒烘干干燥,干燥温度为80℃,冷却后密封待用。
10.根据权利要求1-7任一所述的药物组合物的应用,其特征在于:所述药物组合物制成汤剂、丸剂、散剂、膏剂、丹剂、胶囊或颗粒剂。
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