CN102198262A - 一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 - Google Patents
一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 Download PDFInfo
- Publication number
- CN102198262A CN102198262A CN2011101392425A CN201110139242A CN102198262A CN 102198262 A CN102198262 A CN 102198262A CN 2011101392425 A CN2011101392425 A CN 2011101392425A CN 201110139242 A CN201110139242 A CN 201110139242A CN 102198262 A CN102198262 A CN 102198262A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- preparation
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 132
- 238000002360 preparation method Methods 0.000 title claims abstract description 52
- 241000702670 Rotavirus Species 0.000 title claims abstract description 27
- 208000004232 Enteritis Diseases 0.000 title claims abstract description 23
- 210000003038 endothelium Anatomy 0.000 claims abstract description 20
- 241000206469 Pulsatilla Species 0.000 claims abstract description 7
- 235000004879 dioscorea Nutrition 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims description 54
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 229940079593 drug Drugs 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 241000222640 Polyporus Species 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 20
- 241000792859 Enema Species 0.000 claims description 19
- 239000007920 enema Substances 0.000 claims description 19
- 229940095399 enema Drugs 0.000 claims description 19
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 15
- 230000014759 maintenance of location Effects 0.000 claims description 13
- 239000000341 volatile oil Substances 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 238000000108 ultra-filtration Methods 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 8
- 235000005903 Dioscorea Nutrition 0.000 claims description 6
- 241000234273 Dioscorea Species 0.000 claims description 6
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 6
- 241000212941 Glehnia Species 0.000 claims description 6
- 241000498779 Myristica Species 0.000 claims description 6
- 241000219295 Portulaca Species 0.000 claims description 6
- 241000219780 Pueraria Species 0.000 claims description 6
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims description 6
- 241000207929 Scutellaria Species 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 235000012907 honey Nutrition 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- -1 soak 0.5-1.5 hour Substances 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 235000008504 concentrate Nutrition 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000000703 high-speed centrifugation Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 238000001256 steam distillation Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- 238000003809 water extraction Methods 0.000 claims description 3
- 239000008298 dragée Substances 0.000 claims description 2
- 239000002662 enteric coated tablet Substances 0.000 claims description 2
- 239000007941 film coated tablet Substances 0.000 claims description 2
- 239000007902 hard capsule Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000011505 plaster Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000007940 sugar coated tablet Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 241000581682 Sanguisorba Species 0.000 claims 3
- 210000000952 spleen Anatomy 0.000 abstract description 67
- 206010012735 Diarrhoea Diseases 0.000 abstract description 66
- 230000000694 effects Effects 0.000 abstract description 50
- 210000002784 stomach Anatomy 0.000 abstract description 44
- 210000003734 kidney Anatomy 0.000 abstract description 22
- 208000002193 Pain Diseases 0.000 abstract description 19
- 210000004072 lung Anatomy 0.000 abstract description 18
- 230000001105 regulatory effect Effects 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 9
- 231100000331 toxic Toxicity 0.000 abstract description 9
- 230000002588 toxic effect Effects 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000009545 invasion Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 244000273928 Zingiber officinale Species 0.000 abstract description 2
- 235000006886 Zingiber officinale Nutrition 0.000 abstract description 2
- 230000001174 ascending effect Effects 0.000 abstract description 2
- 235000008397 ginger Nutrition 0.000 abstract description 2
- 240000004510 Agastache rugosa Species 0.000 abstract 1
- 241000304531 Allium macrostemon Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000050051 Chelone glabra Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 241000222684 Grifola Species 0.000 abstract 1
- 244000270834 Myristica fragrans Species 0.000 abstract 1
- 235000009421 Myristica fragrans Nutrition 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- 235000001855 Portulaca oleracea Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 244000294611 Punica granatum Species 0.000 abstract 1
- 235000014360 Punica granatum Nutrition 0.000 abstract 1
- 239000001702 nutmeg Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 33
- 201000010099 disease Diseases 0.000 description 31
- 208000001848 dysentery Diseases 0.000 description 29
- 230000000968 intestinal effect Effects 0.000 description 24
- 206010047700 Vomiting Diseases 0.000 description 22
- 239000008280 blood Substances 0.000 description 22
- 210000004369 blood Anatomy 0.000 description 20
- 230000008673 vomiting Effects 0.000 description 20
- 241000699670 Mus sp. Species 0.000 description 18
- 235000013305 food Nutrition 0.000 description 18
- 230000000844 anti-bacterial effect Effects 0.000 description 17
- 235000005911 diet Nutrition 0.000 description 16
- 230000001717 pathogenic effect Effects 0.000 description 15
- 230000001737 promoting effect Effects 0.000 description 14
- 239000009806 pulsatillae Substances 0.000 description 14
- 208000019637 Infantile Diarrhea Diseases 0.000 description 13
- 206010011224 Cough Diseases 0.000 description 12
- 230000037213 diet Effects 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 230000036528 appetite Effects 0.000 description 11
- 235000019789 appetite Nutrition 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 11
- 230000029087 digestion Effects 0.000 description 11
- 230000003203 everyday effect Effects 0.000 description 11
- 239000007789 gas Substances 0.000 description 11
- 235000019640 taste Nutrition 0.000 description 11
- 210000001835 viscera Anatomy 0.000 description 11
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 230000004087 circulation Effects 0.000 description 10
- 244000052769 pathogen Species 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 210000001113 umbilicus Anatomy 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 9
- 210000002429 large intestine Anatomy 0.000 description 9
- 231100000614 poison Toxicity 0.000 description 9
- 238000005728 strengthening Methods 0.000 description 9
- 230000035922 thirst Effects 0.000 description 9
- 208000019790 abdominal distention Diseases 0.000 description 8
- 230000001142 anti-diarrhea Effects 0.000 description 8
- 201000006549 dyspepsia Diseases 0.000 description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 7
- 230000002159 abnormal effect Effects 0.000 description 7
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 7
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 7
- 229960003321 baicalin Drugs 0.000 description 7
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 7
- 230000002496 gastric effect Effects 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 6
- 208000004880 Polyuria Diseases 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 210000003608 fece Anatomy 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 210000003097 mucus Anatomy 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000010791 quenching Methods 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 238000010792 warming Methods 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 5
- 230000008485 antagonism Effects 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000012258 culturing Methods 0.000 description 5
- 230000013872 defecation Effects 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 230000003871 intestinal function Effects 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000036285 pathological change Effects 0.000 description 5
- 231100000915 pathological change Toxicity 0.000 description 5
- 230000003014 reinforcing effect Effects 0.000 description 5
- 210000000813 small intestine Anatomy 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 229930003347 Atropine Natural products 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- 206010060891 General symptom Diseases 0.000 description 4
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 4
- 208000008454 Hyperhidrosis Diseases 0.000 description 4
- 206010061245 Internal injury Diseases 0.000 description 4
- 206010024642 Listless Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 206010070834 Sensitisation Diseases 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 206010048222 Xerosis Diseases 0.000 description 4
- 230000003187 abdominal effect Effects 0.000 description 4
- 238000001467 acupuncture Methods 0.000 description 4
- 229960000396 atropine Drugs 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 208000019902 chronic diarrheal disease Diseases 0.000 description 4
- 206010061428 decreased appetite Diseases 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 230000000378 dietary effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- ALWKGYPQUAPLQC-UHFFFAOYSA-N neostigmine Chemical compound CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 ALWKGYPQUAPLQC-UHFFFAOYSA-N 0.000 description 4
- 229960002362 neostigmine Drugs 0.000 description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 238000007670 refining Methods 0.000 description 4
- 230000008313 sensitization Effects 0.000 description 4
- 230000035943 smell Effects 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 238000002636 symptomatic treatment Methods 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 3
- 206010008631 Cholera Diseases 0.000 description 3
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 3
- 206010017553 Furuncle Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 244000173853 Sanguisorba officinalis Species 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 241001251949 Xanthium sibiricum Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000002934 diuretic Substances 0.000 description 3
- 230000001882 diuretic effect Effects 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 230000004064 dysfunction Effects 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 208000001780 epistaxis Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 235000021251 pulses Nutrition 0.000 description 3
- 230000001047 pyretic effect Effects 0.000 description 3
- 230000000171 quenching effect Effects 0.000 description 3
- 231100000019 skin ulcer Toxicity 0.000 description 3
- 210000004988 splenocyte Anatomy 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 230000004206 stomach function Effects 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 2
- 208000008710 Amebic Dysentery Diseases 0.000 description 2
- 206010001986 Amoebic dysentery Diseases 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 2
- 206010004016 Bacterial diarrhoea Diseases 0.000 description 2
- 206010048909 Boredom Diseases 0.000 description 2
- 206010010947 Coordination abnormal Diseases 0.000 description 2
- 206010012742 Diarrhoea infectious Diseases 0.000 description 2
- 208000036649 Dysbacteriosis Diseases 0.000 description 2
- 208000027244 Dysbiosis Diseases 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010019705 Hepatic pain Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 206010030302 Oliguria Diseases 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 206010057071 Rectal tenesmus Diseases 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- 241000607760 Shigella sonnei Species 0.000 description 2
- 206010040925 Skin striae Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 208000012886 Vertigo Diseases 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 230000007950 acidosis Effects 0.000 description 2
- 208000026545 acidosis disease Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 230000007140 dysbiosis Effects 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 238000010579 first pass effect Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 210000001624 hip Anatomy 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 208000016290 incoordination Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000031891 intestinal absorption Effects 0.000 description 2
- 150000002630 limonoids Chemical class 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 208000012271 tenesmus Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 231100000889 vertigo Toxicity 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 108700031361 Brachyury Proteins 0.000 description 1
- 208000001378 Carbon Tetrachloride Poisoning Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 239000008589 Cortex Fraxini Substances 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 108010001394 Disaccharidases Proteins 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000371997 Eriocheir sinensis Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 108010060309 Glucuronidase Proteins 0.000 description 1
- 102000053187 Glucuronidase Human genes 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 206010051986 Pneumatosis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 244000171085 Polyporus umbellatus Species 0.000 description 1
- 235000004837 Polyporus umbellatus Nutrition 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 241000209051 Saccharum Species 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 206010039705 Scleritis Diseases 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 231100000643 Substance intoxication Toxicity 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241000244155 Taenia Species 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229940098166 bactrim Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009989 contractile response Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000021551 crystal sugar Nutrition 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 230000000741 diarrhetic effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 229960002768 dipyridamole Drugs 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004362 fungal culture Methods 0.000 description 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
- 229960001625 furazolidone Drugs 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 1
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 1
- 235000002780 gingerol Nutrition 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229940025878 hesperidin Drugs 0.000 description 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 235000021125 infant nutrition Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 201000007772 internal hemorrhoid Diseases 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229930013032 isoflavonoid Natural products 0.000 description 1
- 150000003817 isoflavonoid derivatives Chemical class 0.000 description 1
- 235000012891 isoflavonoids Nutrition 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 235000021332 kidney beans Nutrition 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002955 secretory cell Anatomy 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 229910021647 smectite Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229940100050 virazole Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
菌株 | 株号 | 100%凝胶剂 | 200%凝胶剂 | 300%凝胶剂 |
金黄色葡萄球菌 | M122 | -- | +++ | +++ |
白色葡萄球菌 | M121 | - | ++++ | ++++ |
绿脓杆菌 | Ps207 | - | ++ | +++ |
变形杆菌 | E402 | + | ++ | +++ |
大肠杆菌 | E100 | - | ++ | ++ |
枯草杆菌 | 63051 | + | +++ | ++ |
白喉杆菌 | C102 | + | +++ | ++++ |
肺炎双球菌 | M311 | - | +++ | +++ |
伤寒杆菌 | E686 | ++ | +++ | ++++ |
甲型副伤寒杆菌 | 50073 | ++ | +++ | + |
乙型副伤寒杆菌 | 50094 | + | ++ | ++++ |
乙型溶血链球菌 | M220 | ++ | ++++ | +++ |
组别 | n | 剂量(g/kg) | 小肠推进率(%) |
正常对照组 | 10 | 0 | 72.56±9.74 |
谷参肠安组 | 10 | 0.70 | 67.72±11.45 |
本发明药物低剂量组 | 10 | 0.62 | 70.07±11.24 |
本发明药物中剂量组 | 10 | 1.24 | 65.92±9.57* |
本发明药物高剂量组 | 10 | 1.86 | 61.72±6.31** |
组别 | 剂量(g/kg) | 小肠推进率(%) |
正常对照组 | 0 | 69.18±8.53 |
模型对照组 | 0 | 78.22±8.75 △ |
谷参肠安组 | 0.70 | 70.27±8.06 |
本发明药物低剂量组 | 0.620 | 73.21±11.45 |
本发明药物中剂量组 | 1.24 | 68.54±9.22* |
本发明药物高剂量组 | 1.86 | 66.68±6.67** |
组别 | 剂量(g/kg) | 小肠推进率 |
正常对照组 | 0 | 69.29±13.77 |
阿托品组 | 0 | 68.14±12.98△ |
谷参肠安组 | 0.70 | 66.16±8.47* |
本发明药物低剂量组 | 0.62 | 77.94±20.23** |
本发明药物中剂量组 | 1.24 | 73.35±8.86** |
本发明药物高剂量组 | 1.86 | 64.65±13.27** |
组别 | 例数 | 显效 | 有效 | 无效 | 总有效率(% ) |
治疗组 | 128 | 102 | 21 | 5 | 96.09 |
对照组 | 72 | 37 | 18 | 17 | 76.39 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101392425A CN102198262B (zh) | 2011-05-27 | 2011-05-27 | 一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101392425A CN102198262B (zh) | 2011-05-27 | 2011-05-27 | 一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102198262A true CN102198262A (zh) | 2011-09-28 |
CN102198262B CN102198262B (zh) | 2012-07-11 |
Family
ID=44659417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011101392425A Expired - Fee Related CN102198262B (zh) | 2011-05-27 | 2011-05-27 | 一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102198262B (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103007145A (zh) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | 一种治疗小儿轮状病毒肠炎的中药组合物及其制备方法 |
CN103405742A (zh) * | 2013-08-23 | 2013-11-27 | 王怀珍 | 一种治疗小儿腹泻的药物组合物及其制备方法 |
CN103405743A (zh) * | 2013-08-23 | 2013-11-27 | 尹永红 | 一种用于小儿腹泻的药物制剂 |
CN103550436A (zh) * | 2013-11-15 | 2014-02-05 | 任春红 | 一种治疗小儿轮状病毒性肠炎的中药灌肠剂 |
CN103721224A (zh) * | 2013-12-14 | 2014-04-16 | 郑明立 | 一种治疗慢性非特异性溃疡性结肠炎的药物及其制备方法 |
CN104083695A (zh) * | 2014-07-02 | 2014-10-08 | 卞佳林 | 一种用于治疗急性肠炎的中药制剂及其制作方法和应用 |
CN104338051A (zh) * | 2013-08-01 | 2015-02-11 | 董幼祺 | 一种治疗小儿病毒性腹泻的中药组合物 |
CN104971283A (zh) * | 2015-06-30 | 2015-10-14 | 谭清平 | 一种用于治疗小儿轮状病毒肠炎的中药胶囊 |
CN105012846A (zh) * | 2015-08-10 | 2015-11-04 | 王艳娣 | 一种治疗小儿腹泻的中药组合物 |
CN105056080A (zh) * | 2015-07-24 | 2015-11-18 | 王艳娣 | 一种治疗小儿积滞症的中药组合物 |
CN105169344A (zh) * | 2015-10-14 | 2015-12-23 | 王艳娣 | 一种治疗小儿轮状病毒性肠炎的中药 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102048933A (zh) * | 2010-12-20 | 2011-05-11 | 崔守凤 | 一种治疗小儿腹泻的中药组合物及其制备方法 |
-
2011
- 2011-05-27 CN CN2011101392425A patent/CN102198262B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102048933A (zh) * | 2010-12-20 | 2011-05-11 | 崔守凤 | 一种治疗小儿腹泻的中药组合物及其制备方法 |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103007145B (zh) * | 2012-12-28 | 2014-10-15 | 青岛华仁技术孵化器有限公司 | 一种治疗小儿轮状病毒肠炎的中药组合物及其制备方法 |
CN103007145A (zh) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | 一种治疗小儿轮状病毒肠炎的中药组合物及其制备方法 |
CN104338051A (zh) * | 2013-08-01 | 2015-02-11 | 董幼祺 | 一种治疗小儿病毒性腹泻的中药组合物 |
CN103405742A (zh) * | 2013-08-23 | 2013-11-27 | 王怀珍 | 一种治疗小儿腹泻的药物组合物及其制备方法 |
CN103405743A (zh) * | 2013-08-23 | 2013-11-27 | 尹永红 | 一种用于小儿腹泻的药物制剂 |
CN103405742B (zh) * | 2013-08-23 | 2014-12-10 | 王怀珍 | 一种治疗小儿腹泻的药物组合物及其制备方法 |
CN103550436A (zh) * | 2013-11-15 | 2014-02-05 | 任春红 | 一种治疗小儿轮状病毒性肠炎的中药灌肠剂 |
CN103550436B (zh) * | 2013-11-15 | 2015-08-19 | 任春红 | 一种治疗小儿轮状病毒性肠炎的中药灌肠剂 |
CN103721224A (zh) * | 2013-12-14 | 2014-04-16 | 郑明立 | 一种治疗慢性非特异性溃疡性结肠炎的药物及其制备方法 |
CN104083695A (zh) * | 2014-07-02 | 2014-10-08 | 卞佳林 | 一种用于治疗急性肠炎的中药制剂及其制作方法和应用 |
CN104971283A (zh) * | 2015-06-30 | 2015-10-14 | 谭清平 | 一种用于治疗小儿轮状病毒肠炎的中药胶囊 |
CN105056080A (zh) * | 2015-07-24 | 2015-11-18 | 王艳娣 | 一种治疗小儿积滞症的中药组合物 |
CN105012846A (zh) * | 2015-08-10 | 2015-11-04 | 王艳娣 | 一种治疗小儿腹泻的中药组合物 |
CN105169344A (zh) * | 2015-10-14 | 2015-12-23 | 王艳娣 | 一种治疗小儿轮状病毒性肠炎的中药 |
Also Published As
Publication number | Publication date |
---|---|
CN102198262B (zh) | 2012-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102048933B (zh) | 一种治疗小儿腹泻的中药组合物及其制备方法 | |
CN102198262B (zh) | 一种治疗小儿轮状病毒性肠炎的中药制剂及其制备方法 | |
CN101972338B (zh) | 一种治疗小儿上呼吸道感染的中药制剂及其制备方法 | |
CN103099959B (zh) | 一种治疗溃疡性结肠炎的中药制剂及其制备方法 | |
CN102205107B (zh) | 一种治疗十二指肠溃疡的中药制剂及其制备方法 | |
CN102772781B (zh) | 一种治疗慢性结肠炎的中药制剂及其制备方法 | |
CN101797326A (zh) | 一种治疗肠鸣腹泻的中药制剂及其制备方法 | |
CN103041256B (zh) | 一种治疗小儿反复呼吸道感染的中药制剂 | |
CN102600417A (zh) | 一种治疗牛羊瘤胃鼓气的中药组合物 | |
CN103041257B (zh) | 治疗小儿发热高烧呼吸道感染的中药制剂 | |
CN104522213A (zh) | 适宜三高人群饮用的茶饮及其制备方法 | |
CN103920027A (zh) | 用于治疗急性黄疸型乙型肝炎的药物及其制备方法 | |
CN103041255B (zh) | 治疗小儿咽喉肿痛呼吸道感染的中药制剂 | |
CN102198261B (zh) | 一种治疗老年慢性结肠炎的中药制剂及其制备方法 | |
CN103007145B (zh) | 一种治疗小儿轮状病毒肠炎的中药组合物及其制备方法 | |
CN105435190A (zh) | 用于治疗寒热错杂型哮病的中药组合物及其制备方法 | |
CN104435244A (zh) | 一种有效治疗乳岩的中药组合物 | |
CN103041258B (zh) | 治疗小儿呼吸道感染伴纳差不食的中药制剂 | |
CN101810751B (zh) | 一种治疗小儿肠系膜淋巴结发炎的中药制剂 | |
CN107137689A (zh) | 一种治疗更年期综合征的中药组合物 | |
CN105412643A (zh) | 一种治疗小儿水气凌心型哮喘的喷雾剂及其制备方法 | |
CN105169344A (zh) | 一种治疗小儿轮状病毒性肠炎的中药 | |
CN104707029B (zh) | 一种治疗银屑病的中药 | |
CN105267815A (zh) | 一种治疗小儿肺肾两虚型哮喘的喷雾剂及其制备方法 | |
CN104435707A (zh) | 一种针对久泻久痢、便血的石榴皮中药茶及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Meng Xiaohui Inventor after: Kong Jian Inventor before: Kong Jian |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: KONG JIAN TO: MENG XIAOHUI KONG JIAN |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NANTONG WEEK TOURISM DEVELOPMENT CO., LTD. Free format text: FORMER OWNER: KONG JIAN Effective date: 20130730 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 264006 YANTAI, SHANDONG PROVINCE TO: 226121 NANTONG, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130730 Address after: 226121 Jiangsu province Nantong markets three factory town Road No. 79 Patentee after: Nantong seven Tourism Development Co., Ltd. Address before: 264006 No. 92, Yantai economic and Technological Development Zone, Shandong, Zhujianglu Road Patentee before: Kong Jian |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120711 Termination date: 20180527 |
|
CF01 | Termination of patent right due to non-payment of annual fee |