CN103520669B - 治疗痰湿蕴结证型胸痹心痛的中药 - Google Patents
治疗痰湿蕴结证型胸痹心痛的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗痰湿蕴结证型胸痹心痛的中药，其特征在于由以下重量配比的药材制备而成的：柴胡10份、炒枳实20份、黄莲10份、人参10份、砂仁10份、白术20份、茯苓30份、龙骨15份、牡蛎30份、九节菖蒲10份、瓜萎30份、干姜10份、甘草6份、桂枝10份。本发明选用适宜的药材及其配比，所制成的中药能通阳泄浊，豁痰宣痹，有效治疗因痰湿蕴结证型胸痹心痛，其有效率达87.5%。
Description
技术领域
本发明涉及一种中药，特别是一种治疗痰湿蕴结证型胸痹心痛的中药。
背景技术
胸痹心痛是由于正气亏虚，饮食、情志、寒邪等所引起的以痰浊、瘀血、气滞、寒凝痹阻心脉，以膻中或左胸部发作性憋闷、疼痛为主要临床表现的一种病证。饮食不当，恣食肥甘厚味或经常饱餐过度，日久损伤脾胃，运化失司，酿湿生痰，痰阻气机，上犯心胸，清阳不展，气机不畅，心脉痹阻，遂造成痰湿蕴结证型胸痹心痛。胸痹心痛是威胁中老年人生命健康的重要心系病证之一，随着现代社会生活方式及饮食结构的改变，发病有逐渐增加的趋势，因而本病越来越引起人们的重视。由于本病表现为本虚标实，有着复杂的临床表现及病理变化，而中医药治疗从整体出发，具有综合作用的优势，因而受到广泛的关注。
本发明所涉及的药材的研究现状如下：
柴胡【来源】 本品为伞形科植物柴胡Bupleurum chinense DC.或狭叶柴胡Bupleurum scorzonerifolium Willd.的干燥根。【性味】 苦，微寒。【归经】 归肝、胆经。【功能主治】 和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。
炒枳实【来源】 本品为芸香科植物酸橙Citrus aurantium L. 及其栽培变种或甜橙Citrus sinensis Osbeck 的干燥幼果。【性味】 苦、辛、酸，温。【归经】 归脾、胃经。【功能主治】 破气消积，化痰散痞。用于积滞内停，痞满胀痛，泻痢后重，大便不通，痰滞气阻胸痹，结胸；胃下垂，脱肛，子宫脱垂。
黄莲【来源】 本品为毛茛科植物黄连Coptis chinensis Franch.、三角叶黄连Coptis deltoidea C. Y. Cheng et Hsiao或云连Coptis teeta Wall.的干燥根茎。【性味】 苦，寒。【归经】 归心、脾、胃、肝、胆、大肠经。【功能主治】 清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。
人参【来源】 本品为五加科植物人参Panax ginseng C. A. Mey.的干燥根。【性味】 甘、微苦，平。【归经】 归脾、肺、心经。【功能主治】 大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。
砂仁【来源】 本品为姜科植物阳春砂Amomum villosum Lour. 、绿壳砂Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen 或海南砂Amomum longiligulare T. L. Wu 的干燥成熟果实。【性味】 辛，温。【归经】 归脾、胃、肾经。【功能主治】 化湿开胃，温脾止泻，理气安胎。用于湿浊中阻，脘痞不饥，脾胃虚寒，呕吐泄泻，妊娠恶阻，胎动不安。
桂枝【来源】 本品为樟科植物肉桂 Cinnamomum cassia Presl的干燥嫩枝。【性味】 辛、甘，温。【归经】 归心、肺、膀胱经。【功能主治】 发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
干姜【来源】本品为姜科植物姜Zingiber officinale Rosc.的干燥根茎。【性味】味辛，性热。【归经】归脾、胃、心、肺经。【功能主治】温中散寒，回阳通脉，燥湿消痰，温肺化饮。用于治脘腹冷痛，呕吐，泄泻，亡阳厥逆，寒饮喘咳，寒湿痹痛。
白术【来源】 本品为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。【性味】 苦、甘，温。【归经】 归脾、胃经。【功能主治】 健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
茯苓【来源】 本品为多孔菌科真菌茯苓 Poria cocos （Schw.） Wolf 的干燥菌核。【性味】 甘、淡，平。【归经】 归心、肺、脾、肾经。【功能主治】 利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
龙骨【来源】为古代哺乳动物如象类、犀牛类、三趾马等的骨骼化石。【性味】甘、涩，平。【归经】心，肝，肾，大肠经。【功能主治】镇静，敛汗涩精，生肌敛疮。用于神经衰弱，心悸，失眠，多梦，自汗，盗汗，遗精，遗尿，崩漏，带下；外用治疮疡久溃不敛。
牡蛎【来源】 本品为牡蛎科动物长牡蛎Ostrea gigas Thunberg、大连湾牡蛎Ostrea talienwhanensis Crosse 或近江牡蛎Ostrea rivularis Gould的贝壳。【性味】 咸，微寒。【归经】 归肝、胆、肾经。【功能主治】 重镇安神，潜阳补阴，软坚散结。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，症瘕痞块。
九节菖蒲【来源】为毛茛科植物阿尔泰银莲花的根茎。【性味】辛，微温。【归经】心；肝；脾经。【功能主治】化痰开窍，安神，宣湿醒脾，解毒。主热病神昏，癫痫，气闭耳聋，多梦健忘，胸闷腹胀，食欲不振，风湿痹痛，痈疽，疮疥肿毒。
瓜萎【来源】 本品为葫芦科植物栝楼Trichosanthes kirilowii Maxim. 或双边栝楼Trichosan-thes rosthornii Harms 的干燥成熟果实。【性味】 甘、微苦、寒。【归经】 归肺、胃、大肠经。【功能主治】 清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。
甘草【来源】 本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。【性味】 甘，平。【归经】 归心、肺、脾、胃经 。【功能主治】 补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
发明内容
本发明旨在提供一种治疗痰湿蕴结证型胸痹心痛的中药，通过选择合适的药材及其配比，达到安全有效治愈痰湿蕴结证型胸痹心痛的目的。
为达到上述目的，本发明采用以下技术方案：
一种治疗痰湿蕴结证型胸痹心痛的中药，其特征在于由以下重量配比的药材制备而成的：
柴胡10份、炒枳实20份、黄莲10份、人参10份、砂仁10份、白术20份、茯苓30份、龙骨15份、牡蛎30份、九节菖蒲10份、瓜萎30份、干姜10份、甘草6份、桂枝10份。
痰湿蕴结证型胸痹心痛的病机为痰浊盘踞，胸阳失展，气机痹阻，脉络阻滞。临床上其主要症状表现为：胸闷重而心痛，痰多气短，肢体沉重，形体肥胖，遇雨天而易发作或加重，伴有倦怠乏力，纳呆便溏，咯吐痰涎，舌体胖大且有齿痕，苔浊腻或白滑，脉滑。本发明选用适宜的药材及其配比，所制成的中药能通阳泄浊，豁痰宣痹，有效治疗因痰湿蕴结证型胸痹心痛，其有效率达87.5%。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年12月-2013年3月间共收集了62例痰湿蕴结证型胸痹心痛门诊患者，其中，男29例，女，33例，年龄48-71岁，病情1个月-20个月。随机分为：治疗组40例，对照组22例。两组年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组口服栝萎薤白半夏汤，按照说明书服用。疗程20天。
2.2治疗组口服本发明按照具体实施例1制得的胶囊，早、中、晚各一次。疗程20天。
3、疗效标准及治疗结果
3.1疗效标准：
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率（%） |
| 治疗组 | 50 | 3 | 32 | 5 | 87.5% |
| 空白组 | 22 | 1 | 11 | 10 | 54.5% |
由此可见，本发明制得的药物能够安全有效治疗痰湿蕴结证型胸痹心痛。
具体实施方式
为了更好地理解与实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取柴胡10克、炒枳实20克、黄莲10克、人参10克、砂仁10克、白术20克、茯苓30克、龙骨15克、牡蛎30克、九节菖蒲10克、瓜萎30克、干姜10克、甘草6克、桂枝10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗痰湿蕴结证型胸痹心痛。口服，每日分早、中、晚三次服用。
具体实施例2
称取柴胡10克、炒枳实20克、黄莲10克、人参10克、砂仁10克、白术20克、茯苓30克、龙骨15克、牡蛎30克、九节菖蒲10克、瓜萎30克、干姜10克、甘草6克、桂枝10克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人1天用量的散剂。
用于治疗痰湿蕴结证型胸痹心痛。口服，每日分早、中、晚三次服用。
具体实施例3
称取柴胡10克、炒枳实20克、黄莲10克、人参10克、砂仁10克、白术20克、茯苓30克、龙骨15克、牡蛎30克、九节菖蒲10克、瓜萎30克、干姜10克、甘草6克、桂枝10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人1天用量的颗粒剂。
用于治疗痰湿蕴结证型胸痹心痛。口服，每日分早、中、晚三次服用。
Claims (1)
1.一种治疗痰湿蕴结证型胸痹心痛的中药，其特征在于由以下重量配比的药材制备而成的：
柴胡10份、炒枳实20份、黄连10份、人参10份、砂仁10份、白术20份、茯苓30份、龙骨15份、牡蛎30份、九节菖蒲10份、瓜萎30份、干姜10份、甘草6份、桂枝10份。
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