CN104522661A - 含金银花提取物的保健含片及其生产方法 - Google Patents
含金银花提取物的保健含片及其生产方法 Download PDFInfo
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- CN104522661A CN104522661A CN201410822265.XA CN201410822265A CN104522661A CN 104522661 A CN104522661 A CN 104522661A CN 201410822265 A CN201410822265 A CN 201410822265A CN 104522661 A CN104522661 A CN 104522661A
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- honegsukle flower
- buccal tablets
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Abstract
本发明公开了一种含金银花提取物的保健含片及其生产方法,它包括以下重量份数的原料:金银花提取物18-20、五味子3-5、黄秋葵6-8、枸杞子3-5、茯苓3-5、白术4-6、炙甘草8-10、木蝴蝶3-5,其生产方法是将中药经过回流煎煮提浓缩干燥压片生产而成。该含金银花提取物的保健含片成本低,容易被人体吸收、疗效高,见效快,以金银花提取物为主原料,并加入了几味中草药,具清热解毒、益气滋阴、除湿益燥,和中益气的功效,经常服用可起到调整经气,解除疲劳,增加免疫功能的作用。
Description
技术领域
本发明涉及保健品领域,尤其涉及一种含金银花提取物的保健含片及其生产方法。
背景技术
金银花为忍冬科植物忍冬的干燥花蕾或带初开的花。金银花药食同源,为中医常用药;其性寒,味苦,具有清热解毒、凉散风热之功效,主要用于痈肿疔疮、喉痹、丹毒、热毒血痢、风热感冒、温病发热。金银花的主要有效成分为有机酸中的绿原酸和异绿原酸,其具有抑菌抗病毒、解热、抗炎、保肝、止血、抗氧化、免疫调节等作用。最新研究还表明,绿原酸及其衍生物被确认是鼠肝微粒体中6-磷酸葡萄糖移位酶的特效性抑制剂,显示出其在治疗糖尿病方面的良好前景。临床上很多常用的中成药均含有金银花,这些中成药使用安全、疗效肯定,如银翘解毒片、银黄片、银黄注射液、双黄连注射液、脉络宁注射液等。有文献报道,金银花中绿原酸的提取纯化一般采用水提、树脂纯化、正丁醇或乙酸乙酯萃取、浓缩、干燥。
1抗茵、抗病毒作用
金银花具有较强的抗病原微生物的作用,其抗菌成分为绿原酸、异绿原酸、木樨草素、木樨草素一7一葡萄苷及挥发油等。有研究表明金银花主要对金黄色葡萄球菌、白色葡萄球菌、溶血性链球菌、脑炎杆菌、脑膜炎双球菌、伤寒杆菌、痢疾杆菌、百日咳杆菌、绿脓杆菌、霍乱杆菌等多种革兰阳性菌和革兰阴性菌均有一定的抗菌作用。金银花提取物的体内抗菌实验结果提示对金黄色葡萄球菌感染小鼠可降低其死亡率并可延长存活天数,对脑炎球菌感染小鼠可降低其死亡率,说明金银花提取物用于体内也有较好的抗菌作用。金银花能抑制流感病毒、孤儿病毒、单纯疱疹病毒等所致细胞病变。有实验证明金银花能抑制流感病毒京68—1.ECHOⅡ及单纯疱疹病毒的致细胞病变作用;在鸡胚实验中,无论在感染病毒前6h经卵黄囊给药或于病毒感染后经尿囊给药作模拟试验,金银花对流感病毒68—1的增殖均有明显抑制作用,但对副流感病毒无效;对于流感病毒所致小鼠感染,金银花水提取物保护68%的小鼠免于死亡,并呈量效关系地明显抑制鼠肺中病毒血凝素的效价;免疫荧光法表明金银花提取物还能使病毒感染后48h增殖高峰时鼠肺细支气管内特异性荧光颗粒明显减少,上述结果砉明金银花水提取物在体内外均显示一定抗病毒活性。
2 解热、抗炎作用
金银花的绿原酸和异绿原酸对鹿角菜胶、三连菌苗致热有不同程度的退热作用。通过采用1L-1复制新西兰兔发热模型,运用玻璃微电极细胞外放电记录技术阐明了金银花中枢解热电生理机制。金银花对急慢性炎症均有明显的抑制作用,将金银花醇提取液利用腹腔注射法对大白鼠蛋清性足趾肿胀及外敷法对大白鼠蛋清性足拓肿胀进行试验,结果证明金银花无论注射还是外敷对大鼠足部肿胀均有抑制作用,既能减少炎性渗出也能抑制炎性增生。
3 利胆、保肝作用
金银花含有多种绿原酸具有显著的利胆作用,可增进大鼠的胆汁分泌。金银花总黄酮对卡介苗和脂多糖所致的小鼠免疫性肝损伤具有保护作用,可降低小鼠增加的肝、脾指数,改善病理学变化和肝脏病理学分级,减轻炎性反应,其机制可能与减少自由基产生,抑制细胞膜脂质氧化,减少NO和TNF-α等炎性介质的释放有关。
4 增强免疫功能
金银花具有增强免疫的功能。将大白鼠用金银花水煎液灌胃2周后,分别检测其巨噬细胞吞噬功能,MTI法检测淋巴细胞转化功能,RT-PCR检测TH1细胞分泌的IL-2、TNF-α、IFN-γ的mRNA表达情况。实验结果表明服用金银花后能显著提高巨噬细胞吞噬率及吞噬指数,当金银花用量达到2.5g/kg体重时,能增强机体的淋巴细胞转化率,以及增强TH1细胞分泌IL-2、TNF-α、IFN-γ的能力,显著增强机体的免疫功能。
5 抗早孕作用
采用金银花乙醇提取后之水煎浸膏对小鼠、狗、猴等多种动物做抗生育试验,结果表明金银花乙醇提取液有明显的终止妊娠作用,且随着剂量的增加而增强,尤其对小鼠和狗有显著抗早孕作用。
6 降血脂、血糖作用
实验证明金银花有降血脂、保护胰岛B细胞和弱的降糖功能,能降低多种模型小鼠的血清胆固醇(TC)、动脉粥样硬化指数(AI),提高高密度脂蛋白-胆固醇(HDL-C)含量;在反应内源性脂质代谢紊乱的糖尿病(DM)模型,其主要提高HDL—c的含量来降低AI;在喂饲高脂乳剂造成的外源性高脂DM模型上则以降低TC含量,实现降低AI的目的。
金银花提取物,提取自天然植物金银花,主要成份为绿原酸。可做为药品、保健品、化妆品的原料。
随着社会经济的不断提高,人们的生活水平也在不断提高,人们工作越来越忙,起居饮食也变得不规律,人的身体机能就会下降,身体的免疫力也会降低,虽然目前市面上有保健食品,但是往往产品配方里含有十数种药物配方制成,并且多为药准字号的产品,此类产品一般只针对发生病症的人群才可服用,一般健康人群不能做为日常保健预防食品服用,否则会对身体产生不良影响,此类产品往往药味重,入口酸涩,令人服食口感不佳,并且功效单一,不能满足市场上不同人群的需求。
发明内容
基于目前存在上述存在的问题,本发明提供了一种含金银花提取物的保健含片,以金银花提取物为主原料,并加入了几味中草药,该含片具清热解毒、益气滋阴、除湿益燥,和中益气的功效,经常服用可起到调整经气,解除疲劳,增加免疫功能的作用。
本发明是采用以下技术方案实现的:
一种含金银花提取物的保健含片,它包括以下重量份数的原料:金银花提取物18-20、五味子3-5、黄秋葵6-8、枸杞子3-5、茯苓3-5、白术4-6、炙甘草8-10、木蝴蝶3-5。
优选地,各中药原料的重量份数为:金银花提取物18、五味子3、黄秋葵6、枸杞子3、茯苓3、白术4、炙甘草8、木蝴蝶3。
优选地,各中药原料的重量份数为:金银花提取物19、五味子4、黄秋葵7、枸杞子4、茯苓4、白术5、炙甘草9、木蝴蝶4。
优选地,各中药原料的重量份数为:金银花提取物20、五味子5、黄秋葵8、枸杞子5、茯苓5、白术6、炙甘草10、木蝴蝶5。
所述含金银花提取物的保健含片的生产方法,包含了以下步骤:
步骤1)金银花提取物的提取方法:采摘含苞欲放的金银花花蕾,放到普通的布袋,放到可控温控湿的房子,温度控制在28-48℃,控制方法是28-35℃保持2-3小时,35-40℃保持2-3小时,40-48℃保持2-3小时,湿度控制在80-90%,利用日光灯控光让花开放,用破碎机将花粉碎成泥状,放入容器中,每次按花泥加蒸馏水3-6倍拌匀,静置,用600目铜网筛滤,反复三次,得到溶液,干燥后得到白色精细的金银花提取物粉末备用;
步骤2)按重量份数称取五味子、黄秋葵、枸杞子、茯苓、白术、炙甘草、木蝴蝶分别粉碎,混合在一起;
步骤3)加6倍量水,煎煮3次,每次1.2h,合并滤液,浓缩至60℃时相对密度为1.04的浓缩液,加乙醇至醇浓度为75%,静置4-10h,上清液减压回收乙醇后,加入步骤1中的金银花提取物溶液,混合均匀后,浓缩为稠膏,再加入适量薄荷和淀粉、甜蜜素充分混匀,得到粉末;
步骤4)将粉末用压片机进行压片,压片后,将含片置于60℃环境中,干燥至水分添加量≤5%为止,将干燥好的含片放入塑料包装袋中,进行真空包装。
本发明选取的中药原料中,各药有效成份分析:
金银花 ,又名忍冬(学名:Lonicera japonica),为忍冬科植物忍冬Lonicera japonica Thunb.、红腺忍冬Lonicera hypoglauca Miq.、山银花(毛萼忍冬)Lonicera confusa DC. 或毛花柱忍冬Lonicera dasystyla Rehd.的干燥花蕾或带初开的花。夏初花开放前采收,干燥。 “金银花”一名出自《本草纲目》,由于忍冬花初开为白色,后转为黄色,因此得名金银花。药材金银花为忍冬科忍冬属植物忍冬及同属植物干燥花蕾或带初开的花。金银花,三月开花,五出,微香,蒂带红色,花初开则色白,经一、二日则色黄,故名金银花。又因为一蒂二花,两条花蕊探在外,成双成对,形影不离,状如雄雌相伴,又似鸳鸯对舞,故有鸳鸯藤之称。本种最明显的特征在于具有大形的叶状苞片。它在外貌上有些象华南忍冬,但那个种的苞片狭细而非叶状,萼筒密生短柔毛,小枝密生卷曲的短柔毛,与本种明显不同。这个种的形态变异非常大,无论在枝、叶的毛被、叶的形状和大小以及花冠的长度、毛被和唇瓣与筒部的长度比例等方面,都有很大的变化。但所有这些变化看来较多地同生态环境相联系,并未显示与地理分布之间的相关性。金银花自古被誉为清热解毒的良药。它性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症,均效果显著。金银花提取物,提取自天然植物金银花,主要成份为绿原酸。可做为药品、保健品、化妆品的原料。绿原酸(chlorogenic acid,CGA),又名咖啡鞣酸,是由咖啡酸(eafeic acid)与奎尼酸(quinic acid)形成的缩酸,属于苯丙素类化合物。CGA广泛存在于植物中,以金银花、杜仲中的含量较高,具有广泛的药理作用。绿原酸具有广泛的生物活性,现代科学对绿原酸生物活性的研究已深入到食品、保健、医药和日用化工等多个领域。绿原酸是一种重要的生物活性物质,具有抗菌、抗病毒、增高白血球、保肝利胆、抗肿瘤、降血压、降血脂、清除自由基和兴奋中枢神经系统等作用。
五味子(拉丁学名Schisandra chinensis)为木兰科植物五味子Schisandra chinensis (Turcz.)Baill.或华中五味子Schisandra sphenanthera Rehd. et Wils.的干燥成熟果实。前者习称“北五味子”,后者习称“南五味子”。北五味子:呈不规则的球形或扁球形,直径5~8mm。表面红色、紫红色或暗红色,皱缩,显油润,有的表面呈黑红色或出现“白“白霜”。果肉柔软,种子1~2,肾形,表面棕黄色,有光泽,种皮薄而脆。果肉气微,味酸;种子破碎后,有香气,味辛、微苦。南五味子:粒较小,表面棕红色至暗棕色,干瘪、皱缩、果肉常紧贴种子上。秋季果实成熟时采摘,晒干或蒸后晒干,除去果梗及杂质。唐等《新修本草》载“五味皮肉甘酸,核中辛苦,都有咸味”,故有五味子之名。五味子分为南、北二种。古医书称它荎蕏、玄及、会及,最早列于神农本草经上品中药,能滋补强壮之力,药用价值极高,有强身健体之效。性味:酸、甘,温。归经:归肺,心、肾经。功能主治:收敛固涩,益气生津,补肾宁心。用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠。
黄秋葵,别名秋葵(学名:Abelmoschus esculentus )、黄葵、洋茄、羊角菜、羊角豆、羊角椒、洋辣椒。一年生草本植物,根为直系根主根发达,入土深。茎直立,木质化程度高,圆柱形,高1~2米,有侧枝,绿色或暗紫色,披粗毛。叶互生,叶通常掌状5~7深裂,直径6~15厘米,裂片披针形至三角形,边缘具不规则锯齿,偶有浅裂似械叶状,基部心形,两面均疏被硬毛有。叶柄细长达7~15厘米,疏被硬毛。托叶线形,长7~8毫米。主茎第3节以上除生侧枝外,各节均有1花,两性,黄色,花萼、花瓣格五枚,花单生于叶腋间,花梗长2~3厘米,被倒硬毛;小苞片8~10,线形,长10~13毫米;花萼佛焰苞状,长2~3厘米,5裂,常早落;花黄色,内面基部暗紫色,直径7~12厘米;雄蕊柱长约2.5厘米,平滑无毛;花柱分枝5,柱头盘状,花常在上午8~9时开放,下午凋萎。蒴果长圆形,长5~6厘米,顶端尖,被黄色,或淡鹅黄色。长硬毛;种子肾形,具腺状脉纹,具香味。花期6~10月。采收嫩荚供食用,花和嫩叶也可食用。原产于非洲,之后进入美洲和其他地区,中国也有种植。美国人叫它“植物黄金金秋葵”,是降血糖的良药。黄秋葵可以深加工成花茶、饮料、胶囊、干蔬、油等。黄秋葵的花、种子、根均可入药,对恶疮、痈疖有疗效。另外,黄秋葵低脂、低糖,可以作为减肥食品;由于其含锌和硒等微量元素,可以增强人体防癌抗癌能力;其富含维生素C可预防心血管疾病发生,提高免疫力。另外丰富的维生素C和可溶性纤维(果胶)结合作用,对皮肤有一定温和的保护效应,可以代替一些化学的护肤用品;可溶性纤维还能促进体内有机物质的排泄,减少毒素在体内的积累,降低胆固醇含量。
枸杞子(FRUCTUS LYCII)为茄科植物宁夏枸杞Lycium barbarum L. 的干燥成熟果实。呈类纺锤形或椭圆形,长6~20mm,直径3~10mm。表面红色或暗红色,顶端有小凸起状的花柱痕,基部有白色的果梗痕。果皮柔韧,皱缩;果肉肉质,柔润。种子20~50粒,类肾形,扁而翘,长1.5~1.9mm,宽1~1.7mm,表面浅黄色或棕黄色。气微,味甜。夏、秋二季果实呈红色时采收,热风烘干,除去果梗。或晾至皮皱后,晒干,除去果梗。化学成分:果实含枸杞多糖,又含甜菜碱(betaine)、阿托品、天仙子胺;另含玉蜀黍黄素(zeaxanthin)、酸浆红素(physalein)、隐黄质(cryptoxanthin)、东莨菪素 (scopoletin)、胡萝卜素、核黄素、烟酸、维生素B1、 B2及C.种子含氨基酸:天冬氨酸、脯氨酸、丙氨酸、亮氨酸等。主治滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。枸杞子中含有14种氨基酸,并含有甜菜碱、玉蜀黄素、酸浆果红素等特殊营养成分,使其具有不同凡响的保健功效。枸杞子含有丰富的胡萝卜素、多种维生素和钙、铁等健康眼睛的必需营养物质,故有明目之功,俗称“明眼子”。历代医家治疗肝血不足、肾阴亏虚引起的视物昏化和夜盲症,常常使用枸杞子。著名方剂“杞菊地黄丸”,就以枸杞子为主要药物。
茯苓(Poria cocos Wolf),为多孔菌科真菌茯苓的菌核,出自《神农本草经》,俗称云苓、松苓、茯灵。为寄生在松树根上的菌类植物,形状像甘薯,外皮黑褐色,里面白色或粉红色。用于痰饮咳嗽,痰湿入络,肩背酸痛茯苓既能利水渗湿,又具健脾作用,对于脾虚不能运化水湿,停聚化生痰饮之症,具有治疗作用。可用半夏、陈皮同用,也可配桂枝、白术同用。治痰湿入络、肩酸背痛,可配半夏、枳壳同用。
白术(zhú),拉丁学名 Atractylodes macrocephala 。别名桴蓟,于术,冬白术,淅术,杨桴,吴术,片术、苍术等,属于菊科、苍术属多年生草本植物。高20-60厘米,根状茎结节状;茎直立,通常自中下部长分枝,全部光滑无毛。叶互生,中部茎叶有长3-6厘米的叶柄,叶片通常3-5羽状全裂;极少兼杂不裂而叶为长椭圆形的。侧裂片1-2对,倒披针形、椭圆形或长椭圆形,长4.5-7厘米,宽1.5-2厘米;顶裂片比侧裂片大,倒长卵形、长椭圆形或椭圆形;自中部茎叶向上向下,叶渐小,与中部茎叶等样分裂,接花序下部的叶不裂,椭圆形或长椭圆形,无柄;或大部茎叶不裂,但总兼杂有3-5羽状全裂的叶。全部叶质地薄,纸质,两面绿色,无毛,边缘或裂片边缘有长或短针刺状缘毛或细刺齿。头状花序单生茎枝顶端,植株通常有6-10个头状花序,但不形成明显的花序式排列。苞叶绿色,长3-4厘米,针刺状羽状全裂。总苞大,宽钟状,直径3-4厘米。总苞片9-10层,覆瓦状排列;外层及中外层长卵形或三角形,长6-8毫米;中层披针形或椭圆状披针形,长11-16毫米;最内层宽线形,长2厘米,顶端紫红色。全部苞片顶端钝,边缘有白色蛛丝毛。小花长1.7厘米,紫红色,冠檐5深裂。 瘦果倒圆锥状,长7.5毫米,被顺向顺伏的稠密白色的长直毛。冠毛刚毛羽毛状,污白色,长15厘米,基部结合成环状。花果期8-10月。白术喜凉爽气候,以根茎入药,具有多项药用功能。主要分布于四川、云南、贵州等山区湿地。白术具有健脾益气,燥湿利水,止汗,安胎的功效,用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。《医学启源》记载:“除湿益燥,和中益气,温中,去脾胃中湿,除胃热,强脾胃,进饮食,安胎。”
炙甘草(RADIX GLYCYRRHIZAE PREPARATA),系豆科植物,炙甘草是用蜜烘制的甘草,俗称炮制,就是将蜂蜜置锅中炼成中蜜,改用文火加生甘草片拌炒均匀,3~5 min出锅,置烤房或烘箱60~C烘至不粘手时取出,放凉即可。炙甘草为类圆形或椭圆形切片,表面红棕色或灰棕色,微有光泽,切面黄色至深黄色,形成层环明显,射线放射状。炙甘草汤具有益气滋阴,通阳复脉治疗功效。性味:甘,平。归经:归心、肺、脾、胃经 。功能主治:补脾和胃,益气复脉。用于脾胃虚弱,倦怠乏力,心动悸,脉结代。
木蝴蝶Oroxylum indicum (L.)Vent.为紫葳科植物,别名:千层纸、千张纸、破布子、满天飞。木蝴蝶花冠大,紫红色,果长而大,似船也似剑,种子似白色蝴蝶;属紫葳科。直立小乔木,高6-10米,胸径15-20厘米,树皮灰褐色。大型奇数2-3(-4)回羽状复叶,着生于茎干近顶端,长60130厘米;小叶三角状卵形,长5-13厘米,宽3-10厘米,顶端短渐尖,基部近圆形或心形,偏斜,两面无毛,全缘,叶片千后发蓝色,侧脉5-6对网脉在叶下面明显。总状聚伞花序顶生,粗壮,长40-150厘米;花梗长3-7厘米;花萼钟状,紫色,膜质,果期近木质,长2.2-4.5厘米,宽2-3厘米,光滑,顶端平截,具小苞片。花冠肉质,长3-9厘米,基部粗1-1.5厘米,口部直径5.5-8厘米;檐部下唇3裂,上唇2裂,裂片微反折,花冠在傍晚开放,有恶臭气味。以种子、树皮入药。秋季种子成熟时,摘取蒴果,晒干,剥出种子;树皮随用随采。玉蝴蝶具有清肺利咽、疏肝和胃的效果。主要用于风热咳嗽、声音嘶哑、咽喉疼痛、肝胃气痛。在《本草纲目》中,还没有记载这味药,后人在《本草纲目拾遗》中才有记载。中医药书记载,玉蝴蝶归属肝、胃、肺经。也就是说,玉蝴蝶可以治疗肺、肝、胃三条经脉上的病症。而木蝴蝶有润肺、疏肝、和胃的功效,一药三用,一举三得。
本发明的突出的实质性特点和显著的进步是:
1、本发明的含金银花提取物的保健含片按中医理论将金银花提取物、五味子、黄秋葵、枸杞子、茯苓、白术、炙甘草、木蝴蝶按常规工艺生产而成,参考古今中医学药理研究成就,基于中医学对人体进行综合调理,能够解除疲劳,增加免疫功能的作用;
2、本发明的含金银花提取物的保健含片相比市面上现有保健含片具有天然、安全、无毒、高效、提高人体免疫力的优点,可以调整人体的失衡状态,达到强身健体的功效;
3、本发明的含金银花提取物的保健含片,其采用纯天然中草药配方,饮用后无残留药物,保障了药品的安全性和人体健康;
4、本发明的含金银花提取物的保健含片成本低,容易被人体吸收、疗效高,见效快,对脏腑、经络、气血等方面进行调理,具有清热解毒、益气滋阴、除湿益燥,和中益气的功效,经常服用可起到调整经气,解除疲劳,从而增强人体免疫功能,提高人体体质。
具体实施方式
实施例1
步骤1)金银花提取物的提取方法:采摘含苞欲放的金银花花蕾,放到普通的布袋,放到可控温控湿的房子,温度控制在28-48℃,控制方法是28-35℃保持2-3小时,35-40℃保持2-3小时,40-48℃保持2-3小时,湿度控制在80-90%,利用日光灯控光让花开放,用破碎机将花粉碎成泥状,放入容器中,每次按花泥加蒸馏水3-6倍拌匀,静置,用600目铜网筛滤,反复三次,得到溶液,干燥后得到白色精细的金银花提取物粉末备用;
步骤2)按重量份数称取五味子3、黄秋葵6、枸杞子3、茯苓3、白术4、炙甘草8、木蝴蝶3分别粉碎,混合在一起;
步骤3)加6倍量水,煎煮3次,每次1.2h,合并滤液,浓缩至60℃时相对密度为1.04的浓缩液,加乙醇至醇浓度为75%,静置4-10h,上清液减压回收乙醇后,混合均匀后,浓缩为稠膏,再加入适量薄荷、淀粉、甜蜜素和步骤1中的金银花提取物粉末18,充分混匀,得到粉末;
步骤4)将粉末用压片机进行压片,压片后,将含片置于60℃环境中,干燥至水分添加量≤5%为止,将干燥好的含片放入塑料包装袋中,进行真空包装。
实施例2
步骤1)金银花提取物的提取方法:采摘含苞欲放的金银花花蕾,放到普通的布袋,放到可控温控湿的房子,温度控制在28-48℃,控制方法是28-35℃保持2-3小时,35-40℃保持2-3小时,40-48℃保持2-3小时,湿度控制在80-90%,利用日光灯控光让花开放,用破碎机将花粉碎成泥状,放入容器中,每次按花泥加蒸馏水3-6倍拌匀,静置,用600目铜网筛滤,反复三次,得到溶液,干燥后得到白色精细的金银花提取物粉末备用;
步骤2)按重量份数称取五味子4、黄秋葵7、枸杞子4、茯苓4、白术5、炙甘草9、木蝴蝶4分别粉碎,混合在一起;
步骤3)加6倍量水,煎煮3次,每次1.2h,合并滤液,浓缩至60℃时相对密度为1.04的浓缩液,加乙醇至醇浓度为75%,静置4-10h,上清液减压回收乙醇后,混合均匀后,浓缩为稠膏,再加入适量薄荷、淀粉、甜蜜素和步骤1中的金银花提取物粉末19,充分混匀,得到粉末;
步骤4)将粉末用压片机进行压片,压片后,将含片置于60℃环境中,干燥至水分添加量≤5%为止,将干燥好的含片放入塑料包装袋中,进行真空包装。
实施例3
步骤1)金银花提取物的提取方法:采摘含苞欲放的金银花花蕾,放到普通的布袋,放到可控温控湿的房子,温度控制在28-48℃,控制方法是28-35℃保持2-3小时,35-40℃保持2-3小时,40-48℃保持2-3小时,湿度控制在80-90%,利用日光灯控光让花开放,用破碎机将花粉碎成泥状,放入容器中,每次按花泥加蒸馏水3-6倍拌匀,静置,用600目铜网筛滤,反复三次,得到溶液,干燥后得到白色精细的金银花提取物粉末备用;
步骤2)按重量份数称取金银花提取物20、五味子5、黄秋葵8、枸杞子5、茯苓5、白术6、炙甘草10、木蝴蝶5分别粉碎,混合在一起;
步骤3)加6倍量水,煎煮3次,每次1.2h,合并滤液,浓缩至60℃时相对密度为1.04的浓缩液,加乙醇至醇浓度为75%,静置4-10h,上清液减压回收乙醇后,混合均匀后,浓缩为稠膏,再加入适量薄荷、淀粉、甜蜜素和步骤1中的金银花提取物粉末20,充分混匀,得到粉末;
步骤4)将粉末用压片机进行压片,压片后,将含片置于60℃环境中,干燥至水分添加量≤5%为止,将干燥好的含片放入塑料包装袋中,进行真空包装。
本发明含金银花提取物的保健含片的应用效果
本发明的含金银花提取物的保健含片于2014年初研究并试制出来,并给部分人群进行食用,志愿者136名,其中有精神不振,食欲不佳,口腔溃疡、身体虚弱,中气不足,容易疲劳等症状。采用本发明的含金银花提取物的保健含片进行治疗,口含服,每次1-2片,一日三次,结果感觉疲劳症状的患者服用后有效率达到95%以上,3-5天症状大为减轻,10-14天基本痊愈,除了2名平日较严重者疗效不明显,需要到医院治疗以外,134名均不用去医院,也不服用西药。
典型病例
案例一:杨某,女,28岁,由工作压力大,饮食不健康,作息不规律,导致免疫力降低,容易口腔溃疡,采用本发明的含金银花提取物的保健含片进行治疗,口含服,每次1-2片,一日两次。用药次日杨某的症状减轻,嘱继续用药,用药三天后,患者所有症状消失。其后一个月内未有再复发。
案例二:李某,男,36岁,由于经常加班、熬夜、休息不好,常常感到精神疲惫,食欲不佳,睡眠不好,腰酸腿疼。采用本发明的含金银花提取物的保健含片进行治疗,口含服,每次1-2片,一日两次。用药次日李某的症状减轻,嘱继续用药,用药三天后,患者所有症状消失。其后一个月内未有再复发。
案例三:郭某,男, 48岁,烦躁易怒、经常失眠,舌、唇、齿龈等处在进食、口腔运动时,出现疼痛不适。精神倦怠,肢体酸软乏力,气短懒言。纳少,上腹胀,采用本发明的含金银花提取物的保健含片进行治疗,口含服,每次1-2片,一日两次。患者用药一个礼拜后即感症状减轻,嘱继续用药,用药半个月后,患者所有症状消失。其后一个月内未有再复发。
Claims (5)
1.一种含金银花提取物的保健含片,其特征在于,它包括以下重量份数的原料:金银花提取物18-20、五味子3-5、黄秋葵6-8、枸杞子3-5、茯苓3-5、白术4-6、炙甘草8-10、木蝴蝶3-5。
2.根据权利要求1所述的含金银花提取物的保健含片,其特征在于,各中药原料的重量份数为:金银花提取物18、五味子3、黄秋葵6、枸杞子3、茯苓3、白术4、炙甘草8、木蝴蝶3。
3.根据权利要求1所述的含金银花提取物的保健含片,其特征在于,各中药原料的重量份数为:金银花提取物19、五味子4、黄秋葵7、枸杞子4、茯苓4、白术5、炙甘草9、木蝴蝶4。
4.根据权利要求1所述的含金银花提取物的保健含片,其特征在于,各中药原料的重量份数为:金银花提取物20、五味子5、黄秋葵8、枸杞子5、茯苓5、白术6、炙甘草10、木蝴蝶5。
5.根据权利要求1所述含金银花提取物的保健含片的生产方法,其特征在于,包含了以下步骤:
步骤1)金银花提取物的提取方法:采摘含苞欲放的金银花花蕾,放到普通的布袋,放到可控温控湿的房子,温度控制在28-48℃,控制方法是28-35℃保持2-3小时,35-40℃保持2-3小时,40-48℃保持2-3小时,湿度控制在80-90%,利用日光灯控光让花开放,用破碎机将花粉碎成泥状,放入容器中,每次按花泥加蒸馏水3-6倍拌匀,静置,用600目铜网筛滤,反复三次,得到溶液,干燥后得到白色精细的金银花提取物粉末备用;
步骤2)按重量份数称取五味子、黄秋葵、枸杞子、茯苓、白术、炙甘草、木蝴蝶分别粉碎,混合在一起;
步骤3)加6倍量水,煎煮3次,每次1.2h,合并滤液,浓缩至60℃时相对密度为1.04的浓缩液,加乙醇至醇浓度为75%,静置4-10h,上清液减压回收乙醇后,加入步骤1中的金银花提取物溶液,混合均匀后,浓缩为稠膏,再加入适量薄荷和淀粉、甜蜜素充分混匀,得到粉末;
步骤4)将粉末用压片机进行压片,压片后,将含片置于60℃环境中,干燥至水分添加量≤5%为止,将干燥好的含片放入塑料包装袋中,进行真空包装。
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