CN104507967B - 抗cxcr3抗体 - Google Patents

抗cxcr3抗体 Download PDF

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Publication number
CN104507967B
CN104507967B CN201380015401.8A CN201380015401A CN104507967B CN 104507967 B CN104507967 B CN 104507967B CN 201380015401 A CN201380015401 A CN 201380015401A CN 104507967 B CN104507967 B CN 104507967B
Authority
CN
China
Prior art keywords
antibody
antigen
seq
cxcr3
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380015401.8A
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English (en)
Chinese (zh)
Other versions
CN104507967A (zh
Inventor
M·尤德
J·特德斯通
T·洛迪
K·B·卡特
T·D·康纳斯
J·R·平克尼
E·马斯特约翰
R·丘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CN104507967A publication Critical patent/CN104507967A/zh
Application granted granted Critical
Publication of CN104507967B publication Critical patent/CN104507967B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380015401.8A 2012-01-20 2013-01-18 抗cxcr3抗体 Expired - Fee Related CN104507967B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588936P 2012-01-20 2012-01-20
US61/588,936 2012-01-20
PCT/US2013/022280 WO2013109974A2 (en) 2012-01-20 2013-01-18 Anti-cxcr3 antibodies

Publications (2)

Publication Number Publication Date
CN104507967A CN104507967A (zh) 2015-04-08
CN104507967B true CN104507967B (zh) 2018-10-12

Family

ID=47633576

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380015401.8A Expired - Fee Related CN104507967B (zh) 2012-01-20 2013-01-18 抗cxcr3抗体

Country Status (26)

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US (4) US8865870B2 (enExample)
EP (1) EP2804878B1 (enExample)
JP (3) JP6352812B6 (enExample)
KR (2) KR102073034B1 (enExample)
CN (1) CN104507967B (enExample)
AR (1) AR090056A1 (enExample)
AU (1) AU2013209492B2 (enExample)
BR (1) BR112014017814A8 (enExample)
CA (1) CA2862222A1 (enExample)
CY (1) CY1121335T1 (enExample)
DK (1) DK2804878T3 (enExample)
ES (1) ES2698606T3 (enExample)
HR (1) HRP20181874T1 (enExample)
HU (1) HUE041900T2 (enExample)
IL (2) IL233694A0 (enExample)
LT (1) LT2804878T (enExample)
MX (1) MX359854B (enExample)
PL (1) PL2804878T3 (enExample)
PT (1) PT2804878T (enExample)
RS (1) RS58141B1 (enExample)
RU (1) RU2663141C2 (enExample)
SG (2) SG10201700735PA (enExample)
SI (1) SI2804878T1 (enExample)
TW (1) TWI596112B (enExample)
UY (1) UY34582A (enExample)
WO (1) WO2013109974A2 (enExample)

Families Citing this family (17)

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US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
MA40526A (fr) 2014-08-22 2017-06-28 Sorrento Therapeutics Inc Protéines de fixation antigénique fixant le cxcr3
CN108431041B (zh) 2015-10-29 2022-08-16 艾利妥 抗siglec-9抗体及其使用方法
EP3464349A4 (en) * 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
EP3559036A1 (en) * 2016-12-22 2019-10-30 Sanofi Anti-human cxcr3 antibodies for treatment of vitiligo
KR20190095943A (ko) * 2016-12-22 2019-08-16 사노피 고갈 활성을 갖는 인간화 cxcr3 항체 및 이의 사용 방법
TW201840585A (zh) 2016-12-22 2018-11-16 法商賽諾菲公司 用於白斑病的治療的抗人cxcr3抗體
JP7384811B2 (ja) * 2018-02-16 2023-11-21 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 白斑を処置するための方法及び組成物
KR102074798B1 (ko) * 2018-06-15 2020-02-07 코아스템(주) 자가면역질환 치료에 대한 유효성 예측용 바이오마커, 진단키트 및 치료용 용도
BR112021009325A2 (pt) * 2018-11-14 2021-09-14 Arch Oncology, Inc. Anticorpo monoclonal, ou fragmento de ligação ao antígeno do mesmo; anticorpo biespecífico; método para prevenir ou tratar um câncer suscetível em um ser humano; método de ensaio de expressão de sirp¿ em células tumorais e/ou imunes; e; composição farmacêutica
HRP20231031T1 (hr) 2020-02-26 2023-12-22 Vir Biotechnology, Inc. Protutijela protiv sars-cov-2
BR112022021992A2 (pt) * 2020-04-30 2023-01-03 Arch Oncology Inc Método de tratamento de câncer em um sujeito em necessidade do mesmo
CA3209479A1 (en) 2021-02-03 2022-08-11 Mozart Therapeutics, Inc. Binding agents and methods of using the same
KR20230154020A (ko) * 2021-03-02 2023-11-07 노바록 바이오테라퓨틱스 리미티드 클라우딘-6에 대한 항체 및 이의 용도
AU2022326544A1 (en) * 2021-08-09 2024-02-29 Merck Patent Gmbh Proteins that decouple t cell-mediated tumor cytotoxicity from release of pro-inflammatory cytokines
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
EP4583878A1 (en) 2022-09-09 2025-07-16 Idorsia Pharmaceuticals Ltd Pharmaceutical combination comprising an anti-cd3 antibody and a cxcr3 antagonist

Citations (4)

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Publication number Priority date Publication date Assignee Title
US6184358B1 (en) * 1996-09-10 2001-02-06 Millennium Pharmaceuticals, Inc. IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor
WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
WO2005030793A2 (en) * 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
CN101796073A (zh) * 2007-02-01 2010-08-04 联合基因系统公司 针对cxcr3的人源化抗体

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HUE037489T2 (hu) 2007-08-29 2018-08-28 Sanofi Sa Humanizált anti-CXCR5 antitestek, azok származékai és alkalmazásuk
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184358B1 (en) * 1996-09-10 2001-02-06 Millennium Pharmaceuticals, Inc. IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor
WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
WO2005030793A2 (en) * 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
CN101796073A (zh) * 2007-02-01 2010-08-04 联合基因系统公司 针对cxcr3的人源化抗体

Also Published As

Publication number Publication date
PL2804878T3 (pl) 2019-03-29
IL271697A (en) 2020-02-27
BR112014017814A2 (enExample) 2017-06-20
HRP20181874T1 (hr) 2019-01-11
AU2013209492B2 (en) 2018-02-08
HK1208684A1 (en) 2016-03-11
KR20200014441A (ko) 2020-02-10
WO2013109974A3 (en) 2013-11-07
SI2804878T1 (sl) 2018-12-31
US20130251733A1 (en) 2013-09-26
KR20140116525A (ko) 2014-10-02
UY34582A (es) 2013-09-02
JP2018166506A (ja) 2018-11-01
RU2663141C2 (ru) 2018-08-01
CY1121335T1 (el) 2020-05-29
PT2804878T (pt) 2018-11-29
JP2020072715A (ja) 2020-05-14
CA2862222A1 (en) 2013-07-25
EP2804878B1 (en) 2018-08-22
SG11201406762QA (en) 2014-11-27
BR112014017814A8 (pt) 2017-07-11
LT2804878T (lt) 2018-12-10
US20190119391A1 (en) 2019-04-25
JP2015506945A (ja) 2015-03-05
CN104507967A (zh) 2015-04-08
JP6352812B2 (ja) 2018-07-04
DK2804878T3 (en) 2018-12-17
TW201335188A (zh) 2013-09-01
MX359854B (es) 2018-10-12
JP6646100B2 (ja) 2020-02-14
HUE041900T2 (hu) 2019-06-28
IL233694A0 (en) 2014-09-30
ES2698606T3 (es) 2019-02-05
SG10201700735PA (en) 2017-02-27
US20180086838A1 (en) 2018-03-29
TWI596112B (zh) 2017-08-21
AR090056A1 (es) 2014-10-15
RU2014134043A (ru) 2016-03-20
US20140377806A1 (en) 2014-12-25
AU2013209492A1 (en) 2014-08-14
MX2014008728A (es) 2015-07-06
RS58141B1 (sr) 2019-02-28
WO2013109974A2 (en) 2013-07-25
KR102073034B1 (ko) 2020-02-05
US9765144B2 (en) 2017-09-19
US8865870B2 (en) 2014-10-21
EP2804878A2 (en) 2014-11-26
JP6352812B6 (ja) 2018-08-08

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