RU2663141C2 - Анти-cxcr3 антитела - Google Patents

Анти-cxcr3 антитела Download PDF

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Publication number
RU2663141C2
RU2663141C2 RU2014134043A RU2014134043A RU2663141C2 RU 2663141 C2 RU2663141 C2 RU 2663141C2 RU 2014134043 A RU2014134043 A RU 2014134043A RU 2014134043 A RU2014134043 A RU 2014134043A RU 2663141 C2 RU2663141 C2 RU 2663141C2
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Russia
Prior art keywords
antibody
cxcr3
sequence
cells
fragment
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RU2014134043A
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Russian (ru)
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RU2014134043A (ru
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Мишель ЮД
Дженнифер ТЕДСТОУН
Трейси ЛОДИ
Карен Б. КАРТЕР
Тимоти Д. КОННОРС
Джейсон Роберт ПИНКНИ
Элизабет МАСТЕРДЖОН
Жуйинь ЧУ
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Джензим Корпорейшн
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2014134043A 2012-01-20 2013-01-18 Анти-cxcr3 антитела RU2663141C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588936P 2012-01-20 2012-01-20
US61/588,936 2012-01-20
PCT/US2013/022280 WO2013109974A2 (en) 2012-01-20 2013-01-18 Anti-cxcr3 antibodies

Publications (2)

Publication Number Publication Date
RU2014134043A RU2014134043A (ru) 2016-03-20
RU2663141C2 true RU2663141C2 (ru) 2018-08-01

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RU2014134043A RU2663141C2 (ru) 2012-01-20 2013-01-18 Анти-cxcr3 антитела

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US (4) US8865870B2 (enExample)
EP (1) EP2804878B1 (enExample)
JP (3) JP6352812B6 (enExample)
KR (2) KR20200014441A (enExample)
CN (1) CN104507967B (enExample)
AR (1) AR090056A1 (enExample)
AU (1) AU2013209492B2 (enExample)
BR (1) BR112014017814A8 (enExample)
CA (1) CA2862222A1 (enExample)
CY (1) CY1121335T1 (enExample)
DK (1) DK2804878T3 (enExample)
ES (1) ES2698606T3 (enExample)
HR (1) HRP20181874T1 (enExample)
HU (1) HUE041900T2 (enExample)
IL (2) IL233694A0 (enExample)
LT (1) LT2804878T (enExample)
MX (1) MX359854B (enExample)
PL (1) PL2804878T3 (enExample)
PT (1) PT2804878T (enExample)
RS (1) RS58141B1 (enExample)
RU (1) RU2663141C2 (enExample)
SG (2) SG10201700735PA (enExample)
SI (1) SI2804878T1 (enExample)
TW (1) TWI596112B (enExample)
UY (1) UY34582A (enExample)
WO (1) WO2013109974A2 (enExample)

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US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
EP3485910A2 (en) 2014-08-22 2019-05-22 Sorrento Therapeutics, Inc. Antigen binding proteins that bind cxcr3
WO2017075432A2 (en) 2015-10-29 2017-05-04 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
WO2017205377A2 (en) * 2016-05-23 2017-11-30 New York University Compositions and methods for antibodies targeting staphylococcal leukotoxins
TW201840585A (zh) 2016-12-22 2018-11-16 法商賽諾菲公司 用於白斑病的治療的抗人cxcr3抗體
CN110914298A (zh) * 2016-12-22 2020-03-24 赛诺菲 具有耗减活性的人源化cxcr3抗体及其使用方法
KR20190095942A (ko) * 2016-12-22 2019-08-16 사노피 백반증의 치료를 위한 항-인간 cxcr3 항체
WO2019158675A1 (en) * 2018-02-16 2019-08-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating vitiligo
KR102074798B1 (ko) * 2018-06-15 2020-02-07 코아스템(주) 자가면역질환 치료에 대한 유효성 예측용 바이오마커, 진단키트 및 치료용 용도
CA3119748A1 (en) 2018-11-14 2020-05-22 Arch Oncology, Inc. Therapeutic sirp.alpha. antibodies
EP4245373A3 (en) 2020-02-26 2023-12-20 VIR Biotechnology, Inc. Antibodies against sars-cov-2
AU2021264006A1 (en) * 2020-04-30 2022-12-01 Arch Oncology, Inc. Therapeutic sirpalpha antibodies
US20240101673A1 (en) 2021-02-03 2024-03-28 Mozart Therapeutics, Inc. Binding agents and methods of using the same
TW202246323A (zh) * 2021-03-02 2022-12-01 美商諾瓦拉克生物醫療有限公司 抗claudin—6之抗體及其用途
JP2024531149A (ja) * 2021-08-09 2024-08-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症誘発性サイトカイン放出からt細胞性腫瘍細胞毒性をデカップリングするタンパク質
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
CN120112292A (zh) 2022-09-09 2025-06-06 爱杜西亚药品有限公司 包含抗-cd3抗体及cxcr3拮抗剂的药物组合

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WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
RU2006102570A (ru) * 2003-06-30 2007-08-20 Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) Антитела и их применение
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WO2010103517A1 (en) * 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases

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Publication number Publication date
BR112014017814A2 (enExample) 2017-06-20
AR090056A1 (es) 2014-10-15
EP2804878B1 (en) 2018-08-22
HRP20181874T1 (hr) 2019-01-11
AU2013209492A1 (en) 2014-08-14
JP2018166506A (ja) 2018-11-01
MX2014008728A (es) 2015-07-06
CA2862222A1 (en) 2013-07-25
ES2698606T3 (es) 2019-02-05
PL2804878T3 (pl) 2019-03-29
UY34582A (es) 2013-09-02
CY1121335T1 (el) 2020-05-29
US8865870B2 (en) 2014-10-21
IL233694A0 (en) 2014-09-30
HUE041900T2 (hu) 2019-06-28
SG10201700735PA (en) 2017-02-27
US20190119391A1 (en) 2019-04-25
AU2013209492B2 (en) 2018-02-08
TW201335188A (zh) 2013-09-01
HK1208684A1 (en) 2016-03-11
EP2804878A2 (en) 2014-11-26
JP6646100B2 (ja) 2020-02-14
JP2015506945A (ja) 2015-03-05
US20180086838A1 (en) 2018-03-29
US9765144B2 (en) 2017-09-19
WO2013109974A3 (en) 2013-11-07
IL271697A (en) 2020-02-27
KR20140116525A (ko) 2014-10-02
JP6352812B6 (ja) 2018-08-08
JP6352812B2 (ja) 2018-07-04
CN104507967B (zh) 2018-10-12
PT2804878T (pt) 2018-11-29
JP2020072715A (ja) 2020-05-14
US20140377806A1 (en) 2014-12-25
BR112014017814A8 (pt) 2017-07-11
SI2804878T1 (sl) 2018-12-31
WO2013109974A2 (en) 2013-07-25
RS58141B1 (sr) 2019-02-28
KR102073034B1 (ko) 2020-02-05
SG11201406762QA (en) 2014-11-27
DK2804878T3 (en) 2018-12-17
CN104507967A (zh) 2015-04-08
TWI596112B (zh) 2017-08-21
LT2804878T (lt) 2018-12-10
US20130251733A1 (en) 2013-09-26
MX359854B (es) 2018-10-12
RU2014134043A (ru) 2016-03-20
KR20200014441A (ko) 2020-02-10

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