RU2663141C2 - Анти-cxcr3 антитела - Google Patents

Анти-cxcr3 антитела Download PDF

Info

Publication number
RU2663141C2
RU2663141C2 RU2014134043A RU2014134043A RU2663141C2 RU 2663141 C2 RU2663141 C2 RU 2663141C2 RU 2014134043 A RU2014134043 A RU 2014134043A RU 2014134043 A RU2014134043 A RU 2014134043A RU 2663141 C2 RU2663141 C2 RU 2663141C2
Authority
RU
Russia
Prior art keywords
antibody
cxcr3
sequence
cells
fragment
Prior art date
Application number
RU2014134043A
Other languages
English (en)
Russian (ru)
Other versions
RU2014134043A (ru
Inventor
Мишель ЮД
Дженнифер ТЕДСТОУН
Трейси ЛОДИ
Карен Б. КАРТЕР
Тимоти Д. КОННОРС
Джейсон Роберт ПИНКНИ
Элизабет МАСТЕРДЖОН
Жуйинь ЧУ
Original Assignee
Джензим Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джензим Корпорейшн filed Critical Джензим Корпорейшн
Publication of RU2014134043A publication Critical patent/RU2014134043A/ru
Application granted granted Critical
Publication of RU2663141C2 publication Critical patent/RU2663141C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2014134043A 2012-01-20 2013-01-18 Анти-cxcr3 антитела RU2663141C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588936P 2012-01-20 2012-01-20
US61/588,936 2012-01-20
PCT/US2013/022280 WO2013109974A2 (en) 2012-01-20 2013-01-18 Anti-cxcr3 antibodies

Publications (2)

Publication Number Publication Date
RU2014134043A RU2014134043A (ru) 2016-03-20
RU2663141C2 true RU2663141C2 (ru) 2018-08-01

Family

ID=47633576

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014134043A RU2663141C2 (ru) 2012-01-20 2013-01-18 Анти-cxcr3 антитела

Country Status (26)

Country Link
US (4) US8865870B2 (enExample)
EP (1) EP2804878B1 (enExample)
JP (3) JP6352812B6 (enExample)
KR (2) KR20200014441A (enExample)
CN (1) CN104507967B (enExample)
AR (1) AR090056A1 (enExample)
AU (1) AU2013209492B2 (enExample)
BR (1) BR112014017814A8 (enExample)
CA (1) CA2862222A1 (enExample)
CY (1) CY1121335T1 (enExample)
DK (1) DK2804878T3 (enExample)
ES (1) ES2698606T3 (enExample)
HR (1) HRP20181874T1 (enExample)
HU (1) HUE041900T2 (enExample)
IL (2) IL233694A0 (enExample)
LT (1) LT2804878T (enExample)
MX (1) MX359854B (enExample)
PL (1) PL2804878T3 (enExample)
PT (1) PT2804878T (enExample)
RS (1) RS58141B1 (enExample)
RU (1) RU2663141C2 (enExample)
SG (2) SG11201406762QA (enExample)
SI (1) SI2804878T1 (enExample)
TW (1) TWI596112B (enExample)
UY (1) UY34582A (enExample)
WO (1) WO2013109974A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9592289B2 (en) 2012-03-26 2017-03-14 Sanofi Stable IgG4 based binding agent formulations
EA201790437A1 (ru) 2014-08-22 2017-08-31 Сорренто Терапьютикс, Инк. Антигенсвязывающие белки, связывающиеся с cxcr3
CA3003458A1 (en) 2015-10-29 2017-05-04 Alector Llc Anti-siglec-9 antibodies and methods of use thereof
EP3464349A4 (en) * 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
TW201837053A (zh) * 2016-12-22 2018-10-16 法商賽諾菲公司 具有消耗活性的人源化cxcr3抗體及其使用方法
EP3559036A1 (en) * 2016-12-22 2019-10-30 Sanofi Anti-human cxcr3 antibodies for treatment of vitiligo
US20180244787A1 (en) 2016-12-22 2018-08-30 Sanofi Anti-human cxcr3 antibodies for treatment of vitiligo
JP7384811B2 (ja) * 2018-02-16 2023-11-21 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 白斑を処置するための方法及び組成物
KR102074798B1 (ko) * 2018-06-15 2020-02-07 코아스템(주) 자가면역질환 치료에 대한 유효성 예측용 바이오마커, 진단키트 및 치료용 용도
JP2022507295A (ja) * 2018-11-14 2022-01-18 アーチ オンコロジー，インコーポレイテッド 治療用ＳＩＲＰα抗体
BR112022017048A2 (pt) 2020-02-26 2022-11-16 Vir Biotechnology Inc Anticorpos contra sars-cov-2 e métodos para usar os mesmos
BR112022021992A2 (pt) * 2020-04-30 2023-01-03 Arch Oncology Inc Método de tratamento de câncer em um sujeito em necessidade do mesmo
EP4288455A1 (en) 2021-02-03 2023-12-13 Mozart Therapeutics, Inc. Binding agents and methods of using the same
US20250277026A1 (en) * 2021-03-02 2025-09-04 Novarock Biotherapeutics, Ltd. Antibodies against claudin-6 and uses thereof
CN118103070A (zh) * 2021-08-09 2024-05-28 默克专利有限公司 解偶联t细胞介导的肿瘤细胞毒性与促炎细胞因子释放的蛋白质
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
US20250381184A1 (en) 2022-09-09 2025-12-18 Idorsia Pharmaceuticals Ltd Pharmaceutical combination comprising an anti-cd3 antibody and a cxcr3 antagonist
WO2025185738A1 (zh) * 2024-03-08 2025-09-12 演生潮(北京)生物科技有限公司 靶向cxcr3的抗原结合蛋白及其应用
WO2026069312A1 (en) 2024-09-24 2026-04-02 Yeda Research And Development Co. Ltd. Immune cells expressing an inducible therapeutic agent and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
US6686175B1 (en) * 1996-09-10 2004-02-03 Theodor-Kocher Institute IP-10/MIG receptor designated CXCR3, nucleic acids, and methods of use therefor
RU2006102570A (ru) * 2003-06-30 2007-08-20 Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) Антитела и их применение
WO2008094942A2 (en) * 2007-02-01 2008-08-07 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against cxcr3
WO2010103517A1 (en) * 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US565332A (en) 1896-08-04 Toy for making soap-bubbles
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DE229046T1 (de) 1985-03-30 1987-12-17 Marc Genf/Geneve Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
EP0571613B1 (en) 1991-12-13 2003-09-17 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
ES2162863T3 (es) 1993-04-29 2002-01-16 Unilever Nv Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
JP2826272B2 (ja) 1993-10-26 1998-11-18 タイガースポリマー株式会社 中空樹脂成形品の製造装置及び製造方法
US5565352A (en) 1993-11-24 1996-10-15 Arch Development Corporation Deubiquitinating enzyme: compositions and methods
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
AU734090B2 (en) * 1996-09-10 2001-06-07 Millennium Pharmaceuticals, Inc. CXCR3 chemokine receptor, antibodies, nucleic acids, and methods of use
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
WO2003029471A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of apolipoprotein d
WO2005030793A2 (en) 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
ATE557042T1 (de) * 2004-03-23 2012-05-15 Lilly Co Eli Anti-myostatin-antikörper
AU2005334481A1 (en) 2004-08-11 2007-01-25 Trubion Pharmaceuticals, Inc. Binding domain fusion proteins
AU2007238034A1 (en) 2006-04-14 2007-10-25 Trubion Pharmaceuticals Inc. Binding proteins comprising immunoglobulin hinge and Fc regions having altered Fc effector functions
MX338397B (es) 2007-08-29 2016-04-15 Sanofi Aventis Anticuerpos anti - cxcr5 humanizados, derivados de los mismos y su uso.
WO2010056907A2 (en) 2008-11-12 2010-05-20 The Scripps Research Institute Compounds that induce pancreatic beta-cell expansion
JP5894939B2 (ja) * 2010-02-26 2016-03-30 バイオアークティック ニューロサイエンス アーベー プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686175B1 (en) * 1996-09-10 2004-02-03 Theodor-Kocher Institute IP-10/MIG receptor designated CXCR3, nucleic acids, and methods of use therefor
WO2001072334A2 (en) * 2000-03-27 2001-10-04 Corixa Corporation Methods for treating disease with antibodies to cxcr3
RU2006102570A (ru) * 2003-06-30 2007-08-20 Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) Антитела и их применение
WO2008094942A2 (en) * 2007-02-01 2008-08-07 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against cxcr3
WO2010103517A1 (en) * 2009-03-12 2010-09-16 Rappaport Family Institute For Research In The Medical Sciences Soluble compositions for the treatment of cxcr3-ligand associated diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLARK-LEWIS I. et al., "Structure-Function Relationship between the Human Chemokine Receptor CXCR3 and Its Ligands", J Biol Chem., 2003, 278(1):289-95. *

Also Published As

Publication number Publication date
CY1121335T1 (el) 2020-05-29
AU2013209492A1 (en) 2014-08-14
US20130251733A1 (en) 2013-09-26
IL271697A (en) 2020-02-27
JP2015506945A (ja) 2015-03-05
US20190119391A1 (en) 2019-04-25
US9765144B2 (en) 2017-09-19
PL2804878T3 (pl) 2019-03-29
HRP20181874T1 (hr) 2019-01-11
KR20200014441A (ko) 2020-02-10
RU2014134043A (ru) 2016-03-20
JP6352812B6 (ja) 2018-08-08
DK2804878T3 (en) 2018-12-17
MX359854B (es) 2018-10-12
EP2804878B1 (en) 2018-08-22
HUE041900T2 (hu) 2019-06-28
TW201335188A (zh) 2013-09-01
BR112014017814A8 (pt) 2017-07-11
MX2014008728A (es) 2015-07-06
EP2804878A2 (en) 2014-11-26
US20180086838A1 (en) 2018-03-29
PT2804878T (pt) 2018-11-29
SG11201406762QA (en) 2014-11-27
JP2020072715A (ja) 2020-05-14
CN104507967A (zh) 2015-04-08
US8865870B2 (en) 2014-10-21
SI2804878T1 (sl) 2018-12-31
US20140377806A1 (en) 2014-12-25
JP6646100B2 (ja) 2020-02-14
IL233694A0 (en) 2014-09-30
UY34582A (es) 2013-09-02
HK1208684A1 (en) 2016-03-11
CN104507967B (zh) 2018-10-12
WO2013109974A3 (en) 2013-11-07
RS58141B1 (sr) 2019-02-28
ES2698606T3 (es) 2019-02-05
JP6352812B2 (ja) 2018-07-04
TWI596112B (zh) 2017-08-21
AU2013209492B2 (en) 2018-02-08
JP2018166506A (ja) 2018-11-01
CA2862222A1 (en) 2013-07-25
KR102073034B1 (ko) 2020-02-05
WO2013109974A2 (en) 2013-07-25
AR090056A1 (es) 2014-10-15
LT2804878T (lt) 2018-12-10
KR20140116525A (ko) 2014-10-02
SG10201700735PA (en) 2017-02-27
BR112014017814A2 (enExample) 2017-06-20

Similar Documents

Publication Publication Date Title
RU2663141C2 (ru) Анти-cxcr3 антитела
US12258410B2 (en) Anti-SIRPα antibodies and methods of use thereof
CN108699153B (zh) Pd-l1的结合成员
CN110407941B (zh) Cd39的高亲和力抗体及其用途
KR20080080639A (ko) 항-ｏｘ40ｌ 항체 및 그의 사용 방법
JP7843824B2 (ja) 抗体および使用方法
WO2018119288A1 (en) Anti-human cxcr3 antibodies for treatment of vitiligo
HK1208684B (zh) 抗cxcr3抗體
EP3559036A1 (en) Anti-human cxcr3 antibodies for treatment of vitiligo
KR20260004605A (ko) 길항성 항-cd40 인간화 항체
TW202523698A (zh) 抗ｇｐｒｃ５ｄ抗體及組成物
IL324392A (en) Antibodies targeting human leukocyte antigen cathepsin g peptide complex
HK40016809B (en) High affinity antibodies to cd39 and uses thereof
HK40016809A (en) High affinity antibodies to cd39 and uses thereof