CN104472504A - Sterilization composition containing epoxiconazole and thiabendazole and application thereof - Google Patents
Sterilization composition containing epoxiconazole and thiabendazole and application thereof Download PDFInfo
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- CN104472504A CN104472504A CN201410662716.8A CN201410662716A CN104472504A CN 104472504 A CN104472504 A CN 104472504A CN 201410662716 A CN201410662716 A CN 201410662716A CN 104472504 A CN104472504 A CN 104472504A
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- epoxiconazole
- probenazole
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Abstract
The invention discloses a sterilization composition containing epoxiconazole and thiabendazole and an application thereof. The active components of the sterilization composition are epoxiconazole and thiabendazole, the mass ratio of epoxiconazole to thiabendazole is (1:20) to (20:1), and the content of the active components in the composition is 5-60% in percentage by mass. The sterilization composition disclosed by the invention has high sterilization activity, is capable of delaying the generation and development of pathogens resistance to xenobiotics and reducing prevention and treatment dosages in practical production, and is economical, efficient, safe and environment-friendly. The sterilization composition disclosed by the invention has good prevention and treatment effects on various crop diseases, and has especially remarkable prevention and treatment effects on rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of bactericidal composition and the application thereof that contain epoxiconazole and probenazole.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, one of most important disease on Ye Shi China paddy rice.Its distribution widely, has generation in each paddy rice main producing region of China, and especially in In Middle And Lower Reaches of Changjiang River and South China, harm is very serious, causes output sharply to decline.Selection and popularization disease-resistant variety is one of important measures of the water prevention rice sheath blight, in recent years, although Chinese scholars achieves a lot of progress in breeding for disease resistance, there is no at present and selects the completely immune rice varieties of rice sheath blight disease.Current Rhizoctonia solani Kuhn control still depends on chemical control.Current China adopts the medicament based on jinggangmeisu on the water prevention rice sheath blight always, namely reaches about 15% in rice tillering diseased plant rate in latter stage at the initial stage of a disease and starts to spray medicine control, and achieve certain effect.But existing report display, China's some areas rice sheath blight disease creates pesticide resistance to jinggangmeisu, and the control efficiency of this medicament caused constantly declines.How to continue to control rice sheath blight disease, especially the surrogate-data technique of the water prevention rice sheath blight is filtered out, administer jinggangmeisu pesticide resistance simultaneously and promote the sustainable control of rice sheath blight disease, having become the significant challenge that numerous scientific workers and Rice Cropping person face.
Epoxiconazole is a kind of high-effective broad-spectrum fungicide, and a series of cereal crop such as ten multiple diseases such as damping off, powdery mildew, eyeprint disease have good preventive and therapeutic effect, and can prevent and treat the diseases such as sugar beet, peanut, rape, lawn, coffee, paddy rice and fruit tree.Not only there is good protection, treat and root out activity, and there is interior suction and preferably residual activity.To pathogens such as wheat, powdery mildew of cucumber, rice blast, rice green smut, rice sheath blight disease, bakanae disease of rice, wheat sharp eyespot, wheat scab, root rotof flax, corn northern leaf blight and southern leaf blight, sclerotinia rot of colza, graw mold of tomato, apple canker, melon anthracnose, cucumber fusarium axysporum, cotton verticillium wilt, cotton wilts, there is very high bacteriostatic activity.
Epoxiconazole belongs to triazole bactericidal agent, its Main Function mechanism suppresses the synthesis of germ ergosterol, hinder the formation of germ cell wall, and epoxiconazole molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), compared with bactericide known at present, can more effectively suppress germ fungal pathogens.Epoxiconazole can improve the chitinase activity of crop, causes the contraction of fungi haustorium, and suppress germ to invade, this is epoxiconazole unique characteristic in all triazole type products.Good preventive effect is had, with jinggangmeisu without mutual pesticide resistance to the disease such as anthracnose, white rot on leaf spot, powdery mildew, rust and the grape on the crops such as banana, green onion garlic, celery, Kidney bean, melon, asparagus, peanut, beet.In it, absorption is strong, can be absorbed by plant rapidly and conduct to susceptible position, disease infestation is stopped immediately, and local drug delivery control thoroughly.Lasting period is splendid, and as the bacteriostasis on cereal can reach more than 40 days, effect is stayed in remarkable holding, and reduces times for spraying and labour costs.Effectively can control disease, the activity again by regulatory enzyme improves the biochemical disease resistance of crop self, and the disease resistance of crop itself is strengthened greatly.Can make leaf look greener, thus ensure that crop photosynthesis maximizes, improve output and oil recovery enhancement.
Epoxiconazole is triazole type compounds, its Main Function mechanism is suppress the synthesis of germ ergosterol, with benzimidazole, the bactericide mechanism of action of dithiocarbamates, methoxy acrylic medicament is all not identical, the two is combined as bactericidal composition, effectively can not only solve the production practical problem that jinggangmeisu pesticide resistance area rice sheath blight disease is difficult to prevent and treat, and delay pathogen it is developed immunity to drugs.
The chemical name of epoxiconazole: (2RS, 3RS)-1-[3-(2 monochloro-benzene base)-2,3-epoxy-2-(4 phenyl-monofluoride base) propyl group]-1 hydrogen-1,2,4-triazole.
The chemical structural formula of epoxiconazole is shown below:
Probenazole is a kind of efficient, wide spectrum, systemic fungicide; the plurality of plant diseases such as penicilliosis, anthracnose, gray mold, scab, powdery mildew of orange storing disease, banana disease, wheat scab, bakanae disease of rice, apple core pears can be prevented and treated; protective effect and therapeutic action are had concurrently to control of plant disease; various crop disease can be prevented and treated, with jinggangmeisu without mutual pesticide resistance.
The chemical name of probenazole: 2-(4-thiazolyl)-1H-benzimidazole.
The chemical structural formula of probenazole is shown below:
Epoxiconazole and probenazole bacterium are lower toxicity or micro-virus kind agricultural chemicals, belong to efficient, low toxicity, environmentally friendly type bactericide.Epoxiconazole mainly acts on the synthesis of germ ergosterol, and probenazole acts on the mitosis of thalline, thus reaches the object of sterilization, and the two does not exist mutual pesticide resistance.But a lot of research shows, if these two kinds of medicaments are used alone controlling disease, can pathogen are made in the short period of time to develop immunity to drugs, cause preventive effect to reduce, even prevent and treat failure.Fungicide resistance Action Committee (FRAC) advises, is used by the composite reagent of different mechanism of action, can avoid or delay drug-fast generation.Therefore, the two is combined as bactericidal composition, what effectively can not only solve rice sheath blight disease prevents and treats problem, and can avoid or delay pathogen and develop immunity to drugs to it.
Summary of the invention
The invention provides a kind of bactericidal composition containing epoxiconazole and probenazole, there is bactericidal activity high, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
Technical scheme of the present invention is:
A kind of microbicide compositions containing epoxiconazole and probenazole, it is characterized in that, the active component of described microbicide compositions is epoxiconazole and probenazole, and the mass ratio of probenazole and epoxiconazole is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.
Described active component probenazole and the mass ratio of epoxiconazole are 1:10 to 10:1.
Described probenazole and the mass ratio of epoxiconazole are 1:3-8.
Described probenazole and the mass ratio of epoxiconazole are 1:4-6.
The formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
This microbicide compositions has higher control efficiency to various crop disease, particularly remarkable to rice sheath blight disease controlling effect, for the control of rice sheath blight disease and false smut.
Remarkable result of the present invention and advantage are:
Two classes are had the bactericide of different mechanism of action by the present invention, namely triazole bactericidal agent epoxiconazole and benzimidazole germicide probenazole combined, and be processed into the upper easy-to-use preparation of production, biologically active is high, dosage total in unit are declines, greatly reduce dispenser cost, delaying pathogen pesticide resistance emergence and development to a greater extent simultaneously, reduce disease fungus produces resistance risk to single bactericide, extend the service life of each component in bactericidal composition, thus reach effect that is economic, efficient, environmental protection.
The present invention has higher control efficiency to crop fungal disease, there is notable synergistic effect between two components; Part high price pesticide species can be replaced, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved; In the present invention, epoxiconazole and probenazole all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security; The pesticide resistance of germ to single medicament can be delayed.
First the EC of epoxiconazole and probenazole two single compound (hereinafter referred to as medicament) is measured
50(drug safety index), according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley coefficient of synergism C value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test adopts mycelial growth determination method, makes pastille medium by different disposal, and each process 4 repetitions, connect bacterium after 3 days, investigate the growth inhibitory effect of each process to Rhizoctonia solani Kuhn.By the linear regression analysis between the probit value of preventive effect and the logarithm value of serial drug concentration, obtain the EC50 of each medicament, calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents to have antagonism, and 0.5 < SR < 1.5 represents to have summation action, and SR >=1.5 are synergistic effect.SR value calculating method is as follows:
EC
50(theoretical value)=(a+b)/(a/EC
50A+ b/EC
50B)
SR=EC
50(theoretical value)/EC
50(real value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have synergistic effect
Table 1 epoxiconazole and probenazole composition are to the Wadley method measurement result of Rhizoctonia solani Kuhn
Note: F is epoxiconazole, and S is probenazole.
Can analyze from above data, epoxiconazole and the fungistatic effect of probenazole composition to Rhizoctonia solani Kuhn of different proportion are different, on the whole, its ratio has synergy or addition in the scope of 1:20 to 20:1, and wherein maximum enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but be not limited thereto.
Embodiment
Embodiment 1 (preparation method of 60% probenazole epoxiconazole wetting powder)
Composition of raw materials: by mass percentage
Preparation method: by above-mentioned substance Homogeneous phase mixing, mixture is pulverized through airslide disintegrating mill, obtained wetting powder.
Embodiment 2 (preparation method of 30% probenazole epoxiconazole suspension concentrate)
Preparation method: according to formula, weighs in proportion by individual component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.
Embodiment 3 (preparation method of 40% probenazole epoxiconazole water dispersant)
Preparation method: probenazole, epoxiconazole, Methyl fatty acid amides benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together evenly, particle diameter 5 μm is crushed to through airslide disintegrating mill, obtain female powder, female powder is fully mixed rear granulation with sodium lignin sulfonate, dries, sieves, thus obtained water-dispersible granules.
Embodiment 4 (20% probenazole epoxiconazole suspension concentrate)
Preparation method: with embodiment 2.
Embodiment 5 (45% probenazole epoxiconazole missible oil)
Composition of raw materials: by mass percentage
Preparation method: fully dissolved in dimethylbenzene reactor by active component probenazole, makes A liquid; Active component epoxiconazole is fully dissolved in dimethylbenzene reactor, makes B liquid; Not stopping, under stirring, A liquid is mixed into B liquid, stirring, adding anhydrous calcium salt and NP-10, then adjusting content with solvent xylene.
Embodiment 6 (preparation method of 48% probenazole epoxiconazole missible oil)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Control efficiency is tested:
The field efficiency test of rice sheath blight disease carries out in Fengyang County, and test area is 0.3hm
2, often process in triplicate, in the control of Rise's boot period spray medicine, carry out preventive effect investigation in dispenser after 15 days, control the results are shown in Table 2.Result shows, bactericidal composition containing epoxiconazole and probenazole has good control efficiency to rice sheath blight disease, can reach higher control efficiency under same dose or lower using dosage, and each process preventive effect bacterium of this bactericidal composition is greater than 85%, is significantly higher than contrast medicament.
The land for growing field crops drug effect * of the table 2 probenazole epoxiconazole bactericidal composition water prevention rice sheath blight
Owing to being also the proper control time preventing and treating false smut at Rise's boot period, we have investigated the control efficiency to false smut after chemical control simultaneously, and control the results are shown in Table 3.Result shows, the bactericidal composition containing epoxiconazole and probenazole has good control efficiency to false smut, and the preventive effect under each treatment dosage, all higher than 85%, is significantly higher than the preventive effect of contrast medicament.
Table 3 probenazole epoxiconazole bactericidal composition is to the field efficacy of false smut
From the data of table 2 and table 3, the bactericidal composition containing probenazole and epoxiconazole all has good preventive effect to rice sheath blight disease and false smut, and the preventive effect of different ratio is different.It should be noted that when the proportioning of epoxiconazole and probenazole is 5:1, compared with other processes, under lower consumption, but to two kinds of diseases, there is higher preventive effect, show good synergistic function; And indoor biometrics result also shows, when the proportioning of epoxiconazole and probenazole is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, it is also to be noted that what enumerate above is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, a lot of distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all think the scope of protection of the invention.
Claims (6)
1. one kind contains the microbicide compositions of epoxiconazole and probenazole, it is characterized in that, the active component of described microbicide compositions is epoxiconazole and probenazole, and the mass ratio of probenazole and epoxiconazole is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.
2. the bactericidal composition containing epoxiconazole and probenazole according to claim 1, is characterized in that: described active component probenazole and the mass ratio of epoxiconazole are 1:10 to 10:1.
3. the bactericidal composition containing epoxiconazole and probenazole according to claim 1, is characterized in that: described probenazole and the mass ratio of epoxiconazole are 1:3-8.
4. the bactericidal composition containing epoxiconazole and probenazole according to claim 1, is characterized in that: described probenazole and the mass ratio of epoxiconazole are 1:4-6.
5. the microbicide compositions containing epoxiconazole and probenazole according to claim 1 and 2, is characterized in that: the formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
6. the application of the microbicide compositions containing epoxiconazole and probenazole according to any one of claim 1-2, is characterized in that: for the control of rice sheath blight disease and false smut.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
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| US4464381A (en) * | 1982-05-14 | 1984-08-07 | Basf Aktiengesellschaft | Fungicides containing azolylmethyloxiranes |
| CN101379988A (en) * | 2008-07-04 | 2009-03-11 | 张少武 | Compound bactericidal composition containing epoxiconazole |
| CN103155927A (en) * | 2013-03-28 | 2013-06-19 | 江苏七洲绿色化工股份有限公司 | Sterilization composition containing benzothiostrobin and epoxiconazole |
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2014
- 2014-11-18 CN CN201410662716.8A patent/CN104472504B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464381A (en) * | 1982-05-14 | 1984-08-07 | Basf Aktiengesellschaft | Fungicides containing azolylmethyloxiranes |
| CN101379988A (en) * | 2008-07-04 | 2009-03-11 | 张少武 | Compound bactericidal composition containing epoxiconazole |
| CN103155927A (en) * | 2013-03-28 | 2013-06-19 | 江苏七洲绿色化工股份有限公司 | Sterilization composition containing benzothiostrobin and epoxiconazole |
| CN103828817A (en) * | 2013-03-28 | 2014-06-04 | 江苏七洲绿色化工股份有限公司 | Sterilizing composition containing benzothiostrobin and epoxiconazole |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
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