CN105901001A - Bactericide composition containing metconazole and hymexazol - Google Patents
Bactericide composition containing metconazole and hymexazol Download PDFInfo
- Publication number
- CN105901001A CN105901001A CN201610547356.6A CN201610547356A CN105901001A CN 105901001 A CN105901001 A CN 105901001A CN 201610547356 A CN201610547356 A CN 201610547356A CN 105901001 A CN105901001 A CN 105901001A
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- Prior art keywords
- metconazole
- mould spirit
- mould
- bactericidal composition
- hymexazol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericide composition containing metconazole and hymexazol. The active components of the bactericide composition are metconazole and hymexazol, wherein the mass ratio of metconazole to hymexazol is 1:20 to 20:1, and the mass percentage of the active components in the composition is 5-60%. The bactericide composition has high bactericidal activity, delays the generation and development of drug resistance of pathogens, reduces the preventing and treating dosage in actual production, and is economical, efficient, safe and environment-friendly. The bactericide composition has better preventing and treating effects on multiple crop diseases caused by fusarium and has obvious preventing and treating effects on wheat scab.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of containing metconazole with the bactericidal composition of mould spirit,
For preventing and treating wheat scab.
Background technology
Wheat scab is the disease that a kind of distribution is the widest, and almost all of wheat belt, the whole world has this disease to send out
Raw, especially endanger serious at gentle moist and semi-humid region.Up to now, the most head blight has not been had
The resistant wheat kind of panimmunity.So, wheat scab still relies on chemical prevention on producing.At present,
Prevent and treat on producing the major pharmaceutical agent of wheat scab be carbendazim be the benzimidazole germicide of representative.From
Within 1992, on Haining city Semen Tritici aestivi disease fringe, the world the first Fusarium graminearum Drug resistance to carbendazim detected
Since bacterial strain, successively in Zhejiang, Soviet Union, Lu, the ground such as Anhui find the Drug resistance of this pathogen, and Drug resistance flora
Body ratio rises the most rapidly, and Drug resistance pathogen distribution constantly expands, and at present, East China is because of drug resistance
Property and be faced with the danger that the existing bactericidal agent for preventing and treating head blight such as carbendazim are failed.How to continue to control gibberella saubinetii
Disease, the popular harm especially controlling carbendazim-resistance head blight has become numerous scientific workers and grower
The key subjects faced.
Metconazole (Metconazole), is again hydroxyl bacterium azoles, chemical name: 5-(4-chlorphenyl)-2,2-dimethyl
-1-(1,2,4-triazol-1-yl methyl)-cyclopentanol, crystalline solid white, tasteless, for Wu Yu chemical company of Japan
In the trendy triazole bactericidal agent of early 1990s exploitation, take off for C-14 in ergosterol biosynthesis
Methylase inhibitors, makes somatic cells film function be destroyed.Thus, suppress or disturb thalline appresorium and
The formation of the growth of haustorium, mycelia and spore, also can cause film seepage to be aggravated, thus reduce pathogen pathogenicity.
Although the mechanism of action is as other triazole bactericidal agents, but activity profile then difference is bigger.Two kinds of isomers have
Bactericidal activity, but Cis activity is higher than trans.The antifungal of metconazole is composed widely, and activity is splendid.Leaf
Bacterium azoles field is used and cereal crops septoria musiva, fusarium and handle rest fungus are planted disease is had excellent effect.Metconazole simultaneous interpretation
System biocide agent is compared, and dosage is extremely low and prevent and treat frumentum to plant disease scope the widest.Metconazole be a kind of efficiently, wide spectrum,
The triazole bactericidal agent of interior absorption, has protection, treatment, an eradicant action, thus be widely used in by ascomycetes,
The preventing and treating of the fungus-caused multiple diseases such as basidiomycetes.Metconazole is the effective agent preventing and treating wheat scab at present
One of, the severity of wheat head blight can not only be reduced, the pathogenic bacteria poison falling ill in wheat grain can be reduced simultaneously
Element pollutes, and ensures food safety.
Metconazole molecular formula: C17H22ClN3O, structural formula:
Mould spirit (hymexaxzol) is a kind of systemic fungicide and plant growth regulator.True to various plants
Fungus diseases, all has notable preventing and treating such as Fusarium spp., Seedling corruption bacterium, pythium spp, rhizoctonia, root shell bacterium, snow germ etc.
Effect, be widely used in Oryza sativa L., Semen Tritici aestivi, Cotton Gossypii, Radix Betae, Nicotiana tabacum L., vegetable, nursery stock, fruit tree, frumentum,
The crop pest that oil section, melon, lawn, flowers and other crops are caused by above-mentioned pathogenic fungi.Strongly soil sterilization
With seed disinfection, various soil-borne diseases there is specially good effect；Promote plant growth and well developed root system, various life in anti-seedling stage
Reason disease and herbicide damage.
Mould spirit molecular formula is: C4H5NO2, structural formula is:
Metconazole and mould spirit single dose life-time service, easily make disease develop immunity to drugs, cause dosage to strengthen,
The problem that preventive effect reduces, the lasting period shortens, is unfavorable for environment sustainable development.And the difference mechanism of action is effective
Composition compounds, and is to delay disease to develop immunity to drugs conventional method, and according to the effect in production application
Really, judging that this compounds is potentiation or antagonism.The obvious formula of complex role, can be obvious
Improve preventive effect, be substantially reduced the dosage of pesticide, also can expand fungicidal spectrum, improve germicidal efficiency.
Summary of the invention
The invention provides a kind of containing metconazole with the bactericidal composition of mould spirit, there is bactericidal activity high, delay
Pathogen Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection,
Specially good effect is had in wheat scab preventing and treating.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easily use of production
Preparation, be used alone in two kinds of compositions and compare, there is biological activity high, dosage total in unit are
Decline, greatly reduce dispenser cost, delay pathogen Drug resistance to produce to a greater extent and development simultaneously,
Reduce pathogenic fungi and single antibacterial is produced the risk of resistance, extend making of each component in bactericidal composition
With the life-span, thus realize economy, efficiently, the goal of the invention of environmental protection.
The technical scheme is that
A kind of containing metconazole with the microbicide compositions of mould spirit, it is characterised in that described microbicide compositions
Active component is metconazole and mould spirit, and the mass ratio of metconazole and mould spirit is 1:20 to 20:1, combination
In thing, active component weight/mass percentage composition is 5-60%.
It is described containing metconazole and the bactericidal composition of mould spirit, it is characterised in that: described active component leaf bacterium
The mass ratio of azoles and mould spirit is 1:10 to 10:1.
It is described containing metconazole and the bactericidal composition of mould spirit, it is characterised in that: described metconazole and mould
The mass ratio of spirit is 1:3-8.
It is described containing metconazole and the bactericidal composition of mould spirit, it is characterised in that: described metconazole and mould
The mass ratio of spirit is 1:4-6.
It is described containing metconazole and the microbicide compositions of mould spirit, it is characterised in that: described microbicide compositions
Dosage form be wettable powder, suspending agent or cream.
The described application of the microbicide compositions containing metconazole and mould spirit, it is characterised in that: this antimicrobial combination
Thing various crop microbial to reaping hook disease has higher prevention effect, to wheat scab prevention effect particularly
Significantly.
Remarkable result and the advantage of the present invention be:
The present invention has higher prevention effect to Semen Tritici aestivi fungal disease, there is notable synergistic and make between two components
With；Part high price pesticide species can be replaced, and reduce dosage, effectively reduce ecological disruption and environmental pollution,
And wheat yield and quality can be improved；In the present invention, metconazole and mould spirit all belong to the toxicity such as low, and to people and animals,
Beneficial organism, Environmental security；The pathogenic bacteria Drug resistance to single medicament can be delayed.
First metconazole and the EC of mould clever two single compounds (hereinafter referred to as medicament) are measured50(safety of medicine
Property index), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to
Wadley coefficient of synergism C value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is fusarium graminearum, but does not limit so.Test uses mycelial growth algoscopy, by not
Pastille culture medium is made with processing, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process to gibberella saubinetii
The growth inhibitory effect of pathogenic bacteria.By linear time between probit value and the logarithm value of series drug concentration of preventive effect
Return analysis, obtain the EC50 of each medicament, calculate coefficient of synergism (SR) according to Wadley method, and make accordingly
Overall merit.SR≤0.5 represents have antagonism, and 0.5 ＜ SR ＜ 1.5 represents have summation action, SR
>=1.5 is potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 metconazole and the mould spirit compositions Wadley method measurement result to wheat scab
Note: Y is metconazole, and E is mould spirit.
Can analyze from data above, the metconazole of different proportion and mould spirit compositions are to fusarium graminearum
Fungistatic effect is different, and on the whole, its ratio has potentiation in the range of 1:20 to 20:1 or adds
And effect, wherein maximum enhancing proportions be the proportioning of metconazole and mould spirit be 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% metconazole mould spirit wettable powder)
Composition of raw materials: by mass percentage
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder
Agent.
Embodiment 2 (preparation method of 30% metconazole mould spirit suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters,
Suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter 2
Within Wei meter, grind and stir after terminating, obtain suspending agent product
Embodiment 3 (preparation method of 40% metconazole mould spirit suspending agent)
Preparation method: same as in Example 2.
Embodiment 4 (preparation method of 20% metconazole mould missible oil cream)
Preparation method: fully dissolved in dimethylbenzene reactor by active component metconazole, makes A liquid；To live
The property mould spirit of component is fully dissolved in dimethylbenzene reactor, makes B liquid；By A under not stopping stirring
Liquid is mixed into B liquid, stirs, and adds anhydrous calcium salt and NP-10, then adjusts with solvent xylene and contain
Amount.
Embodiment 5 (preparation method of the 45% mould missible oil of metconazole)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Embodiment 6 (preparation method of the 48% mould missible oil of metconazole)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Prevention effect is tested:
The field efficiency test of wheat scab is carried out in suburb, Bengbu, and test area is 0.3hm2, often process
In triplicate, carry out spraying medicine preventing and treating at jan flowering wheat, carry out preventive effect investigation, preventing and treating knot after 15 days in dispenser
Fruit is shown in Table 2.Result shows, wheat scab is had well by the bactericidal composition containing metconazole and mould spirit
Prevention effect, higher prevention effect, and this sterilization group can be reached under same dose or relatively low using dosage
Each process preventive effect bacterium of compound, more than 85%, is significantly higher than comparison medicament.
Table 2 metconazole mould spirit bactericidal composition prevents and treats land for growing field crops drug effect * of wheat scab
The field efficiency test of bakanae disease of rice is located at suburb, Bengbu, and this field bakanae disease of rice is toward average annual moderate
Occur, test area 0.3hm2, often process in triplicate, before rice growing, carry out Medicament soaked seed process, plant
The volume ratio that son mixes with medicament is 1:1, and seed soaking time is 10 hours, in rice seedling investigation bakanae disease
Sickness rate, preventing and treating the results are shown in Table 3.Result shows, the bactericidal composition containing metconazole and mould spirit is to Oryza sativa L.
Bakanae disease has good prevention effect, and the preventive effect under each treatment dosage is above 83%, is significantly higher than comparison medicine
The preventive effect of agent.
Table 3 metconazole mould spirit bactericidal composition seed soaking field efficacy (seed and medicine to bakanae disease of rice
The volume ratio of agent mixing is 1:1) *
From table 2 and the data of table 3, Fusariumsp is caused by the bactericidal composition containing metconazole and mould spirit
Wheat scab and bakanae disease of rice be respectively provided with good preventive effect, and the preventive effect of different ratio is different.Value
It is noted that when the proportioning of metconazole and mould spirit is 5:1, process with other compared with, relatively low
But two kinds of diseases had higher preventive effect under consumption, it is shown that preferably synergistic function；And indoor biometrics
Result also indicates that, when the proportioning of metconazole and mould spirit is 5:1, the coefficient of synergism measured is the highest, the two
Result consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.It is clear that the invention is not restricted to
Above embodiment, it is also possible to have many variations.Those of ordinary skill in the art directly can derive from present disclosure
Or all deformation associated, all it is considered the scope of protection of the invention.
Claims (6)
1. one kind contains metconazole and the bactericidal composition of mould spirit, it is characterised in that the active component of described microbicide compositions is metconazole and mould spirit, and the mass ratio of metconazole and mould spirit is 1:20 to 20:1, and in compositions, active component weight/mass percentage composition is 5-60%.
It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: described active component metconazole and the mass ratio of mould spirit are 1:10 to 10:1.
It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: the mass ratio of described metconazole and mould spirit is 1:3-8.
It is the most according to claim 1 containing metconazole with the bactericidal composition of mould spirit, it is characterised in that: the mass ratio of described metconazole and mould spirit is 1:4-6.
It is the most according to claim 1 and 2 containing metconazole with the microbicide compositions of mould spirit, it is characterised in that: the dosage form of described microbicide compositions is wettable powder, suspending agent or cream.
Microbicide compositions application containing metconazole and mould spirit the most according to claim 1 and 2, it is characterised in that: described bactericidal composition gibberella saubinetii microbial to reaping hook disease has the highest prevention effect.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610547356.6A CN105901001A (en) | 2016-07-12 | 2016-07-12 | Bactericide composition containing metconazole and hymexazol |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610547356.6A CN105901001A (en) | 2016-07-12 | 2016-07-12 | Bactericide composition containing metconazole and hymexazol |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
| CN107926959A (en) * | 2017-11-14 | 2018-04-20 | 浙江禾本科技有限公司 | A kind of highly efficiency compositional fungicide and preparation method thereof |
| CN108911839A (en) * | 2018-07-03 | 2018-11-30 | 陕西标正作物科学有限公司 | Fertilizer granules containing bactericidal composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719106A (en) * | 2012-10-16 | 2014-04-16 | 海利尔药业集团股份有限公司 | Suspension seed coating agent containing tebuconazole and hymexazol |
-
2016
- 2016-07-12 CN CN201610547356.6A patent/CN105901001A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719106A (en) * | 2012-10-16 | 2014-04-16 | 海利尔药业集团股份有限公司 | Suspension seed coating agent containing tebuconazole and hymexazol |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
| CN107926959A (en) * | 2017-11-14 | 2018-04-20 | 浙江禾本科技有限公司 | A kind of highly efficiency compositional fungicide and preparation method thereof |
| CN107926959B (en) * | 2017-11-14 | 2021-04-09 | 浙江禾本科技股份有限公司 | Efficient compound bactericide and preparation method thereof |
| CN108911839A (en) * | 2018-07-03 | 2018-11-30 | 陕西标正作物科学有限公司 | Fertilizer granules containing bactericidal composition |
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Application publication date: 20160831 |