CN105010357B - Bactericidal composition and its application - Google Patents
Bactericidal composition and its application Download PDFInfo
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- CN105010357B CN105010357B CN201410165490.0A CN201410165490A CN105010357B CN 105010357 B CN105010357 B CN 105010357B CN 201410165490 A CN201410165490 A CN 201410165490A CN 105010357 B CN105010357 B CN 105010357B
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Abstract
The present invention provides a kind of bactericidal composition and its application, and its active ingredient lures amine (A) and a kind of triazole class compounds (B) for first thiophene, and (A) is 50 with the weight ratio of (B):1‑1:50.Triazole class compounds (B) can select triazole type hydroxy derivatives, triazole type dioxolanyl derivatives or triazolinthione analog derivative, such as Tebuconazole, hexaconazole, Difenoconazole, propiconazole, prothioconazoles.Active ingredient (A) has obvious synergistic effect with (B) compounding, can effectively reduce the amount of application of each single dose.Said composition allows the auxiliary element for using to be processed into any formulation in can adding remaining agricultural chemicals.The bactericidal composition is mainly used in the fungus diseases such as preventing and treating pepper anthracnose, early blight of tomato, rice blast, wheat powdery mildew, sigatoka.
Description
Technical field
The present invention relates to a kind of bactericidal composition, a kind of compounding for luring amine and triazole class compounds containing first thiophene is particularly related to
Microbicide compositions and its application.
Background technology
Agricultural chemicals has played great function, but not science with quick effective and lower-price characteristic in agricultural is increased production without increasing the work force
Medication and single drug already lead to the drug-fast continuous enhancing of germ and pvs oryzae and oryzicola is continuously increased, meanwhile, frequently make
Financial burden is also increased with agricultural chemicals, and result in environmental pollution and a series of serious ecological problems of agricultural product security and society
Problem.With the continuous improvement of people's living standard, concern to environmental protection, safety and quality to agricultural product are proposed
Requirement higher.Therefore, how Scientific Usage of Drugs, reduce chemical pesticide consumption, improve drug effect, as plant protection art be badly in need of
The problem of solution.
It is a kind of thiadiazole plant disease-proof activator that first thiophene lures amine, the general entitled N- of chemistry (5- methyl isophthalic acids, 3- thiazoles-
2- yls) -4- methyl isophthalic acids, 2,3- thiadiazoles -5- formamides, its structural formula is such as shown in (I).Current result of study shows, the change
Compound has induction disease resisting effect well to virus disease, and mechanism of action is induction plant generation system, the disease-resistant work of wide spectrum
Property.Plant disease-proof activator is the class novelty agricultural chemicals for receiving much concern in recent years, itself has no obvious bactericidal activity, but
Can be as the immunoactivator of plant, inducer of systemic acquired resistance, so as to reach the purpose of defending and fighting against diseases.Wherein, BTH
(diazosulfide, the production of Syngenta Co., Ltd of Switzerland) and TDL (tiadinil, Nihon Nihyaku Co., Ltd's production) are such medicament
Representative Cultivars, widely applied in agricultural production at present.But because first thiophene lures amine single dose unstable in variable rate technology,
Preventive effect has certain fluctuation, and to the plant that has fallen ill without good therapeutic action.
Triazole class compounds be a class efficiently, wide spectrum, the bactericide with good Uptake and translocation, with protecting, control
Treat and eradicant action.Its mechanism of action is that the biosynthesis for suppressing germ ergosterol is destroyed somatic cells function, from
And suppress or interference thalline appresorium and the development of haustorium, mycelia and spore row into.Such compound includes Tebuconazole, own azoles
Alcohol, Difenoconazole, propiconazole, prothioconazoles etc., it is effective to sac fungus, basidiomycetes, Fungi Imperfecti, to the disease of various crop
Evil has good prevention effect.But, this series bactericidal agent is used alone for a long time, and preventive effect declines, and faces the wind for developing immunity to drugs
Danger, meanwhile, this series bactericidal agent has certain inhibitory action when beyond using metering to the growth of crop.
Its structural formula of Tebuconazole is as shown in (II).It is sterol demethylation inhibitor, is the seed for Important Economic crop
Treatment or the efficient germicide of foliage spray, can effectively prevent and treat various rust, powdery mildew, net blotch, the root of cereal crop
Maize ear rot, head blight, smut and kind pass zonate spot etc..Because single dose chronicity is used, most of crops produce tight to this medicine
The resistance to the action of a drug of weight, causes consumption to increase, drug effect reduction.
Its structural formula of hexaconazole is as shown in (III).Sterol demethylation inhibitors, to fungi especially Basidiomycota and son
The disease that Nang Junmen causes has the protection and therapeutic action of broad spectrum activity.Destruction and the cell membrane important composition composition wheat of prevention germ
The biosynthesis of angle sterol, causes cell membrane to be formed, and makes germ dead.With interior suction, protection and therapeutic activity.
Its structural formula of prothioconazoles is as shown in (IV).It is that a kind of New-type wide-spectrum triazole thioketone that Beyer Co., Ltd develops is sterilized
Agent, is mainly used in preventing and treating numerous diseases such as cereal, wheat class legume crop, and prothioconazoles toxicity is low, and without teratogenesis, mutagenesis type is right
Embryo is non-toxic, to human and environment safety.Its mechanism of action is the precursor for suppressing sterol in fungi --- lanosterol or 2,4- are sub-
Demethylation effect on methyl dihydro wool steroid 14.
The content of the invention
For above-mentioned situation, the present invention provides a kind of bactericidal composition and its application, to meet agricultural production the need for, group
Active component included in compound has mutually synergistic effect to improve preventive effect and be beneficial to delay the drug-fast generation of germ.
Bactericidal composition of the invention, its active ingredient lures amine and triazole class compounds, first thiophene to lure amine and triazole for first thiophene
The weight ratio of class compound is 1：50-50:1, preferable ratio is 25:1-1:25, remaining uses and can connect to be allowed in agricultural chemicals
The auxiliary element received.
It, containing the triazole of active group 1,2,4- on main chain, is ergot steroid that triazole class compounds its chemical constitution common features is
Alcohol synthetic inhibitor, the features such as with high-efficiency broad spectrum.
Triazole class compounds of the present invention are more preferably that triazole type hydroxy derivatives, triazole type dioxolanyl spread out
Biological or triazolinthione analog derivative.
The chemical constitution common feature of triazole type hydroxy derivatives is to contain hydroxyl, substituted-phenyl and 1,2,4- tri- on main chain
Oxazolyl group, wherein Tebuconazole, hexaconazole are its most typical representatives, it has also become the ripe product of in the market.
The chemical constitution common feature of triazole type dioxolanyl derivatives is to contain dioxolanyl, substituted benzene on main chain
Base and 1, wherein 2,4- triazole groups, propiconazole, Difenoconazole are most typical representative.
The chemical constitution common feature of triazolinthione analog derivative is to contain 3- thio -1 on main chain, 2,4- triazole groups,
Prothioconazoles are the products having been commercialized at present, and prothioconazoles are a kind of New-type wide-spectrum triazolinthione series bactericidal agents, are mainly used in
Numerous diseases such as cereal, wheat class legume crop are prevented and treated, prothioconazoles toxicity is low, without teratogenesis, mutagenesis type is non-toxic to embryo,
To human and environment safety.
Triazole type hydroxy derivatives of the present invention are preferably Tebuconazole or hexaconazole；The triazole type dioxolanyl spreads out
Biology is preferably Difenoconazole or propiconazole；The triazolinthione analog derivative is preferably prothioconazoles.
The auxiliary agent used in composition of the invention including wetting agent, dispersant, emulsifying agent, solvent and filler etc. and its
He is beneficial to the known substance that active ingredient is stablized in the formulation and drug effect is played, and is all to commonly use in pesticidal preparations or allow to use
Various composition, have no specific restriction, possess composition and consumption according to recipe requirements by simple experiment determine.
Bactericidal composition of the invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is wettable powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.
Product described in the invention can be provided in finished product preparation form, i.e., each material is blended in compound, combination
The composition of thing can also be provided with unit dose form, directly directly be mixed in bucket or tank using preceding, needed for being then diluted to
Concentration.
The multiple diseases that bactericidal composition of the invention can be used to prevent and treat on the crops such as paddy rice, wheat, vegetables, fruit tree are especially
It is suitable for the plant diseases such as preventing and treating pepper anthracnose, wheat powdery mildew, rice blast, early blight of tomato.Of the invention group
Compound can be applied by common method, such as cast, injection, spraying, dusting or spread, and its amount of application is with weather condition or crop
State change.
Compared with prior art, the beneficial effects of the present invention are：1st, compared with single dose, there is compounding obvious collaboration to increase
Effect is acted on, and improves prevention effect；2nd, composition is made up of two kinds of different active ingredients of mechanism of action, is conducive to overcoming and prolongs
The drug-fast generation of slow germ；3rd, medicament mixture reduces dosage, so as to reduce cost and alleviate the pollution to environment；
4th, compared with triazole bactericidal agent is used alone, the risk reduction of poisoning is produced.
Specific embodiment
For the technical problem, technical scheme and the advantage that to be solved embodiments of the invention are clearer, below by apparatus
Body embodiment is described in detail, but the present invention is limited to absolutely not these examples.As described below is only the present invention preferably embodiment,
Only it is used to explain the present invention, therefore can not be interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that it is all
Any modification, equivalent and improvement for being made within the spirit and principles in the present invention etc., should be included in protection of the invention
Within the scope of.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is to develop and develop novel pesticide and preventing and treating at present agriculturally
A kind of effective and quick way of resistance germ.After the pestsides synthesis of different cultivars, a large amount of three kinds of effects classes are typically exhibited
Type：Summation action, synergistic effect and antagonism.Compound synergic is formulated well, can significantly improve actual prevention effect, drop
The usage amount of low agricultural chemicals, is the important means of integrated control disease so as to help to delay the drug-fast generation speed of germ.
Application Example：
First thiophene lures amine and Tebuconazole compounding to rice blast indoor harmacological effect determination test：
For examination pathogen：Rice blast fungus.
Test method：Using live body method, each treatment is repeated 5 times, and Lesion size is measured after 6d, calculates EC50 and common poison
Coefficient, result of the test see the table below 1.
The first thiophene of table 1 lures amine and Tebuconazole compounding to determine the indoor harmacological effect of rice blast
| Reagent agent | Regression equation | CTC | |
| First thiophene lures amine (A) | 49.5106 | Y=2.8392+1.27550x | — |
| Tebuconazole (B) | 32.1991 | Y=2.7512+1.4914x | — |
| (A:B)50:1 | 33.1616 | Y=2.7092+1.5425x | 136.86 |
| 25:1 | 26.1875 | Y=2.7481+1.5880x | 172.72 |
| 5:1 | 23.7905 | Y=2.7810+1.6122x | 190.99 |
| 1:1 | 19.8000 | Y=2.8108+1.6883x | 197.08 |
| 1:5 | 22.4791 | Y=2.8238+1.6099x | 152.106 |
| 1:25 | 22.6204 | Y=2.8337+1.5993x | 144.29 |
| 1:50 | 25.9221 | Y=2.7811+1.5696x | 125.07 |
Note：Co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 ＜ CTC ＜ 120 represent summation action；CTC≤80
Indicate antagonism.
Toxicity Determination result shows that first thiophene lures amine and Tebuconazole to compound, and there is excellent preventing and treating to imitate to rice blast
Really, prevention effect is better than single dose kind.
Inventor has found that first thiophene lures amine to be compounded with other triazole type hydroxy derivatives (such as hexaconazole), first thiophene by test
Amine is lured to be compounded with triazole type dioxolanyl derivatives (such as propiconazole, Difenoconazole), first thiophene lures amine to spread out with triazole thioketone
Biological (such as prothioconazoles) compounding, there is similar prevention effect to rice blast.
First thiophene lures amine and hexaconazole compounding to test pepper anthracnose indoor pot：
The first thiophene of table 2 lures amine and hexaconazole to compound the indoor pot test of pesticide effectiveness to pepper anthracnose
| Reagent agent | Regression equation | CTC | |
| First thiophene lures amine (A) | 46.3843 | Y=2.8527+1.2886x | — |
| Hexaconazole (C) | 37.8163 | Y=2.9311+1.3114x | — |
| (A:C)50:1 | 27.4546 | Y=2.7877+1.4685x | 143.88 |
| 25:1 | 24.5952 | Y=2.8064+1.5772x | 186.96 |
| 5:1 | 22.5352 | Y=2.8722+1.5728x | 198.34 |
| 1:1 | 20.3046 | Y=2.9158+1.5939x | 205.19 |
| 1:5 | 21.2351 | Y=2.8919+1.5885x | 183.74 |
| 1:25 | 22.5654 | Y=2.8050+1.6218x | 168.79 |
| 1:50 | 26.3244 | Y=2.8059+1.5448x | 144.18 |
Note：Co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 ＜ CTC ＜ 120 represent summation action；CTC≤80
Indicate antagonism.
Indoor harmacological effect measurement result shows that first thiophene lures amine and hexaconazole to compound, and there is excellent preventing and treating to imitate to pepper anthracnose
Really, prevention effect is better than single dose kind.
Inventor has found that first thiophene lures amine to be compounded with other triazole type hydroxy derivatives (such as Tebuconazole), first thiophene by test
Amine is lured to be compounded with triazole type dioxolanyl derivatives (such as propiconazole, Difenoconazole), first thiophene lures amine to spread out with triazole thioketone
Biological (such as prothioconazoles) compounding, there is similar prevention effect to pepper anthracnose.
First thiophene lures amine and propiconazole compound to sigatoka indoor harmacological effect determination test：
For examination pathogen：Sigatoka bacterium.
Test method：Using live body method, each treatment is repeated 5 times, and lesion diameter is measured after 6d, calculates EC50 and common poison
Coefficient, result of the test see the table below 3.
The first thiophene of table 3 lures amine and propiconazole compound to determine the indoor harmacological effect of sigatoka bacterium
| Reagent agent | Regression equation | CTC | |
| First thiophene lures amine (A) | 46.3843 | Y=2.8527+1.2886x | — |
| Propiconazole (D) | 47.8639 | Y=2.5361+1.4666x | — |
| (A:D)50:1 | 33.8819 | Y=2.2354+1.8070x | 126.53 |
| 25:1 | 31.6851 | Y=2.2797+1.8125x | 135.59 |
| 5:1 | 30.6072 | Y=2.2833+1.8284x | 142.49 |
| 1:1 | 27.7356 | Y=2.3022+1.8695x | 163.64 |
| 1:5 | 31.3965 | Y=2.3453+1.7735x | 150.70 |
| 1:25 | 33.9511 | Y=2.3273+1.7459x | 141.68 |
| 1:50 | 37.6636 | Y=2.3813+1.6617x | 128.02 |
Note：Co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 ＜ CTC ＜ 120 represent summation action；CTC≤80
Indicate antagonism.
Indoor harmacological effect measurement result shows, first thiophene lures amine and the propiconazole compound there is excellent preventing and treating to imitate to sigatoka
Really, prevention effect is better than single dose kind.
Inventor has found that first thiophene lures amine and other triazole type dioxolanyl derivatives (such as Difenoconazole) by test
Compounding, first thiophene lures amine to be compounded with triazole type hydroxy derivatives (such as Tebuconazole, hexaconazole), and first thiophene lures amine to derive with triazole thioketone
Thing (such as prothioconazoles) is compounded, and has similar prevention effect to sigatoka.
First thiophene lures amine and Difenoconazole compounding to early blight of tomato indoor harmacological effect determination test：
For examination pathogen：Early blight of tomato germ.
Test method：Using pot-culture method, each treatment is repeated 5 times, and lesion diameter is measured after 6d, calculates EC50 and common poison
Coefficient, result of the test see the table below 4.
The first thiophene of table 4 lures amine and Difenoconazole compounding to determine the indoor harmacological effect of early blight of tomato
| Reagent agent | Regression equation | CTC | |
| First thiophene lures amine (A) | 38.2096 | Y=2.7970+1.3924x | — |
| Difenoconazole (E) | 61.3129 | Y=2.5612+1.3643x | — |
| (A:E)50:1 | 31.7498 | Y=2.2998+1.7981x | 121.24 |
| 25:1 | 29.0769 | Y=2.3083+1.8392x | 133.34 |
| 5:1 | 28.4101 | Y=2.3373+1.8320x | 143.51 |
| 1:1 | 27.5963 | Y=2.3694+1.8257x | 170.60 |
| 1:5 | 35.2994 | Y=2.3161+1.7340x | 157.79 |
| 1:25 | 38.7513 | Y=2.2200+1.7503x | 154.62 |
| 1:50 | 49.3195 | Y=2.2287+1.6369x | 122.86 |
Note：Co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 ＜ CTC ＜ 120 represent summation action；CTC≤80
Indicate antagonism.
Indoor harmacological effect measurement result shows, it is excellent anti-that first thiophene lures amine and Difenoconazole compounding to have tomato late blight
Effect is controlled, prevention effect is better than single dose kind.
Inventor has found that first thiophene lures amine multiple with other triazole type dioxolanyl derivatives (such as propiconazole) by test
Match somebody with somebody, first thiophene lures amine to be compounded with triazole type hydroxy derivatives (such as Tebuconazole, hexaconazole), and first thiophene lures amine and triazolinthione analog derivative
(such as prothioconazoles) are compounded, and have similar prevention effect to tomato late blight.
First thiophene lures amine and prothioconazoles compounding to wheat powdery mildew indoor harmacological effect determination test：
For examination pathogen：Wheat powdery mildew.
Test method：Using pot-culture method, each treatment is repeated 5 times, and lesion area is investigated after 6d and accounts for the hundred of total blade area
Divide ratio, calculate EC50 and co-toxicity coefficient, result of the test see the table below 5.
The first thiophene of table 5 lures amine and prothioconazoles compounding to determine the indoor harmacological effect of wheat powdery mildew
| Reagent agent | Regression equation | CTC | |
| First thiophene lures amine (A) | 39.3018 | Y=2.8687+1.3367x | — |
| Prothioconazoles (F) | 69.0821 | Y=2.5454+1.3345x | — |
| (A:F)50:1 | 32.1789 | Y=2.1927+1.8508x | 120.58 |
| 25:1 | 28.8968 | Y=2.4310+1.7586x | 138.30 |
| 5:1 | 30.1094 | Y=2.2482+1.8609x | 140.64 |
| 1:1 | 29.1536 | Y=2.2530+1.8755x | 171.85 |
| 1:5 | 36.6733 | Y=2.1214+1.8402x | 167.25 |
| 1:25 | 40.4831 | Y=2.1179+1.7931x | 165.81 |
| 1:50 | 46.1487 | Y=2.1085+1.7375x | 123.92 |
Note：Co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 ＜ CTC ＜ 120 represent summation action；CTC≤80
Indicate antagonism.
Indoor harmacological effect measurement result shows that first thiophene lures amine and prothioconazoles to compound has excellent preventing and treating to wheat powdery mildew
Effect, prevention effect is better than single dose kind.
Inventor has found by test, and first thiophene lures amine and first thiophene to lure amine and triazole type hydroxy derivatives (such as Tebuconazole, own azoles
Alcohol) compounding, first thiophene lures amine to be compounded with triazole type dioxolanyl derivatives (such as propiconazole, Difenoconazole), to wheat white powder
Disease has similar prevention effect.
Bactericidal composition of the invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is wettable powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.Percentage in all formulas
It is weight percentage.The processing technology of the various formulations of the present composition is prior art, can be had according to different situations
Changed.
Embodiment 1：51% first thiophene lures amine ● difenoconazole suspending agent
The each components such as active compound, wetting dispersing agent, antifreezing agent, thickener, defoamer are weighed in proportion standby, through high speed shear
It is well mixed, then be sanded 2-3 hours by sand mill, make its average grain diameter in 2-5 microns, obtain final product 51% first thiophene and lure amine
● difenoconazole suspending agent.
According to the mechanism of action, the Difenoconazole in the present embodiment can be replaced other triazole type dioxolanyl derivatives
(such as propiconazole), or triazole type hydroxy derivatives (such as hexaconazole, Tebuconazole), or triazolinthione analog derivative is (such as
Prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
Tested with pesticidal preparations early blight of tomato obtained in above-described embodiment
Test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This experiment
Dosing sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is respectively that the first thiophene of commercially available agricultural chemicals 24% is lured
Amine suspending agent and 50% difenoconazole water dispersible granule and clear water control.
Test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect method after being investigated before dispenser and being prevented and treated
For：Taken a little per cell diagonal, every is extracted 10 plants of investigation, account for whole blade area with the lesion area on every plant of blade hundred
Point rate is classified, and result of the test see the table below 6：
The first thiophene of table 6 lures amine and Difenoconazole to compound the prevention effect to early blight of tomato
Field efficacy result shows that it is excellent that first thiophene lures amine and Difenoconazole compounding to have the prevention effect of early blight of tomato
Good prevention effect, prevention effect is better than single dose kind.
Embodiment 2：26% first thiophene lures amine ● Tebuconazole wettable powder
The each components such as active component, dispersant, wetting agent and filler are well mixed in the ratio of formula, through mechanical crushing
Again through air-flow crushing, be then well mixed, measure the quality index such as content and suspensibility it is qualified after, obtain final product 26% first thiophene and lure amine ●
Tebuconazole wettable powder.
According to the mechanism of action, the Tebuconazole in the present embodiment can be replaced other triazole type hydroxy derivatives (such as hexaconazole
Deng), or triazole type dioxolanyl derivatives (such as Difenoconazole, propiconazole), or triazolinthione analog derivative is (such as
Prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
Tested with pesticidal preparations pepper anthracnose obtained in above-described embodiment
Test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This experiment
Dosing sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is respectively that the first thiophene of commercially available agricultural chemicals 25% is lured
Amine suspending agent and 43% Tebuconazole SC and clear water control.
Test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect method after being investigated before dispenser and being prevented and treated
For：Taken a little per cell diagonal, every is extracted 10 plants of investigation, account for whole blade area with the lesion area on every plant of blade hundred
Point rate is classified, and result of the test see the table below 7：
The first thiophene of table 7 lures amine and Tebuconazole to compound the prevention effect to pepper anthracnose
Field efficacy result shows that it is excellent that first thiophene lures amine and Tebuconazole compounding to have the prevention effect of pepper anthracnose
Prevention effect, prevention effect is better than single dose kind.
Embodiment 3：30% first thiophene lures amine ● hexaconazole oil-suspending agent
It is standby each components such as active compound, emulsifying agent, wetting dispersing agent, organic roc profit soil and methyl oleate to be weighed by formula rate
With, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make its average grain diameter in 2-5 microns, obtain final product
30% first thiophene lures amine ● hexaconazole oil-suspending agent.
According to the mechanism of action, the hexaconazole in the present embodiment can be replaced other triazole type hydroxy derivatives (such as Tebuconazole
Deng), or triazole type dioxolanyl derivatives (such as propiconazole, Difenoconazole), or triazolinthione analog derivative is (such as
Prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
Tested with pesticidal preparations rice blast obtained in above-described embodiment
Test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This experiment
Dosing sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is respectively that the first thiophene of commercially available agricultural chemicals 25% is lured
Amine suspending agent and 30% hexaconazole suspending agent and clear water control.
Test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect method after being investigated before dispenser and being prevented and treated
For：Taken a little per cell diagonal, every is extracted 10 plants of investigation, account for whole blade area with the lesion area on every plant of blade hundred
Point rate is classified, and result of the test see the table below 8：
The first thiophene of table 8 lures amine and hexaconazole to compound the prevention effect to rice blast
Field efficacy result shows that first thiophene lures amine and Tebuconazole to compound has excellent prevention effect to rice blast,
Prevention effect is better than single dose kind.
Embodiment 4：30% first thiophene lures amine ● propiconazole suspended emulsion
The each component such as active compound, wetting dispersing agent, emulsifying agent and antifreezing agent, water is weighed by formula rate standby, first thiophene is lured
The components such as amine, wetting dispersing agent, antifreeze through high speed shear it is well mixed after through grinding particle diameter to 2-5um, by propiconazole and breast
Agent is made oil phase in being dissolved in cyclohexanone, be poured slowly into first thiophene lure amine suspending agent in, shear-mixed uniformly obtain 24% first thiophene
Lure amine ● propiconazole suspended emulsion agent.
According to the mechanism of action, the propiconazole in the present embodiment can be replaced other triazole type dioxolanyl derivatives (such as
Difenoconazole etc.), or triazole type hydroxy derivatives (such as hexaconazole, Tebuconazole), or triazolinthione analog derivative is (such as
Prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
Tested with pesticidal preparations sigatoka obtained in above-described embodiment
Test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This experiment
Dosing sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is respectively that the first thiophene of commercially available agricultural chemicals 24% is lured
Amine suspending agent and 250g/l propiconazoles suspending agent and clear water control.
Test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect method after being investigated before dispenser and being prevented and treated
For：Taken a little per cell diagonal, every is extracted 10 plants of investigation, account for whole blade area with the lesion area on every plant of blade hundred
Point rate is classified, and result of the test see the table below 9：
The first thiophene of table 9 lures amine and propiconazole compound to the prevention effect of sigatoka
Field efficacy result shows, first thiophene lures amine and the propiconazole compound to have excellent prevention effect to sigatoka,
Prevention effect is better than single dose kind.
Embodiment 5：24% first thiophene lures amine ● prothioconazoles suspending agent
The each components such as active compound, wetting dispersing agent, antifreezing agent, thickener, defoamer are weighed in proportion standby, through high speed shear
It is well mixed, then be sanded 2-3 hours by sand mill, make its average grain diameter in 2-5 microns, that is, obtain 24% first thiophene and lure
Amine ● prothioconazoles suspending agent.
According to the mechanism of action, the triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxy penta
Ring group derivative (such as propiconazole, Difenoconazole), or triazole type hydroxy derivatives (such as hexaconazole, Tebuconazole), with
And other triazole class compounds, to form new embodiment.
Embodiment 6：26% first thiophene lures amine ● prothioconazoles water dispersible granules
Each component is well mixed, once mixture is obtained.Once mixture, again through air-flow crushing, obtains secondary through mechanical crushing
Mixture.To the water that secondary mixture quality 10%-15% is added in secondary mixture, it is well mixed, then through extruder grain, shape
Into column or spherical particle, finally it is dried, that is, obtains 26% first thiophene and lure amine ● prothioconazoles water dispersible granules.
According to the mechanism of action, the triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxy penta
Ring group derivative (such as propiconazole, Difenoconazole), or triazole type hydroxy derivatives (such as hexaconazole, Tebuconazole), with
And other triazole class compounds, to form new embodiment.
Embodiment 7：1% first thiophene lures amine ● prothioconazoles suspending agent
The each components such as active compound, wetting dispersing agent, antifreezing agent, thickener, defoamer are weighed in proportion standby, through high speed shear
It is well mixed, then be sanded 2-3 hours by sand mill, make its average grain diameter in 2-5 microns, that is, obtain 51% first thiophene and lure
Amine ● prothioconazoles suspending agent.
According to the mechanism of action, the triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxy penta
Ring group derivative (such as propiconazole, Difenoconazole), or triazole type hydroxy derivatives (such as hexaconazole, Tebuconazole), with
And other triazole class compounds, to form new embodiment.
Tested with pesticidal preparations wheat powdery mildew obtained in above-described embodiment
Test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This experiment
Dosing sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is respectively that the first thiophene of commercially available agricultural chemicals 25% is lured
Amine suspending agent and 25% prothioconazoles suspending agent and clear water control
Test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect method after being investigated before dispenser and being prevented and treated
For：Taken a little per cell diagonal, every is extracted 10 plants of investigation, account for whole blade area with the lesion area on every plant of blade hundred
Point rate is classified, and result of the test see the table below 10：
The first thiophene of table 10 lures amine and prothioconazoles to compound the prevention effect to wheat powdery mildew
Field efficacy result shows that first thiophene lures amine and prothioconazoles to compound, and there is excellent preventing and treating to imitate to wheat powdery mildew
Really, prevention effect is better than single dose kind.
Claims (7)
1. a kind of bactericidal composition, it is characterised in that：Active ingredient lures amine and triazole class compounds, the first thiophene to lure amine for first thiophene
It is 50 with the weight ratio of triazole class compounds:1-1:50；
The triazole class compounds are that triazole type hydroxy derivatives, triazole type dioxolanyl derivatives or triazole thioketone derive
Thing；
The triazole type hydroxy derivatives are Tebuconazole or hexaconazole, and the triazole type dioxolanyl derivatives are phenyl ether methyl cyclic
Azoles or propiconazole, the triazolinthione analog derivative are prothioconazoles.
2. bactericidal composition according to claim 1, it is characterised in that：The first thiophene lures the weight of amine and triazole class compounds
Amount is than being 25:1-1:25.
3. bactericidal composition according to claim 1 and 2, it is characterised in that：Also contain agricultural chemicals in the bactericidal composition
Preparation auxiliary element, to be made the formulation for being adapted to agriculturally use.
4. bactericidal composition according to claim 3, it is characterised in that：The pesticidal preparations auxiliary element is solvent, breast
One or more in agent, dispersant, stabilizer, antifreezing agent or wetting agent.
5. bactericidal composition according to claim 3, it is characterised in that：The formulation of the bactericidal composition is wettable powder
Agent, aqueous suspension agent, oil-suspending agent, suspended emulsion or water dispersible granules.
6. the application of the bactericidal composition described in claim 1, it is characterised in that：For preventing and treating plant epiphyte class disease.
7. the application of bactericidal composition according to claim 6, it is characterised in that：For preventing and treating pepper anthracnose, tomato
Early blight, rice blast, wheat powdery mildew, sigatoka.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582906A (en) * | 1981-03-16 | 1986-04-15 | Stauffer Chemical Company | 4-phenyl-1,2,3-thiadiazoles as herbicide extenders |
| CN1810808A (en) * | 2006-02-20 | 2006-08-02 | 南开大学 | New [1,2,3]-thiobiazole derivative and its synthesis and use |
| CN101091490A (en) * | 2007-01-12 | 2007-12-26 | 南开大学 | New type heterocycle bactericide and composition |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582906A (en) * | 1981-03-16 | 1986-04-15 | Stauffer Chemical Company | 4-phenyl-1,2,3-thiadiazoles as herbicide extenders |
| CN1810808A (en) * | 2006-02-20 | 2006-08-02 | 南开大学 | New [1,2,3]-thiobiazole derivative and its synthesis and use |
| CN101091490A (en) * | 2007-01-12 | 2007-12-26 | 南开大学 | New type heterocycle bactericide and composition |
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