CN106719647A - A kind of microbicide compositions comprising anthraquinone analog compound and metrafenone - Google Patents
A kind of microbicide compositions comprising anthraquinone analog compound and metrafenone Download PDFInfo
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- CN106719647A CN106719647A CN201710007343.4A CN201710007343A CN106719647A CN 106719647 A CN106719647 A CN 106719647A CN 201710007343 A CN201710007343 A CN 201710007343A CN 106719647 A CN106719647 A CN 106719647A
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- metrafenone
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- physcion
- emodin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
Abstract
The invention provides a kind of microbicide compositions comprising anthraquinone analog compound and metrafenone, said composition includes two kinds of effective constituents As and B, active component A is selected from the one kind in Chrysophanol, rheum emodin, Physcion, Rhein, aloe-emodin in anthraquinone analog compound, active component B is metrafenone, and the weight ratio between two components is 1:0.1~70.Present invention also offers the Preparation method and use of said composition.Result of the test shows that the above-mentioned bactericidal composition synergy that the present invention is provided is obvious, it is often more important that amount of application is reduced, use cost reduction.The bactericidal composition can effectively prevent and treat some specific bacteriums or the fungal disease of crop.Compounded by by the bactericide of different mechanism of action and the mode of action, there is effect well for expanding fungicidal spectrum and delaying germ resistance and improve the aspects such as prevention effect.
Description
Technical field
It is more particularly to a kind of with the bactericidal composition for improving performance, tool the invention belongs to agriculture plant protection field
Say it is to be related to a kind of microbicide compositions comprising anthraquinone analog compound and metrafenone body.
Background technology
Rheum emodin, Rhein, Physcion, Chrysophanol and aloe-emodin etc. and the like are planted from Chinese herbal medicine
The class highly active vegetable source bactericide extracted in root, the stem of thing rheum officinale, belongs to anthraquinone analog compound.Field of medicaments these
Compound is widely used, and such as immunoregulation effect, scavenging activated oxygen effect, antibacterial, anti-inflammatory, antivirus action, diuresis is made
With the protective effect damaged to cerebrum ischemia, cardiovascu- lar effects, antitumor action.In recent years, these anthraquinone analog compounds
Agriculture field is just progressively applied to, for preventing and treating fungi or bacterial disease, powdery mildew, frost to veterinary antibiotics, cereal etc.
The multiple diseases such as mildew, gray mold, anthracnose have good prevention effect, at the same to people and animals' low toxicity, it is environmentally friendly, with it
His chemical agent no interactions resistance, with preferable Uptake and translocation effect, lasting effect is strong.Its bactericidal action mechanism is by interference
The biosynthesis of disease fungus cell membrane chitin, suppresses sprouting, the growth of mycelia, the formation of haustorium of pathogen spore, from
And spreading for disease is blocked, and also can induce crop and produce degeneration-resistant defense reaction, reach the effect of diseases prevention.
Metrafenone (Metrafenone) is the Benzophenones bactericide of German BASF exploitation, be mainly used in preventing and treating cereal,
The diseases such as the powdery mildew and eye spot disease of the crop such as grape and cucumber.Its mechanism of action is unique, attached during spore germination by disturbing
The development of born of the same parents and formed, suppress the spore germination of powdery mildew；Secondly, by foundation and the shape of disturbing polarity actin tissue
Into, form the mycelium apical cell of germ and be interfered and suppress, so that mycelial normal development and growth are hindered, it is right
Powdery mildew has significant preventive and therapeutic action.
Actual agricultural chemicals experience have shown that, repeat and single-minded apply a kind of reactive compound to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of many, to reduce the danger of refractory fungal bacterial strain selectivity, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.Enter by by the reactive compound with the different mechanisms of action
Row combination, can delaying drug resistance generation, reduction amount of application, reduction cost accounting.
The content of the invention
The purpose of the present invention is directed to bactericide resistance and pedo relict problem in actual applications, filters out difference and kills
The bactericide of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
Prevented and treated in agriculture field it is a further object to provide comprising two kinds of effective constituents As and B bactericidal compositions
The application of corps diseases.
The purpose of the present invention can be reached by following measures：
A kind of composition pesticide with synergistic effect, said composition includes two kinds of active components of A and B, and active component A is
Anthraquinone analog compound, active component B is metrafenone, and the weight ratio between two components is 1:0.1~70, wherein, Anthraquinones chemical combination
Thing is selected from the one kind in Chrysophanol, rheum emodin, Rhein, Physcion or aloe-emodin.
Inventor is found by experiment that composition of the invention is for preventing and treating crops bacterium or fungal disease preventing and treating
Synergy is obvious, it is often more important that amount of application is reduced, and reduces use cost.Component A is different from the compound structure type of component B,
Mechanism of action is different, and both can expand fungicidal spectrum at compounding, and can to a certain extent delay the generation of pathogen resistance
The no interactions resistance and development speed, and component A and component B between.
Weight ratio in microbicide compositions of the present invention between active component A and the components of active component B two is 1:0.1~
70.To make the drug effect synergistic effect between two components more notable, the weight ratio between active component A and the components of active component B two
1 can be further optimized to：1~60.Described active component A is preferably Physcion, described Physcion and benzene
The weight ratio of bacterium ketone is 1:1~60.
In further preferred technical scheme, weight between A and the components of B two is than can arbitrarily in the model of following proportionings
10 are adjusted in enclosing:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、
1:8、1:9、1:10、1:11、1:12、1:13、1:14、1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:
23、1:24、1:25、1:26、1:27、1:28、1:29、1:30、1:31、1:32、1:33、1:34、1:35、1:36、1:37、1:
38、1:39、1:40、1:41、1:42、1:43、1:44、1:45、1:46、1:47、1:48、1:49、1:50、1:51、1:52、1:
53、1:54、1:55、1:56、1:57、1:58、1:59、1:60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:
68、1:69、1:70, it is also possible to selected in the range of two proportionings of any of the above are constituted, these ratios are appreciated that
It is weight ratio, it is also possible to including mol ratio.
Composition of the invention can be made the formulation allowed on agricultural chemicals by active component and insecticides adjuvant or auxiliary material.Enter one
Step, said composition constitutes agriculture by the active component of 2~85% weight portions and the insecticides adjuvant of 98~15% weight portions or auxiliary material
The formulation allowed on medicine.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, particularly in terms of fungi or bacterial disease that agriculture field prevents and treats some crops (such as veterinary antibiotics, cereal)
Purposes.
Above-mentioned composition can specifically include insecticides adjuvant or auxiliary material, for example carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickener, adhesive, surfactant or fertilizer etc..Can mix during administration conventional
Auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, and they are typically the material commonly used during formulation,
For example natural or regeneration mineral matter, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The application process of the present composition includes being used for composition of the invention the aerial part of plant growth, especially
It is leaf portion or blade face.Can select to soak seed or be applied to controlling object surface.The frequency and amount of application of administration depend on pathogen
Biology and weather life condition.Can be by the growth place of plant, such as rice field is soaked with the liquid preparation of composition, or
In solid form be applied in soil composition by person, and such as in granular form (soil application), composition can be by soil through planting
Thing root enters in plant (systemic action).
Composition of the invention can be prepared into acceptable various formulations on agricultural chemicals, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, aqua, aqueous emulsion, microemulsion, encapsulated form, mother liquor, female powder etc.,
In a kind of preferred scheme, formulation of the invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.Root
The purpose and ambient conditions to be reached according to the property of these compositions and using composition, can select composition to spray
Mist, atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
Composition of the invention can be prepared into various formulations with known method, by active ingredient and auxiliary agent, such as solvent,
Solid carrier, it is necessary to when can also uniformly mix together with surfactant, grind, be prepared into required formulation.
Above-mentioned solvent may be selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
The octanoic acid of esters of gallic acid, such as Dibutyl phthalate or phthalandione two, such as fat hydrocarbon, thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, such as highly polar solvent, N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide, and vegetable oil, such as soybean oil.
Above-mentioned solid carrier, is such as used for pulvis and dispersibles the typically natural mineral fillers, such as talcum, kaolinite of agent
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or having
The prefabricated material for granulating of machine property is used as carrier, particularly dolomite.
The chemical property of the active ingredient in composition of the invention, suitable surfactant is sulfomethylated lignin
Acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
The condensation product of alcohol sulfate, aliphatic acid and sulphated fatty alcohol glycol ether, also sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
Naphthalene sulfonic acids and phenol and the condensation product of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, bay acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Two kinds of active ingredients show as synergistic effect in composition of the invention, and the activity of said composition is than using individualized
The expected summation of activity of compound, and the independent activity of single compound is more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal control spectrum, instant effect, more longlasting prevention effect, by only once or minority is several times using just
Plant pest fungi can preferably be controlled and the possible administration interval time is broadened.These characteristics are plant epiphyte controls
Especially needed in practice process processed.
Microbicide compositions of the invention can be applied to agriculture field preventing and treating corps diseases aspect, farming referred herein
Thing disease particularly uncinula necator, powdery mildew of cucumber, cucumber downy mildew, balsam pear powdery mildew, graw mold of tomato, wheat white powder
Disease, rice blast.But composition of the invention is in addition to it can prevent and treat foregoing disease, moreover it is possible to the specific illness of preventing and treating include but
It is not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Rice sheath blight disease, water
Rice false smut, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, the leaf blight of corn, corn southern leaf blight), cucumber
Disease is (such as：Powdery mildew of cucumber, cucumber anthracnose, gray mold of cucumber, cucumber bacterial angular leaf spot etc.), tomato disease (such as：Tomato
Powdery mildew, anthracnose of tomato, tomato virus disease, tomato bacterial angular leaf spot etc.), grape disease (such as：Downy mildew of garpe, grape
Gray mold), apple disease (such as：Ring rot of apple, apple anthracnose etc.), citrus disease (such as：Oranges and tangerines scab simultaneously, oranges and tangerines anthrax
Disease), tobacco diseases (such as：Wildfire, Alternaria alternate), rape disease (such as：Sclerotinia rot of colza), cotton disease (such as：Cotton
Flower verticillium wilt, cotton wilt) etc..
Other features that bactericidal composition of the invention shows are mainly：1st, composition mixture of the invention has obvious
Synergistic effect；2nd, because two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, in the absence of friendship
Mutual resistance, can delay two single doses that produced resistance problem is used alone；3rd, composition of the invention is to crop safety, preventive effect
It is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, synergy significantly, shows significantly to controlling object
Synergy and complementation.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain the present invention, limit is not used to
The fixed present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
Percentage is weight percentage in all formulas of following examples.The processing work of the various preparations of the present composition
Skill is prior art, can be varied from according to different situations.
First, formulation prepares embodiment
(1) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickener and water by matching somebody with somebody
Side ratio be well mixed, through sand milling and/or high speed shear after, obtain semi-finished product, after analysis mend be mixed with water filtering i.e.
Obtain finished product.
(1) active component A (Chrysophanol) prepares suspending agent with metrafenone
Embodiment 1：40% Chrysophanol metrafenone suspending agent
Chrysophanol 20%, metrafenone 20%, xanthans 5%, methyl naphthalene sulfonate formaldehyde condensate 8%, dimethylbenzene 6%,
Ammonium sulfate 5%, water complements to 100%.
Embodiment 2：62% Chrysophanol metrafenone suspending agent
Chrysophanol 2%, metrafenone 60%, remaining component is prepared according to the method for embodiment 1.
(2) active component A (rheum emodin) prepares suspending agent with metrafenone
Embodiment 3：40% rheum emodin metrafenone suspending agent
Rheum emodin 20%, metrafenone 20%, remaining component is prepared according to the method for embodiment 1.
Embodiment 4：62% rheum emodin metrafenone suspending agent
Rheum emodin 2%, metrafenone 60%, remaining component is prepared according to the method for embodiment 1.
(3) active component A (Physcion) prepares suspending agent with metrafenone
Embodiment 5：40% Physcion metrafenone suspending agent
Physcion 20%, metrafenone 20%, remaining component is prepared according to the method for embodiment 1.
Embodiment 6：62% Physcion metrafenone suspending agent
Physcion 2%, metrafenone 60%, remaining component is prepared according to the method for embodiment 1.
(4) active component A (Rhein) prepares suspending agent with metrafenone
Embodiment 7：40% Rhein metrafenone suspending agent
Rhein 20%, metrafenone 20%, remaining component is prepared according to the method for embodiment 1.
Embodiment 8：62% Rhein metrafenone suspending agent
Rhein 2%, metrafenone 60%, remaining component is prepared according to the method for embodiment 1.
(5) active component A (aloe-emodin) prepares suspending agent with metrafenone
Embodiment 9：40% aloe-emodin metrafenone suspending agent
Aloe-emodin 20%, metrafenone 20%, remaining component is prepared according to the method for embodiment 1.
Embodiment 10：62% aloe-emodin metrafenone suspending agent
Aloe-emodin 2%, metrafenone 60%, remaining component is prepared according to the method for embodiment 1.
(2) processing of aqueous emulsion and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickener and water by matching somebody with somebody
Side ratio be well mixed, through sand milling and/or high speed shear after, obtain semi-finished product, after analysis mend be mixed with water filtering i.e.
Obtain finished product.
(1) active component A (Chrysophanol) prepares aqueous emulsion with metrafenone
Embodiment 11：22% Chrysophanol metrafenone aqueous emulsion
Chrysophanol 20%, metrafenone 2%, xanthans 5%, methyl naphthalene sulfonate formaldehyde condensate 8%, dimethylbenzene 6%, sulphur
Sour ammonium 5%, water complements to 100%.
(2) active component A (rheum emodin) prepares aqueous emulsion with metrafenone
Embodiment 12：22% rheum emodin metrafenone aqueous emulsion
Rheum emodin 20%, metrafenone 2%, remaining component is prepared according to the method for embodiment 11.
(3) active component A (Physcion) prepares aqueous emulsion with metrafenone
Embodiment 13：22% Physcion metrafenone aqueous emulsion
Physcion 20%, metrafenone 2%, remaining component is prepared according to the method for embodiment 11.
(4) active component A (Rhein) prepares aqueous emulsion with metrafenone
Embodiment 14：22% Rhein metrafenone aqueous emulsion
Rhein 20%, metrafenone 2%, remaining component is prepared according to the method for embodiment 11.
(5) active component A (aloe-emodin) prepares aqueous emulsion with metrafenone
Embodiment 15：22% aloe-emodin metrafenone aqueous emulsion
Aloe-emodin 20%, metrafenone 2%, remaining component is prepared according to the method for embodiment 11.
(3) processing of wettable powder and embodiment
Active components A and B activity composition and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Prepared wettable powder after broken.
(1) active component A (Chrysophanol) prepares wettable powder with metrafenone
Embodiment 16：27.5% Chrysophanol metrafenone wettable powder
Chrysophanol 2.5%, metrafenone 25%, xanthans 5%, lignosulfonates 6%, alkylsulfonate 6%, bentonite
8%, precipitated calcium carbonate complements to 100%.
Embodiment 17：31.5% Chrysophanol metrafenone wettable powder
Chrysophanol 1.5%, metrafenone 30%, remaining component is prepared according to the method for embodiment 16.
(2) active component A (rheum emodin) prepares wettable powder with metrafenone
Embodiment 18：27.5% rheum emodin metrafenone wettable powder
Rheum emodin 2.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 16.
Embodiment 19：31.5% rheum emodin metrafenone wettable powder
Rheum emodin 1.5%, metrafenone 30%, remaining component is prepared according to the method for embodiment 16.
(3) active component A (Physcion) prepares wettable powder with metrafenone
Embodiment 20：27.5% Physcion metrafenone wettable powder
Physcion 2.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 16.
Embodiment 21：31.5% Physcion metrafenone wettable powder
Physcion 1.5%, metrafenone 30%, remaining component is prepared according to the method for embodiment 16.
(4) active component A (Rhein) prepares wettable powder with metrafenone
Embodiment 22：27.5% Rhein metrafenone wettable powder
Rhein 2.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 16.
Embodiment 23：31.5% Rhein metrafenone wettable powder
Rhein 1.5%, metrafenone 30%, remaining component is prepared according to the method for embodiment 16.
(5) active component A (aloe-emodin) prepares wettable powder with metrafenone
Embodiment 24：27.5% aloe-emodin metrafenone wettable powder
Aloe-emodin 2.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 16.
Embodiment 25：31.5% aloe-emodin metrafenone wettable powder
Aloe-emodin 1.5%, metrafenone 30%, remaining component is prepared according to the method for embodiment 16.
(4) processing of microemulsion and embodiment
By active components A and metrafenone, it is well mixed in the ratio of formula with solvent, surfactant, stabilizer, water,
Microemulsion product is obtained afterwards.
(1) active component A (Chrysophanol) prepares microemulsion with metrafenone
Embodiment 26：41% Chrysophanol metrafenone microemulsion
Chrysophanol 1%, metrafenone 40%, dimethyl sulfoxide (DMSO) 15%, diphenyl phenol polyethenoxy polyformaldehyde condensation product 8%,
Magnesium stearate 6%, water complements to 100%.
Embodiment 27：25.5% Chrysophanol metrafenone microemulsion
Chrysophanol 0.5%, metrafenone 25%, toluene 15%, alkylbenzene naphthalene sulfonate 11%, odium stearate 7%, water is supplied
To 100%.
(2) active component A (rheum emodin) prepares microemulsion with metrafenone
Embodiment 28：41% rheum emodin metrafenone microemulsion
Rheum emodin 1%, metrafenone 40%, remaining component is prepared according to the method for embodiment 26.
Embodiment 29：25.5% rheum emodin metrafenone microemulsion
Rheum emodin 0.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 27.
(3) active component A (Physcion) prepares microemulsion with metrafenone
Embodiment 30：41% Physcion metrafenone microemulsion
Physcion 1%, metrafenone 40%, remaining component is prepared according to the method for embodiment 26.
Embodiment 31：25.5% Physcion metrafenone microemulsion
Physcion 0.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 27.
(4) active component A (Rhein) prepares microemulsion with metrafenone
Embodiment 32：41% Rhein metrafenone microemulsion
Rhein 1%, metrafenone 40%, remaining component is prepared according to the method for embodiment 26.
Embodiment 33：25.5% Rhein metrafenone microemulsion
Rhein 0.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 27.
(5) active component A (aloe-emodin) prepares microemulsion with metrafenone
Embodiment 34：41% aloe-emodin metrafenone microemulsion
Aloe-emodin 1%, metrafenone 40%, remaining component is prepared according to the method for embodiment 26.
Embodiment 35：25.5% aloe-emodin metrafenone microemulsion
Aloe-emodin 0.5%, metrafenone 25%, remaining component is prepared according to the method for embodiment 27.
(5) processing of water dispersible granules and embodiment
It is well mixed, active component activity packet A and active component B through gas in the ratio of formula with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, water dispersible granules is obtained after drying screening and produces
Product.
(1) active component A (Chrysophanol) prepares water dispersible granules with metrafenone
Embodiment 36：85.4% Chrysophanol metrafenone water dispersible granules
Chrysophanol 1.4%, metrafenone 84%, gelatin 2%, sodium acid carbonate 5%, polyacrylamide 4%, white carbon supply is extremely
100%.
Embodiment 37：35.5% Chrysophanol metrafenone water dispersible granules
Chrysophanol 0.5%, metrafenone 35%, bentonite 4%, pull open powder 2%, aluminium chloride 4%, precipitated calcium carbonate is complemented to
100%.
(2) active component A (rheum emodin) prepares water dispersible granules with metrafenone
Embodiment 38：85.4% rheum emodin metrafenone water dispersible granules
Rheum emodin 1.4%, metrafenone 84%, remaining component is prepared according to the method for embodiment 36.
Embodiment 39：35.5% rheum emodin metrafenone water dispersible granules
Rheum emodin 0.5%, metrafenone 35%, remaining component is prepared according to the method for embodiment 37.
(3) active component A (Physcion) prepares microemulsion with metrafenone
Embodiment 40：85.4% Physcion metrafenone water dispersible granules
Physcion 1.4%, metrafenone 84%, remaining component is prepared according to the method for embodiment 36.
Embodiment 41：35.5% Physcion metrafenone water dispersible granules
Physcion 0.5%, metrafenone 35%, remaining component is prepared according to the method for embodiment 37.
(4) active component A (Rhein) prepares microemulsion with metrafenone
Embodiment 42：85.4% Rhein metrafenone water dispersible granules
Rhein 1.4%, metrafenone 84%, remaining component is prepared according to the method for embodiment 36.
Embodiment 43：35.5% Rhein metrafenone water dispersible granules
Rhein 0.5%, metrafenone 35%, remaining component is prepared according to the method for embodiment 37.
(5) active component A (aloe-emodin) prepares microemulsion with metrafenone
Embodiment 44：85.4% aloe-emodin metrafenone water dispersible granules
Aloe-emodin 1.4%, metrafenone 84%, remaining component is prepared according to the method for embodiment 36.
Embodiment 45：35.5% aloe-emodin metrafenone water dispersible granules
Aloe-emodin 0.5%, metrafenone 35%, remaining component is prepared according to the method for embodiment 37.
2nd, drug effect checking test
(1) Assays Example
The incidence of whole strain blade is investigated according to experiment grade scale, disease index and prevention effect is calculated.
Prevention effect is converted into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with least square method
Concentration EC50 in calculating virulence equation and suppressing, the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixture theoretical toxicity index (TTI)] * 100
CTC≤80, composition shows as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1st, Chrysophanol and metrafenone compounding are tested uncinula necator toxicity test
The Chrysophanol of table 1. is compounded to uncinula necator toxicity test interpretation of result with metrafenone
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Chrysophanol | 1.02 | 100.00 | \ | \ |
| Metrafenone | 10.15 | 10.05 | \ | \ |
| Chrysophanol：Metrafenone=1:80 | 7.78 | 13.10 | 11.16 | 117.40 |
| Chrysophanol：Metrafenone=1:70 | 7.38 | 13.83 | 11.32 | 122.18 |
| Chrysophanol：Metrafenone=1:60 | 6.97 | 14.63 | 11.52 | 126.96 |
| Chrysophanol：Metrafenone=1:50 | 6.65 | 15.33 | 11.81 | 129.78 |
| Chrysophanol：Metrafenone=1:40 | 6.11 | 16.71 | 12.24 | 136.45 |
| Chrysophanol：Metrafenone=1:30 | 5.67 | 17.99 | 12.95 | 138.91 |
| Chrysophanol：Metrafenone=1:20 | 5.04 | 20.23 | 14.33 | 141.13 |
| Chrysophanol：Metrafenone=1:10 | 4.07 | 25.08 | 18.23 | 137.62 |
| Chrysophanol：Metrafenone=1:1 | 1.44 | 70.64 | 55.03 | 128.37 |
| Chrysophanol：Metrafenone=1:0.1 | 0.91 | 112.43 | 91.82 | 122.44 |
| Chrysophanol：Metrafenone=1:0.05 | 0.90 | 112.81 | 95.72 | 117.86 |
As a result (table 1) show, in Chrysophanol：Metrafenone=1:In 1~70 interval range, it is right that Chrysophanol is compounded with metrafenone
The prevention effect of uncinula necator is significantly improved, and illustrates that the two compounding has significant synergistic effect to uncinula necator preventing and treating.And
Outside above protection domain, both then show the effect of addition.
2nd, rheum emodin and metrafenone compounding are tested cucumber downy mildew toxicity test
The rheum emodin of table 2. is compounded to cucumber downy mildew toxicity test interpretation of result with metrafenone
As a result (table 2) show, in rheum emodin：Metrafenone=1:In 0.1~70 interval range, rheum emodin is compounded with metrafenone
Prevention effect to cucumber downy mildew is significantly improved, and illustrates that the two compounding has significant synergistic effect to cucumber downy mildew preventing and treating.
And outside above protection domain, both then show the effect of addition.
3rd, Physcion and metrafenone compounding are tested rice blast toxicity test
The Physcion of table 3. is compounded to rice blast toxicity test interpretation of result with metrafenone
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Physcion | 2.05 | 100.00 | \ | \ |
| Metrafenone | 15.03 | 13.64 | \ | \ |
| Physcion：Metrafenone=1:80 | 11.71 | 17.50 | 14.71 | 119.02 |
| Physcion：Metrafenone=1:70 | 10.92 | 18.78 | 14.86 | 126.42 |
| Physcion：Metrafenone=1:60 | 10.46 | 19.60 | 15.06 | 130.18 |
| Physcion：Metrafenone=1:50 | 9.86 | 20.80 | 15.33 | 135.62 |
| Physcion：Metrafenone=1:40 | 9.18 | 22.33 | 15.75 | 141.83 |
| Physcion：Metrafenone=1:30 | 8.50 | 24.11 | 16.43 | 146.77 |
| Physcion：Metrafenone=1:20 | 7.23 | 28.34 | 17.75 | 159.62 |
| Physcion：Metrafenone=1:10 | 6.46 | 31.72 | 21.49 | 147.59 |
| Physcion：Metrafenone=1:1 | 2.81 | 72.92 | 56.82 | 128.34 |
| Physcion：Metrafenone=1:0.1 | 1.80 | 113.77 | 92.15 | 123.46 |
| Physcion：Metrafenone=1:0.05 | 1.94 | 105.61 | 95.89 | 110.14 |
As a result (table 3) show, in Physcion：Metrafenone=1:In 0.1~70 interval range, Physcion and benzene
Bacterium ketone compounds and the prevention effect of rice blast is significantly improved, and illustrates that the two compounding has significant increasing to rice blast preventing and treating
Effect is acted on.And outside above protection domain, both then show the effect of addition.
4th, Rhein and metrafenone compounding are tested graw mold of tomato toxicity test
The Rhein of table 4. is compounded to graw mold of tomato toxicity test interpretation of result with metrafenone
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Rhein | 3.27 | 100.00 | \ | \ |
| Metrafenone | 16.49 | 19.83 | \ | \ |
| Rhein：Metrafenone=1:80 | 13.03 | 25.09 | 20.82 | 120.51 |
| Rhein：Metrafenone=1:70 | 12.44 | 26.29 | 20.96 | 125.42 |
| Rhein：Metrafenone=1:60 | 11.70 | 27.95 | 21.14 | 132.18 |
| Rhein：Metrafenone=1:50 | 11.21 | 29.18 | 21.40 | 136.32 |
| Rhein：Metrafenone=1:40 | 10.82 | 30.23 | 21.79 | 138.75 |
| Rhein：Metrafenone=1:30 | 10.04 | 32.56 | 22.42 | 145.24 |
| Rhein：Metrafenone=1:20 | 8.83 | 37.05 | 23.65 | 156.69 |
| Rhein：Metrafenone=1:10 | 8.03 | 40.73 | 27.12 | 150.21 |
| Rhein：Metrafenone=1:1 | 4.34 | 75.37 | 59.92 | 125.79 |
| Rhein：Metrafenone=1:0.1 | 2.93 | 111.69 | 92.71 | 120.47 |
| Rhein：Metrafenone=1:0.05 | 2.94 | 111.24 | 96.18 | 115.66 |
As a result (table 4) show, in Rhein：Metrafenone=1:In 0.1~70 interval range, Rhein is compounded with metrafenone
Prevention effect to graw mold of tomato is significantly improved, and illustrates that the two compounding has significant synergistic effect to graw mold of tomato preventing and treating.
And outside above protection domain, both then show the effect of addition.
5th, aloe-emodin and metrafenone compounding are tested sclerotinia rot of colza toxicity test
The aloe-emodin of table 5. is compounded to sclerotinia rot of colza toxicity test interpretation of result with metrafenone
As a result (table 5) show, in aloe-emodin：Metrafenone=1:In 0.1~70 interval range, aloe-emodin and benzene
Bacterium ketone compounds and the prevention effect of sclerotinia rot of colza is significantly improved, and illustrates that the two compounding has significant increasing to sclerotinia rot of colza preventing and treating
Effect is acted on.And outside above protection domain, both then show the effect of addition.
(2) field efficacy checking test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second dispenser is carried out after 7 days, each treatment 4
Individual cell, each square meter of cell 20.In 11 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of every investigation, investigates the lesion area in whole strain per blade and accounts for the percentage of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and more than 50% or the full leaf that lesion area accounts for leaf area are withered.
1st, Chrysophanol and metrafenone compounding field efficacy experiment
The Chrysophanol of table 6 is with metrafenone mixture to powdery mildew of cucumber prevention effect
Measurement result (table 6) shows that Chrysophanol is significantly improved with the compounding of metrafenone to powdery mildew of cucumber preventive effect, illustrates two
Person's compounding has significant synergistic effect to powdery mildew of cucumber.
2nd, rheum emodin and metrafenone compounding field efficacy experiment
The rheum emodin of table 7 is with metrafenone mixture to pear scab prevention effect
Measurement result (table 7) shows that rheum emodin is significantly improved with metrafenone mixture to the preventive effect of pear scab, illustrates the two
Compounding has significant synergistic effect to pear scab.
3rd, Physcion and metrafenone compounding field efficacy experiment
The Physcion of table 8 is with metrafenone mixture to celery septoria disease prevention effect
Measurement result (table 8) shows that Physcion is significantly improved with metrafenone mixture to the preventive effect of celery septoria disease, is said
Bright the two compounding has significant synergistic effect to celery septoria disease.
4th, Rhein and metrafenone compounding field efficacy experiment
The Rhein of table 9 is with metrafenone mixture to banana anthracnose prevention effect
Measurement result (table 8) shows that Rhein is significantly improved with metrafenone mixture to the preventive effect of banana anthracnose, illustrates two
Person's compounding has significant synergistic effect to banana anthracnose.
5th, Rhein and metrafenone compounding field efficacy experiment
The aloe-emodin of table 10 is with metrafenone mixture to Alternaria alternate prevention effect
Measurement result (table 8) shows that aloe-emodin is significantly improved with metrafenone mixture to the preventive effect of Alternaria alternate, is said
Bright the two compounding has significant synergistic effect to Alternaria alternate.
Claims (9)
1. a kind of composition pesticide, it is characterised in that described composition includes two kinds of active components of A and B, and active component A is anthracene
Quinones, active component B is metrafenone, and the weight ratio between two components is 1:0.1~70, wherein, described Anthraquinones
Compound is selected from any one in Chrysophanol, rheum emodin, Rhein, Physcion and aloe-emodin.
2. composition pesticide according to claim 1, it is characterised in that described active component A and the weight of active component B
Amount is than being 1:1~60.
3. composition pesticide according to claim 1 and 2, it is characterised in that described active component A is Physcion,
Described Physcion is 1 with the weight ratio of metrafenone:1~60.
4. the composition pesticide according to any one in claims 1 to 3, it is characterised in that said composition is by active component
The formulation allowed on agricultural chemicals is made with insecticides adjuvant or auxiliary material.
5. composition pesticide according to claim 4, it is characterised in that said composition by 2~85% weight portions activearm
Divide the formulation allowed on insecticides adjuvant or auxiliary material the composition agricultural chemicals with 98~15% weight portions.
6. composition pesticide according to claim 4, it is characterised in that described formulation is suspending agent, aqueous emulsion, wettable
Property pulvis, water dispersible granules or microemulsion.
7. the composition pesticide according to claim 4 or 5, it is characterised in that the insecticides adjuvant or auxiliary material be selected from carrier,
One or more in solvent, dispersant, wetting agent, adhesive, thickener, adhesive, surfactant or fertilizer.
8. the composition pesticide in claim 1~7 described in any one agriculture field preventing and treating corps diseases in terms of use
On the way.
9. application according to claim 8, it is characterised in that in terms of agriculture field prevents and treats veterinary antibiotics, cereal disease
Purposes.
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Cited By (1)
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| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102361551A (en) * | 2009-03-26 | 2012-02-22 | 巴斯夫欧洲公司 | Use of synthetic and biological fungicides in combination for controlling harmful fungi |
| CN106172470A (en) * | 2016-07-26 | 2016-12-07 | 王瑞明 | A kind of bactericidal composition preventing and treating Oryza sativa L. powdery mildew |
| CN106234379A (en) * | 2016-08-31 | 2016-12-21 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions |
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2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102361551A (en) * | 2009-03-26 | 2012-02-22 | 巴斯夫欧洲公司 | Use of synthetic and biological fungicides in combination for controlling harmful fungi |
| CN106172470A (en) * | 2016-07-26 | 2016-12-07 | 王瑞明 | A kind of bactericidal composition preventing and treating Oryza sativa L. powdery mildew |
| CN106234379A (en) * | 2016-08-31 | 2016-12-21 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107232213A (en) * | 2017-06-14 | 2017-10-10 | 江苏辉丰农化股份有限公司 | Microbicide compositions containing anthraquinone analog compound and polyoxin |
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