CN106234379A - A kind of microbicide compositions - Google Patents
A kind of microbicide compositions Download PDFInfo
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- CN106234379A CN106234379A CN201610793432.1A CN201610793432A CN106234379A CN 106234379 A CN106234379 A CN 106234379A CN 201610793432 A CN201610793432 A CN 201610793432A CN 106234379 A CN106234379 A CN 106234379A
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- metrafenone
- microbicide compositions
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a kind of microbicide compositions, said composition comprises two kinds of effective constituents A and B, and active component A is to have the structural compounds of formula I, and active component B is metrafenone, and the weight ratio between two components is 1:0.1～30.Present invention also offers the Preparation method and use of said composition.Result of the test shows, the above-mentioned bactericidal composition potentiation that the present invention provides is obvious, it is often more important that amount of application reduces, and use cost reduces.This bactericidal composition can effectively prevent and treat some specific antibacterial or fungal disease of crop.By the antibacterial of different mechanism of action and model of action is compounded, for expanding fungicidal spectrum and delaying the aspects such as fungus, bacterial resistance and raising prevention effect to have well effect.
Description
Technical field
The invention belongs to agriculture plant protection field, particularly relate to a kind of bactericidal composition having and improving performance, tool
Say body and relate to a kind of bactericidal composition comprising BIT class and metrafenone.
Background technology
BIT compounds is a kind of novel, wide-spectrum bactericide, is mainly used in preventing and treating and treatment Cereal
The various bacteria such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, mainly includes destroying pathogenic bacteria nucleus knot
Structure so that it is lose cardia and exhaustion is dead and the metabolism of interference pathogenic bacteria cell so that it is physiologic derangement, ultimately results in dead
Die two aspects.Using can effectively protect plant not infected by pathogen at disease early period of origination, disease takes the circumstances into consideration to increase after occurring
Dosage can substantially control spreading of pathogenic bacteria, thus reaches protection and the dual function rooted out.
Metrafenone (Metrafenone) is the benzophenone derivatives antibacterial of a kind of novelty, be suitable for frumentum, Fructus Vitis viniferae and
The diseases such as the powdery mildew of the crops such as Fructus Cucumidis sativi and eye spot disease.Its mechanism of action by interference spore germination time appresorium growth with
Formed, and by disturbing foundation and the formation of polarity actin tissue, can effectively suppress and hinder the infringement of Powdery Mildew,
There is obvious preventive and therapeutic action, and there is the inhibitor of dimethylation and anilino-pyrimidine series bactericidal agent without handing over
Resistance mutually, biological activity is better than triazolone and cyprodinil etc..
Actual pesticide experience have shown that, repeats and single-minded one reactive compound of using is to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of Duo, the most dangerous, the most generally for reducing refractory fungal bacterial strain
The mixture using different activities compound prevents and treats harmful fungoid.By the reactive compound with the different mechanism of action is entered
Row combination, delaying drug resistance can produce, reduces amount of application, reduce cost accounting.
Summary of the invention
It is an object of the invention to, for antibacterial resistance in actual applications and pedo relict problem, filter out difference and kill
The antibacterial of bacterium principle compounds, and obtains new a kind of microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide comprise two kinds of effective constituents A and the preparation method of B bactericidal composition and
The application of agriculture field preventing and treating corps diseases.
The purpose of the present invention can be reached by following measures:
A kind of microbicide compositions with potentiation, said composition comprises two kinds of active components of A and B, wherein activity
Component A is to have the structural compounds of formula I, and active component B is metrafenone.
In formula I, R is selected from H or C1～C8Alkyl.
C in the present invention1～C8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-pro-pyl, isopropyl), C4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl etc.), C6Alkyl, C7Alkyl, C8Alkyl.It includes but not limited to C1～C6Alkyl, C1～C5
Alkyl, C1～C4Alkyl etc..
In a kind of preferred version, R is selected from H or C1～C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula I, when R is H, A is BIT (being called for short BIT in description).
In formula I, when R is CH3Time, A is 2-methyl isophthalic acid, and 2-benzisothiazole-3-ketone (is called for short MBIT) in description.
In formula I, when R is C4H9Time, A is 2-butyl-BIT, and " butyl " in this formula is preferred
Normal-butyl (is called for short BBIT) in description.
Inventor is found by experiment that, the compositions of the present invention is for preventing and treating crops antibacterial or fungal disease preventing and treating
Potentiation is obvious, it is often more important that amount of application reduces, and reduces use cost.Compound structure type containing component A and component B is not
With, mechanism of action is different, and both are compounding can expand fungicidal spectrum, and can delay the product of pathogen resistance to a certain extent
No interactions resistance between life and development speed, and component A and component B.
The weight ratio between two components in microbicide compositions of the present invention is 1:0.1～30.For making the medicine between two components
Effect potentiation is the most notable, weight ratio between weight two component of component A and component B can be optimized to further 1:1～
20。
In a kind of preferably scheme, the weight ratio between A and B two component can at random be entered in the range of following proportioning
Row sum-equal matrix 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:
9、1:10、1:11、1:12、1:13、1:14、1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、
1:25,1:26,1:27,1:28,1:29,1:30, it is also possible to select in the range of two proportionings of any of the above are formed,
These ratios can be understood as weight ratio, it is also possible to includes mol ratio.
The compositions of the present invention can be made, by active component and insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.Enter one
Step, said composition by 2～80% weight portion active component with 98～20% weight portion insecticides adjuvant or adjuvant form agriculture
The dosage form allowed on medicine.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, the particularly purposes in terms of preventing and treating the fungus of some crop or antibacterial.
Above-mentioned composition specifically can comprise insecticides adjuvant or adjuvant, such as carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickening agent, binding agent, surfactant or fertilizer etc..Can mix conventional during using
Auxiliary agent.
Suitably auxiliary agent or adjuvant can be solid or liquid, the material that they are conventional during being typically formulation,
Mineral that is the most natural or that regenerate, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent.
The application process of the present composition includes the aerial parts that the compositions of the present invention is used for plant growing, especially
It is leaf portion or blade face.Seed soaking can be selected or be applied in controlling object surface.Frequency and the amount of application used depend on pathogen
Biology and weather conditions of existence.The growth place of plant, such as rice field, can be soaked with the liquid preparation of compositions, or
Compositions is applied in soil by person in solid form, and as in granular form (soil application), compositions can be by soil through planting
Thing root enters in plant (systemic action).
The compositions of the present invention can be prepared as acceptable various dosage forms on pesticide, includes but not limited to cream, suspension
Agent, wettable powder, water dispersible granules, powder, granule, water preparation, aqueous emulsion, microemulsion, poison bait, mother solution, female powder etc., in one
In preferred version, the dosage form of the present invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The character of a little compositionss and use compositions purpose to be reached and ambient conditions, can select compositions to spray,
Atomizing, dust, broadcast sowing or sprinkle the method watered or the like and use.
The compositions of the present invention can be prepared as various dosage form by available known method, can by effective ingredient with help
Agent, such as solvent, solid carrier, can uniformly mix together with surfactant when needing, grind, be prepared as required agent
Type.
Above-mentioned solvent is selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two octanoic acid, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N-methyl-2-pyrrolidine
Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, as powder and the typically natural mineral fillers, such as Talcum, kaolinite that dispersible agent
Soil, montmorillonite or active hargil.In order to manage the physical property of compositions, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers is porous type, as floating
Stone, Bentonite or bentonite；Suitably non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or have
Machine character be prefabricated into granular material as carrier, particularly dolomite.
According to the chemical property of the effective ingredient in the compositions of the present invention, suitable surfactant is sulfomethylated lignin
Acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the also condensation substance of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
LOMAR PWA EINECS 246-676-2 and phenol and the condensation substance of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, lauric acid Polyethylene Glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When preparing liquid or solid dosage form, first active component A can be dissolved in some specific alkaline matter, form benzene
And isothiazoline slaine, suitable alkaline matter includes: alkali carbonate, alkali metal hydroxide are (such as sodium hydroxide, hydrogen
Potassium oxide), alkali metal alkoxyl carbonate, alkali metal alcoholates or Bis(methoxy)magnesium.
In the compositions of the present invention, two kinds of effective ingredient show as synergistic effect, and the specific activity of said composition uses individualized
The activity expection summation of compound, and the independent activity of individualized compound is the most notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal controls spectrum, instant effect, more longlasting prevention effect, pass through only once or minority is used more several times
Good controls plant pest fungus and broadens the possible administration interval time.These characteristics are that plant epiphyte controls practice
During especially need.
The microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases aspect, as Fructus Lycopersici esculenti shot hole,
Cucurbita pepo L. blight dis-ease, cucumber downy mildew, garlic stem maize ear rot, pepper powdery mildew and Chinese cabbage white blister etc., patent the most of the present invention is also
Can prevent and treat other disease of crop, include but not limited to that wheat diseases is (such as: wheat scab, wheat powdery mildew, Semen Tritici aestivi
Rust etc.), rice disease (such as: rice sheath blight disease, rice green smut, rice blast, paddy bacterial streak etc.), corn disease
Evil (such as: smut of maize, the leaf blight of corn, corn southern leaf blight), cucumber disease are (such as: cucumber downy mildew, powdery mildew of cucumber, Huang
Melon anthrax, cucumber bacterial angular leaf spot etc.), tomato disease (such as: anthracnose of tomato, graw mold of tomato, tomato bacterial angle speckle
Sick etc.), grape disease (such as: downy mildew of garpe, grape grey mould, uncinula necator), apple disease is (such as ring rot of apple, Herba Marsileae Quadrifoliae
Really anthrax etc.), citrus disease (citrus bacterial canker disease, Citrus scab also, citrus anthracnose), tobacco diseases (wildfire)
Deng.
Other feature shown of the bactericidal composition of the present invention mainly shows themselves in that 1, the compositions mixture of present invention tool
There is obvious potentiation；2, widely different due to two single dose chemical constitutions of this compositions, the mechanism of action is entirely different, no
There is cross resistance, two single doses can be delayed to be used alone produced resistance problem；3, the compositions of the present invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, potentiation is notable, shows controlling object bright
Aobvious potentiation and complementary action.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit
Determine the present invention, all any amendment, equivalent and improvement etc. made within the spirit and principles in the present invention, should be included in
Within protection scope of the present invention.
In all formula of following example, percentage ratio is all weight percentage.The processing work of the various preparation of the present composition
Skill is prior art, can be varied from according to different situations.
One, dosage form prepares embodiment
(1) processing of water dispersible granules and embodiment
By active component activity packet A and active component B, mix homogeneously in the ratio of formula, through gas with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, prepares water dispersible granules and produce after drying screening
Product.
(1) active component A (BIT) and metrafenone prepare water dispersible granules
Embodiment 1:44%BIT metrafenone water dispersible granules (1:10)
BIT 4%, metrafenone 40%, methyl naphthalene sulfonate formaldehyde condensate 8%, xanthan gum 6%, sodium lignin sulfonate
6%, bentonite 7%, Kaolin complements to 100%.
(2) active component A (MBIT) and metrafenone prepare water dispersible granules
Embodiment 2:44%MBIT metrafenone water dispersible granules
MBIT 4%, metrafenone 40%, remaining component is prepared according to the method for embodiment 1.
(3) active component A (BBIT) and metrafenone prepare water dispersible granules
Embodiment 3:44%BBIT metrafenone water dispersible granules
BBIT 4%, metrafenone 40%, remaining component is prepared according to the method for embodiment 1.
(2) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickening agent and water by joining
The ratio mix homogeneously of side, after sand milling and/or high speed shear, obtains semi-finished product, adds water mix homogeneously and filter i.e. after analysis
Obtain finished product.
(1) active component A (BIT) and metrafenone prepare suspending agent
Embodiment 4:50%BIT metrafenone suspending agent (1:1)
BIT 25%, metrafenone 25%, aliphatic alcohol sulfate 6%, alkylaryl polyglycol ether 5%, Ketohexamethylene 5%,
Water complements to 100%.
Embodiment 5:31%BIT metrafenone suspending agent (1:30)
BIT 1%, metrafenone 30%, xanthan gum 6%, lauric acid polyglycol ether acetal 6%, ethylene glycol 6%, ammonium sulfate
5%, water complements to 100%.
(2) active component A (MBIT) and metrafenone prepare suspending agent
Embodiment 6:50%MBIT metrafenone suspending agent
MBIT 25%, metrafenone 25%, remaining component is prepared according to the method for embodiment 4.
Embodiment 7:31%MBIT metrafenone suspending agent
MBIT 1%, metrafenone 30%, remaining component is prepared according to the method for embodiment 5.
(3) active component A (BBIT) and metrafenone prepare suspending agent
Embodiment 8:50%BBIT metrafenone suspending agent
BBIT 25%, metrafenone 25%, remaining component is prepared according to the method for embodiment 4.
Embodiment 9:31%BBIT metrafenone suspending agent
BBIT 1%, metrafenone 30%, remaining component is prepared according to the method for embodiment 5.
(3) processing of wettable powder and embodiment
Active components A is sufficiently mixed, through ultrafine crusher powder with various auxiliary agents and filler etc. in proportion with B activity composition
Wettable powder is prepared after broken.
(1) active component A (BIT) and metrafenone prepare wettable powder
Embodiment 10:55%BIT metrafenone wettable powder (10:1)
BIT 50%, metrafenone 5%, benzene sulfonate 9%, lignosulfonates 5%, kieselguhr 5%, precipitated calcium carbonate is mended
Foot is to 100%.
Embodiment 11:42%BIT metrafenone wettable powder (1:20)
BIT 2%, metrafenone 40%, methyl naphthalene sulfonate formaldehyde condensate 8%, sorbitol ester 9%, calcite 5% is high
Ridge soil complements to 100%.
(2) active component A (MBIT) and metrafenone prepare wettable powder
Embodiment 12:55%MBIT metrafenone wettable powder
MBIT 50%, metrafenone 5%, remaining component is prepared according to the method for embodiment 10.
Embodiment 13:42%MBIT metrafenone wettable powder
MBIT 2%, metrafenone 40%, remaining component is prepared according to the method for embodiment 11.
(3) active component A (BBIT) and metrafenone prepare wettable powder
Embodiment 14:55%BBIT metrafenone wettable powder
BBIT 50%, metrafenone 5%, remaining component is prepared according to the method for embodiment 10.
Embodiment 15:42%BBIT metrafenone wettable powder
BBIT 2%, metrafenone 40%, remaining component is prepared according to the method for embodiment 11.
Two, drug effect checking test
(1) Assays Example
Investigate the incidence of whole strain blade according to test grade scale, calculate disease index and prevention effect.
Prevention effect is converted into probability value (y), and medicinal liquid is done height (μ g/ml) and is converted into logarithm value (x), with least square
Method calculates concentration EC50 in virulence equation and suppression, calculates toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] * 100
CTC≤80, compositions shows as antagonism, 80 ＜ CTC ＜ 120, and compositions shows as summation action, CTC >=
120, compositions shows as potentiation.
1, BIT is compounding with metrafenone tests Fructus Lycopersici esculenti shot hole toxicity test
Table 1.BIT is compounding with metrafenone to Fructus Lycopersici esculenti shot hole toxicity test interpretation of result
Result (table 1) shows, in the interval range of 1:0.1-30, BIT is compounding with metrafenone to be prevented Fructus Lycopersici esculenti shot hole
Control effect to significantly improve, illustrate that the two compounding prevents and treats Fructus Lycopersici esculenti shot hole has significant potentiation.And this protection domain it
Outward, both are then shown as summation action.
2, MBIT is compounding with metrafenone tests Cucurbita pepo L. blight dis-ease toxicity test
Table 2.MBIT is compounding with metrafenone to Cucurbita pepo L. blight dis-ease toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| MBIT | 20.17 | 100.00 | \ | \ |
| Metrafenone | 12.52 | 161.10 | \ | \ |
| MBIT: metrafenone=1:40 | 10.42 | 193.61 | 159.61 | 121.30 |
| MBIT: metrafenone=1:30 | 9.94 | 202.92 | 159.13 | 127.52 |
| MBIT: metrafenone=1:20 | 9.37 | 215.15 | 158.19 | 136.01 |
| MBIT: metrafenone=1:10 | 8.89 | 226.89 | 155.55 | 145.87 |
| MBIT: metrafenone=1:1 | 11.44 | 176.39 | 130.55 | 135.11 |
| MBIT: metrafenone=1:0.1 | 15.06 | 133.97 | 105.55 | 126.92 |
| MBIT: metrafenone=1:0.05 | 16.28 | 123.91 | 102.91 | 120.41 |
| MBIT: metrafenone=1:0.03 | 17.22 | 117.11 | 101.97 | 114.85 |
Result (table 2) shows, in the interval range of 1:0.1-30, MBIT is compounding with metrafenone to Cucurbita pepo L. blight dis-ease
Prevention effect significantly improves, and illustrates that the two compounding prevents and treats Cucurbita pepo L. blight dis-ease has significant potentiation.And at this protection model
Outside enclosing, both are then shown as summation action.
3, cucumber downy mildew toxicity test is tested by BBIT with metrafenone
Table 3.BBIT is compounding with metrafenone to cucumber downy mildew toxicity test interpretation of result
Result (table 3) shows, in the interval range of 1:0.1-30, BBIT is compounding with metrafenone to be prevented cucumber downy mildew
Control effect to significantly improve, illustrate that the two compounding prevents and treats cucumber downy mildew has significant potentiation.And this protection domain it
Outward, both are then shown as summation action.
(2) field efficacy checking test
Test method: at the initial stage of a disease, carries out immediately spraying for the first time, carries out second time dispenser, each process 4 after 7 days
Individual community, each community 20 square meter.11 days investigation statistics incidences before medicine and after second time medicine, 5, each community is random
Sampling, every some investigation 5 strain crops, investigate the lesion area of every blade in whole strain and account for percentage rate the classification of blade area, calculate
Disease index and prevention effect.
Expection preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale:
0 grade: without scab；
1 grade: leaf spot lesion is less than 5, length is less than 1cm；
3 grades: leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades: leaf spot lesion 11-25, part scab is linked to be sheet, and lesion area accounts for the 10-25% of leaf area；
7 grades: leaf spot lesion more than 26, scab is linked to be sheet, and lesion area accounts for the 26-50% of leaf area；
9 grades: scab is linked to be sheet, more than the 50% or full leaf that lesion area accounts for leaf area is withered.
1, BIT and metrafenone compound field efficacy experiment
Table 4 BIT and metrafenone mixture are to garlic stem maize ear rot prevention effect
Measurement result (table 4) shows, garlic stem maize ear rot preventive effect is significantly improved by BIT with the compounding of metrafenone, and the two is described
Compounding have significant potentiation to garlic stem maize ear rot.
2, MBIT and metrafenone compound field efficacy experiment
Table 5 MBIT and metrafenone mixture are to pepper powdery mildew prevention effect
Measurement result (table 5) shows, the preventive effect of pepper powdery mildew is significantly improved by MBIT with metrafenone mixture, and the two is described
Compounding have significant potentiation to pepper powdery mildew.
3, BBIT and metrafenone compound field efficacy experiment
Table 6 BBIT and metrafenone mixture are to Chinese cabbage white blister prevention effect
Measurement result (table 6) shows, the preventive effect of Chinese cabbage white blister is significantly improved by BBIT with metrafenone mixture, and the two is described
Compounding have significant potentiation to pear tree Chinese cabbage white blister.
Claims (10)
1. a microbicide compositions, it is characterised in that described compositions comprises two kinds of active components of A and B, wherein activity group
Dividing A is the structural compounds with formula I, and active component B is metrafenone, and the weight ratio between two components is 1:0.1～30
In formula I, R is selected from H or C1～C8Alkyl.
Microbicide compositions the most according to claim 1, it is characterised in that in formula I, R is selected from H or C1～C4Alkyl.
Microbicide compositions the most according to claim 1, it is characterised in that in formula I, R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A is respectively BIT, 2-methyl isophthalic acid, 2-benzisothiazole-3-ketone or
2-butyl-1,2-benzisothiazole-3-ketone.
Microbicide compositions the most according to claim 1, it is characterised in that active component A and the weight ratio of active component B
For 1:1～20.
5. according to the microbicide compositions described in any one in Claims 1 to 4, it is characterised in that said composition is become by activity
Divide and make, with insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.
Microbicide compositions the most according to claim 5, it is characterised in that said composition is by 2～80% activity of weight portion
Component with 98～20% weight portion insecticides adjuvant or adjuvant composition pesticide on allow dosage form.
Microbicide compositions the most according to claim 5, it is characterised in that described dosage form is wettable powder, suspending agent
Or water dispersible granules.
8. according to the microbicide compositions described in claim 5 or 6, it is characterised in that described insecticides adjuvant or adjuvant are selected from carrying
One or more in body, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent, surfactant or fertilizer.
9. in Claims 1 to 4 microbicide compositions described in any one in terms of agriculture field preventing and treating corps diseases
Purposes.
10. in Claims 1 to 4, microbicide compositions described in any one prevents and treats Fructus Lycopersici esculenti shot hole, Cucurbita pepo L. at agriculture field
Purposes in terms of reed blight dis-ease, cucumber downy mildew, garlic stem maize ear rot, pepper powdery mildew or Chinese cabbage white blister.
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| CN201610793432.1A CN106234379A (en) | 2016-08-31 | 2016-08-31 | A kind of microbicide compositions |
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Cited By (2)
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| CN106719647A (en) * | 2017-01-05 | 2017-05-31 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions comprising anthraquinone analog compound and metrafenone |
| CN106922683A (en) * | 2017-03-21 | 2017-07-07 | 江苏辉丰农化股份有限公司 | Composition pesticide containing BIT and Thidiazuron |
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