CN106538557A - Bactericidal composition comprising BIT class and azoles mepanipyrim - Google Patents
Bactericidal composition comprising BIT class and azoles mepanipyrim Download PDFInfo
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- CN106538557A CN106538557A CN201610888087.XA CN201610888087A CN106538557A CN 106538557 A CN106538557 A CN 106538557A CN 201610888087 A CN201610888087 A CN 201610888087A CN 106538557 A CN106538557 A CN 106538557A
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- microbicide compositions
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- 0 C*=C1[N+](*)[S-]c2c1cccc2 Chemical compound C*=C1[N+](*)[S-]c2c1cccc2 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Abstract
The invention provides a kind of microbicide compositions, said composition includes two kinds of effective constituents As and B, and active component A is the structural compounds with formula (I), and active component B is azoles mepanipyrim, and the weight ratio between two components is 10～1:1～40.Present invention also offers the Preparation method and use of said composition.Result of the test shows that the above-mentioned bactericidal composition synergy that the present invention is provided is obvious, it is often more important that amount of application is reduced, and use cost is reduced.The bactericidal composition can effectively prevent and treat some specific bacteriums of crop or fungal disease.By the bactericide of different mechanism of action and the mode of action is compounded, for expanding fungicidal spectrum and delay fungi, bacterial resistance and improve the aspect such as prevention effect and have to act on well.
Description
Technical field
The invention belongs to agriculture plant protection field, more particularly to a kind of bactericidal composition with improvement performance, tool
Say it is to be related to a kind of bactericidal composition comprising BIT class and azoles mepanipyrim body.
Background technology
BIT class compound is a kind of new, wide-spectrum bactericide, is mainly used in preventing and treating and treats Cereal
The various bacterias such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, it is main to include destruction germ nucleus knot
Structure so as to lose cardia and exhaustion is dead and the metabolism of interference germ cell so as to physiologic derangement, ultimately results in dead
Die two aspects.Disease early period of origination using can effective protection plant do not infected by pathogen, disease increases as one sees fit after occurring
Dosage can substantially control spreading for germ, so as to the double action for reaching protection and root out.
Azoles mepanipyrim (Ametoctradin) is a triazolo pyrimidine series bactericidal agent, belongs to mitochondrial respiratory inhibitor, right
Downy mildew and phytophthora class Oomycete fungal have control action.Azoles mepanipyrim is a kind of bactericide of high selectivity, can high efficient and flexible ground
Prevent and treat downy mildew and late blight.The product resistance of rainwater washing against, can redistribute in blade, and cover crop grows up healthy and sound, fully
Play growth potential.
Actual agricultural chemicals experience have shown that, repeats and single-minded applies a kind of reactive compound to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of many, be that reduction refractory fungal bacterial strain is selectively dangerous, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance produce, reduce amount of application, reduce cost accounting.
The content of the invention
The purpose of the present invention is, for bactericide resistance and pedo relict problem in actual applications, to filter out difference and kill
The bactericide of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide include two kinds of effective constituents As and B bactericidal compositions preventing and treating in agriculture field
The application of corps diseases.
The purpose of the present invention can be reached by following measures：
A kind of microbicide compositions with synergistic effect, said composition include two kinds of active components of A and B, wherein activity
Component A is the structural compounds with formula (I), and active component B is azoles mepanipyrim.
In formula (I), R is selected from H or C1～C8Alkyl.
C in the present invention1～C8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-propyl, isopropyl), C4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl etc.), C6Alkyl, C7Alkyl, C8Alkyl.It includes but is not limited to C1～C6Alkyl, C1～C5
Alkyl, C1～C4Alkyl etc..
In a kind of preferred version, R is selected from H or C1～C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula (I), when R is H, A is BIT (abbreviation BIT in specification).
In formula (I), when R is CH3When, A be 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones (abbreviation MBIT in specification).
In formula (I), when R is C4H9When, A is 2- butyl-BIT, and " butyl " in the formula is preferably
Normal-butyl (abbreviation BBIT in specification).
Inventor is found by experiment that the composition of the present invention is, for preventing and treating crops bacterium or fungal disease, to prevent
Control synergy obvious, it is often more important that amount of application is reduced, reduce use cost.Compound structure type containing component A Yu component B
Difference, mechanism of action are different, and both can expand fungicidal spectrum at compounding, and can delay pathogen resistance to a certain extent
Produce the no interactions resistance and development speed, and component A and component B between.
Weight ratio between two components in microbicide compositions of the present invention is 10～1:1～40.To make between two components
Drug effect synergistic effect is more notable, and the weight ratio between two component of weight of component A and component B can further be optimized to 1：1
～30.
In a kind of preferred scheme, the weight ratio between two component of A and B arbitrarily can enter in the range of following proportionings
Row adjustment 10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:
9、1:10、1:11、1:12、1:13、1:14、1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、
1:25、1:26、1:27、1:28、1:29、1:30、1:31、1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:
40, it is also possible to selected in the range of two proportionings of any of the above are constituted, these ratios can be understood as weight ratio,
Mol ratio can be included.
The composition of the present invention can be made up the formulation allowed on agricultural chemicals of active component and insecticides adjuvant or auxiliary material.Enter one
Step, said composition makes agriculture with the insecticides adjuvant of 98～20% weight portions or auxiliary material by the active component of 2～80% weight portions
The formulation allowed on medicine.
The invention provides the bactericidal composition comprising component A and component B is in terms of agriculture field preventing and treating corps diseases
Purposes, particularly prevent and treat some crops fungi or bacterial disease in terms of purposes.
Above-mentioned composition can specifically include insecticides adjuvant or auxiliary material, for example carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickener, adhesive, surfactant or fertilizer etc..Can mix during administration conventional
Auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, the material that they are commonly used during being typically formulation,
The mineral matter of such as natural or regeneration, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The application process of the present composition includes the aerial part that the composition of the present invention is used for plant growth, especially
It is leaf portion or blade face.Can select to soak seed or be applied in controlling object surface.The frequency and amount of application of administration depends on pathogen
Biology and weather life condition.Can be by the growth place of plant, such as rice field is soaked with the liquid preparation of composition, or
Person is applied to composition in soil in solid form, and such as in granular form (soil application), composition can be planted by soil Jing
Thing root is entered in plant body (systemic action).
The composition of the present invention can be prepared into acceptable various formulations on agricultural chemicals, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, aqua, aqueous emulsion, microemulsion, poison bait, mother liquor, female powder etc., in one kind
In preferred version, the formulation of the present invention adopts wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The property of a little compositions and apply composition purpose to be reached and ambient conditions, can select by composition to spray,
Atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
The composition of the present invention can be prepared into various formulations by available known method, can by active ingredient with help
Agent, such as solvent, solid carrier, can uniformly be mixed together with surfactant when needing, be ground, the agent required for being prepared into
Type.
Above-mentioned solvent may be selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, and phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two is sad, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, such as highly polar solvent, N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, is such as used for pulvis and dispersibles the typically natural mineral fillers of agent, such as talcum, kaolinite
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or having
The prefabricated material for granulating of machine property is used as carrier, particularly dolomite.
The chemical property of the active ingredient in composition of the invention, suitable surfactant are sulfomethylated lignin
Acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
The condensation product of alcohol sulfate, aliphatic acid and sulphated fatty alcohol glycol ether, also sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
Naphthalene sulfonic acids and phenol and the condensation product of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, bay acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When liquid or solid dosage forms is prepared, active component A can be dissolved in into some specific alkaline matters first, form benzene
And isothiazoline slaine, suitable alkaline matter includes：Alkali carbonate, alkali metal hydroxide are (such as NaOH, hydrogen
Potassium oxide), alkali metal alkoxyl carbonate, alkali metal alcoholates or magnesium methoxide.
In the composition of the present invention, two kinds of active ingredients show as synergistic effect, and the activity of said composition compares using individualized
The expected summation of activity of compound, and the independent activity of single compound is more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal control spectrum, instant effect, more longlasting prevention effect, by only once or minority is applied more several times
Good control plant pest fungi and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
During especially need.
In terms of the microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases, targeted concrete disease
Disease includes but is not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Paddy rice
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, corn are big
Pinta, corn southern leaf blight), cucumber disease (such as：The bacillary angle spot of cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, cucumber
Disease etc.), tomato disease (such as：Anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as：Grape
Downy mildew, grape grey mould, uncinula necator), apple disease (such as ring rot of apple, apple anthracnose etc.), citrus disease (mandarin orange
Tangerine canker, oranges and tangerines scab simultaneously, citrus anthracnose), tobacco diseases (wildfire) etc..
Other features for showing of the bactericidal composition of the present invention are mainly shown as：1st, composition mixture of the invention tool
There is obvious synergistic effect；2nd, as two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, no
There is cross resistance, can delay two single doses that produced resistance problem is used alone；3rd, composition of the invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, synergy significantly, is shown to controlling object bright
Aobvious synergy and complementation.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to limit only to explain the present invention
The fixed present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
In all formulas of following examples, percentage is weight percentage.The processing work of the various preparations of the present composition
Skill is prior art, can be varied from according to different situations.
First, formulation prepares embodiment
(1) processing of water dispersible granules and embodiment
By active component activity packet A and active component B, it is well mixed in the ratio of formula with auxiliary agent and filler, Jing gas
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, water dispersible granules is obtained and produces after drying screening
Product.
(1) active component A (BIT) prepares water dispersible granules with azoles mepanipyrim
Embodiment 1：10%BIT azoles mepanipyrims water dispersible granules (1:1)
BIT 5%, azoles mepanipyrim 5%, gelatin 3%, polyacrylamide 3%, sodium acid carbonate 5%, white carbon supply is extremely
100%
Embodiment 2：21%BIT azoles mepanipyrims water dispersible granules (1:20)
BIT 1%, azoles mepanipyrim 20%, bentonite 8%, Nekal BX 6%, aluminium chloride 5%, precipitated calcium carbonate is supplied
To 100%
(2) active component A (MBIT) prepares water dispersible granules with azoles mepanipyrim
Embodiment 3：10%MBIT azoles mepanipyrim water dispersible granules
MBIT 5%, azoles mepanipyrim 5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 4：21%MBIT azoles mepanipyrim water dispersible granules
MBIT 1%, azoles mepanipyrim 20%, remaining component are prepared according to the method for embodiment 2.
(3) active component A (BBIT) prepares water dispersible granules with azoles mepanipyrim
Embodiment 5：10%BBIT azoles mepanipyrim water dispersible granules
BBIT 5%, azoles mepanipyrim 5%, remaining component are prepared according to the method for embodiment 1.
Embodiment 6：21%BBIT azoles mepanipyrim water dispersible granules
BBIT 1%, azoles mepanipyrim 20%, remaining component are prepared according to the method for embodiment 2.
(2) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickener and water by matching somebody with somebody
The ratio of side is well mixed, and Jing after sand milling and/or high speed shear, obtains semi-finished product, mends and be mixed with water filtration i.e. after analysis
Obtain finished product.
(1) active component A (BIT) prepares suspending agent with azoles mepanipyrim
Embodiment 7：16.5%BIT azoles mepanipyrims suspending agent (10:1)
BIT 15%, azoles mepanipyrim 1.5%, methyl anyl alcohol 5%, sodium alginate 4%, polyethylene glycol 4%, silicone oil
0.02%, water complements to 100%.
Embodiment 8：31%BIT azoles mepanipyrims suspending agent (1:30)
BIT 1%, azoles mepanipyrim 30%, fatty acid polyethylene glycol ester 10%, xanthans 8%, propane diols 8%, silicone oil
0.05%, water complements to 100%.
(2) active component A (MBIT) prepares suspending agent with azoles mepanipyrim
Embodiment 9：16.5%MBIT azoles mepanipyrim suspending agents
MBIT 15%, azoles mepanipyrim 1.5%, remaining component are prepared according to the method for embodiment 7.
Embodiment 10：31%MBIT azoles mepanipyrim suspending agents
MBIT 1%, azoles mepanipyrim 30%, remaining component are prepared according to the method for embodiment 8.
(3) active component A (BBIT) prepares suspending agent with azoles mepanipyrim
Embodiment 11：16.5%BBIT azoles mepanipyrim suspending agents
BBIT 15%, azoles mepanipyrim 1.5%, remaining component are prepared according to the method for embodiment 7.
Embodiment 12：31%BBIT azoles mepanipyrim suspending agents
BBIT 1%, azoles mepanipyrim 30%, remaining component are prepared according to the method for embodiment 8.
(3) processing of wettable powder and embodiment
Active components A and B activity composition and various auxiliary agents and filler etc. are sufficiently mixed in proportion, Jing ultrafine crusher powder
Prepared wettable powder after broken.
(1) active component A (BIT) prepares wettable powder with azoles mepanipyrim
Embodiment 13:33%BIT azoles mepanipyrims wettable powder (1:10)
BIT 3%, azoles mepanipyrim 30%, spaonin powder 10%, lauryl sodium sulfate 8%, Silica hydrogel 6%, kaolin are mended
Enough to 100%.
Embodiment 14:61.5%BIT azoles mepanipyrims wettable powder (1:40)
BIT 1.5%, azoles mepanipyrim 60%, sodium alkyl benzene sulfonate 15%, sodium lignin sulfonate 8%, ammonium sulfate 6%, in vain
Carbon black complements to 100%.
(2) active component A (MBIT) prepares wettable powder with azoles mepanipyrim
Embodiment 15：33%MBIT azoles mepanipyrim wettable powders
MBIT 3%, azoles mepanipyrim 30%, remaining component are prepared according to the method for embodiment 13.
Embodiment 16：61.5%MBIT azoles mepanipyrim wettable powders
MBIT 1.5%, azoles mepanipyrim 60%, remaining component are prepared according to the method for embodiment 14.
(3) active component A (BBIT) prepares wettable powder with azoles mepanipyrim
Embodiment 17：33%BBIT azoles mepanipyrim wettable powders
BBIT 3%, azoles mepanipyrim 30%, remaining component are prepared according to the method for embodiment 13.
Embodiment 18：61.5%BBIT azoles mepanipyrim wettable powders
BBIT 1.5%, azoles mepanipyrim 60%, remaining component are prepared according to the method for embodiment 14.
2nd, drug effect checking test
(1) Assays Example
The incidence of whole strain blade is investigated according to test grade scale, disease index and prevention effect is calculated.
Prevention effect is converted into into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with least square method
Concentration EC50 in calculating virulence equation and suppressing, calculates the toxicity index and co-toxicity coefficient (CTC) of medicament according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] * 100
CTC≤80, composition show as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1st, BIT and azoles mepanipyrim compounding are tested to capsicum spot blight toxicity test
Table 1.BIT is compounded to capsicum spot blight toxicity test interpretation of result with azoles mepanipyrim
As a result (table 1) shows that BIT compounds the prevention effect to capsicum spot blight with azoles mepanipyrim and significantly improves, and illustrates two
Person's compounding has significant synergistic effect to the preventing and treating of capsicum spot blight.
2nd, MBIT and azoles mepanipyrim compounding are tested to pumpkin angular leaf spot toxicity test
Table 2.MBIT is compounded to pumpkin angular leaf spot toxicity test interpretation of result with azoles mepanipyrim
As a result (table 2) shows that MBIT compounds the prevention effect to pumpkin angular leaf spot with azoles mepanipyrim and significantly improves, and illustrates two
Person's compounding has significant synergistic effect to the preventing and treating of pumpkin angular leaf spot.
3rd, BBIT and azoles mepanipyrim are tested to garlic rust toxicity test
Table 3.BBIT is compounded to garlic rust toxicity test interpretation of result with azoles mepanipyrim
As a result (table 3) shows that BBIT compounds the prevention effect to garlic rust with azoles mepanipyrim and significantly improves, and illustrates the two
Compounding has significant synergistic effect to the preventing and treating of garlic rust.
(2) field efficacy checking test
Test method：At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each 20 square meter of cell.11 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell are random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage of blade area and be classified, calculate
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion more than 26, scab are linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
1st, BIT and the compounding field efficacy experiment of azoles mepanipyrim
4 BIT of table is with azoles mepanipyrim mixture to target prevention effect
Measurement result (table 4) shows that BIT is significantly improved to target preventive effect with the compounding of azoles mepanipyrim, explanation
The two compounding has significant synergistic effect to target.
2nd, MBIT and the compounding field efficacy experiment of azoles mepanipyrim
5 MBIT of table is with azoles mepanipyrim mixture to downy mildew of garpe prevention effect
Measurement result (table 5) shows that MBIT is significantly improved to the preventive effect of downy mildew of garpe with azoles mepanipyrim mixture, illustrates two
Person's compounding has significant synergistic effect to downy mildew of garpe.
3rd, BBIT and the compounding field efficacy experiment of azoles mepanipyrim
6 BBIT of table is with azoles mepanipyrim mixture to Chinese cabbage white blister prevention effect
Measurement result (table 6) shows that BBIT is significantly improved to the preventive effect of Chinese cabbage white blister with azoles mepanipyrim mixture, illustrates two
Person's compounding has significant synergistic effect to Chinese cabbage white blister.
Claims (9)
1. a kind of microbicide compositions, it is characterised in that described composition includes two kinds of active components of A and B, wherein activearm
A is divided to be the structural compounds with formula (I), active component B is azoles mepanipyrim, and the weight ratio between two components is 10～1:1～
40
In formula (I), R is selected from H or C1～C8Alkyl.
2. microbicide compositions according to claim 1, it is characterised in that in formula (I), R are selected from H or C1～C4Alkyl.
3. microbicide compositions according to claim 1, it is characterised in that in formula (I), R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A be respectively BIT, 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones or
2- butyl -1,2- benzisothiazole-3-ketones.
4. microbicide compositions according to claim 1, it is characterised in that the weight ratio of active component A and active component B
For 1：1～30.
5. microbicide compositions according to any one in Claims 1 to 4, it is characterised in that said composition by activity into
Divide the formulation allowed on agricultural chemicals is made with insecticides adjuvant or auxiliary material.
6. microbicide compositions according to claim 5, it is characterised in that activity of the said composition by 2～80% weight portions
The insecticides adjuvant or auxiliary material of component and 98～20% weight portions makes the formulation allowed on agricultural chemicals.
7. microbicide compositions according to claim 5 or 6, it is characterised in that described formulation is wettable powder, outstanding
Floating agent, water dispersible granules, aqueous emulsion or microemulsion.
8. microbicide compositions according to claim 5 or 6, it is characterised in that the insecticides adjuvant or auxiliary material are selected from carrying
One or more in body, solvent, dispersant, wetting agent, adhesive, thickener, adhesive, surfactant or fertilizer.
9. the microbicide compositions in claim 1～8 described in any one are in terms of agriculture field preventing and treating corps diseases
Purposes.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610888087.XA CN106538557A (en) | 2016-10-10 | 2016-10-10 | Bactericidal composition comprising BIT class and azoles mepanipyrim |
| PCT/CN2017/115089 WO2018068772A1 (en) | 2016-10-10 | 2017-12-07 | Bactericidal composition containing benzisothiazolinone and ametoctradin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610888087.XA CN106538557A (en) | 2016-10-10 | 2016-10-10 | Bactericidal composition comprising BIT class and azoles mepanipyrim |
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| CN106538557A true CN106538557A (en) | 2017-03-29 |
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| WO (1) | WO2018068772A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018068772A1 (en) * | 2016-10-10 | 2018-04-19 | 江苏辉丰生物农业股份有限公司 | Bactericidal composition containing benzisothiazolinone and ametoctradin |
| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU3004684A (en) * | 1984-06-29 | 1986-01-02 | Ivon Watkins-Dow Ltd. | Fungicidal compositions |
| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | Microbicidal composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN103314968A (en) * | 2013-06-09 | 2013-09-25 | 江苏辉丰农化股份有限公司 | Bactericidal composition with synergistic effect |
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| EP1772055A1 (en) * | 2005-10-04 | 2007-04-11 | Rohm and Haas France SAS | Synergistic microbicidal compositions comprising a N-alkyl-1,2-benzoisothiazolin-3-one |
| JP2009149610A (en) * | 2007-12-20 | 2009-07-09 | Rohm & Haas Co | Synergistic microbicidal composition |
| JP5210360B2 (en) * | 2009-07-30 | 2013-06-12 | ローム アンド ハース カンパニー | Synergistic microbicidal composition |
| CN103828821B (en) * | 2012-11-27 | 2016-01-13 | 陕西汤普森生物科技有限公司 | A kind of bactericidal composition containing azoles mepanipyrim and methoxy acrylic |
| CN103843790A (en) * | 2012-12-06 | 2014-06-11 | 陕西汤普森生物科技有限公司 | Fungicidal composition containing ametoctradin |
| JP2015044791A (en) * | 2013-07-29 | 2015-03-12 | クミアイ化学工業株式会社 | Agricultural and horticultural pest control agent and method for controlling pest |
| CN106538557A (en) * | 2016-10-10 | 2017-03-29 | 江苏辉丰农化股份有限公司 | Bactericidal composition comprising BIT class and azoles mepanipyrim |
-
2016
- 2016-10-10 CN CN201610888087.XA patent/CN106538557A/en not_active Withdrawn
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2017
- 2017-12-07 WO PCT/CN2017/115089 patent/WO2018068772A1/en active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3004684A (en) * | 1984-06-29 | 1986-01-02 | Ivon Watkins-Dow Ltd. | Fungicidal compositions |
| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | Microbicidal composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN103314968A (en) * | 2013-06-09 | 2013-09-25 | 江苏辉丰农化股份有限公司 | Bactericidal composition with synergistic effect |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018068772A1 (en) * | 2016-10-10 | 2018-04-19 | 江苏辉丰生物农业股份有限公司 | Bactericidal composition containing benzisothiazolinone and ametoctradin |
| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018068772A1 (en) | 2018-04-19 |
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