CN106234378A - A kind of microbicide compositions - Google Patents
A kind of microbicide compositions Download PDFInfo
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- CN106234378A CN106234378A CN201610619370.2A CN201610619370A CN106234378A CN 106234378 A CN106234378 A CN 106234378A CN 201610619370 A CN201610619370 A CN 201610619370A CN 106234378 A CN106234378 A CN 106234378A
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- active component
- olefin conversion
- microbicide compositions
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- 0 *N1Sc2scccc2C1=* Chemical compound *N1Sc2scccc2C1=* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention provides a kind of microbicide compositions, said composition comprises two kinds of effective constituents A and B, and active component A is to have the structural compounds of formula I, and active component B is olefin conversion, and the weight ratio between two components is 1:0.1～30.Present invention also offers the Preparation method and use of said composition.Result of the test shows, the above-mentioned bactericidal composition potentiation that the present invention provides is obvious, it is often more important that amount of application reduces, and use cost reduces.This bactericidal composition can effectively prevent and treat some specific fungal disease of crop.By being compounded by the antibacterial of difference mechanism of action and model of action, effectively reduce the amount of application of each single dose, for expanding fungicidal spectrum and delaying the aspects such as fungus, fungus resistant and raising prevention effect to have well effect.
Description
Technical field
The invention belongs to agriculture plant protection field, particularly relate to a kind of bactericidal composition having and improving performance, tool
Say body and relate to a kind of bactericidal composition comprising BIT class and olefin conversion.
Background technology
BIT compounds is a kind of novel, wide-spectrum bactericide, is mainly used in preventing and treating and treatment Cereal
The various bacteria such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, mainly includes destroying pathogenic bacteria nucleus knot
Structure so that it is lose cardia and exhaustion is dead and the metabolism of interference pathogenic bacteria cell so that it is physiologic derangement, ultimately results in dead
Die two aspects.Using can effectively protect plant not infected by pathogen at disease early period of origination, disease takes the circumstances into consideration to increase after occurring
Dosage can substantially control spreading of pathogenic bacteria, thus reaches protection and the dual function rooted out.
Olefin conversion (diniconazole) is a kind of triazole bactericidal agent antibacterial, is to have protection, treatment, eradicant action
Broad-spectrum germicide.Its mechanism of action suppresses 14 α-demethylation effect in the ergosterol biosynthesis of fungus, causes
Ergosterol lacks, and causes fungal cell membrane abnormal, and final fungus is dead, and the lasting period is permanent.To people and animals, beneficial insect, ring
Border safety.Specially good effect is had for capsule bacterium, the microbial plurality of plant diseases of load such as powdery mildew, rust, smut, scab etc..
It addition, the disease that also mould to tail spore, spherical cavity bacterium, sclerotinite, sclerotium bacteria, rhizoctonia cause has good effect.
Actual pesticide experience have shown that, repeats and single-minded one reactive compound of using is to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of Duo, the most dangerous, the most generally for reducing refractory fungal bacterial strain
The mixture using different activities compound prevents and treats harmful fungoid.By the reactive compound with the different mechanism of action is entered
Row combination, delaying drug resistance can produce, reduces amount of application, reduce cost accounting.
Summary of the invention
It is an object of the invention to, for antibacterial resistance in actual applications and pedo relict problem, filter out difference and kill
The antibacterial of bacterium principle compounds, and obtains new a kind of microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide comprise two kinds of effective constituents A and the preparation method of B bactericidal composition and
The application of agriculture field preventing and treating corps diseases.
The purpose of the present invention can be reached by following measures:
A kind of microbicide compositions with potentiation, said composition comprises two kinds of active components of A and B, wherein activity
Component A is to have the structural compounds of formula I, and active component B is olefin conversion.
In formula I, R is selected from H or C1～C8Alkyl.
C in the present invention1～C8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-pro-pyl, isopropyl), C4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl etc.), C6Alkyl, C7Alkyl, C8Alkyl.It includes but not limited to C1～C6Alkyl, C1～C5
Alkyl, C1～C4Alkyl etc..
In a kind of preferred version, R is selected from H or C1～C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula I, when R is H, A is BIT (being called for short BIT in description).
In formula I, when R is CH3Time, A is 2-methyl isophthalic acid, and 2-benzisothiazole-3-ketone (is called for short MBIT) in description.
In formula I, when R is C4H9Time, A is 2-normal-butyl-BIT, and " butyl " in this formula is
Normal-butyl (is called for short BBIT) in description.
Inventor is found by experiment that, the compositions of the present invention is for preventing and treating crops antibacterial or fungal disease preventing and treating
Potentiation is obvious, it is often more important that amount of application reduces, and reduces use cost.Compound structure type containing component A and component B is not
With, mechanism of action is different, and both are compounding can expand fungicidal spectrum, and can delay the product of pathogen resistance to a certain extent
No interactions resistance between life and development speed, and component A and component B.
The weight ratio between two components in microbicide compositions of the present invention is 1:0.1～30, preferably 1:0.2～30, for
Making the drug effect potentiation between two components the most notable, the weight ratio between weight two component of component A and component B can enter one
Step is optimized to 1:0.2～20
The compositions of the present invention can be made, by active component and insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.Enter one
Step, said composition by 5～80% weight portion active component with 95～20% the insecticides adjuvant of weight portion form on pesticide fair
The dosage form permitted.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, the particularly purposes in terms of preventing and treating the fungus of some crop or antibacterial.
Above-mentioned composition specifically can comprise insecticides adjuvant or adjuvant, such as carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickening agent, binding agent, surfactant or fertilizer etc..Can mix conventional during using
Auxiliary agent.
Suitably auxiliary agent or adjuvant can be solid or liquid, the material that they are conventional during being typically formulation,
Mineral that is the most natural or that regenerate, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent.
The application process of the present composition includes the aerial parts that the compositions of the present invention is used for plant growing, especially
It is leaf portion or blade face.Seed soaking can be selected or be applied in controlling object surface.Frequency and the amount of application used depend on pathogen
Biology and weather conditions of existence.The growth place of plant, such as rice field, can be soaked with the liquid preparation of compositions, or
Compositions is applied in soil by person in solid form, and as in granular form (soil application), compositions can be by soil through planting
Thing root enters in plant (systemic action).
The compositions of the present invention can be prepared as acceptable various dosage forms on pesticide, includes but not limited to cream, suspension
Agent, wettable powder, water dispersible granules, powder, granule, water preparation, aqueous emulsion, microemulsion, poison bait, mother solution, female powder etc., in one
In preferred version, the dosage form of the present invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The character of a little compositionss and use compositions purpose to be reached and ambient conditions, can select compositions to spray,
Atomizing, dust, broadcast sowing or sprinkle the method watered or the like and use.
The compositions of the present invention can be prepared as various dosage form by available known method, can by effective ingredient with help
Agent, such as solvent, solid carrier, can uniformly mix together with surfactant when needing, grind, be prepared as required agent
Type.
Above-mentioned solvent is selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two octanoic acid, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N-methyl-2-pyrrolidine
Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, as powder and the typically natural mineral fillers, such as Talcum, kaolinite that dispersible agent
Soil, montmorillonite or active hargil.In order to manage the physical property of compositions, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers is porous type, as floating
Stone, Bentonite or bentonite；Suitably non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or have
Machine character be prefabricated into granular material as carrier, particularly dolomite.
According to the chemical property of the effective ingredient in the compositions of the present invention, suitable surfactant is sulfomethylated lignin
Acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the also condensation substance of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
LOMAR PWA EINECS 246-676-2 and phenol and the condensation substance of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, lauric acid Polyethylene Glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When preparing liquid dosage form, first active component A can be dissolved in alkaline matter, form benzisothiazole metal
Salt, suitable alkaline matter includes: alkali carbonate, alkali metal hydroxide (such as sodium hydroxide, potassium hydroxide), alkali metal
Alkoxyl carbonate, alkali metal alcoholates or Bis(methoxy)magnesium.
In the compositions of the present invention, two kinds of effective ingredient show as synergistic effect, and the specific activity of said composition uses individualized
The activity expection summation of compound, and the independent activity of individualized compound is the most notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal controls spectrum, instant effect, more longlasting prevention effect, pass through only once or minority is used more several times
Good controls plant pest fungus and broadens the possible administration interval time.These characteristics are that plant epiphyte controls practice
During especially need.
The microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases aspect, and targeted is concrete sick
Disease includes but not limited to peach tree Bacterial septicaemia syndrome, wildfire, rice sheath blight disease, cucumber bacterial angular leaf spot, Cucumis satiuus L.
Mildew, bacterial leaf streak of rice, Characters of Erwinia chrysanthemi pv. zeae, Stewart's wilt, watermelon blight, Fructus Vitis viniferae downy mildew
Disease, bacterial wilt of tomato, Fructus Solani melongenae bacterial wilt, rice green smut, bacterial leaf streak of rice, pepper anthracnose, Fructus Litchi Peptic Ulcers, Portugal
Grape anthrax, tobacco bacterial wilt, cucumber anthracnose, celery septoria disease, Rhizoma Nelumbinis damping-off, powdery mildew of strawberry, downy mildew of lettuce, celery
Dish gray mold, Fructus Pruni Bacterial septicaemia syndrome, Peach canker disease, downy mildew, Cotton Gossypii bacterial angular leaf spot, the bacillary leaf of Fructus Cucumidis sativi are withered
Sick etc..
Other feature shown of the bactericidal composition of the present invention mainly shows themselves in that 1, the compositions mixture of present invention tool
There is obvious potentiation；2, widely different due to two single dose chemical constitutions of this compositions, the mechanism of action is entirely different, no
There is cross resistance, two single doses can be delayed to be used alone produced resistance problem；3, the compositions of the present invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, potentiation is notable, shows controlling object bright
Aobvious potentiation and complementary action.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit
Determine the present invention, all any amendment, equivalent and improvement etc. made within the spirit and principles in the present invention, should be included in
Within protection scope of the present invention.
In all formula of following example, percentage ratio is all weight percentage.The processing work of the various preparation of the present composition
Skill is prior art, can be varied from according to different situations.
One, dosage form prepares embodiment
(1) processing of wettable powder and embodiment
Active components A is sufficiently mixed, through ultrafine crusher powder with various auxiliary agents and filler etc. in proportion with active component B
Wettable powder is prepared after broken.
1, active component A (BIT) and active component B prepare wettable powder
Embodiment 1:11%BIT olefin conversion wettable powder
BIT 10%, olefin conversion 1%, Bentonite 5%, aliphatic alcohol sulfate 4%, dolomite 3%, Kaolin complements to
100%.
Embodiment 2:6%BIT olefin conversion wettable powder
BIT 1%, olefin conversion 5%, benzenesulfonic acid potassium 3%, alkylaryl sulfonates 5%, white carbon 4%, Talcum complements to
100%.
Embodiment 3:10.5%BIT olefin conversion wettable powder
BIT 0.5%, olefin conversion 10%, white carbon 5%, Bentonite 3%, alkylsulfonate 5%, bentonite complements to
100%.
2, active component A (MBIT) and active component B prepare suspending agent
Embodiment 4:11%MBIT olefin conversion wettable powder
MBIT 10%, olefin conversion 1%, remaining component is prepared according to the method for embodiment 1.
Embodiment 5:6%MBIT olefin conversion wettable powder
MBIT 1%, olefin conversion 5%, remaining component is prepared according to the method for embodiment 2.
Embodiment 6:10.5%MBIT olefin conversion wettable powder
MBIT 0.5%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 3.
3, active component A (BBIT) and active component B prepare wettable powder
Embodiment 7:11%BBIT olefin conversion wettable powder
BBIT 10%, olefin conversion 1%, remaining component is prepared according to the method for embodiment 1.
Embodiment 8:6%BBIT olefin conversion wettable powder
BBIT 1%, olefin conversion 5%, remaining component is prepared according to the method for embodiment 2.
Embodiment 9:10.5%BBIT olefin conversion wettable powder
BBIT 0.5%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 3.
(2) processing of water dispersible granules and embodiment
By active component active component A and active component B, mix homogeneously in the ratio of formula, through gas with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, prepares water dispersible granules and produce after drying screening
Product.
1, active component A (BIT) and active component B prepare water dispersible granules
Embodiment 10:20%BIT diniconazole water dispersible granule
BIT 10%, olefin conversion 10%, sodium lignin sulfonate 5%, ammonium alkyl sulfate 4%, Bentonite complements to 100%.
Embodiment 11:11%BIT diniconazole water dispersible granule
BIT 1%, olefin conversion 10%, ethoxylated isooctyl-phenol 3%, dodecyl naphthalene sulfonic acid potassium 5%, alkylsulfonate
4%, lightweight potassium carbonate complements to 100%.
Embodiment 12:31%BIT diniconazole water dispersible granule
BIT 1%, olefin conversion 30%, lignin sulfonic acid potassium 4%, ammonium sulfate 5%, alkyl naphthalene sulfonic acid potassium 5%, Kaolin is mended
Foot is to 100%.
2, active component A (MBIT) and active component B prepare water dispersible granules
Embodiment 13:20%MBIT diniconazole water dispersible granule
MBIT 10%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 10.
Embodiment 14:11%MBIT diniconazole water dispersible granule
MBIT 1%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 11.
Embodiment 15:31%MBIT diniconazole water dispersible granule
MBIT 1%, olefin conversion 30%, remaining component is prepared according to the method for embodiment 12.
3, active component A (BBIT) and active component B prepare water dispersible granules
Embodiment 16:20%BBIT diniconazole water dispersible granule
BBIT 10%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 10.
Embodiment 17:11%BBIT diniconazole water dispersible granule
BBIT 1%, olefin conversion 10%, remaining component is prepared according to the method for embodiment 11.
Embodiment 18:31%BBIT diniconazole water dispersible granule
BBIT 1%, olefin conversion 30%, remaining component is prepared according to the method for embodiment 12.
(3) processing of suspending agent and embodiment
By active component active component A and active component B, with each component such as dispersant, wetting agent, thickening agent and water by joining
The ratio mix homogeneously of side, after sand milling and/or high speed shear, obtains semi-finished product, adds water mix homogeneously and filter i.e. after analysis
Obtain finished product.
1, active component A (BIT) and active component B prepare suspending agent
Embodiment 19:12%BIT diniconazole suspending agent
BIT 10%, olefin conversion 2%, Kaolin 5%, Ketohexamethylene 5%, alkylaryl polyglycol ether 5%, water complements to
100%.
Embodiment 20:32%BIT diniconazole suspending agent
BIT 2%, olefin conversion 30%, kieselguhr 4%, ethanol 4%, alkyl sodium sulfate, ethoxylated castor oil 4%, water
Complement to 100%.
Embodiment 21:6.5%BIT diniconazole suspending agent
BIT 0.25%, olefin conversion 6.25%, bentonite 5%, ethylene glycol 4%, benzenesulfonic acid potassium 5%, the poly-second of lauric acid two
Alcohol ether acetal 3%, water complements to 100%.
2, active component A (MBIT) and active component B prepare suspending agent
Embodiment 22:12%MBIT diniconazole suspending agent
MBIT 10%, olefin conversion 2%, remaining component is prepared according to the method for embodiment 19.
Embodiment 23:32%MBIT diniconazole suspending agent
MBIT 2%, olefin conversion 30%, remaining component is prepared according to the method for embodiment 20.
Embodiment 24:6.5%MBIT diniconazole suspending agent
MBIT 0.25%, olefin conversion 6.25%, remaining component is prepared according to the method for embodiment 21.
3, active component A (BBIT) and active component B prepare suspending agent
Embodiment 25:12%BBIT diniconazole suspending agent
BBIT 10%, olefin conversion 2%, remaining component is prepared according to the method for embodiment 19.
Embodiment 26:32%BBIT diniconazole suspending agent
BBIT 2%, olefin conversion 30%, remaining component is prepared according to the method for embodiment 20.
Embodiment 27:6.5%BBIT diniconazole suspending agent
BBIT 0.25%, olefin conversion 6.25%, remaining component is prepared according to the method for embodiment 21.
Two, drug effect checking test
(1) Assays Example
Investigate the incidence of whole strain blade according to test grade scale, calculate disease index and prevention effect.
Prevention effect is converted into probability value (y), and medicinal liquid is done height (μ g/ml) and is converted into logarithm value (x), with least square
Method calculates concentration EC50 in virulence equation and suppression, calculates toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] * 100
CTC≤80, compositions shows as antagonism, 80 ＜ CTC ＜ 120, and compositions shows as summation action, CTC >=
120, compositions shows as potentiation.
1, BIT is compounding with olefin conversion tests toxicity test
Table 1.BIT is compounding with olefin conversion to cucumber downy mildew toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Olefin conversion | 50.34 | 100.00 | \ | \ |
| BIT | 30.23 | 166.52 | \ | \ |
| BIT: olefin conversion=1:0.1 | 25.85 | 194.73 | 160.48 | 121.34 |
| BIT: olefin conversion=1:0.2 | 26.14 | 192.57 | 155.44 | 123.89 |
| BIT: olefin conversion=1:1 | 28.41 | 177.21 | 133.26 | 132.98 |
| BIT: olefin conversion=1:5 | 33.21 | 151.58 | 111.09 | 136.45 |
| BIT: olefin conversion=1:10 | 33.73 | 149.26 | 106.05 | 140.75 |
| BIT: olefin conversion=1:15 | 35.74 | 140.83 | 104.16 | 135.21 |
| BIT: olefin conversion=1:20 | 36.98 | 136.12 | 103.17 | 131.94 |
| BIT: olefin conversion=1:25 | 39.20 | 128.43 | 102.56 | 125.23 |
| BIT: olefin conversion=1:30 | 40.20 | 125.21 | 102.15 | 122.58 |
Result (table 1) shows, BIT prevention effect to cucumber downy mildew compounding with olefin conversion significantly improves, and the two is described
Compounding have significant potentiation to cucumber downy mildew preventing and treating.Experiment finds, the compound proportion of BIT and olefin conversion is not in the present invention
In the range of time be difficult to that there is synergistic function.
2, MBIT is compounding with olefin conversion tests toxicity test
Table 2.MBIT is compounding with olefin conversion to mandarin tree shot hole toxicity test interpretation of result
Result (table 2) shows, MBIT prevention effect to mandarin tree shot hole compounding with olefin conversion significantly improves, and illustrates two
Person is compounding has significant potentiation to the preventing and treating of mandarin tree shot hole.Experiment finds, MBIT does not exists with the compound proportion of olefin conversion
It is difficult to time in the scope of the present invention that there is synergistic function.
3, BBIT is compounding with olefin conversion tests toxicity test
Table 3.BBIT is compounding with olefin conversion to wheat rust toxicity test interpretation of result
| Medicament title | EC50(μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Olefin conversion | 39.82 | 100.00 | \ | \ |
| BBIT | 25.98 | 153.27 | \ | \ |
| BBIT: olefin conversion=1:0.1 | 21.05 | 189.17 | 148.43 | 127.45 |
| BBIT: olefin conversion=1:0.2 | 21.36 | 186.38 | 144.39 | 129.08 |
| BBIT: olefin conversion=1:1 | 23.16 | 171.95 | 126.64 | 135.78 |
| BBIT: olefin conversion=1:5 | 26.21 | 151.94 | 108.88 | 139.55 |
| BBIT: olefin conversion=1:10 | 26.56 | 149.90 | 104.84 | 142.98 |
| BBIT: olefin conversion=1:15 | 27.52 | 144.68 | 103.33 | 140.02 |
| BBIT: olefin conversion=1:20 | 28.27 | 140.84 | 102.54 | 137.36 |
| BBIT: olefin conversion=1:25 | 29.15 | 136.62 | 102.05 | 133.88 |
| BBIT: olefin conversion=1:30 | 30.09 | 132.35 | 101.72 | 130.11 |
Result (table 3) shows, BBIT prevention effect to wheat rust compounding with olefin conversion significantly improves, and illustrates that the two is multiple
Pairing wheat rust preventing and treating has significant potentiation.Experiment finds, the compound proportion of BBIT and olefin conversion is not the present invention's
In the range of time be difficult to that there is synergistic function.
(2) field efficacy checking test
Test method: at the initial stage of a disease, carries out immediately spraying for the first time, carries out second time dispenser, each process 4 after 7 days
Individual community, each community 20 square meter.11 days investigation statistics incidences before medicine and after second time medicine, 5, each community is random
Sampling, every some investigation 5 strain crops, investigate the lesion area of every blade in whole strain and account for percentage rate the classification of blade area, calculate
Disease index and prevention effect.
Expection preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale:
0 grade: without scab；
1 grade: leaf spot lesion is less than 5, length is less than 1cm；
3 grades: leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades: leaf spot lesion 11-25, part scab is linked to be sheet, and lesion area accounts for the 10-25% of leaf area；
7 grades: leaf spot lesion more than 26, scab is linked to be sheet, and lesion area accounts for the 26-50% of leaf area；
9 grades: scab is linked to be sheet, more than the 50% or full leaf that lesion area accounts for leaf area is withered.
1, BIT and olefin conversion compound field efficacy experiment
Table 4 BIT and olefin conversion mixture are to pear scab prevention effect
Measurement result (table 4) shows, the preventive effect of pear scab is significantly improved by BIT with olefin conversion mixture, and the two is described
Compounding have significant potentiation to pear scab.
2, MBIT and olefin conversion compound field efficacy experiment
Table 5 MBIT and olefin conversion mixture are to sigatoka prevention effect
Measurement result (table 5) shows, the preventive effect of sigatoka is significantly improved by MBIT with olefin conversion mixture, and the two is described
Compounding have significant potentiation to sigatoka.
3, BBIT and olefin conversion compound field efficacy experiment
Table 6 BBIT and olefin conversion mixture are to rice sheath blight disease controlling effect
Measurement result (table 6) shows, the preventive effect of rice sheath blight disease is significantly improved by BBIT with olefin conversion mixture, and the two is described
Compounding have significant potentiation to rice sheath blight disease.
Claims (10)
1. a microbicide compositions, it is characterised in that described compositions comprises two kinds of active components of A and B, wherein activity group
Dividing A is the structural compounds with formula I, and active component B is olefin conversion, and the weight ratio between two components is 1:0.1～30,
In formula I, R is selected from H or C1～C8Alkyl.
Microbicide compositions the most according to claim 1, it is characterised in that in formula I, R is selected from H or C1～C4Alkyl.
Microbicide compositions the most according to claim 2, it is characterised in that in formula I, R is selected from H ,-CH3Or-C4H9, right
The active component A answered is respectively 1,2-benzisothiazole-3-ketone, 2-methyl isophthalic acid, 2-benzisothiazole-3-ketone or the positive fourth of 2-
Base-1,2-benzisothiazole-3-ketone.
Microbicide compositions the most according to claim 1, it is characterised in that active component A and the weight ratio of active component B
For 1:0.2～30.
Microbicide compositions the most according to claim 4, it is characterised in that active component A and the weight ratio of active component B
For 1:0.2～20.
6. according to the microbicide compositions described in any one in Claims 1 to 5, it is characterised in that said composition is become by activity
Divide and make, with insecticides adjuvant or adjuvant, the dosage form allowed on pesticide.
Microbicide compositions the most according to claim 6, it is characterised in that said composition is by 5～80% activity of weight portion
Component with 95～20% weight portion insecticides adjuvant composition pesticide on allow dosage form.
Microbicide compositions the most according to claim 6, it is characterised in that described dosage form is wettable powder, water-dispersible
Granule or suspending agent.
Microbicide compositions the most according to claim 6, it is characterised in that described insecticides adjuvant or adjuvant are selected from carrier, molten
One or more in agent, dispersant, wetting agent, adhesive, thickening agent, binding agent, surfactant or fertilizer.
10. in Claims 1 to 5 microbicide compositions described in any one in terms of agriculture field preventing and treating corps diseases
Purposes.
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| CN201610619370.2A CN106234378A (en) | 2016-08-01 | 2016-08-01 | A kind of microbicide compositions |
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| CN201610619370.2A CN106234378A (en) | 2016-08-01 | 2016-08-01 | A kind of microbicide compositions |
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| CN106234378A true CN106234378A (en) | 2016-12-21 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338165A (en) * | 2017-03-31 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions including emodin derivates and polysaccharide |
| CN108338166A (en) * | 2017-03-31 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions including emodin derivates and amides |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | Microbicidal composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
-
2016
- 2016-08-01 CN CN201610619370.2A patent/CN106234378A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | Microbicidal composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108338165A (en) * | 2017-03-31 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions including emodin derivates and polysaccharide |
| CN108338166A (en) * | 2017-03-31 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions including emodin derivates and amides |
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Application publication date: 20161221 |