CN105010357A - Sterilization composition and application thereof - Google Patents
Sterilization composition and application thereof Download PDFInfo
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- CN105010357A CN105010357A CN201410165490.0A CN201410165490A CN105010357A CN 105010357 A CN105010357 A CN 105010357A CN 201410165490 A CN201410165490 A CN 201410165490A CN 105010357 A CN105010357 A CN 105010357A
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Abstract
The invention provides a sterilization composition and application thereof. The sterilization composition contains active ingredients namely methyl amine (A) and a triazole compound (B), wherein the weight ratio of the methyl amine (A) to the triazole compound (B) is (50:1)-(1:50); the triazole compound (B) can be selected from triazole hydroxyl derivatives, triazole dioxolane derivatives or triazolethione compounds, such as tebuconazole, hexaconazole, difenoconazole, propiconazole and prothioconazole; the methyl amine (A) and the triazole compound (B) are compounded so as to exert obvious synergism, and the application amount of each single dosage can be effectively reduced. According to the invention, other auxiliary ingredients which are used allowably in pesticides can be added in the sterilization composition, and thus any dosage form can be processed; the sterilization composition is mainly used for preventing and controlling fungus diseases such as pepper anthracnose, tomato early blight, rice blast, wheat powdery mildew and sigatoka.
Description
Technical field
The present invention relates to a kind of bactericidal composition, refer to a kind of the composite bactericide composition and the application thereof that lure amine and triazole class compounds containing first thiophene especially.
Background technology
Agricultural chemicals has played great function with effectively quick and lower-price characteristic in agricultural produce guarantor receives, but Scientific Usage of Drugs and single drug have not caused the continuous increase of the drug-fast continuous enhancing of germ and pvs oryzae and oryzicola, simultaneously, use agricultural chemicals to too increase financial burden frequently, and result in environmental pollution and a series of serious ecological problem of agricultural product security and social concern.Along with improving constantly of people's living standard, the concern to environmental protection, the safety to agricultural product and quality are proposed higher requirement.Therefore, how Scientific Usage of Drugs, reduces the consumption of chemical pesticide, improves drug effect, becomes the problem that plant protection art is badly in need of solving.
First thiophene lures amine to be a kind of thiadiazole plant disease-proof activator, and chemistry general N-by name (5-methyl isophthalic acid, 3-thiazol-2-yl)-4-methyl isophthalic acid, 2,3-thiadiazoles-5-formamide, its structural formula is as shown in (I).Current result of study display, this compounds on viral disease has good inducing anti-disease effect, and mechanism of action is the anti-disease activity that inducing plant produces system, wide spectrum.Plant disease-proof activator is the novel agricultural chemicals of a class received much concern in recent years, itself there is no obvious bactericidal activity, but can as the immunoactivator of plant, inducer of systemic acquired resistance, thus the object reaching defending and fighting against diseases.Wherein, the Representative Cultivars that BTH (diazosulfide, Syngenta Co., Ltd of Switzerland produces) and TDL (tiadinil, Nihon Nihyaku Co., Ltd produces) is such medicament, is applied widely at present in agricultural production.But because first thiophene lures amine single dose unstable at variable rate technology, preventive effect has certain fluctuation, and to the plant fallen ill without good therapeutic action.
Triazole class compounds is that a class is efficient, wide spectrum, have the bactericide of good Uptake and translocation, has protection, treats and eradicant action.Its mechanism of action suppresses the biosynthesis of germ ergosterol that somatic cells function is damaged, thus suppress or the growth of interference thalline appresorium and haustorium, mycelia become with the row of spore.This compounds comprises Tebuconazole, own azoles alcohol, Difenoconazole, propiconazole, prothioconazoles etc., all effective to sac fungi, basidiomycetes, imperfect fungus, has good control efficiency to the disease of various crop.But this series bactericidal agent is used alone for a long time, preventive effect declines, and faces the risk developed immunity to drugs, and meanwhile, this series bactericidal agent all has certain inhibitory action when exceeding and using metering to the growth of crop.
Its structural formula of Tebuconazole is as shown in (II).Be sterol demethylation inhibitor, be the efficient germicide of seed treatment for Important Economic crop or foliage spray, effectively can prevent and treat multiple rust, powdery mildew, net blotch, root rot, the head blight of cereal crop, smut and plant and pass zonate spot etc.Because single dose chronicity uses, most of crop produces serious pesticide resistance to this medicine, causes consumption to increase, and drug effect reduces.
Own its structural formula of azoles alcohol is as shown in (III).Sterol demethylation inhibitors, the disease caused fungi especially Basidiomycota and Ascomycota has protection and the therapeutic action of broad spectrum activity.The biosynthesis of the cell membrane important composition composition ergosterol of destruction and prevention germ, causes cell membrane not formed, and makes germ dead.There is interior suction, protection and therapeutic activity.
Its structural formula of prothioconazoles is as shown in (IV).Be a kind of New-type wide-spectrum triazolinthione series bactericidal agent of Beyer Co., Ltd's development, be mainly used in preventing and treating numerous disease such as cereal, wheat class legume crop, prothioconazoles toxicity is low, and without teratogenesis, mutagenesis type, to embryo's avirulence, to human and environment safety.Its mechanism of action is the precursor of sterol in Antifungi---the demethylation effect on lanosterol or 2,4-methylene dihydro wool steroid 14.
Summary of the invention
For above-mentioned situation, the invention provides a kind of bactericidal composition and application thereof, to meet the needs of agricultural production, the active component comprised in composition has mutually synergistic effect to improve preventive effect and is of value to and delays the drug-fast generation of germ.
Bactericidal composition of the present invention, its active ingredient is that first thiophene lures amine and triazole class compounds, and first thiophene lures the weight ratio of amine and triazole class compounds to be 1:50-50:1, and good ratio is 25:1-1:25, and all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
Its chemical constitution common feature of triazole class compounds is that main chain contains active group 1,2,4-triazole, is ergosterol synthetic inhibitor, has the features such as high-efficiency broad spectrum.
Triazole class compounds of the present invention is triazole type hydroxy derivatives, triazole type dioxolanyl derivatives or triazolinthione analog derivative more preferably.
The chemical constitution common feature of triazole type hydroxy derivatives is that wherein Tebuconazole, own azoles alcohol are its most typical representatives containing hydroxyl, substituted-phenyl and 1,2,4-triazole group on main chain, has become product ripe on market.
The chemical constitution common feature of triazole type dioxolanyl derivatives is that wherein propiconazole, Difenoconazole are most typical representative containing dioxolanyl, substituted-phenyl and 1,2,4-triazole group on main chain.
The chemical constitution common feature of triazolinthione analog derivative is containing 3-sulfo--1 on main chain, 2,4-triazole group, prothioconazoles is current business-like product, and prothioconazoles is a kind of New-type wide-spectrum triazolinthione series bactericidal agent, be mainly used in preventing and treating numerous disease such as cereal, wheat class legume crop, prothioconazoles toxicity is low, without teratogenesis, and mutagenesis type, to embryo's avirulence, to human and environment safety.
Triazole type hydroxy derivatives of the present invention is preferably Tebuconazole or own azoles alcohol; Described triazole type dioxolanyl derivatives is preferably Difenoconazole or propiconazole; Described triazolinthione analog derivative is preferably prothioconazoles.
The auxiliary agent used in composition of the present invention comprises wetting agent, dispersant, emulsifier, solvent and filler etc. and other are of value to the known substance that active ingredient is stablized in the formulation and drug effect plays, all various compositions that are conventional in pesticidal preparations or permission use, there is no specific restriction, possess composition and consumption is determined by simple experiment according to recipe requirements.
Bactericidal composition of the present invention can be prepared into any one formulation of applicable agricultural use by known method, reasonable formulation is wetting powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.
Product described in the invention can finished product preparation form provide, and namely in compound, each material mixes, and the composition of composition also can provide with unit dose form, directly directly mixes in bucket or tank, be then diluted to required concentration before using.
Bactericidal composition of the present invention can be used for the multiple diseases of preventing and treating on the crops such as paddy rice, wheat, vegetables, fruit tree and is especially suitable for the plant diseases such as control pepper anthracnose, wheat powdery mildew, rice blast, early blight of tomato.Composition of the present invention can be used by common method, and as cast, injection, spraying, dusting or spread, its amount of application is with weather condition or crop condition change.
Compared with prior art, beneficial effect of the present invention is: 1, compared with single dose, and composite have obvious synergistic function, improves control efficiency; 2, composition is made up of the active ingredient that two kinds of mechanism of action are different, is conducive to overcoming and delay the drug-fast generation of germ; 3, medicament mixture decreases dosage, thus reduces cost and alleviate the pollution to environment; 4, be used alone compared with triazole bactericidal agent, the risk producing poisoning reduces.
Embodiment
For embodiments of the invention will be solved technical problem, technical scheme and advantage clearly, will be described in detail with specific embodiment below, but the present invention is limited to absolutely not these examples.The following stated is only the good embodiment of the present invention, only in order to explain the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is current development novel pesticide and the one of preventing and treating agriculturally resistance germ effectively and efficiently mode.After the pestsides synthesis of different cultivars, usually show a large amount of three kinds of type of action: summation action, synergistic effect and antagonism.Compound synergic is well filled a prescription, and can significantly improve actual control efficiency, and reducing the usage amount of agricultural chemicals, thus contribute to delaying the drug-fast generation speed of germ, is the important means of integrated control disease.
Application Example:
First thiophene lure amine and Tebuconazole composite to rice blast indoor harmacological effect determination test:
For examination pathogen: rice blast fungus.
Test method: adopt live body method, each process repeats 5 times, measures Lesion size after 6d, calculates EC50 and co-toxicity coefficient, and result of the test sees the following form 1.
Table 1 first thiophene lures amine and the composite indoor harmacological effect to rice blast of Tebuconazole to measure
| Reagent agent | EC 50 | Regression equation | CTC |
| First thiophene lures amine (A) | 49.5106 | Y＝2.8392+1.27550x | — |
| Tebuconazole (B) | 32.1991 | Y＝2.7512+1.4914x | — |
| (A:B)50:1 | 33.1616 | Y＝2.7092+1.5425x | 136.86 |
| 25:1 | 26.1875 | Y＝2.7481+1.5880x | 172.72 |
| 5:1 | 23.7905 | Y＝2.7810+1.6122x | 190.99 |
| 1:1 | 19.8000 | Y＝2.8108+1.6883x | 197.08 |
| 1:5 | 22.4791 | Y＝2.8238+1.6099x | 152.106 |
| 1:25 | 22.6204 | Y＝2.8337+1.5993x | 144.29 |
| 1:50 | 25.9221 | Y＝2.7811+1.5696x | 125.07 |
Note: co-toxicity coefficient (CTC) >=120 indicates synergistic effect; 80 < CTC < 120 represent summation action; CTC≤80 indicate antagonism.
Toxicity Determination result shows, and first thiophene lures amine and Tebuconazole is composite has excellent control efficiency to rice blast, and control efficiency is better than single dose kind.
Inventor finds through test, first thiophene lure amine and other triazole type hydroxy derivatives (as own azoles alcohol) composite, first thiophene lure amine and triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole) composite, first thiophene lure amine and triazolinthione analog derivative (as prothioconazoles) composite, have similar control efficiency to rice blast.
First thiophene lures amine and own azoles alcohol is composite tests pepper anthracnose indoor pot:
Table 2 first thiophene lures amine and the composite indoor pot test of pesticide effectiveness to pepper anthracnose of own azoles alcohol
| Reagent agent | EC 50 | Regression equation | CTC |
| First thiophene lures amine (A) | 46.3843 | Y＝2.8527+1.2886x | — |
| Own azoles alcohol (C) | 37.8163 | Y＝2.9311+1.3114x | — |
| (A:C)50:1 | 27.4546 | Y＝2.7877+1.4685x | 143.88 |
| 25:1 | 24.5952 | Y＝2.8064+1.5772x | 186.96 |
| 5:1 | 22.5352 | Y＝2.8722+1.5728x | 198.34 |
| 1:1 | 20.3046 | Y＝2.9158+1.5939x | 205.19 |
| 1:5 | 21.2351 | Y＝2.8919+1.5885x | 183.74 |
| 1:25 | 22.5654 | Y＝2.8050+1.6218x | 168.79 |
| 1:50 | 26.3244 | Y＝2.8059+1.5448x | 144.18 |
Note: co-toxicity coefficient (CTC) >=120 indicates synergistic effect; 80 < CTC < 120 represent summation action; CTC≤80 indicate antagonism.
Indoor harmacological effect measurement result shows, and first thiophene lures amine and own azoles alcohol is composite has excellent control efficiency to pepper anthracnose, and control efficiency is better than single dose kind.
Inventor finds through test, first thiophene lure amine and other triazole type hydroxy derivatives (as Tebuconazole) composite, first thiophene lure amine and triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole) composite, first thiophene lure amine and triazolinthione analog derivative (as prothioconazoles) composite, have similar control efficiency to pepper anthracnose.
First thiophene lures amine and propiconazole compound to sigatoka indoor harmacological effect determination test:
For examination pathogen: sigatoka bacterium.
Test method: adopt live body method, each process repeats 5 times, measures lesion diameter after 6d, calculates EC50 and co-toxicity coefficient, and result of the test sees the following form 3.
Table 3 first thiophene lures amine and propiconazole compound to measure the indoor harmacological effect of sigatoka bacterium
| Reagent agent | EC 50 | Regression equation | CTC |
| First thiophene lures amine (A) | 46.3843 | Y＝2.8527+1.2886x | — |
| Propiconazole (D) | 47.8639 | Y＝2.5361+1.4666x | — |
| (A:D)50:1 | 33.8819 | Y＝2.2354+1.8070x | 126.53 |
| 25:1 | 31.6851 | Y＝2.2797+1.8125x | 135.59 |
| 5:1 | 30.6072 | Y＝2.2833+1.8284x | 142.49 |
| 1:1 | 27.7356 | Y＝2.3022+1.8695x | 163.64 |
| 1:5 | 31.3965 | Y＝2.3453+1.7735x | 150.70 |
| 1:25 | 33.9511 | Y＝2.3273+1.7459x | 141.68 |
| 1:50 | 37.6636 | Y＝2.3813+1.6617x | 128.02 |
Note: co-toxicity coefficient (CTC) >=120 indicates synergistic effect; 80 < CTC < 120 represent summation action; CTC≤80 indicate antagonism.
Indoor harmacological effect measurement result shows, and first thiophene lures amine and propiconazole compound to have excellent control efficiency to sigatoka, and control efficiency is better than single dose kind.
Inventor finds through test, first thiophene lure amine and other triazole type dioxolanyl derivatives (as Difenoconazole) composite, first thiophene lure amine and triazole type hydroxy derivatives (as Tebuconazole, own azoles alcohol) composite, first thiophene lure amine and triazolinthione analog derivative (as prothioconazoles) composite, have similar control efficiency to sigatoka.
First thiophene lure amine and Difenoconazole composite to early blight of tomato indoor harmacological effect determination test:
For examination pathogen: early blight of tomato germ.
Test method: adopt pot-culture method, each process repeats 5 times, measures lesion diameter after 6d, calculates EC50 and co-toxicity coefficient, and result of the test sees the following form 4.
Table 4 first thiophene lures amine and the composite indoor harmacological effect to early blight of tomato of Difenoconazole to measure
| Reagent agent | EC 50 | Regression equation | CTC |
| First thiophene lures amine (A) | 38.2096 | Y＝2.7970+1.3924x | — |
| Difenoconazole (E) | 61.3129 | Y＝2.5612+1.3643x | — |
| (A:E)50:1 | 31.7498 | Y＝2.2998+1.7981x | 121.24 |
| 25:1 | 29.0769 | Y＝2.3083+1.8392x | 133.34 |
| 5:1 | 28.4101 | Y＝2.3373+1.8320x | 143.51 |
| 1:1 | 27.5963 | Y＝2.3694+1.8257x | 170.60 |
| 1:5 | 35.2994 | Y＝2.3161+1.7340x | 157.79 |
| 1:25 | 38.7513 | Y＝2.2200+1.7503x | 154.62 |
| 1:50 | 49.3195 | Y＝2.2287+1.6369x | 122.86 |
Note: co-toxicity coefficient (CTC) >=120 indicates synergistic effect; 80 < CTC < 120 represent summation action; CTC≤80 indicate antagonism.
Indoor harmacological effect measurement result shows, and first thiophene lures amine and Difenoconazole is composite has excellent control efficiency to tomato late blight, and control efficiency is better than single dose kind.
Inventor finds through test, first thiophene lure amine and other triazole type dioxolanyl derivatives (as propiconazole) composite, first thiophene lure amine and triazole type hydroxy derivatives (as Tebuconazole, own azoles alcohol) composite, first thiophene lure amine and triazolinthione analog derivative (as prothioconazoles) composite, have similar control efficiency to tomato late blight.
First thiophene lure amine and prothioconazoles composite to wheat powdery mildew indoor harmacological effect determination test:
For examination pathogen: wheat powdery mildew.
Test method: adopt pot-culture method, each process repeats 5 times, and 6d " Invest, Then Investigate " lesion area accounts for the percentage of total blade area, calculates EC50 and co-toxicity coefficient, and result of the test sees the following form 5.
Table 5 first thiophene lures amine and the composite indoor harmacological effect to wheat powdery mildew of prothioconazoles to measure
| Reagent agent | EC 50 | Regression equation | CTC |
| First thiophene lures amine (A) | 39.3018 | Y＝2.8687+1.3367x | — |
| Prothioconazoles (F) | 69.0821 | Y＝2.5454+1.3345x | — |
| (A:F)50:1 | 32.1789 | Y＝2.1927+1.8508x | 120.58 |
| 25:1 | 28.8968 | Y＝2.4310+1.7586x | 138.30 |
| 5:1 | 30.1094 | Y＝2.2482+1.8609x | 140.64 |
| 1:1 | 29.1536 | Y＝2.2530+1.8755x | 171.85 |
| 1:5 | 36.6733 | Y＝2.1214+1.8402x | 167.25 |
| 1:25 | 40.4831 | Y＝2.1179+1.7931x | 165.81 |
| 1:50 | 46.1487 | Y＝2.1085+1.7375x | 123.92 |
Note: co-toxicity coefficient (CTC) >=120 indicates synergistic effect; 80 < CTC < 120 represent summation action; CTC≤80 indicate antagonism.
Indoor harmacological effect measurement result shows, and first thiophene lures amine and prothioconazoles is composite has excellent control efficiency to wheat powdery mildew, and control efficiency is better than single dose kind.
Inventor finds through test, first thiophene lure amine and first thiophene lure amine and triazole type hydroxy derivatives (as Tebuconazole, own azoles alcohol) composite, first thiophene lure amine and triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole) composite, have similar control efficiency to wheat powdery mildew.
Bactericidal composition of the present invention can be prepared into any one formulation of applicable agricultural use by known method, reasonable formulation is wetting powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.In all formulas, percentage is all weight percentage.The processing technology of the various formulation of the present composition is prior art, can change to some extent according to different situations.
Embodiment 1:51% first thiophene lures amine ● difenoconazole suspending agent
Take each components such as former medicine, wetting dispersing agent, antifreezing agent, thickener, defoamer in proportion for subsequent use, mix through high speed shear, again by sand mill sand milling 2-3 hour, make its average grain diameter at 2-5 microns, obtain 51% first thiophene and lure amine ● difenoconazole suspending agent.
According to the mechanism of action, Difenoconazole in the present embodiment can be replaced other triazole type dioxolanyl derivatives (as propiconazole etc.), or triazole type hydroxy derivatives (as own azoles alcohol, Tebuconazole etc.), or triazolinthione analog derivative (as prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
With the pesticidal preparations early blight of tomato test that above-described embodiment is obtained
Test process: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is that commercially available agricultural chemicals 24% first thiophene lures amine suspending agent and 50% difenoconazole water dispersible granule and clear water to contrast respectively.
Test method: each plot area is 50m
2, repeat 4 times, the inspection drug effect method before dispenser after Investigation and Prevention is: every community diagonal is got a little, and often is extracted 10 strain investigation, and the percentage accounting for whole blade area with the lesion area on every strain blade carrys out classification, and result of the test sees the following form 6:
Table 6 first thiophene lures amine and the composite control efficiency to early blight of tomato of Difenoconazole
Field efficacy result shows, first thiophene lures amine and the composite control efficiency to early blight of tomato of Difenoconazole to have excellent control efficiency, and control efficiency is better than single dose kind.
Embodiment 2:26% first thiophene lures amine ● Tebuconazole wetting powder
The ratio of each components such as active component, dispersant, wetting agent and filler in formula is mixed, through mechanical crushing again through air-flow crushing, then mix, record the quality index such as content and suspensibility qualified after, obtain 26% first thiophene and lure amine ● Tebuconazole wetting powder.
According to the mechanism of action, Tebuconazole in the present embodiment can be replaced other triazole type hydroxy derivatives (as own azoles alcohol etc.), or triazole type dioxolanyl derivatives (as Difenoconazole, propiconazole etc.), or triazolinthione analog derivative (as prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
With the pesticidal preparations pepper anthracnose test that above-described embodiment is obtained
Test process: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is that commercially available agricultural chemicals 25% first thiophene lures amine suspending agent and 43% Tebuconazole SC and clear water to contrast respectively.
Test method: each plot area is 50m
2, repeat 4 times, the inspection drug effect method before dispenser after Investigation and Prevention is: every community diagonal is got a little, and often is extracted 10 strain investigation, and the percentage accounting for whole blade area with the lesion area on every strain blade carrys out classification, and result of the test sees the following form 7:
Table 7 first thiophene lures amine and the composite control efficiency to pepper anthracnose of Tebuconazole
Field efficacy result shows, first thiophene lures amine and the composite control efficiency to pepper anthracnose of Tebuconazole to have excellent control efficiency, and control efficiency is better than single dose kind.
Embodiment 3:30% first thiophene lures amine ● own azoles alcohol oil-suspending agent
Each components such as former medicine, emulsifier, wetting dispersing agent, organic roc profit soil and methyl oleate are taken for subsequent use by formula rate, mix through high speed shear, again by sand mill sand milling 2-3 hour, make its average grain diameter at 2-5 microns, obtain 30% first thiophene and lure amine ● own azoles alcohol oil-suspending agent.
According to the mechanism of action, own azoles alcohol in the present embodiment can be replaced other triazole type hydroxy derivatives (as Tebuconazole etc.), or triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole etc.), or triazolinthione analog derivative (as prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
With the pesticidal preparations rice blast test that above-described embodiment is obtained
Test process: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is that commercially available agricultural chemicals 25% first thiophene lures amine suspending agent and 30% hexaconazole suspending agent and clear water to contrast respectively.
Test method: each plot area is 50m
2, repeat 4 times, the inspection drug effect method before dispenser after Investigation and Prevention is: every community diagonal is got a little, and often is extracted 10 strain investigation, and the percentage accounting for whole blade area with the lesion area on every strain blade carrys out classification, and result of the test sees the following form 8:
Table 8 first thiophene lures amine and the composite control efficiency to rice blast of own azoles alcohol
Field efficacy result shows, first thiophene lures amine and Tebuconazole is composite has excellent control efficiency to rice blast, and control efficiency is better than single dose kind.
Embodiment 4:30% first thiophene lures amine ● propiconazole suspended emulsion
Each component such as former medicine, wetting dispersing agent, emulsifier and antifreezing agent, water etc. is taken for subsequent use by formula rate, first thiophene is lured the components such as amine, wetting dispersing agent, antifreeze after high speed shear mixes through grinding particle diameter to 2-5um, propiconazole and emulsifier are dissolved in cyclohexanone and make oil phase, slowly pour that first thiophene lures in amine suspending agent, namely shear-mixed evenly obtains 24% first thiophene and lure amine into ● the agent of propiconazole suspended emulsion.
According to the mechanism of action, propiconazole in the present embodiment can be replaced other triazole type dioxolanyl derivatives (as Difenoconazole etc.), or triazole type hydroxy derivatives (as own azoles alcohol, Tebuconazole etc.), or triazolinthione analog derivative (as prothioconazoles etc.), and other triazole class compounds, to form new embodiment.
With the pesticidal preparations sigatoka test that above-described embodiment is obtained
Test process: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is that commercially available agricultural chemicals 24% first thiophene lures amine suspending agent and 250g/l propiconazole suspending agent and clear water to contrast respectively.
Test method: each plot area is 50m
2, repeat 4 times, the inspection drug effect method before dispenser after Investigation and Prevention is: every community diagonal is got a little, and often is extracted 10 strain investigation, and the percentage accounting for whole blade area with the lesion area on every strain blade carrys out classification, and result of the test sees the following form 9:
Table 9 first thiophene lures amine and propiconazole compound to the control efficiency of sigatoka
Field efficacy result shows, first thiophene lures amine and propiconazole compound to have excellent control efficiency to sigatoka, and control efficiency is better than single dose kind.
Embodiment 5:24% first thiophene lures amine ● prothioconazoles suspending agent
Take each components such as former medicine, wetting dispersing agent, antifreezing agent, thickener, defoamer in proportion for subsequent use, mix through high speed shear, again by sand mill sand milling 2-3 hour, make its average grain diameter at 2-5 microns, namely obtain 24% first thiophene and lure amine ● prothioconazoles suspending agent.
According to the mechanism of action, triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole etc.), or triazole type hydroxy derivatives (as own azoles alcohol, Tebuconazole etc.), and other triazole class compounds, to form new embodiment.
Embodiment 6:26% first thiophene lures amine ● prothioconazoles water dispersible granules
Each component is mixed, obtains once mixture.Once mixture again through air-flow crushing, obtains secondary mixture through mechanical crushing.In secondary mixture, add the water of secondary mixture quality 10%-15%, mix, then through extruder grain, form column or spherical particle, finally carry out drying, namely obtain 26% first thiophene and lure amine ● prothioconazoles water dispersible granules.
According to the mechanism of action, triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole etc.), or triazole type hydroxy derivatives (as own azoles alcohol, Tebuconazole etc.), and other triazole class compounds, to form new embodiment.
Embodiment 7:1% first thiophene lures amine ● prothioconazoles suspending agent
Take each components such as former medicine, wetting dispersing agent, antifreezing agent, thickener, defoamer in proportion for subsequent use, mix through high speed shear, again by sand mill sand milling 2-3 hour, make its average grain diameter at 2-5 microns, namely obtain 51% first thiophene and lure amine ● prothioconazoles suspending agent.
According to the mechanism of action, triazole thioketone compounds prothioconazoles in the present embodiment can be replaced triazole type dioxolanyl derivatives (as propiconazole, Difenoconazole etc.), or triazole type hydroxy derivatives (as own azoles alcohol, Tebuconazole etc.), and other triazole class compounds, to form new embodiment.
With the pesticidal preparations wheat powdery mildew test that above-described embodiment is obtained
Test process: test is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, and contrast medicament is that commercially available agricultural chemicals 25% first thiophene lures amine suspending agent and 25% prothioconazoles suspending agent and clear water to contrast respectively
Test method: each plot area is 50m
2, repeat 4 times, the inspection drug effect method before dispenser after Investigation and Prevention is: every community diagonal is got a little, and often is extracted 10 strain investigation, and the percentage accounting for whole blade area with the lesion area on every strain blade carrys out classification, and result of the test sees the following form 10:
Table 10 first thiophene lures amine and the composite control efficiency to wheat powdery mildew of prothioconazoles
Field efficacy result shows, first thiophene lures amine and prothioconazoles is composite has excellent control efficiency to wheat powdery mildew, and control efficiency is better than single dose kind.
Claims (9)
1. a bactericidal composition, is characterized in that: active ingredient is that first thiophene lures amine and triazole class compounds, and described first thiophene lures the weight ratio of amine and triazole class compounds to be 50:1-1:50.
2. bactericidal composition according to claim 1, is characterized in that: described first thiophene lures the weight ratio of amine and triazole class compounds to be 25:1-1:25.
3. bactericidal composition according to claim 1, is characterized in that: described triazole class compounds is triazole type hydroxy derivatives, triazole type dioxolanyl derivatives or triazolinthione analog derivative.
4. bactericidal composition according to claim 3, is characterized in that: described triazole type hydroxy derivatives is Tebuconazole or own azoles alcohol; Described triazole type dioxolanyl derivatives is Difenoconazole or propiconazole; Described triazolinthione analog derivative is prothioconazoles.
5. according to described bactericidal composition arbitrary in Claims 1-4, it is characterized in that: also containing pesticidal preparations auxiliary element in described bactericidal composition, to make the formulation being applicable to agriculturally using.
6. bactericidal composition according to claim 5, is characterized in that: described pesticidal preparations auxiliary element is one or more in solvent, emulsifier, dispersant, stabilizing agent, antifreezing agent or wetting agent.
7. bactericidal composition according to claim 5, is characterized in that: the formulation of described bactericidal composition is wetting powder, aqueous suspension agent, oil-suspending agent, suspended emulsion or water dispersible granules.
8. the application of bactericidal composition according to claim 1, is characterized in that: for preventing and treating plant epiphyte class disease.
9. the application of bactericidal composition according to claim 8, is characterized in that: for preventing and treating pepper anthracnose, early blight of tomato, rice blast, wheat powdery mildew, sigatoka.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107801729A (en) * | 2016-09-09 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801721A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801724A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN108094431A (en) * | 2016-11-24 | 2018-06-01 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN109122701A (en) * | 2017-06-16 | 2019-01-04 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
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| US4582906A (en) * | 1981-03-16 | 1986-04-15 | Stauffer Chemical Company | 4-phenyl-1,2,3-thiadiazoles as herbicide extenders |
| CN1810808A (en) * | 2006-02-20 | 2006-08-02 | 南开大学 | New [1,2,3]-thiobiazole derivative and its synthesis and use |
| CN101091490A (en) * | 2007-01-12 | 2007-12-26 | 南开大学 | New type heterocycle bactericide and composition |
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| US4582906A (en) * | 1981-03-16 | 1986-04-15 | Stauffer Chemical Company | 4-phenyl-1,2,3-thiadiazoles as herbicide extenders |
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Cited By (5)
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| CN107801721A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801724A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801729A (en) * | 2016-09-09 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN108094431A (en) * | 2016-11-24 | 2018-06-01 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN109122701A (en) * | 2017-06-16 | 2019-01-04 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
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