CN105941450A - Bactericidal composition containing metconazole and prochloraz - Google Patents
Bactericidal composition containing metconazole and prochloraz Download PDFInfo
- Publication number
- CN105941450A CN105941450A CN201610547149.0A CN201610547149A CN105941450A CN 105941450 A CN105941450 A CN 105941450A CN 201610547149 A CN201610547149 A CN 201610547149A CN 105941450 A CN105941450 A CN 105941450A
- Authority
- CN
- China
- Prior art keywords
- prochloraz
- metconazole
- bactericidal composition
- mass ratio
- bactericidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing metconazole and prochloraz. Metconazole and prochloraz are used as active components of the bactericidal composition. The mass ratio of the metconazole to prochloraz is (1 to 20) to (20 to 1); the percentage by mass of the active components in the composition is 5-60%. The bactericidal composition has high bactericidal activity; meanwhile, generation and development of pesticide resistance of pathogens are delayed; meanwhile, the consumption of the pesticide for prevention and treatment in the actual production is reduced; the bactericidal composition is economical, efficient, safe and environmental-friendly, and is especially remarkable in effect of preventing and treating rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of containing metconazole with the bactericidal composition of Prochloraz, it is used for
Prevent and treat rice sheath blight disease.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, on Ye Shi China Oryza sativa L.
One of most important disease.Its distribution widely, has generation in China each Oryza sativa L. main producing region, especially on ground, the middle and lower reach of Yangtze River
District and South China, harm is very serious, causes yield drastically to decline.Selection-breeding and popularization disease-resistant variety, be preventing and treating rice banded sclerotial blight
One of sick important measures, in recent years, although Chinese scholars achieves a lot of progress in terms of breeding for disease resistance, but there is no at present
Select the rice varieties of immunity complete to rice sheath blight disease.Rhizoctonia solani Kuhn preventing and treating at present is also to rely on chemical control.
China is preventing and treating the medicament having been used up in rice sheath blight disease based on jingganmycin, the most i.e. at rice tillering at present
Diseased plant rate reached about 15% and started to spray medicine preventing and treating latter stage, and achieved certain effect.But have been reported display, China's part
Area rice sheath blight disease has created Drug resistance to jingganmycin, and the prevention effect of this medicament caused constantly declines.If
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique preventing and treating rice sheath blight disease, administer jingganmycin drug resistance simultaneously
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Metconazole, is again hydroxyl bacterium azoles, chemical name: 5-(4-chlorphenyl)-2,2-dimethyl-1-(1,2,4-triazol-1-yl
Methyl)-cyclopentanol, crystalline solid white, tasteless, the trendy triazole developed in early 1990s for Wu Yu chemical company of Japan
Series bactericidal agent, for C-14 demethylation enzyme inhibitor in ergosterol biosynthesis, makes somatic cells film function be destroyed.Cause
And, suppress or disturb thalline appresorium and the formation of the growth of haustorium, mycelia and spore, film seepage also can be caused to aggravate, thus
Reduce pathogen pathogenicity.Although the mechanism of action is as other triazole bactericidal agents, but activity profile then difference is bigger.Two kinds different
Structure body has bactericidal activity, but Cis activity is higher than trans.The antifungal of metconazole is composed widely, and activity is splendid.Leaf bacterium
Azoles field is used and cereal crops septoria musiva, fusarium and handle rest fungus are planted disease is had excellent effect.Metconazole is with tradition biocide agent phase
Ratio, dosage is extremely low and prevent and treat frumentum to plant disease scope the widest.Metconazole is a kind of efficient, triazole type sterilization of wide spectrum, interior absorption
Agent, has protection, treatment, eradicant action, thus is widely used in by the fungus-caused multiple diseases such as ascomycetes, basidiomycetes
Preventing and treating.Metconazole is one of effective agent preventing and treating rice sheath blight disease at present, can not only reduce the serious of the field water sheath and culm blight of rice
Degree, can reduce the pathogenic toxin falling ill in wheat grain simultaneously and pollute, ensure food safety.
Metconazole molecular formula: C17H22ClN3O, structural formula:
Prochloraz, chemical name: N-propyl group-N-[2-(2,4,6-Trichlorophenoxy) ethyl]-imidazoles-1-Methanamide, miaow
Fresh amine is broad-spectrum germicide, suppresses ergosterol biosynthesis, has protection and eradicant action, to various crop ascomycetes and
Fungi Imperfecti disease has notable preventive effect.Can be used for preventing and treating the many diseases on cereal crop stem, leaf, fringe.
Prochloraz molecular formula C15H16Cl3N3O2, structural formula is:
Metconazole and Prochloraz single dose life-time service, easily make disease develop immunity to drugs, and causes dosage increasing, preventive effect fall
The problem that low, the lasting period shortens, is unfavorable for environment sustainable development.And the effective ingredient of the difference mechanism of action compounds, it is
Delay disease to develop immunity to drugs conventional method, and according to the effect in production application, judge this compounding be that potentiation is made
With still antagonism.The obvious formula of complex role, can significantly improve preventive effect, is substantially reduced the dosage of pesticide, also
Fungicidal spectrum can be expanded, improve germicidal efficiency.
Summary of the invention
The invention provides a kind of containing metconazole with the bactericidal composition of Prochloraz, there is bactericidal activity high, delay cause of disease
Thing Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection, at preventing and treating rice banded sclerotial blight
Specially good effect is had in disease.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easy-to-use system of production
Agent, is used alone in two kinds of compositions and compares, and has biological activity high, and dosage total in unit are declines, and is substantially reduced
Dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces pathogenic fungi and kill single
Microbial inoculum produces the risk of resistance, extends the service life of each component in bactericidal composition, thus realizes economy, efficient, environmental protection
Goal of the invention.
The technical scheme is that
A kind of containing metconazole with the microbicide compositions of Prochloraz, it is characterised in that the activity of described microbicide compositions
Component be the mass ratio of metconazole and Prochloraz, metconazole and Prochloraz be 1:20 to 20:1, active component quality in compositions
Percentage composition is 5-60%.
Described containing metconazole and the bactericidal composition of Prochloraz, it is characterised in that: described active component metconazole and
The mass ratio of Prochloraz is 1:10 to 10:1.
It is described containing metconazole and the bactericidal composition of Prochloraz, it is characterised in that: described metconazole and Prochloraz
Mass ratio is 1:3-8.
It is described containing metconazole and the bactericidal composition of Prochloraz, it is characterised in that: described metconazole and Prochloraz
Mass ratio is 1:4-6.
It is described containing metconazole and the microbicide compositions of Prochloraz, it is characterised in that: the agent of described microbicide compositions
Type is suspending agent or cream.
The described application of the microbicide compositions containing metconazole and Prochloraz, it is characterised in that: this microbicide compositions pair
Rice sheath blight disease controlling effect is especially pronounced.
Remarkable result and the advantage of the present invention be:
The present invention has good prevention effect to rice sheath blight disease, there is notable synergistic effect between two components；Can replace
Part high price pesticide species, and reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve wheat yield and
Quality；In the present invention, metconazole and Prochloraz all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security；Disease can be delayed
The bacterium Drug resistance to single medicament.
First metconazole and the EC of Prochloraz two single compound (hereinafter referred to as medicament) are measured50(drug safety refers to
Mark), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley coefficient of synergism C
Value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of Rhizoctonia solani Kuhn is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC of each medicament50,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 ＜
SR ＜ 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 metconazole and the Prochloraz compositions Wadley method measurement result to rice sheath blight disease
Note: Y is metconazole, and M is Prochloraz.
Can analyze from data above, antibacterial to Rhizoctonia solani Kuhn of the metconazole of different proportion and Prochloraz compositions
Effect is different, and on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1, increases most
Effect ratio is 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% metconazole Prochloraz wettable powder)
Composition of raw materials: by mass percentage
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 2 (preparation method of 30% metconazole Prochloraz suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters, and suction divides
Dissipating tank high speed shear to be fully ground through sand mill after 3 minutes, control solid constituent particle diameter is within 2 microns, and grinding terminates
After stir, obtain suspending agent product.
Embodiment 3 (preparation method of 40% metconazole Prochloraz suspending agent)
Preparation method: same as in Example 2.
Embodiment 4 (preparation method of 20% metconazole Prochloraz cream)
Preparation method: fully dissolved in dimethylbenzene reactor by active component metconazole, makes A liquid；By active component
Prochloraz fully dissolves in DMF reactor, makes B liquid；Under not stopping stirring, A liquid is mixed into B liquid, is sufficiently stirred for all
Even, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.Embodiment 5 (45% metconazole Prochloraz breast
The preparation method of oil)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Embodiment 6 (preparation method of 48% metconazole Prochloraz cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 4.
Prevention effect is tested:
The field efficiency test of rice sheath blight disease is carried out in suburb, Bengbu, and test area is 0.3hm2, often process repetition
Three times, carrying out latter stage spraying medicine preventing and treating at rice tillering, carry out preventive effect investigation in dispenser after 15 days, preventing and treating the results are shown in Table 2.Result table
Bright, the bactericidal composition containing metconazole and Prochloraz has good prevention effect to rice sheath blight disease, at same dose or
Higher prevention effect can be reached under relatively low using dosage, and each process preventive effect bacterium of this bactericidal composition is more than 85%, significantly
Higher than comparison medicament.
Table 2 metconazole Prochloraz bactericidal composition prevents and treats land for growing field crops drug effect * of rice sheath blight disease
It should be noted that when the proportioning of metconazole and Prochloraz is 5:1, compared with other process, in relatively low use
But there is higher preventive effect, it is shown that preferably synergistic function under amount；And indoor biometrics result also indicates that, metconazole and miaow
When the proportioning of fresh amine is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. one kind contains metconazole and the bactericidal composition of Prochloraz, it is characterised in that the active component of described microbicide compositions
Mass ratio for metconazole and Prochloraz, metconazole and Prochloraz is 1:20 to 20:1, active component percent mass in compositions
Content is 5-60%.
It is the most according to claim 1 containing metconazole with the bactericidal composition of Prochloraz, it is characterised in that: described active group
The mass ratio dividing metconazole and Prochloraz is 1:10 to 10:1.
It is the most according to claim 1 containing metconazole with the bactericidal composition of Prochloraz, it is characterised in that: described metconazole
It is 1:3-8 with the mass ratio of Prochloraz.
It is the most according to claim 1 containing metconazole with the bactericidal composition of Prochloraz, it is characterised in that: described metconazole
It is 1:4-6 with the mass ratio of Prochloraz.
It is the most according to claim 1 and 2 containing metconazole with the bactericidal composition of Prochloraz, it is characterised in that: described sterilization
The dosage form of agent compositions is wettable powder, suspending agent or cream.
Bactericidal composition application containing metconazole and Prochloraz the most according to claim 1 and 2, it is characterised in that: described
Bactericidal composition rice banded sclerotial blight disease is had the highest prevention effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610547149.0A CN105941450A (en) | 2016-07-12 | 2016-07-12 | Bactericidal composition containing metconazole and prochloraz |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610547149.0A CN105941450A (en) | 2016-07-12 | 2016-07-12 | Bactericidal composition containing metconazole and prochloraz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105941450A true CN105941450A (en) | 2016-09-21 |
Family
ID=56900641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610547149.0A Pending CN105941450A (en) | 2016-07-12 | 2016-07-12 | Bactericidal composition containing metconazole and prochloraz |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105941450A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106719767A (en) * | 2017-01-17 | 2017-05-31 | 上海悦联生物科技有限公司 | A kind of composition pesticide containing metconazole and Prochloraz |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1663375A (en) * | 2005-02-05 | 2005-09-07 | 西北农林科技大学无公害农药研究服务中心 | Prochloraz-containing bactericidal microemulsion and preparation method thereof |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN102090410A (en) * | 2009-12-14 | 2011-06-15 | 安阳市安林生物化工有限责任公司 | Myclobutanil-prochloraz hot fog |
| CN102150678A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing prochloraz |
| CN103918693A (en) * | 2014-03-31 | 2014-07-16 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and prochloraz |
-
2016
- 2016-07-12 CN CN201610547149.0A patent/CN105941450A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1663375A (en) * | 2005-02-05 | 2005-09-07 | 西北农林科技大学无公害农药研究服务中心 | Prochloraz-containing bactericidal microemulsion and preparation method thereof |
| CN102090410A (en) * | 2009-12-14 | 2011-06-15 | 安阳市安林生物化工有限责任公司 | Myclobutanil-prochloraz hot fog |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN102150678A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing prochloraz |
| CN103918693A (en) * | 2014-03-31 | 2014-07-16 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and prochloraz |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106719767A (en) * | 2017-01-17 | 2017-05-31 | 上海悦联生物科技有限公司 | A kind of composition pesticide containing metconazole and Prochloraz |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104412981B (en) | A kind of bactericidal composition of fluorine-containing ether bacterium amide and methoxy acrylic | |
| CN105010357B (en) | Bactericidal composition and its application | |
| CN105900996A (en) | Bactericide composition containing metconazole and fluxapyroxad | |
| CN106070237A (en) | A kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles and application thereof | |
| CN105901001A (en) | Bactericide composition containing metconazole and hymexazol | |
| CN104137836B (en) | A kind of bactericidal composition of fluorine-containing azoles bacterium aniline and methoxy acrylic | |
| CN104472497A (en) | Bactericide composition for preventing and treating soybean root rot disease | |
| CN105941450A (en) | Bactericidal composition containing metconazole and prochloraz | |
| CN104054730B (en) | A kind of bactericidal composition and application thereof containing chlorine nalidixic bacterium ester and thifluzamide | |
| CN105831132A (en) | Sterilization composition containing benzothiostrobin and fluoride ether bacteria amide | |
| CN105010364B (en) | The bactericidal composition and its application of a kind of probenazole-containing and thifluzamide | |
| CN106577696A (en) | Tetramycin-containing pesticidal composition | |
| CN104412983B (en) | A kind of efficient bactericidal composite of fluorine-containing ether bacterium amide | |
| CN103039492B (en) | Pesticide compound bactericide | |
| CN107396926A (en) | It is a kind of to increase composition containing the antibacterial of DCPTA and methoxy acrylic | |
| CN104472504B (en) | A kind of bactericidal composition and application thereof containing epoxiconazole and probenazole | |
| CN104488891A (en) | Powdery mildew control sterilization composition | |
| CN105638686B (en) | A kind of combination sterilization composition containing tiger glue adipic acid copper | |
| CN106172474A (en) | A kind of containing metconazole with the bactericidal composition of Silthiopham | |
| CN103444722B (en) | A kind of Quinoxyfen-containinsterilization and the bactericidal composition of triazole type | |
| CN106689143A (en) | Triflumizole and chloroisobromine cyanuric acid-containing synergetic bactericide composition and preparation method thereof | |
| CN105900993A (en) | Bactericide composition containing fluxapyroxad and dimethachlon | |
| CN104137832A (en) | Bactericidal composition containing trifloxystrobin and oligosaccharins and use of bactericidal composition | |
| CN106172475A (en) | A kind of Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham | |
| CN106172422A (en) | A kind of containing metconazole with the bactericidal composition of fluorine azoles bacterium aniline |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination |