CN104054730B - A kind of bactericidal composition and application thereof containing chlorine nalidixic bacterium ester and thifluzamide - Google Patents
A kind of bactericidal composition and application thereof containing chlorine nalidixic bacterium ester and thifluzamide Download PDFInfo
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- CN104054730B CN104054730B CN201410280475.0A CN201410280475A CN104054730B CN 104054730 B CN104054730 B CN 104054730B CN 201410280475 A CN201410280475 A CN 201410280475A CN 104054730 B CN104054730 B CN 104054730B
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- thifluzamide
- bacterium ester
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- nalidixic bacterium
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Abstract
The invention discloses a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide, the active component of described microbicide compositions is chlorine nalidixic bacterium ester and thifluzamide, the mass ratio of thifluzamide and chlorine nalidixic bacterium ester is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.It is high that microbicide compositions of the present invention has bactericidal activity, delays the drug-fast emergence and development of pathogen simultaneously, and reduce in production reality and prevent and treat dosage, economic, efficient, safety, environmental protection.The present invention has good control efficiency to various crop disease, particularly remarkable to the control efficiency of rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of bactericidal composition and the application thereof that contain chlorine nalidixic bacterium ester and thifluzamide.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, one of most important disease on Ye Shi China paddy rice.Its distribution widely, has generation in each paddy rice main producing region of China, and especially in In Middle And Lower Reaches of Changjiang River and South China, harm is very serious, causes output sharply to decline.Selection and popularization disease-resistant variety is one of important measures of the water prevention rice sheath blight, in recent years, although Chinese scholars achieves a lot of progress in breeding for disease resistance, there is no at present and selects the completely immune rice varieties of rice sheath blight disease.Current Rhizoctonia solani Kuhn control still depends on chemical control.Current China adopts the medicament based on jinggangmeisu on the water prevention rice sheath blight always, namely reaches about 15% in rice tillering diseased plant rate in latter stage at the initial stage of a disease and starts to spray medicine control, and achieve certain effect.But existing report display, China's some areas rice sheath blight disease creates pesticide resistance to jinggangmeisu, and the control efficiency of this medicament caused constantly declines.If continue to control rice sheath blight disease, especially the surrogate-data technique of the water prevention rice sheath blight is filtered out, administer jinggangmeisu pesticide resistance simultaneously and promote the sustainable control of rice sheath blight disease, having become the significant challenge that numerous scientific workers and Rice Cropping person face.
Chlorine nalidixic bacterium ester is a kind of high-effective broad-spectrum fungicide, has very high bacteriostatic activity to pathogens such as wheat, powdery mildew of cucumber, rice blast, rice green smut, rice sheath blight disease, bakanae disease of rice, wheat sharp eyespot, wheat scab, root rotof flax, corn northern leaf blight and southern leaf blight, sclerotinia rot of colza, graw mold of tomato, apple canker, melon anthracnose, cucumber fusarium axysporum, cotton verticillium wilt, cotton wilts.Its Main Function mechanism is the respiration affecting thalline, with jinggangmeisu without mutual pesticide resistance.
Chlorine nalidixic bacterium ester is methoxy acrylic ester compounds, its Main Function mechanism is the respiration affecting thalline, chlorine nalidixic bacterium ester then mechanism of action is novel, with benzimidazole, the bactericide mechanism of action of the different mechanism of action such as dithiocarbamates, ergosterol biosynthesis inhibitor is all not identical, the two is combined as bactericidal composition, effectively can not only solve the production practical problem that jinggangmeisu pesticide resistance area rice sheath blight disease is difficult to prevent and treat, and delay pathogen it is developed immunity to drugs.
The chemical name of chlorine nalidixic bacterium ester: N-methoxyl group-N-[2-[[(3,5,6-trichloropyridine-2-base) oxygen] methyl] phenyl] methyl carbamate
The chemical structural formula of chlorine nalidixic bacterium ester is as follows:
Thifluzamide is again thiophene fluorine bacterium amine, it is the phenyl amide compound containing thiazole ring, belongs to succinate dehydrogenase inhibitors, has strong Uptake and translocation and long lasting effect, can prevent and treat various crop disease, particularly the fungus-caused disease of basidiomycetes Rhizoctonia has good control efficiency.Its Main Function mechanism suppresses succinate dehydrogenase in germ tricarbonic acid cycle, causes thalline dead.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially special efficacy is had, with jinggangmeisu without mutual pesticide resistance to the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc.
The chemical name of thifluzamide: the bromo-2-methyl of 2', 6'-bis--4'-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide
The chemical structural formula of thifluzamide is as follows:
Chlorine nalidixic bacterium ester and thifluzamide bacterium are lower toxicity or micro-virus kind agricultural chemicals, belong to efficient, low toxicity, environmentally friendly type bactericide.Chlorine nalidixic bacterium ester mainly acts on the electron transmission in thalline respiratory chain thus suppresses to breathe, and the succinate dehydrogenase of thifluzamide effect and thalline, thus the object reaching sterilization, the two does not exist mutual pesticide resistance.But a lot of research shows, if these two kinds of medicaments are used alone controlling disease, can pathogen are made in the short period of time to develop immunity to drugs, cause preventive effect to reduce, even prevent and treat failure.Fungicide resistance Action Committee (FRAC) advises, is used by the composite reagent of different mechanism of action, can avoid or delay drug-fast generation.Therefore, the two is combined as bactericidal composition, what effectively can not only solve rice sheath blight disease prevents and treats problem, and can avoid or delay pathogen and develop immunity to drugs to it.
Summary of the invention
The invention provides a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide, there is bactericidal activity high, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
Technical scheme of the present invention is:
A kind of microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide, it is characterized in that, the active component of described microbicide compositions is chlorine nalidixic bacterium ester and thifluzamide, and the mass ratio of thifluzamide and chlorine nalidixic bacterium ester is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.
Described active component thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:10 to 10:1.
Described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:3-8.
Described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:4-6.
The formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
This microbicide compositions has higher control efficiency to various crop disease, particularly remarkable to rice sheath blight disease controlling effect, for the control of rice sheath blight disease and false smut.
Remarkable result of the present invention and advantage are:
Two classes are had the bactericide of different mechanism of action by the present invention, namely methoxy acrylic bactericide chlorine nalidixic bacterium ester and SDHI series bactericidal agent thifluzamide combined, and be processed into the upper easy-to-use preparation of production, biologically active is high, dosage total in unit are declines, greatly reduce dispenser cost, delaying pathogen pesticide resistance emergence and development to a greater extent simultaneously, reduce disease fungus produces resistance risk to single bactericide, extend the service life of each component in bactericidal composition, thus reach effect that is economic, efficient, environmental protection.
The present invention has higher control efficiency to crop fungal disease, there is notable synergistic effect between two components; Part high price pesticide species can be replaced, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved; In the present invention, chlorine nalidixic bacterium ester and thifluzamide all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security; The pesticide resistance of germ to single medicament can be delayed.
First the EC of chlorine nalidixic bacterium ester and thifluzamide two single compound (hereinafter referred to as medicament) is measured
50(drug safety index), according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley coefficient of synergism C value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test adopts mycelial growth determination method, makes pastille medium by different disposal, and each process 4 repetitions, connect bacterium after 3 days, investigate the growth inhibitory effect of each process to Rhizoctonia solani Kuhn.By the linear regression analysis between the probit value of preventive effect and the logarithm value of serial drug concentration, obtain the EC50 of each medicament, calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents to have antagonism, and 0.5 < SR < 1.5 represents to have summation action, and SR >=1.5 are synergistic effect.SR value calculating method is as follows:
EC
50(theoretical value)=(a+b)/(a/EC
50A+ b/EC
50B)
SR=EC
50(theoretical value)/EC
50(real value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have synergistic effect
Table 1 thifluzamide and chlorine nalidixic bacterium ester composition are to the Wadley method measurement result of Rhizoctonia solani Kuhn
Note: L is chlorine nalidixic bacterium ester, and S is thifluzamide.
Can analyze from above data, chlorine nalidixic bacterium ester and the fungistatic effect of thifluzamide composition to Rhizoctonia solani Kuhn of different proportion are different, on the whole, its ratio has synergy or addition in the scope of 1:20 to 20:1, and wherein maximum enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but be not limited thereto.
Embodiment
Embodiment 1 (preparation method of 60% thifluzamide chlorine nalidixic bacterium ester wetting powder)
Composition of raw materials: by mass percentage
Preparation method: by above-mentioned substance Homogeneous phase mixing, mixture is pulverized through airslide disintegrating mill, obtained wetting powder.
Embodiment 2 (preparation method of 30% thifluzamide chlorine nalidixic bacterium ester suspending agent)
Preparation method: according to formula, weighs in proportion by individual component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.
Embodiment 3 (preparation method of 40% thifluzamide chlorine nalidixic bacterium ester water dispersible granules)
Preparation method: thifluzamide, chlorine nalidixic bacterium ester, Methyl fatty acid amides benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together evenly, particle diameter 5 μm is crushed to through airslide disintegrating mill, obtain female powder, female powder is fully mixed rear granulation with sodium lignin sulfonate, dries, sieves, thus obtained water-dispersible granules.
Embodiment 4 (20% thifluzamide chlorine nalidixic bacterium ester suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (45% thifluzamide chlorine nalidixic bacterium ester missible oil)
Composition of raw materials: by mass percentage
Preparation method: fully dissolved in dimethylbenzene reactor by active component thifluzamide, makes A liquid; Active component chlorine nalidixic bacterium ester is fully dissolved in dimethylbenzene reactor, makes B liquid; Not stopping, under stirring, A liquid is mixed into B liquid, stirring, adding anhydrous calcium salt and NP-10, then adjusting content with solvent xylene.
Embodiment 6 (preparation method of 48% thifluzamide chlorine nalidixic bacterium ester missible oil)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Control efficiency is tested:
The field efficiency test of rice sheath blight disease carries out in Fengyang County, and test area is 0.3hm
2, often process in triplicate, in the control of Rise's boot period spray medicine, carry out preventive effect investigation in dispenser after 15 days, control the results are shown in Table 2.Result shows, bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide has good control efficiency to rice sheath blight disease, can reach higher control efficiency under same dose or lower using dosage, and each process preventive effect bacterium of this bactericidal composition is greater than 85%, is significantly higher than contrast medicament.
The land for growing field crops drug effect * of the table 2 thifluzamide chlorine nalidixic bacterium ester bactericidal composition water prevention rice sheath blight
Owing to being also the proper control time preventing and treating false smut at Rise's boot period, we have investigated the control efficiency to false smut after chemical control simultaneously, and control the results are shown in Table 3.Result shows, the bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide has good control efficiency to false smut, and the preventive effect under each treatment dosage, all higher than 85%, is significantly higher than the preventive effect of contrast medicament.
Table 3 thifluzamide chlorine nalidixic bacterium ester bactericidal composition is to the field efficacy of false smut
From the data of table 2 and table 3, the bactericidal composition containing thifluzamide and chlorine nalidixic bacterium ester all has good preventive effect to rice sheath blight disease and false smut, and the preventive effect of different ratio is different.It should be noted that when the proportioning of chlorine nalidixic bacterium ester and thifluzamide is 5:1, compared with other processes, under lower consumption, but to two kinds of diseases, there is higher preventive effect, show good synergistic function; And indoor biometrics result also shows, when the proportioning of chlorine nalidixic bacterium ester and thifluzamide is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, it is also to be noted that what enumerate above is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, a lot of distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all think the scope of protection of the invention.
Claims (5)
1. one kind contains the microbicide compositions of chlorine nalidixic bacterium ester and thifluzamide, it is characterized in that, the active component of described microbicide compositions is chlorine nalidixic bacterium ester and thifluzamide, and the mass ratio of thifluzamide and chlorine nalidixic bacterium ester is 1:10 to 10:1, and in composition, active component mass percentage is 5-60%.
2. the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:3-8.
3. the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:4-6.
4. the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: the formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
5. the application of the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: for the control of rice sheath blight disease and false smut.
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| 新杀菌剂氯啶菌酯及其合成工艺;周德锋等;《农化新世纪》;20080831;第13页左栏 * |
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