CN104054730A - Bactericidal composition containing triclopyricarb and thifluzamide and application thereof - Google Patents
Bactericidal composition containing triclopyricarb and thifluzamide and application thereof Download PDFInfo
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- CN104054730A CN104054730A CN201410280475.0A CN201410280475A CN104054730A CN 104054730 A CN104054730 A CN 104054730A CN 201410280475 A CN201410280475 A CN 201410280475A CN 104054730 A CN104054730 A CN 104054730A
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- thifluzamide
- bacterium ester
- chlorine nalidixic
- nalidixic bacterium
- bactericidal composition
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Abstract
The invention discloses a bactericidal composition containing triclopyricarb and thifluzamide. The bactericidal composition consists of active components of triclopyricarb and thifluzamide in the mass ratio of 20:1-1:20, and the active components account for 5-60%. The bactericidal composition provided by the invention has high bactericidal activity, and delays the emergence and development of pathogen resistance, and reduces the dosage of prevention in actual production, and has the advantages of economical performance, high efficiency, safety and environment-friendliness. The bactericidal composition provided by the invention has good control effect on a variety of crop diseases, particularly significant control effect on rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of bactericidal composition and application thereof containing chlorine nalidixic bacterium ester and thifluzamide.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, one of most important disease on Ye Shi China paddy rice.Its distribution is very extensive, in each paddy rice main producing region of China, has generation, especially in In Middle And Lower Reaches of Changjiang River and South China, endangers very seriously, causes output sharply to decline.Selection and popularization disease-resistant variety, is one of important measures that prevent and treat rice sheath blight disease, in recent years, although Chinese scholars has obtained a lot of progress aspect breeding for disease resistance, there is no at present and selects the completely immune rice varieties of rice sheath blight disease.Rhizoctonia solani Kuhn control at present still depends on chemical control.At present China adopts in rice sheath blight disease that to take jinggangmeisu be main medicament preventing and treating always, in rice tillering diseased plant rate in latter stage, reaches 15% left and right at the initial stage of a disease and starts to spray medicine control, and obtained certain effect.But existing report demonstration, China's some areas rice sheath blight disease has produced pesticide resistance to jinggangmeisu, and the control efficiency of this medicament causing constantly declines.If continue to control rice sheath blight disease, especially filter out the alternative medicament of preventing and treating rice sheath blight disease, the sustainable control of administering jinggangmeisu pesticide resistance simultaneously and promoting rice sheath blight disease, has become the significant challenge that numerous scientific workers and Rice Cropping person face.
Chlorine nalidixic bacterium ester is a kind of high-effective broad-spectrum fungicide, and the pathogens such as wheat, powdery mildew of cucumber, rice blast, rice green smut, rice sheath blight disease, bakanae disease of rice, wheat sharp eyespot, wheat scab, root rotof flax, corn northern leaf blight and southern leaf blight, sclerotinia rot of colza, graw mold of tomato, apple canker, melon anthracnose, cucumber fusarium axysporum, cotton verticillium wilt, cotton wilt are had to very high bacteriostatic activity.Its Main Function mechanism is the respiration that affects thalline, with jinggangmeisu without mutual pesticide resistance.
Chlorine nalidixic bacterium ester is methoxy acrylic ester compounds, its Main Function mechanism is for affecting the respiration of thalline, chlorine nalidixic bacterium ester mechanism of action is novel, with benzimidazole, the bactericide mechanism of action of the different mechanism of action such as dithiocarbamates, ergosterol biosynthesis inhibitor is all not identical, the two is combined as bactericidal composition, can not only effectively solve the production practical problem that jinggangmeisu pesticide resistance area rice sheath blight disease is difficult to control, and delay pathogen it is developed immunity to drugs.
The chemical name of chlorine nalidixic bacterium ester: N-methoxyl group-N-[2-[[(3,5,6-trichloropyridine-2-yl) oxygen] methyl] phenyl] methyl carbamate
The chemical structural formula of chlorine nalidixic bacterium ester is as follows:
Thifluzamide is again thiophene fluorine bacterium amine, it is the phenyl amide compound containing thiazole ring, belongs to succinate dehydrogenase inhibitors, has strong interior conductivity and the long lasting effect of inhaling, can prevent and treat various crop disease, particularly the fungus-caused disease of basidiomycetes Rhizoctonia has good control efficiency.Its Main Function mechanism is to suppress succinate dehydrogenase in germ tricarbonic acid cycle, causes thalline dead.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially the fungus-caused disease of Basidiomycetes is had to special efficacy as banded sclerotial blight, damping off etc., with jinggangmeisu without mutual pesticide resistance.
The chemical name of thifluzamide: 2', the bromo-2-methyl-4'-of 6'-bis-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide
The chemical structural formula of thifluzamide is as follows:
Chlorine nalidixic bacterium ester and thifluzamide bacterium are lower toxicity or micro-virus kind agricultural chemicals, belong to efficient, low toxicity, environmentally friendly type bactericide.Thereby chlorine nalidixic bacterium ester is mainly to act on electronics transmission in thalline respiratory chain to suppress to breathe, the succinate dehydrogenase of thifluzamide effect and thalline, thus reach the object of sterilization, there is not mutual pesticide resistance in the two.But a lot of research shows, if these two kinds of medicaments make separately, for preventing and treating disease, can make in the short period of time pathogen develop immunity to drugs, causes preventive effect to reduce, and even prevents and treats unsuccessfully.Fungicide resistance Action Committee (FRAC) suggestion, is used the composite reagent of different mechanism of action, can avoid or delay drug-fast generation.Therefore, the two is combined as to bactericidal composition, can not only effectively solves the problem of preventing and treating of rice sheath blight disease, and can avoid or delay pathogen it is developed immunity to drugs.
Summary of the invention
The invention provides a kind of bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide, there is bactericidal activity high, delay pathogen pesticide resistance and produce and develop, and dosage total in unit are is declined, economical, efficient, environmental protection.
Technical scheme of the present invention is:
A kind of microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide, it is characterized in that, the active component of described microbicide compositions is chlorine nalidixic bacterium ester and thifluzamide, and the mass ratio of thifluzamide and chlorine nalidixic bacterium ester is 1:20 to 20:1, and in composition, active component quality percentage composition is 5-60%.
Described active component thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:10 to 10:1.
Described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:3-8.
Described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:4-6.
The formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
This microbicide compositions has higher control efficiency to various crop disease, particularly remarkable to rice sheath blight disease controlling effect, for the control of rice sheath blight disease and false smut.
Remarkable result of the present invention and advantage are:
The present invention has two classes in the bactericide of different mechanism of action, be that methoxy acrylic bactericide chlorine nalidixic bacterium ester and SDHI series bactericidal agent thifluzamide are combined, and be processed into and produce easy-to-use preparation, biologically active is high, dosage total in unit are declines, greatly reduce dispenser cost, delaying to a greater extent the generation of pathogen pesticide resistance and development simultaneously, reduced disease fungus and single bactericide has been produced to the risk of resistance, extend the service life of each component in bactericidal composition, thereby reached effect economic, efficient, environmental protection.
The present invention has higher control efficiency to crop fungal disease, has notable synergistic effect between two components; Can replace part high price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and can improve crop yield and quality; In the present invention, chlorine nalidixic bacterium ester and thifluzamide all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security; Can delay the pesticide resistance of germ to single medicament.
First measure the EC of chlorine nalidixic bacterium ester and thifluzamide two single compounds (hereinafter to be referred as medicament)
50(drug safety index), according to the EC of two single medicaments
50by Wadley method, set the portfolio ratio of two medicaments, and according to Wadley coefficient of synergism C value, determine suitable composition ratio, then by the abundant method of Sun Yun, verified.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test adopts mycelial growth determination method, by different disposal, makes pastille medium, and each processes 4 repetitions, connects bacterium after 3 days, and each processes the growth inhibitory effect to Rhizoctonia solani Kuhn investigation.By the linear regression analysis between the probit value of preventive effect and the logarithm value of serial drug concentration, obtain the EC50 of each medicament, according to Wadley method, calculate coefficient of synergism (SR), and make accordingly overall merit.SR≤0.5 represents to have antagonism, and 0.5 < SR < 1.5 represents to have summation action, and SR >=1.5 are synergistic effect.SR value calculating method is as follows:
EC
50(theoretical value)=(a+b)/(a/EC
50A+ b/EC
50B)
SR=EC
50(theoretical value)/EC
50(real value)
SR≤0.5, two kinds of medicaments antagonistic action that has been mixed
SR=0.5～1.5, two kinds of medicaments addition that has been mixed
SR >=1.5, two kinds of medicaments synergistic effect that has been mixed
Table 1 thifluzamide and the chlorine nalidixic bacterium ester composition Wadley method measurement result to Rhizoctonia solani Kuhn
Note: L is chlorine nalidixic bacterium ester, and S is thifluzamide.
From above data, can analyze, the chlorine nalidixic bacterium ester of different proportion and thifluzamide composition are different to the fungistatic effect of Rhizoctonia solani Kuhn, on the whole, its ratio has synergy or addition at 1:20 in the scope of 20:1, and wherein maximum enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but be not limited to this.
Embodiment
Embodiment 1 (preparation method of 60% thifluzamide chlorine nalidixic bacterium ester wetting powder)
Composition of raw materials: by mass percentage
Preparation method: above-mentioned substance is evenly mixed, and mixture is pulverized through airslide disintegrating mill, makes wetting powder.
Embodiment 2 (preparation method of 30% thifluzamide chlorine nalidixic bacterium ester suspending agent)
Preparation method: according to formula, individual component is weighed in proportion, add ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear is fully ground by sand mill for 3 minutes, controls solid constituent particle diameter in 2 microns, grinding stirs after finishing, and obtains suspending agent product.
Embodiment 3 (preparation method of 40% thifluzamide chlorine nalidixic bacterium ester water dispersible granules)
Preparation method: after thifluzamide, chlorine nalidixic bacterium ester, methyl fatty acid amide benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together evenly, through airslide disintegrating mill, be crushed to particle diameter 5 μ m, obtain female powder, female powder is fully mixed to rear granulation, dries, sieves with sodium lignin sulfonate, thereby make water-dispersible granules.
Embodiment 4 (20% thifluzamide chlorine nalidixic bacterium ester suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (45% thifluzamide chlorine nalidixic bacterium ester missible oil)
Composition of raw materials: by mass percentage
Preparation method: active component thifluzamide is fully dissolved in dimethylbenzene reactor, make A liquid; Active component chlorine nalidixic bacterium ester is fully dissolved in dimethylbenzene reactor, make B liquid; Not stopping, under stirring, A liquid is sneaked into B liquid, stir, add anhydrous calcium salt and NP-10, then with solvent xylene, adjust content.
Embodiment 6 (preparation method of 48% thifluzamide chlorine nalidixic bacterium ester missible oil)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Control efficiency test:
The field efficiency test of rice sheath blight disease carries out in Fengyang County, and test area is 0.3hm
2, every processing in triplicate, in the control of Rise's boot period spray medicine, is carried out preventive effect investigation after 15 days in dispenser, and control the results are shown in Table 2.Result shows, the bactericidal composition that contains chlorine nalidixic bacterium ester and thifluzamide has good control efficiency to rice sheath blight disease, under same dose or lower using dosage, can reach higher control efficiency, and the preventive effect bacterium of respectively processing of this bactericidal composition is greater than 85%, is significantly higher than contrast medicament.
Table 2 thifluzamide chlorine nalidixic bacterium ester bactericidal composition is prevented and treated the land for growing field crops drug effect * of rice sheath blight disease
Because at Rise's boot period being also prevents and treats preventing and treating optimum period of false smut, we have investigated the control efficiency to false smut after chemical control simultaneously, and control the results are shown in Table 3.Result shows, the bactericidal composition that contains chlorine nalidixic bacterium ester and thifluzamide has good control efficiency to false smut, and the preventive effect under each treatment dosage, all higher than 85%, is significantly higher than the preventive effect of contrast medicament.
The field efficacy of table 3 thifluzamide chlorine nalidixic bacterium ester bactericidal composition to false smut
From the data of table 2 and table 3, the bactericidal composition that contains thifluzamide and chlorine nalidixic bacterium ester all has good preventive effect to rice sheath blight disease and false smut, and the preventive effect of different proportionings is different.It should be noted that when the proportioning of chlorine nalidixic bacterium ester and thifluzamide is 5:1, compare with other processing, under lower consumption, but two kinds of diseases are had to higher preventive effect, shown good synergistic function; And indoor biometrics result also shows, when the proportioning of chlorine nalidixic bacterium ester and thifluzamide is 5:1, the coefficient of synergism of measuring is the highest, and the result of the two is consistent.
Finally, it is also to be noted that, what more than enumerate is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, can also have a lot of distortion.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention, all think the scope of protection of the invention.
Claims (6)
1. the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide, it is characterized in that, the active component of described microbicide compositions is chlorine nalidixic bacterium ester and thifluzamide, and the mass ratio of thifluzamide and chlorine nalidixic bacterium ester is 1:20 to 20:1, and in composition, active component quality percentage composition is 5-60%.
2. the bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: described active component thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:10 to 10:1.
3. the bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:3-8.
4. the bactericidal composition containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1, is characterized in that: described thifluzamide and the mass ratio of chlorine nalidixic bacterium ester are 1:4-6.
5. the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide according to claim 1 and 2, is characterized in that: the formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
6. according to the application of the microbicide compositions containing chlorine nalidixic bacterium ester and thifluzamide described in claim 1-2 any one, it is characterized in that: for the control of rice sheath blight disease and false smut.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
| CN106922689A (en) * | 2017-04-03 | 2017-07-07 | 佛山市瑞生通科技有限公司 | A kind of bactericidal composition of the mycin of second containing fen and thifluzamide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371153A (en) * | 2012-04-28 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Sterilization composition with thifluzamide and methoxy acrylics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371153A (en) * | 2012-04-28 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Sterilization composition with thifluzamide and methoxy acrylics |
Non-Patent Citations (1)
| Title |
|---|
| 周德锋等: "新杀菌剂氯啶菌酯及其合成工艺", 《农化新世纪》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076139A (en) * | 2015-09-06 | 2015-11-25 | 安徽出入境检验检疫局检验检疫技术中心 | Bactericidal composition containing fluopyram and fluazinam |
| CN106922689A (en) * | 2017-04-03 | 2017-07-07 | 佛山市瑞生通科技有限公司 | A kind of bactericidal composition of the mycin of second containing fen and thifluzamide |
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