CN105010364B - The bactericidal composition and its application of a kind of probenazole-containing and thifluzamide - Google Patents
The bactericidal composition and its application of a kind of probenazole-containing and thifluzamide Download PDFInfo
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- CN105010364B CN105010364B CN201510392790.7A CN201510392790A CN105010364B CN 105010364 B CN105010364 B CN 105010364B CN 201510392790 A CN201510392790 A CN 201510392790A CN 105010364 B CN105010364 B CN 105010364B
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- probenazole
- thifluzamide
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- disease
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- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 56
- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 40
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- 230000000694 effects Effects 0.000 claims abstract description 17
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- 241000894006 Bacteria Species 0.000 claims description 7
- -1 thiophene furan Acid amides Chemical class 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 5
- 239000004562 water dispersible granule Substances 0.000 claims description 4
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- 238000009472 formulation Methods 0.000 claims description 2
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- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
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- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of probenazole-containing and the bactericidal composition of thifluzamide, the active component of the microbicide compositions is probenazole and thifluzamide, and thifluzamide is 1 with the mass ratio of probenazole：20 to 20:1, active component weight/mass percentage composition is 5 60% in composition.Microbicide compositions of the invention have bactericidal activity high, while delaying the drug-fast generation of pathogen and development, and prevent and treat dosage in reduction produce reality, economical, efficient, safe and environment-friendly.The present invention has good prevention effect to various crop disease, and the prevention effect to rice sheath blight disease is especially pronounced.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, and in particular to the bactericidal composition of a kind of probenazole-containing and thifluzamide and
Its application.
Background technology
It, by the popular disease in the microbial worldwide scope of miliary damping-off, is also on China paddy rice that rice sheath blight disease is
One of most important disease.Its distribution widely, has generation in each paddy rice main producing region of China, especially on middle and lower reach of Yangtze River ground
Area and South China, harm are very serious, cause yield drastically to decline.Seed selection and popularization disease-resistant variety, are preventing and treating rice banded sclerotial blights
One of important measures of disease, in recent years, although domestic and foreign scholars achieve many progress in terms of breeding for disease resistance, but there is no at present
Select to the completely immune rice varieties of rice sheath blight disease.Current Rhizoctonia solani Kuhn preventing and treating is also to rely on chemical control.
Current China has been used up the medicament based on jinggangmeisu on rice sheath blight disease is prevented and treated, and is at the initial stage of a disease in rice tillering
Latter stage diseased plant rate reaches 15% or so and starts spray preventing and treating, and achieves certain effect.But have been reported display, China part
Regional rice sheath blight disease has generated the resistance to the action of a drug to jinggangmeisu, and the prevention effect of the caused medicament constantly declines.If
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique for preventing and treating rice sheath blight disease, while administering the anti-medicine of jinggangmeisu
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Probenazole belongs to benzimidazole germicide, is a kind of efficient, wide spectrum, systemic fungicide, can prevent and treat oranges and tangerines
Storage disease, banana disease, wheat scab, bakanae disease of rice, the penicilliosis of apple core pears, anthracnose, gray mold, black star
The plurality of plant diseases such as disease, powdery mildew, have protective effect and therapeutic action concurrently to control of plant disease, can prevent and treat various crop disease
Evil, with the jinggangmeisu no interactions resistance to the action of a drug.
The chemical name of probenazole：2- (4- thiazolyls) -1H- benzimidazoles.
The chemical structural formula of probenazole is shown below：
Thifluzamide is called thiophene fluorine bacterium amine, and it is the phenyl amide compound containing thiazole ring, belongs to succinate dehydrogenase suppression
Preparation, with strong Uptake and translocation and lasting effect long, can prevent and treat various crop disease, particularly basidiomycetes Rhizoctonia fungi and draw
The disease for rising has good prevention effect.Its Main Function mechanism is to suppress succinate dehydrogenase in germ tricarboxylic acid cycle, is led
Cause thalline dead.Thifluzamide is to Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas
It is active Deng pathomycete, especially there is special efficacy to the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping-off etc., with Jing Gang
The mycin no interactions resistance to the action of a drug.
The chemical name of thifluzamide：The bromo- 2- methyl -4'- trifluoromethoxies -4- Trifluoromethyl-1s of 2', 6'- bis-, 3- thiophenes
Diazole -5- hydroxyl anilides
The chemical structural formula of thifluzamide is shown below：
Probenazole and thifluzamide bacterium are lower toxicity or micro-virus kind agricultural chemicals, belong to efficient, low toxicity, environmentally friendly type sterilization
Agent.Probenazole is mainly the succinate dehydrogenase of the cell division for acting on fungi, thifluzamide effect and thalline, so as to reach
Sterilized purpose, the two does not exist the interaction resistance to the action of a drug.But many researchs show, if both medicaments are used alone to prevent curing the disease
Evil, can in the short period of time make pathogen develop immunity to drugs, and cause preventive effect to reduce, or even preventing and treating failure.Fungicide resistance
Action Committee（FRAC）Suggestion, the composite reagent of different mechanism of action is used, and can avoid or delay drug-fast generation.
Therefore, the two is combined as bactericidal composition, can not only effectively solve the problem of preventing and treating of rice sheath blight disease, and can avoid or
Pathogen is delayed to develop immunity to drugs it.
The content of the invention
It is high with bactericidal activity the invention provides a kind of probenazole-containing and the bactericidal composition of thifluzamide, delay disease
The original resistance to the action of a drug is produced and developed, and declines dosage total in unit area, economic, efficient, environmental protection.
The technical scheme is that：
A kind of microbicide compositions of probenazole-containing and thifluzamide, it is characterised in that the work of the microbicide compositions
Property component be probenazole and thifluzamide, the mass ratio of thifluzamide and probenazole is 1：20 to 20:1, activearm in composition
Weight/mass percentage composition is divided to be 5-60%.
Described active component thifluzamide is 1 with the mass ratio of probenazole：10 to 10:1.
Described thifluzamide is 1 with the mass ratio of probenazole：3-8.
Described thifluzamide is 1 with the mass ratio of probenazole：4-6.
The formulation of the microbicide compositions is suspending agent, missible oil, water dispersible granules or wettable powder.
This microbicide compositions has prevention effect higher to various crop disease, to rice sheath blight disease controlling effect particularly
Significantly, for the preventing and treating of rice sheath blight disease and false smut.
Remarkable result of the invention and advantage are：
Two classes are had the present invention bactericide of different mechanism of action, i.e. benzimidazole germicide probenazole and SDHI classes
Bactericide thifluzamide is combined, and is processed into the upper easy-to-use preparation of production, and bioactivity is high, total use in unit area
Dose declines, and greatly reduces dispenser cost, while delaying the pathogen resistance to the action of a drug to produce and develop to a greater extent, reduces
Disease fungus produces the risk of resistance to single bactericide, the service life of each component in bactericidal composition is extended, so as to reach
To effect economic, efficiently, environmentally friendly.
The present invention has prevention effect higher to crop fungal disease, there is notable synergistic effect between two components；Can
Instead of part high price pesticide species, and dosage is reduced, effectively reduce ecological disruption and environmental pollution, and can improve and make produce
Amount and quality；Probenazole and thifluzamide belong to low toxicity in the present invention, and to people and animals, beneficial organism, Environmental security；Can
Delay germ to the resistance to the action of a drug of single medicament.
Probenazole and the single compound of thifluzamide two are determined first（Hereinafter referred to as medicament）EC50（Drug safety refers to
Mark）, according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley methods, and according to Wadley coefficient of synergism C
Value, it is determined that suitable composition ratio, is then verified by the abundant methods of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but is not limited so.Experiment uses mycelial growth determination method, by different disposal
Pastille culture medium is made, respectively 4 repetitions for the treatment of, after connecing bacterium 3 days, investigate growth inhibition effect of each treatment to Rhizoctonia solani Kuhn
Really.By the linear regression analysis between the probit value of preventive effect and the logarithm value of serial drug concentration, the EC of each medicament is obtained50,
Coefficient of synergism is calculated according to Wadley methods（SR）, and overall merit is made accordingly.SR≤0.5 represents has antagonism, 0.5
＜ SR ＜ 1.5 represent there is summation action, and SR >=1.5 are synergistic effect.SR value calculating methods are as follows：
EC50(theoretical value)=（a+b）/(a/EC50A+b/EC50B)
SR= EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5~1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have synergistic effect
The Wadley method measurement results of the thifluzamide of table 1 and probenazole composition to Rhizoctonia solani Kuhn
| Proportioning（S：SF） | Regression equation | Coefficient correlation | SR | |
| Probenazole（S） | Y=2.617X+6.010 | 0.9941 | 0.411 | |
| Thifluzamide（SF） | Y=1.397X+6.081 | 0.9948 | 0.168 | |
| 20:1 | Y=0.782X+5.479 | 0.9882 | 0.2442 | 1.5746 |
| 10:1 | Y=1.104X+5.725 | 0.9776 | 0.2203 | 1.6488 |
| 5:1 | Y=1.142X+5.915 | 0.9888 | 0.1579 | 2.0973 |
| 1:1 | Y=0.989X+5.800 | 0.9863 | 0.1551 | 1.5377 |
| 1:5 | y=0.401x+5.3657 | 0.9308 | 0.1225 | 1.5213 |
| 1:10 | Y=1.359X+6.284 | 0.9794 | 0.1127 | 1.5753 |
| 1:20 | Y=0.753X+5.630 | 0.9923 | 0.1458 | 1.1856 |
Note：S is probenazole, and SF is thifluzamide.
Can be analyzed from data above, probenazole and the suppression of the thifluzamide composition to Rhizoctonia solani Kuhn of different proportion
Bacterium effect is different, and on the whole, its ratio is 1：20 to 20：There are synergy or addition in the range of 1, wherein maximum
Enhancing proportions are 5：1.
With reference to embodiment, the invention will be further described, but not limited to this.
Specific embodiment
(the preparation method of 60% thifluzamide probenazole wettable powder of embodiment 1）
Composition of raw materials：By mass percentage
Active component thifluzamide 10%
Active component probenazole 50%
NNO 6%
Amine carbonate 3%
White carbon 10%
Kaolin surplus.
Preparation method：Above-mentioned substance is uniformly mixed, mixture is crushed through airslide disintegrating mill, wettable powder is obtained.
(the preparation method of 30% thifluzamide probenazole suspending agent of embodiment 2）
Active component thifluzamide 15%
Active component probenazole 15%
Sodium lignin sulfonate 6%
BY140 4%
Xanthans 0.1%
Propane diols 1%
Phosphate defoamer 0.1%
Water surplus.
Preparation method：According to formula, individual component is weighed in proportion, add ball mill ball milling 30 minutes, filtering is pumped into and divides
Dissipate tank high speed shear to be fully ground through sand mill after 3 minutes, within 2 microns, grinding terminates control solid constituent particle diameter
After stir, obtain final product suspending agent product.(the preparation method of 40% thifluzamide probenazole water dispersible granules of embodiment 3）
Active component thifluzamide 5%
Active component probenazole 35%
Methyl fatty acid amides benzene sulfonic acid sodium salt 5%
Sodium carbonate 3%
Sodium lignin sulfonate 6%
Attapulgite surplus.
Preparation method：Thifluzamide, probenazole, Methyl fatty acid amides benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together
After closing uniformly, 5 μm of particle diameter is crushed to through airslide disintegrating mill, obtains female powder, granulated after female powder and sodium lignin sulfonate are sufficiently mixed,
Drying, sieving, so as to water-dispersible granules are obtained.
(the 20% thifluzamide probenazole suspending agent of embodiment 4）
Active component thifluzamide 15%
Active component probenazole 5%
Sodium lignin sulfonate 6%
BY140 4%
Xanthans 0.1%
Propane diols 1%
Phosphate defoamer 0.1%
Water surplus.
Preparation method：With embodiment 2.
(the 45% thifluzamide probenazole missible oil of embodiment 5）
Composition of raw materials：By mass percentage
Active component thifluzamide 35%
Active component probenazole 10%
Anhydrous calcium salt 5%
NP-10 5%
Dimethylbenzene surplus.
Preparation method：Active component thifluzamide is fully dissolved in dimethylbenzene reactor, A liquid is made；By activearm
Divide probenazole fully to be dissolved in dimethylbenzene reactor, be made B liquid；A liquid is mixed into B liquid in the case where stirring is not stopped, is fully stirred
Mix uniform, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.
(the preparation method of 48% thifluzamide probenazole missible oil of embodiment 6）
Composition of raw materials：By mass percentage
Active component thifluzamide 36%
Active component probenazole 12%
DMF 30%
Anhydrous calcium salt 5%
NP-10 5%
Dimethylbenzene surplus.
Preparation method：With embodiment 5.
Prevention effect is tested：
The field efficiency test of rice sheath blight disease is carried out in Fengyang County, and test area is 0.3hm2, often process in triplicate,
Sprayed in Rise's boot period and prevented and treated, preventive effect investigation is carried out after 15 days in dispenser, preventing and treating the results are shown in Table 2.Result shows, contains thiophene bacterium
The bactericidal composition of spirit and thifluzamide has good prevention effect to rice sheath blight disease, in same dose or relatively low use agent
Amount is lower to reach prevention effect higher, and each treatment preventive effect bacterium of the bactericidal composition is more than 85%, is significantly higher than comparison medicine
Agent.
The thifluzamide probenazole bactericidal composition of table 2 prevents and treats the crop field drug effect * of rice sheath blight disease
Due to being also the proper control time for preventing and treating false smut in Rise's boot period, we have investigated after chemical control to rice simultaneously
The prevention effect of bent disease, preventing and treating the results are shown in Table 3.Result shows that the bactericidal composition containing probenazole and thifluzamide is bent to rice
Disease has good prevention effect, and the preventive effect under each treatment dosage is above 85%, is significantly higher than the preventive effect of comparison medicament.
Field efficacy of the thifluzamide probenazole bactericidal composition of table 3 to false smut
From table 2 and the data of table 3, the bactericidal composition containing thifluzamide and probenazole is to rice sheath blight disease and rice
Bent disease is respectively provided with good preventive effect, and the preventive effect of different ratio is different.It is worth noting that, working as probenazole and thifluzamide
Proportioning be 5：When 1, compared with other treatment, but there is preventive effect higher to two kinds of diseases under relatively low consumption, it is shown that
Preferable synergistic function；And indoor biometricses result is also indicated that, the proportioning of probenazole and thifluzamide is 5：When 1, determined
Coefficient of synergism highest, the result of the two is consistent.
Finally, in addition it is also necessary to it is noted that listed above is only several specific embodiments of the invention.Obviously, this hair
The bright embodiment for being not limited to the above, can also there is many variations.One of ordinary skill in the art can be from disclosed by the invention interior
All deformations that appearance is directly derived or associated, are considered the scope of protection of the invention.
Claims (6)
1. a kind of bactericidal composition of probenazole-containing and thifluzamide, it is characterised in that the active component of the bactericidal composition
It is probenazole and thifluzamide, thifluzamide is 1 with the mass ratio of probenazole：20 to 10:1, active component quality in composition
Percentage composition is 5-60%.
2. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, it is characterised in that：Described activity
Component thifluzamide is 1 with the mass ratio of probenazole：10 to 10:1.
3. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, it is characterised in that：Described thiophene furan
Acid amides is 1 with the mass ratio of probenazole：3-8.
4. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, it is characterised in that：Described thiophene furan
Acid amides is 1 with the mass ratio of probenazole：4-6.
5. the bactericidal composition of probenazole-containing according to claim 1 and 2 and thifluzamide, it is characterised in that：It is described to kill
The formulation of bacteria composition is suspending agent, missible oil, water dispersible granules or wettable powder.
6. the application of probenazole-containing and the bactericidal composition of thifluzamide according to claim any one of 1-2, its feature
It is：For the preventing and treating of rice sheath blight disease and false smut.
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