CN106070237A - A kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles and application thereof - Google Patents
A kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles and application thereof Download PDFInfo
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- CN106070237A CN106070237A CN201610547486.XA CN201610547486A CN106070237A CN 106070237 A CN106070237 A CN 106070237A CN 201610547486 A CN201610547486 A CN 201610547486A CN 106070237 A CN106070237 A CN 106070237A
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- Prior art keywords
- fluxapyroxad
- bacterium azoles
- nitrile bacterium
- bactericidal composition
- containsterilization
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles, the active component of described microbicide compositions is fluxapyroxad and nitrile bacterium azoles, fluxapyroxad is 1:20 to 20:1 with the mass ratio of nitrile bacterium azoles, and in compositions, active component weight/mass percentage composition is 5 60%.It is high that the microbicide compositions of the present invention has bactericidal activity, delays the drug-fast generation of pathogen and development simultaneously, and minimizing produces in reality and prevents and treats dosage, economical, efficient, safe and environment-friendly.The present invention has good prevention effect to various crop disease, especially pronounced to the prevention effect of rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to a kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles
And application.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, on Ye Shi China Oryza sativa L.
One of most important disease.Its distribution widely, has generation in China each Oryza sativa L. main producing region, especially on ground, the middle and lower reach of Yangtze River
District and South China, harm is very serious, causes yield drastically to decline.Selection-breeding and popularization disease-resistant variety, be preventing and treating rice banded sclerotial blight
One of sick important measures, in recent years, although Chinese scholars achieves a lot of progress in terms of breeding for disease resistance, but there is no at present
Select the rice varieties of immunity complete to rice sheath blight disease.Rhizoctonia solani Kuhn preventing and treating at present is also to rely on chemical control.
China is preventing and treating the medicament having been used up in rice sheath blight disease based on jingganmycin, the most i.e. at rice tillering at present
Diseased plant rate reached about 15% and started to spray medicine preventing and treating latter stage, and achieved certain effect.But have been reported display, China's part
Area rice sheath blight disease has created Drug resistance to jingganmycin, and the prevention effect of this medicament caused constantly declines.How
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique preventing and treating rice sheath blight disease, administer jingganmycin drug resistance simultaneously
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Fluxapyroxad (fluxapyroxad), chemical name: 3-(difluoro)-1-methyl-N-(3', 4', 5'-trifluoro [1,
1'-biphenyl]-2-base)-1-H-pyrazoles-4-amide, fluxapyroxad belongs to pyrazole amide series bactericidal agent, and succinate dehydrogenase suppresses
Agent, preventing and treating is had both.It can suppress the Repiration of fungus, suppresses spore-germination, and germ tube extends, mycelial growth and spore shape
Become.Can be used for the multiple fungal disease controlling and suppressing in various crop.By superior lasting effect and lasting transmission characteristic
It is integrated in one.
Fluxapyroxad molecular formula C18H12F5N3O, structural formula is:
Nitrile bacterium azoles (Myclobutanil), chemical name: 2-(4-chlorphenyl)-2-(1H, 1,2,4-triazole-1-methyl) is own
Nitrile, is class tool protection and an interior absorption triazole bactericidal agent for therapeutic activity.Mainly the biological of ergosterol of pathogen is closed
Become inhibitory action, ascomycetes, basidiomycetes have been respectively provided with preferable prevention effect.This agent lasting period is long, to crop safety, has one
Determine stimulating growth effect.Suitable for crop and safety: Fructus Mali pumilae, pears, drupe, Fructus Vitis viniferae, calabash, gardening ornamental crops are Semen Tritici aestivi, big
Wheat, Herba bromi japonici, Cotton Gossypii and Oryza sativa L. etc..To crop safety.To powdery mildew, scab, canker, rust, brown spot, graywall, black
Fringe disease has good preventive effect.
Nitrile bacterium azoles molecular formula: C15H17ClN4, molecular structural formula:
Fluxapyroxad and nitrile bacterium azoles bacterium are lower toxicity or micro-virus kind pesticide, belong to efficiently, low toxicity, environmentally friendly type kill
Microbial inoculum.Nitrile bacterium azoles mainly acts on the synthesis of pathogenic bacteria ergosterol, and fluxapyroxad acts on the Repiration of thalline, thus
Reaching the purpose of sterilization, there is not mutual Drug resistance in the two.But a lot of researchs show if both medicaments are used alone prevent and treat
Disease, can make pathogen develop immunity to drugs in the short period of time, cause preventive effect to reduce, even prevent and treat failure.Antibacterial drug resistance
Property Action Committee (FRAC) suggestion, the composite reagent of different mechanism of action is used, can avoid or delay drug-fast product
Raw.Therefore, the two is combined as bactericidal composition, can not only effectively solve the problem of preventing and treating of rice sheath blight disease, and can keep away
Exempt from or delay pathogen that it is developed immunity to drugs.
Summary of the invention
The invention provides a kind of Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles, there is bactericidal activity high, delay
Pathogen Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection.
The technical scheme is that
A kind of Fluxapyroxad-containsterilization and the microbicide compositions of nitrile bacterium azoles, it is characterised in that described microbicide compositions
Active component is fluxapyroxad and nitrile bacterium azoles, and fluxapyroxad is 1:20 to 20:1 with the mass ratio of nitrile bacterium azoles, in compositions
Active component weight/mass percentage composition is 5-60%.
Described active component fluxapyroxad is 1:10 to 10:1 with the mass ratio of nitrile bacterium azoles.
Described fluxapyroxad is 1:3-8 with the mass ratio of nitrile bacterium azoles.
Described fluxapyroxad is 1:4-6 with the mass ratio of nitrile bacterium azoles.
The dosage form of described microbicide compositions is suspending agent, cream, water dispersible granules or wettable powder.
This microbicide compositions has higher prevention effect to various crop disease, to rice sheath blight disease controlling effect particularly
Significantly, for the preventing and treating of rice sheath blight disease.
Remarkable result and the advantage of the present invention be:
Two classes are had the antibacterial of different mechanism of action, i.e. triazole bactericidal agent nitrile bacterium azoles and pyrazol acid amide by the present invention
Antibacterial fluxapyroxad is combined, and is processed into the upper easy-to-use preparation of production, and biological activity is high, total in unit are
Dosage declines, and greatly reduces dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces
Pathogenic fungi produces the risk of resistance to single antibacterial, extends the service life of each component in bactericidal composition, thus
Reach economic, efficient, the effect of environmental protection.
The present invention has higher prevention effect to crop fungal disease, there is notable synergistic effect between two components;Can
Replace part high price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and can improve and make produce
Amount and quality;In the present invention, fluxapyroxad and nitrile bacterium azoles all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security;
The pathogenic bacteria Drug resistance to single medicament can be delayed.
First fluxapyroxad and the EC of nitrile bacterium azoles two single compound (hereinafter referred to as medicament) are measured50(drug safety
Index), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley coefficient of synergism C
Value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of Rhizoctonia solani Kuhn is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC50 of each medicament,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 <
SR < 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5~1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 fluxapyroxad and the nitrile bacterium azoles compositions Wadley method measurement result to Rhizoctonia solani Kuhn
Note: F is fluxapyroxad, and J is nitrile bacterium azoles.
Can analyze from data above, the fluxapyroxad of different proportion and nitrile bacterium azoles compositions are to Rhizoctonia solani Kuhn
Fungistatic effect is different, and on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1,
Big enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% fluxapyroxad nitrile bacterium azoles wettable powder)
Composition of raw materials: by mass percentage
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 2 (preparation method of 30% fluxapyroxad nitrile bacterium azole suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters, and suction divides
Dissipating tank high speed shear to be fully ground through sand mill after 3 minutes, control solid constituent particle diameter is within 2 microns, and grinding terminates
After stir, obtain suspending agent product.
Embodiment 3 (preparation method of 40% fluxapyroxad nitrile bacterium azoles water dispersible granules)
Preparation method: by fluxapyroxad, nitrile bacterium azoles, Methyl fatty amide benzene sulfonic acid sodium salt, sodium carbonate, attapulgite together
After mix homogeneously, it is crushed to particle diameter 5 μm through jet mill, obtains female powder, make after mother's powder is sufficiently mixed with sodium lignin sulfonate
Grain, dry, sieve, thus prepare water-dispersible granules.
Embodiment 4 (20% fluxapyroxad nitrile bacterium azole suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (45% fluxapyroxad nitrile bacterium azoles cream)
Composition of raw materials: by mass percentage
Preparation method: active component fluxapyroxad fully dissolved in dimethylbenzene reactor, makes A liquid;By activity
Component nitrile bacterium azoles fully dissolves in dimethylbenzene reactor, makes B liquid;Under not stopping stirring, A liquid is mixed into B liquid, fully
Stir, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.
Embodiment 6 (preparation method of 48% fluxapyroxad nitrile bacterium azoles cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Prevention effect is tested:
The field efficiency test of rice sheath blight disease is carried out in Fengyang County, and test area is 0.3hm2, often process in triplicate,
In Rise's boot period spray medicine preventing and treating, carrying out preventive effect investigation after 15 days in dispenser, preventing and treating the results are shown in Table 2.Result shows, containing fluorine azoles
The bactericidal composition of bacterium amide and nitrile bacterium azoles has good prevention effect to rice sheath blight disease, in same dose or relatively low use
Higher prevention effect can be reached under dosage, and each process preventive effect bacterium of this bactericidal composition is more than 85%, is significantly higher than comparison
Medicament.
Table 2 fluxapyroxad myclobutanil fungicidal composition prevents and treats land for growing field crops drug effect * of rice sheath blight disease
From the data of table 2, rice sheath blight disease is had good by the bactericidal composition containing fluxapyroxad and nitrile bacterium azoles
Good preventive effect, and the preventive effect of different ratio is different.It should be noted that when the proportioning of fluxapyroxad and nitrile bacterium azoles is 5:
When 1, compared with other process, but disease is had under relatively low consumption higher preventive effect, it is shown that preferably Synergistic
Effect;And indoor biometrics result also indicates that, when the proportioning of fluxapyroxad and nitrile bacterium azoles is 5:1, the coefficient of synergism measured is
Height, the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. a Fluxapyroxad-containsterilization and the bactericidal composition of nitrile bacterium azoles, it is characterised in that active group of described bactericidal composition
Being divided into fluxapyroxad and nitrile bacterium azoles, fluxapyroxad is 1:20 to 20:1 with the mass ratio of nitrile bacterium azoles, activity group in compositions
Dividing weight/mass percentage composition is 5-60%.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of nitrile bacterium azoles, it is characterised in that: described work
Property component fluxapyroxad and nitrile bacterium azoles mass ratio be 1:10 to 10:1.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of nitrile bacterium azoles, it is characterised in that: described fluorine
Azoles bacterium amide is 1:3-8 with the mass ratio of nitrile bacterium azoles.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of nitrile bacterium azoles, it is characterised in that: described fluorine
Azoles bacterium amide is 1:4-6 with the mass ratio of nitrile bacterium azoles.
Fluxapyroxad-containsterilization the most according to claim 1 and 2 and the bactericidal composition of nitrile bacterium azoles, it is characterised in that: described
The dosage form of bactericidal composition is suspending agent, cream, water dispersible granules or wettable powder.
6., according to the Fluxapyroxad-containsterilization described in any one of claim 1-2 and the application of the bactericidal composition of nitrile bacterium azoles, it is special
Levy and be: for the preventing and treating of rice sheath blight disease.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107258796A (en) * | 2017-06-21 | 2017-10-20 | 天峨县平昌生态农业有限公司 | A kind of bactericidal composition available for controlling powdery mildew |
CN108294013A (en) * | 2018-02-02 | 2018-07-20 | 深圳诺普信农化股份有限公司 | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and its application |
CN114586791A (en) * | 2022-03-10 | 2022-06-07 | 青岛恒宁生物科技有限公司 | Bactericidal composition containing fluxapyroxad and application thereof |
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CN104365610A (en) * | 2010-08-05 | 2015-02-25 | 拜耳知识产权有限责任公司 | Active compounds combinations comprising prothioconazole and fluxapyroxad |
CN104585181A (en) * | 2014-12-30 | 2015-05-06 | 海利尔药业集团股份有限公司 | Fungicidal composition containing fluxapyroxad and prothioconazole |
CN104604883A (en) * | 2015-01-21 | 2015-05-13 | 浙江泰达作物科技有限公司 | Sterilizing composition containing fluxapyroxad and ipconazole as well as application of sterilizing composition |
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Patent Citations (4)
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CN104365610A (en) * | 2010-08-05 | 2015-02-25 | 拜耳知识产权有限责任公司 | Active compounds combinations comprising prothioconazole and fluxapyroxad |
CN103385256A (en) * | 2012-05-07 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Synergistic sterilization composition containing Xemium and triazoles |
CN104585181A (en) * | 2014-12-30 | 2015-05-06 | 海利尔药业集团股份有限公司 | Fungicidal composition containing fluxapyroxad and prothioconazole |
CN104604883A (en) * | 2015-01-21 | 2015-05-13 | 浙江泰达作物科技有限公司 | Sterilizing composition containing fluxapyroxad and ipconazole as well as application of sterilizing composition |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107258796A (en) * | 2017-06-21 | 2017-10-20 | 天峨县平昌生态农业有限公司 | A kind of bactericidal composition available for controlling powdery mildew |
CN108294013A (en) * | 2018-02-02 | 2018-07-20 | 深圳诺普信农化股份有限公司 | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and its application |
CN114586791A (en) * | 2022-03-10 | 2022-06-07 | 青岛恒宁生物科技有限公司 | Bactericidal composition containing fluxapyroxad and application thereof |
CN114586791B (en) * | 2022-03-10 | 2024-03-08 | 青岛恒宁生物科技有限公司 | Sterilization composition containing fluxapyroxad and application thereof |
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