CN105918336A - Bactericidal composition containing prothioconazole and prothioconazole - Google Patents
Bactericidal composition containing prothioconazole and prothioconazole Download PDFInfo
- Publication number
- CN105918336A CN105918336A CN201610547520.3A CN201610547520A CN105918336A CN 105918336 A CN105918336 A CN 105918336A CN 201610547520 A CN201610547520 A CN 201610547520A CN 105918336 A CN105918336 A CN 105918336A
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- CN
- China
- Prior art keywords
- prothioconazoles
- rosickyite azoles
- bactericidal composition
- prothioconazole
- azoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention discloses a bactericidal composition containing prothioconazole and prothioconazole. Active components of the bactericidal composition are prothioconazole and prothioconazole, a mass ratio of the prothioconazole to the prothioconazole is 1: 20 to 20: 1, and the mass percent of the active components in the composition is 5 to 60 percent. The bactericidal composition has high bactericidal activity, can also delay the pesticide resistance of pathogen, reduces the consumption of prevention pesticides in real production, and is economical, efficient, safe and environmentally friendly. The bactericidal composition has a higher prevention and control effect for various crops diseases caused by fusarium.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of containing prothioconazoles and the bactericidal composition of rosickyite azoles and
Application.
Background technology
Wheat scab is the disease that a kind of distribution is the widest, and almost all of wheat belt, the whole world has this disease to occur,
Especially endanger serious at gentle moist and semi-humid region.Up to now, the most head blight is not had the resistance of immunity completely
Wheat breed.So, wheat scab still relies on chemical prevention on producing.At present, on producing, wheat scab is prevented and treated
Major pharmaceutical agent be carbendazim be the benzimidazole germicide of representative.Detected on Haining city Semen Tritici aestivi disease fringe from 1992
Since the world the first Fusarium graminearum drug-fast strain to carbendazim, successively in Zhejiang, Soviet Union, Lu, the ground such as Anhui find this disease
The Drug resistance of former bacterium, and Drug resistance flora body ratio rises the most rapidly, Drug resistance pathogen distribution constantly expands, at present,
East China has been faced with the danger that the existing bactericidal agent for preventing and treating head blight such as carbendazim are failed because of Drug resistance.How to continue to control
Wheat scab, the popular harm especially controlling carbendazim-resistance head blight has become numerous scientific workers and grower
The key subjects faced.
Prothioconazoles (English name: prothioconazole), chemical name is 2-(2-(1-chlorine cyclopropyl)-3-(2-
Chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1, in 2,4-triazole-3-sulfur generations, be the triazole thioketone broad-spectrum sterilization of Bayer exploitation
Agent, registers for 2004 in multiple countries.2007 multiple for Semen Tritici aestivi, Semen arachidis hypogaeae, vegetable etc. in the U.S., Canada's registration
Disease control.The mechanism of action and feature are the precursor-lanosterol i.e. demethylation inhibitors (DMIs) of sterol in suppression fungus.
This medicine not only activity has a good systemic activity, excellent protection, treats and shovel activity and the lasting period is long.By substantial amounts of field
Between the test of pesticide effectiveness, result shows that rosickyite azoles does not only has the best safety to crop, and preventing disease theraping effect is good, and has volume increase
Effect, compared with triazole bactericidal agent, rosickyite azoles has broader spectrum of bactericidal activity.
Prothioconazoles molecular formula is: C14H15Cl2N3OS, structural formula is as follows:
Rosickyite azoles is again albendazole or albendazole, belongs to benzimidazoles compound, chemical constitution and carbendazim phase
Similar, it is widely used in medicine.This compound is exploited for agricultural recently, and various crop fungal disease is had well by performance
Prevention effect.The mechanism of action of rosickyite azoles is similar to carbendazim, but and incomplete same, suppression pathogenic fungi growth same
Time, moreover it is possible to promote that crop turns blue or green and effect of increasing both production and income.
Prothioconazoles and rosickyite azoles bacterium are lower toxicity or micro-virus kind pesticide, belong to efficient, low toxicity, environmentally friendly type sterilization
Agent, to no skin irritation, but a lot of research shows, both medicaments are used alone controlling disease, can be in relatively short period of time
Inside make pathogen develop immunity to drugs, cause preventive effect to reduce, even prevent and treat failure.If two kinds of medicaments are used alone preventing and treating gibberella saubinetii
Disease, has higher resistance risk so that it is lost efficacy in a short time.Fungicide resistance Action Committee (FRAC) advises, will
The composite reagent of different mechanism of action uses, and can avoid or delay drug-fast generation.Therefore, the two is combined as sterilization group
Compound, can not only effectively solve the production practical problem that wheat scab is difficult to prevent and treat, and pathogen can be delayed to produce it
Raw Drug resistance.
Summary of the invention
The invention provides a kind of containing prothioconazoles with the bactericidal composition of rosickyite azoles, there is bactericidal activity high, delay disease
Original Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection, red at preventing and treating Semen Tritici aestivi
Specially good effect is had in mildew.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easy-to-use system of production
Agent, is used alone in two kinds of compositions and compares, and has biological activity high, and dosage total in unit are declines, and is substantially reduced
Dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces pathogenic fungi and kill single
Microbial inoculum produces the risk of resistance, extends the service life of each component in bactericidal composition, thus realizes economy, efficient, environmental protection
Goal of the invention.
The technical scheme is that
A kind of containing prothioconazoles with the microbicide compositions of rosickyite azoles, it is characterised in that the work of described microbicide compositions
Property component be prothioconazoles and rosickyite azoles, the mass ratio of rosickyite azoles and prothioconazoles is 1:20 to 20:1, activity group in compositions
Dividing weight/mass percentage composition is 5-60%.
It is described containing prothioconazoles and the bactericidal composition of rosickyite azoles, it is characterised in that: described active component rosickyite azoles
It is 1:10 to 10:1 with the mass ratio of prothioconazoles.
It is described containing prothioconazoles and the bactericidal composition of rosickyite azoles, it is characterised in that: described rosickyite azoles and rosickyite bacterium
The mass ratio of azoles is 1:3-8.
It is described containing prothioconazoles and the bactericidal composition of rosickyite azoles, it is characterised in that: described rosickyite azoles and rosickyite bacterium
The mass ratio of azoles is 1:4-6.
It is described containing prothioconazoles and the microbicide compositions of rosickyite azoles, it is characterised in that: described microbicide compositions
Dosage form is wettable powder, water dispersible granules, suspending agent or cream.
The described application of the microbicide compositions containing prothioconazoles and rosickyite azoles, it is characterised in that: this microbicide compositions
Various crop disease microbial to reaping hook has higher prevention effect.
Remarkable result and the advantage of the present invention be:
The present invention has higher prevention effect to gibberella saubinetii disease, there is notable synergistic effect between two components；Can generation
For part high price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield can be improved
And quality；In the microbicide compositions of the present invention, prothioconazoles and rosickyite azoles all belong to the toxicity such as low, and to people and animals, have prebiotic
Thing, Environmental security；The pathogenic bacteria Drug resistance to single medicament can be delayed.
First prothioconazoles and the EC of rosickyite azoles two single compound (hereinafter referred to as medicament) are measured50(drug safety refers to
Mark), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley coefficient of synergism C
Value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is fusarium graminearum, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of fusarium graminearum is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC50 of each medicament,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 ＜
SR ＜ 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 rosickyite azoles and the prothioconazoles compositions Wadley method measurement result to wheat scab
Can analyze from data above, fusarium graminearum is pressed down by the prothioconazoles of different proportion with rosickyite azoles compositions
Bacterium effect is different, and on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1, wherein maximum
Enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% rosickyite azoles prothioconazoles wettable powder)
Composition of raw materials: by mass percentage
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 2 (preparation method of 30% rosickyite azoles prothioconazoles suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters, and suction divides
Dissipating tank high speed shear to be fully ground through sand mill after 3 minutes, control solid constituent particle diameter is within 2 microns, and grinding terminates
After stir, obtain suspending agent product.
Embodiment 3 (preparation method of 40% prothioconazoles rosickyite azoles water dispersible granules)
Preparation method: rosickyite azoles, prothioconazoles, Methyl fatty amide benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together
After closing uniformly, be crushed to particle diameter 5 μm through jet mill, obtain female powder, mother powder and sodium lignin sulfonate are sufficiently mixed rear pelletize,
Dry, sieve, thus prepare water-dispersible granules.
Embodiment 4 (20% rosickyite azoles prothioconazoles suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (45% rosickyite azoles prothioconazoles cream)
Composition of raw materials: by mass percentage
Preparation method: fully dissolved in dimethylbenzene reactor by active component prothioconazoles, makes A liquid；
Active component rosickyite azoles is fully dissolved in dimethylbenzene reactor, makes B liquid；By A under not stopping stirring
Liquid is mixed into B liquid, stirs, and adds anhydrous calcium salt and NP-10, then adjusts content with solvent xylene.
Embodiment 6 (preparation method of 48% rosickyite azoles prothioconazoles cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Prevention effect is tested:
The field efficiency test of wheat scab is carried out in Fengyang County, and test area is 0.3hm2, often process in triplicate,
Carrying out spraying medicine preventing and treating at jan flowering wheat, carry out preventive effect investigation after 15 days in dispenser, preventing and treating the results are shown in Table 2.Result shows, contains
The bactericidal composition of prothioconazoles and rosickyite azoles has good prevention effect to wheat scab, at same dose or relatively low make
With reaching higher prevention effect under dosage, and each process preventive effect bacterium of this bactericidal composition is more than 85%, and it is right to be significantly higher than
According to medicament.
Table 2 rosickyite azoles prothioconazoles bactericidal composition prevents and treats land for growing field crops drug effect * of wheat scab
From the data of table 2, the Semen Tritici aestivi microbial to reaping hook of the bactericidal composition containing prothioconazoles and rosickyite azoles is red
Mildew has good preventive effect, and the preventive effect of different ratio is different.It should be noted that when prothioconazoles and rosickyite azoles
When proportioning is 5:1, compared with other process, under relatively low consumption, but two kinds of diseases had higher preventive effect, it is shown that relatively
Good synergistic function；And indoor biometrics result also indicates that, when the proportioning of prothioconazoles and rosickyite azoles is 5:1, measured
Coefficient of synergism is the highest, and the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. one kind contains prothioconazoles and the bactericidal composition of rosickyite azoles, it is characterised in that active group of described microbicide compositions
Being divided into prothioconazoles and rosickyite azoles, rosickyite azoles is 1:20 to 20:1 with the mass ratio of prothioconazoles, active component matter in compositions
Amount percentage composition is 5-60%.
It is the most according to claim 1 containing prothioconazoles with the bactericidal composition of rosickyite azoles, it is characterised in that: described activity
Component rosickyite azoles is 1:10 to 10:1 with the mass ratio of prothioconazoles.
It is the most according to claim 1 containing prothioconazoles with the bactericidal composition of rosickyite azoles, it is characterised in that: described rosickyite
Azoles is 1:3-8 with the mass ratio of prothioconazoles.
It is the most according to claim 1 containing prothioconazoles with the bactericidal composition of rosickyite azoles, it is characterised in that: described rosickyite
Azoles is 1:4-6 with the mass ratio of prothioconazoles.
The most according to claim 1 and 2 containing prothioconazoles with the bactericidal composition of rosickyite azoles, it is characterised in that to kill described in:
The dosage form of bacteria composition is suspending agent, cream, water dispersible granules or wettable powder.
6. according to described in any one of claim 1-5 containing prothioconazoles and the application of the bactericidal composition of rosickyite azoles, its feature
It is: for the preventing and treating of various crop disease microbial to reaping hook, gibberella saubinetii disease is had the highest prevention effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610547520.3A CN105918336A (en) | 2016-07-12 | 2016-07-12 | Bactericidal composition containing prothioconazole and prothioconazole |
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| CN201610547520.3A CN105918336A (en) | 2016-07-12 | 2016-07-12 | Bactericidal composition containing prothioconazole and prothioconazole |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430426A (en) * | 2014-11-26 | 2015-03-25 | 广东中迅农科股份有限公司 | Pesticide composition containing alcohol sterene and albendazole |
| CN106342903A (en) * | 2016-08-23 | 2017-01-25 | 赖丰光 | Pesticide composition containing pesticidal plant |
| CN116267995A (en) * | 2023-02-28 | 2023-06-23 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Sterilization composition for preventing and treating wheat scab and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| CN103444742A (en) * | 2013-09-24 | 2013-12-18 | 南京农业大学 | Sterilization composition containing metconazole and albendazole |
| CN104430427A (en) * | 2014-12-30 | 2015-03-25 | 贵州道元生物技术有限公司 | Root-knot nematode preventing pesticide |
-
2016
- 2016-07-12 CN CN201610547520.3A patent/CN105918336A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| CN103444742A (en) * | 2013-09-24 | 2013-12-18 | 南京农业大学 | Sterilization composition containing metconazole and albendazole |
| CN104430427A (en) * | 2014-12-30 | 2015-03-25 | 贵州道元生物技术有限公司 | Root-knot nematode preventing pesticide |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430426A (en) * | 2014-11-26 | 2015-03-25 | 广东中迅农科股份有限公司 | Pesticide composition containing alcohol sterene and albendazole |
| CN104430426B (en) * | 2014-11-26 | 2017-11-28 | 广东中迅农科股份有限公司 | A kind of composition pesticide containing steroid enol and rosickyite azoles |
| CN106342903A (en) * | 2016-08-23 | 2017-01-25 | 赖丰光 | Pesticide composition containing pesticidal plant |
| CN116267995A (en) * | 2023-02-28 | 2023-06-23 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Sterilization composition for preventing and treating wheat scab and application thereof |
| CN116267995B (en) * | 2023-02-28 | 2023-11-03 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Sterilization composition for preventing and treating wheat scab and application thereof |
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