CN103416416B - A kind of bactericidal composition containing tiadinil - Google Patents

A kind of bactericidal composition containing tiadinil Download PDF

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Publication number
CN103416416B
CN103416416B CN201210153369.7A CN201210153369A CN103416416B CN 103416416 B CN103416416 B CN 103416416B CN 201210153369 A CN201210153369 A CN 201210153369A CN 103416416 B CN103416416 B CN 103416416B
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Prior art keywords
tiadinil
active component
active
bactericidal composition
composition containing
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CN201210153369.7A
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CN103416416A (en
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张伟
梁晓娟
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Shaanxi Yitianfeng Crop Technology Co ltd
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Shaanxi Welch Crop Protection Co Ltd
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Priority to CN201210153369.7A priority Critical patent/CN103416416B/en
Priority to CN201610087466.9A priority patent/CN105613520B/en
Publication of CN103416416A publication Critical patent/CN103416416A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a kind of bactericidal composition containing tiadinil, the bactericidal composition that contains active components A and active component B, active components A is selected from tiadinil, active component B is selected from following any one compound: dimethomorph, metalaxyl and salt, Propamocarb and salt, white urea cyanogen, and the weight ratio of active components A and active component B is 1 ︰ 80 ~ 60 ︰ 1. The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, has expanded fungicidal spectrum, and has that dosage is little, resistance of rainwater washing against, the obvious feature of synergy.<!--1-->

Description

A kind of bactericidal composition containing tiadinil
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition containing tiadinil cropApplication in disease.
Technical background
Tiadinil (Tiadinil), molecular formula: C11H10ClN3OS, chemical name: 3'-is chloro-4,4'-dimethyl-1,2,3-thiadiazoles-5-formailide, this medicament has well interior absorption, canBy root absorption, and be transmitted to rapidly other positions, be suitable for the water surface and use, the lasting period is long,Leaf blast disease and fringe rice blast are had to good prevention effect.
Dimethomorph (Dimethomorph) chemical name: (E, Z)-4-[3-(4-chlorphenyl) 3-(3,4-Dimethoxyphenyl) acryloyl] morpholine, molecular formula: C21H22ClNO4, this product is single-minded ovicidal bacteriumGuiding principle fungi bactericide, its effect feature is to destroy the formation of cell envelope, to oomycetes history of lifeThere is effect in each stage, particularly responsive at the formation stages of sporangiophore and egg spore, at the utmost pointUnder low concentration, (< 0.25 μ g/ml) is suppressed. With phenylamide medicament without cross resistance.
Metalaxyl (Metalaxyl) chemical name: D, L-N-(2,6-3,5-dimethylphenyl)-N-(2'-firstOxygen base acetyl) methyl lactamine, molecular formula: C15H21NO4. The salt of metalaxyl refers to Metalaxyl-M(Metalaxyl-M) chemical name: N-(2,6-xylyl)-N-(methoxyl group acetyl group)-D-alanine methyl esters. The systemic fungicide of metalaxyl and the protection of salt tool and therapeutic action, can quiltThe root of plant, stem, leaf absorb, and transfer to each device of plant with moisture content in plantOfficial, can do cauline leaf processing, seed treatment and soil treatment, to downy mildew, phytophthora,The caused disease of pythium spp is effective.
Propamocarb (Propamocarb) chemical name: 3-(dimethylamino) propyl carbamic acid thirdEster, molecular formula: C9H21N2O2Cl. The salt of Propamocarb refers to propamocarb (PropamocaRbhydrochloride) chemical name: propyl group-3-(dimethylamino) propyl carbamic acid saltHydrochlorate. Propamocarb and salt have local systemic action, also can be used as impregnation process and seed protectionAgent.
Frost urea cyanogen (cymoxanil) chemical name: 2-cyano group-N-[(ethylamino-) carbonyl]-2-(methoxyl groupImido grpup) acetamide, molecular formula: C7H10N4O3. Frost urea cyanogen has contact and local systemic action, can suppress spore germination, effective to downy mildew of garpe, epidemic disease etc., mixed with protective fungicideIn order to extend the lasting period.
Summary of the invention
Tiadinil, metalaxyl and salt, Propamocarb and salt, dimethomorph, white urea cyanogen single dose make for a long timeWith bringing degradation problem under resistance generation, drug effect, the bactericidal composition that the present invention proposes containsThere are active components A and active component B, and appropriate surfactant and carrier.
Containing a bactericidal composition for tiadinil, contain active components A and active component B, its featureBe: active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, described active componentA is selected from tiadinil, and active component B is selected from metalaxyl and salt, Propamocarb and salt, dimethomorph, one in white urea cyanogen. Active components A and active component B preferably weight ratio are 1 ︰ 60 ~ 40︰ 1; More preferably the weight ratio of tiadinil and dimethomorph is 1 ︰ 20 ~ 10 ︰ 1, thiophene acyl bacteriumThe weight ratio of amine and metalaxyl and salt is 1 ︰ 30 ~ 5 ︰ 1, the weight of tiadinil and Propamocarb and saltAmount is than being 1 ︰ 35 ~ 5 ︰ 1, and the weight ratio of tiadinil and white urea cyanogen is 1 ︰ 20 ~ 10 ︰ 1.
The disease of the described bactericidal composition containing tiadinil for preventing and treating crops, described farmingThing comprises cereal crops, legume crop, oil crops, fibre crops, sugar crop, melonCrop, fruits crop, dry fruit crop, hobby crop, root crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop.
Described disease comprise black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight,Droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold.
The amount of application when content of active component depends on independent use in the present composition, also depends onIn mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, also simultaneouslyRelevant with target disease. What in composition, the weight percentage of active component was gross weight conventionally1%～90%, be preferably 5%～80%. According to different preparation types, active component content modelEnclose different. Conventionally, liquid preparation contains 1%～60% active material by weight, betterGround is 5%～50%; Solid pharmaceutical preparation contains 5%～80% active material by weight, is preferably10%～80%。
In bactericidal composition of the present invention, at least contain a kind of surfactant, activity while being beneficial to useThe dispersion of component in water. Surface-active contents is 2%～30% of total formulation weight amount, and surplus isSolid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer. According toDifferent dosage form, can also contain stabilizing agent known in those skilled in the art, antifreeze in preparationDeng.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, by active component withAfter liquid flux or solid carrier mix, then add surfactant as dispersant, stabilizing agent,One or more in wetting agent, binding agent, defoamer etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
When making wettable powder, composition comprises following constituent content: active components A 1% ~ 80%, aliveProperty composition B1% ~ 60%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, filler surplus.
When making water dispersible granules, composition comprises following constituent content: active components A 1% ~ 80%,Active component B1% ~ 60%, dispersant 3% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%,Binding agent 0 ~ 4%, filler surplus.
When making suspending agent, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, defoamer 0.01% ~ 2%,Thickener 0% ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, solvent 0 ~ 30%, emulsifying agent 1% ~ 15%, antifreeze 0 ~ 8%, thickener0% ~ 2%, defoamer 0.01% ~ 2%, deionized water are supplied surplus.
When making microemulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, solvent 0 ~ 30%, emulsifying agent 3% ~ 20%, antifreeze 0 ~ 8%, defoamer0.01% ~ 2%, stabilizing agent 0 ~ 4%, deionized water is supplied surplus.
When making microcapsule suspending agent, composition comprises following constituent content: active components A0.1% ~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 10%, dispersant 1% ~ 10%, solvent 0 ~ 10%, emulsifying agent 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, deionized water add to100%。
When making microcapsule suspension-suspending agent, composition comprises following constituent content: active components A 0.1%~ 50%, active component B0.1% ~ 50%, macromolecule cyst material 2% ~ 12%, surfactant 3% ~ 15%, solvent 1% ~ 15%, emulsifying agent 1% ~ 6%, defoamer 0.01% ~ 2%, thickener 0.05% ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
When making suspension emulsion, composition comprises following constituent content: active components A 0.1% ~ 50%, activityComposition B0.1% ~ 50%, dispersant 2% ~ 10%, defoamer 0.01% ~ 2%, solvent 0 ~ 15%, increasingThick dose 0% ~ 2%, emulsifying agent 2% ~ 12%, antifreeze 0 ~ 8%, stabilizing agent 0 ~ 3%, deionized water add to100%。
Wettable powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, preventive effect higher thanSingle dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmentPollute; (3) expanded fungicidal spectrum, to multiple diseases as black spot, epidemic disease, powdery mildew, frostMildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight,Late blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold are allThere is greater activity.
Detailed description of the invention
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is weightPercentage, but the present invention is not limited thereto.
Example 1 ~ 20 wettable powder
Tiadinil, active ingredient B, dispersant, wetting agent, filler are mixed, mixed in mixed cylinderClose evenly, after airslide disintegrating mill is pulverized, mix again, can be made into of the present invention canWP product. Specifically in table 1.
The each component of table 1 example 1 ~ 20 and content
Example 21 ~ 33 water dispersible granules
By tiadinil, active ingredient B, dispersant, wetting agent, binding agent, disintegrant, filler oneRise through air-flow crushing and obtain the particle diameter needing, obtain the materials of granulating. Quantitatively send item to fluidisationIn bed granulating drier, after granulating and being dried, make water dispersible granules of the present invention and produceProduct. Specifically in table 2.
The each component of table 2 example 21 ~ 33 and content
Example 34 ~ 45 suspending agents
Dispersant, wetting agent, defoamer, thickener, antifreeze are mixed through high speed shear, adding tiadinil, active ingredient B, surplus is supplied by deionized water, ball milling in ball mill2 ~ 3 hours, make diameter of particle all below 5 μ m, make oil-suspending agent of the present invention and produceProduct. Specifically in table 3.
The each component of table 3 example 34 ~ 45 and content
Example 46 ~ 50 suspension emulsions
By dispersant, defoamer, thickener, antifreeze, stabilizing agent, solvent warp in above-mentioned formulation materialCross high speed shear-mixed even, add tiadinil, in ball mill, ball milling 2 ~ 3 hours, makes micro-Grain particle diameter all, below 5 μ m, makes tiadinil suspending agent, then activity is becomePoint B, emulsifying agent and various auxiliary agent in suspending agent, make this with the direct emulsification of high speed agitatorBright described suspension emulsion product. Specifically in table 4.
The each component of table 4 example 46 ~ 50 and content
Example 51 ~ 60 aqueous emulsions
Tiadinil, active ingredient B, solvent, emulsifying agent are added together, make to be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention. ToolBody is in table 5.
The each component of table 5 example 51 ~ 60 and content
Example 61 ~ 64 microcapsule suspending agents
By tiadinil, active component B, macromolecule cyst material, solvent, make to be dissolved into evenlyOil phase, under shearing condition, joins oil phase to contain emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus is supplied by deionized water, bi-material is at oil-water interfacesReact, form macromolecule cyst wall, make the finely disseminated microcapsule suspension of the present compositionAgent product. Specifically in table 6.
The each component of table 6 example 60 ~ 63 and content
Example 65,66 microcapsule suspensions-suspending agent
By tiadinil, macromolecule cyst material, solvent, make to be dissolved into even oil phase, by oilUnder shearing condition, join in the aqueous phase solution that contains emulsifying agent, pH adjusting agent, make pointLoose good microcapsule suspending agent. By dispersant, wetting agent, defoamer, thickener process at a high speedShear-mixed is even, adds active component B, and in ball mill, ball milling 2 ~ 3 hours, makes particulate grainFootpath all, below 5 μ m, makes suspending agent, then suspending agent is joined to micro-capsule suspensionAqueous phase solution in, deionized water is supplied surplus, makes the present composition finely disseminated micro-Capsule suspension-suspending agent product. Specifically in table 7.
Table 7 example 65,66 each component and content
By mutual to active component B dimethomorph, Propamocarb and salt, metalaxyl and salt in table 1 ~ 7, white urea cyanogenChange, can make novel formulation.
The embodiment of the present invention is the method that adopts Toxicity Determination and field test to combine. First pass throughToxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage,SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect, on this basis, then carry out field test.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is by active ingredientContent is established respectively 5 dosage processing, establishes clear water contrast. With reference to " farm-chemical indoor determination testCriterion bactericide " carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ. After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growthInhibiting rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and it is right that liquor strength (μ g/mL) converts toNumerical value (x), is tried to achieve virulence regression equation (y=a+bx) with least square method, and calculates thusGo out the EC of every kind of medicament50Value. Calculate the different proportioning synergies of two medicaments according to Wadley method simultaneouslyRatio (SR), SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 be synergistic effect. Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is tiadinil;
B selects to the one in dimethomorph, Propamocarb and salt, white urea cyanogen, metalaxyl and salt.
Application Example two:
For trying disease: cucumber downy mildew.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine the former medicine of tiadinil and dimethomorph and the two different joining through pilot studyThan effective inhibition concentration scope of mixture.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 8 tiadinil and dimethomorph
As shown in Table 8, tiadinil and dimethomorph proportioning in the time of 1 ︰ 80 ~ 60 ︰ 1 to cucumber downy mildewSynergy ratio SR be all greater than 1.5, illustrate that both all show mixture in 1 ︰ 80 ~ 60 ︰ 1 scopesGo out synergistic effect, when the proportioning of tiadinil and dimethomorph is during at 1 ︰ 20 ~ 10 ︰ 1, synergy is doneWith more obviously outstanding, synergy ratio is all more than 2.00. Especially when tiadinil and alkene acylSynergy ratio maximum when morpholine weight ratio is 1:2, synergistic effect is the most obvious. Try through applicantThe proportioning of issuing after examination and approval existing tiadinil and dimethomorph is 10:1,9:1,8:1,7:1,6:1、5：1、4：1、3：1、2：1、1：1、2：3、1：2、1：3、1：4、1：5, when 1:6,1:7,1:8,1:9,1:10,1:15,1:20, tiadinil withDimethomorph composite to black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight,Droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold control have obvious synergistic effect, synergy ratio is all more than 1.50.
Application Example three:
For trying disease: tomato late blight.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine that through pilot study tiadinil and metalaxyl and the former medicine of salt and the two are differentEffective inhibition concentration scope of proportioning mixture.
Toxicity test result
The composite toxicity test analysis of results table to tomato late blight of table 9 tiadinil and metalaxyl and salt
As shown in Table 9, tiadinil and metalaxyl and salt proportioning in the time of 1 ︰ 80 ~ 60 ︰ 1 to tomato late blightSick synergy ratio SR is all greater than 1.5, illustrates that both all show mixture in 1 ︰ 80 ~ 60 ︰ 1 scopesReveal synergistic effect, when the proportioning of tiadinil and metalaxyl and salt is during at 1 ︰ 25 ~ 5 ︰ 1, increaseEffect effect is more outstanding, and synergy ratio is all more than 2.20. Especially when tiadinil and first frostSynergy ratio maximum when spirit and salt weight ratio are 1:5, synergistic effect is the most obvious. Through applicantTest find the proportioning of tiadinil and metalaxyl and salt be 5:1,1:1,1:2,1:3,1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、1：12、1：13,, when 1:14,1:15,1:20,1:25, tiadinil and metalaxyl and salt are composite rightBlack spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust,Phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spotThe control of defoliation, rice blast, gray mold has obvious synergistic effect, and synergy ratio all exists1.50 more than.
Application Example four:
For trying disease: cucumber downy mildew.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine that through pilot study tiadinil and Propamocarb and the former medicine of salt and the two are differentEffective inhibition concentration scope of proportioning mixture.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 10 tiadinil and Propamocarb and salt
As shown in Table 10, tiadinil and Propamocarb and salt proportioning in the time of 1 ︰ 80 ~ 60 ︰ 1 to cucumber downy mildewSick synergy ratio SR is all greater than 1.5, illustrates that both all show mixture in 1 ︰ 80 ~ 60 ︰ 1 scopesReveal synergistic effect, when the proportioning of tiadinil and Propamocarb and salt is during at 1 ︰ 30 ~ 5 ︰ 1, increaseEffect effect is more obviously outstanding, and synergy ratio is all more than 2.20. Especially when tiadinil withSynergy ratio maximum when Propamocarb and salt weight ratio are 1:6, synergistic effect is the most obvious. Through ShenAsk someone to test and find that the proportioning of tiadinil and Propamocarb and salt is 5:1,1:1,1:2,1:3、1：4、1：5、1：6、1：7、1：8、1：9、1：10, when 1:11,1:12,1:13,1:14,1:15,1:20,1:25,1:30, tiadinil and Propamocarb and salt are composite to black spot, epidemic disease, powdery mildew, downy mildew, charcoalSubcutaneous ulcer disease, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight,The control of balck shank, samping off, scab, spot defoliation, rice blast, gray mold hasSignificantly synergistic effect, synergy ratio is all more than 1.50.
Application Example five:
For trying disease: downy mildew of garpe.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design: determine tiadinil and the former medicine of white urea cyanogen and the two different proportioning through pilot studyEffective inhibition concentration scope of mixture.
Toxicity test result
The composite toxicity test analysis of results table to downy mildew of garpe of table 11 tiadinil and white urea cyanogen
As shown in Table 11, the proportioning of tiadinil and white urea cyanogen in the time of 1 ︰ 80 ~ 60 ︰ 1 to downy mildew of garpeSynergy ratio SR be all greater than 1.5, illustrate that both all show mixture in 1 ︰ 80 ~ 60 ︰ 1 scopesGo out synergistic effect, when the proportioning of tiadinil and white urea cyanogen is during at 1 ︰ 15 ~ 10 ︰ 1, synergistic effectMore obviously outstanding, synergy ratio is all more than 2.10. Especially when tiadinil and white urea cyanogenSynergy ratio maximum when weight ratio is 2:3, synergistic effect is the most obvious. Send out through applicant's testThe proportioning of existing tiadinil and white urea cyanogen is 10:1,9:1,8:1,7:1,6:1,5:1、4：1、3：1、2：1、1：1、2:3、1：2、1：3、1：4、1：5、1:6、When 1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15, tiadinilWith white urea cyanogen composite to black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight,Droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold control have obvious synergistic effect, synergy ratio is all more than 1.50.
Application Example six tiadinils and active component B and the composite downy mildew of garpe drug effect of preventing and treating thereofTest
This test arrangement is in Xianyang, Shanxi province city, and test medicine is by the limited public affairs of Shaanxi Wei Erqi crop protectionDepartment researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% dimethomorphWettable powder (commercial), 25% metalaxyl wettable powder (commercial), 35% Propamocarb waterAgent (commercial), 20% white urea cyanogen wettable powder (autogamy).
The investigation downy mildew of garpe state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once,Dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculatePreventive effect. Experimental result is as follows:
Table 12 tiadinil and active component B and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 12, tiadinil and active component B can effectively prevent and treat downy mildew of garpe after composite, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to markTarget crop has no adverse effects.
Application Example seven tiadinils and active component B and composite control cucumber downy mildew drug effect thereofTest
This test arrangement is in Changan District, Xi'an City, Shanxi Province, and test medicine is by Shaanxi Wei Erqi crop protectionCo., Ltd researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% alkeneMorpholide wettable powder (commercial), 25% metalaxyl wettable powder (commercial), 20% essenceMetalaxyl missible oil (autogamy), 35% Propamocarb aqua (commercial), 20% white urea cyanogen wettable powderAgent (autogamy).
The investigation cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 daysOnce, be total to dispenser 2 times. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease indexAnd calculate preventive effect. Experimental result is as follows:
Table 13 tiadinil and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 13, tiadinil and active component B can effectively prevent and treat cucumber downy mildew after composite, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to markTarget crop has no adverse effects.
Application Example eight tiadinils and active component B and the examination of composite control tomato blight drug effect thereofTest
This test arrangement is in Weinan City Dali County, Shaanxi Province, and test medicine is by Shaanxi Wei Erqi crop protectionCo., Ltd researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% alkeneMorpholide wettable powder (commercial), 25% metalaxyl wettable powder (commercial),20% Metalaxyl-M missible oil (autogamy), 35% Propamocarb aqua (commercial), 20% white urea cyanogen are wettableProperty pulvis (autogamy).
The investigation tomato blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total toDispenser 2 times. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate anti-Effect. Experimental result is as follows:
Table 14 tiadinil and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 14, after tiadinil and active component B are composite, can effectively prevent and treat tomato blight,Prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to targetCrop has no adverse effects.
Application Example nine tiadinils and active component B and composite control rice blast drug effect thereofTest
This test arrangement is at Shaanxi Province's Hanzhong City, and test medicine is by the limited public affairs of Shaanxi Wei Erqi crop protectionDepartment researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% dimethomorphWettable powder (commercial), 25% metalaxyl wettable powder (commercial), 35% Propamocarb waterAgent (commercial), 20% white urea cyanogen wettable powder (autogamy).
The investigation rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once,Dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculatePreventive effect. Experimental result is as follows:
Table 15 tiadinil and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 15, tiadinil and active component B can effectively prevent and treat rice blast after composite, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to markTarget crop has no adverse effects.
Application Example ten tiadinils and active component B and the composite late blight of potato of preventing and treating thereofThe test of pesticide effectiveness
This test arrangement is in Jingyang County, Shaanxi Province, and test medicine is by the limited public affairs of Shaanxi Wei Erqi crop protectionDepartment researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% dimethomorphWettable powder (commercial), 25% metalaxyl wettable powder (commercial), 20% Metalaxyl-MMissible oil (autogamy), 35% Propamocarb aqua (commercial), 20% white urea cyanogen wettable powder (autogamy)。
The investigation late blight of potato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index meterCalculate preventive effect. Experimental result is as follows:
Table 16 tiadinil and active component B and the composite late blight of potato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 16, tiadinil and active component B can effectively prevent and treat horse after compositeBell potato late blight, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. In test medicationIn scope, target crop is had no adverse effects.
Application Example 11 tiadinils and active component B and composite control grey mould fruit rot of strawberry medicine thereofEffect test
This test arrangement is in Weinan City suburb, Shaanxi Province, and test medicine is had by Shaanxi Wei Erqi crop protectionLimit company researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% alkene acylMorpholine wettable powder (commercial), 25% metalaxyl wettable powder (commercial), 35% downy mildewPrestige aqua (commercial), 20% white urea cyanogen wettable powder (autogamy).
The investigation grey mould fruit rot of strawberry state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once,Dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculatePreventive effect. Experimental result is as follows:
Table 17 tiadinil and active component B and the composite control grey mould fruit rot of strawberry test of pesticide effectiveness thereof
As can be seen from Table 17, tiadinil and active component B can effectively prevent and treat grey mould fruit rot of strawberry after composite, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to markTarget crop has no adverse effects.
Application Example 12 tiadinils and active component B and composite control wheat leaf blight medicine thereofEffect test
This test arrangement is at Xian District, Shanxi Province suburban area, and test medicine is had by Shaanxi Wei Erqi crop protectionLimit company researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 50% alkene acylMorpholine wettable powder (commercial), 25% metalaxyl wettable powder (commercial), 20% smart firstFrost missible oil (autogamy), 35% Propamocarb aqua (commercial), 20% white urea cyanogen wettable powder(autogamy).
The investigation wheat leaf blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once,Dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculatePreventive effect. Experimental result is as follows:
Table 18 tiadinil and active component B and the composite control wheat leaf blight test of pesticide effectiveness thereof
As can be seen from Table 18, tiadinil and active component B can effectively prevent and treat wheat leaf blight after composite, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Test scope of medication in to markTarget crop has no adverse effects.
Application Example 13 tiadinils and active component B and composite control rose powdery mildew thereofThe test of pesticide effectiveness
This test arrangement is at Jinan City, Shandong Province Pingying County, and test medicine is by Shaanxi Wei Erqi crop protectionCo., Ltd researches and develops, provides, contrast medicament 24% tiadinil suspending agent (autogamy), 25% firstThe clever wettable powder of frost (commercial), 35% Propamocarb aqua (commercial), 20% Metalaxyl-M breastOil (autogamy), 50% dimethomorph wettable powder (commercial), 20% white urea cyanogen wettable powderAgent (autogamy).
The investigation rose powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, dispenser 2 times altogether. Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index meterCalculate preventive effect. Experimental result is as follows:
Table 19 tiadinil and active component B and the composite control rose powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 19, tiadinil and active component B can effectively prevent and treat rose white powder after compositeDisease, prevention effect is all better than the preventive effect of single dose, and the preventive effect phase is long. Right in test scope of medicationTarget crop has no adverse effects.
After draw through different local throughout the country tests, tiadinil and dimethomorph, first frostSpirit and salt, Propamocarb and salt, white urea cyanogen composite rear to the black spot in various crop, epidemic disease,Powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, the Common Diseases such as gray mold preventive effect all more than 95%, be better than single dose preventive effect, synergistic effect is brightAobvious.

Claims (6)

1. the bactericidal composition containing tiadinil, it is characterized in that effective active composition is active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, and described active components A is tiadinil, and active component B is dimethomorph.
2. the bactericidal composition containing tiadinil according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1.
3. the bactericidal composition containing tiadinil according to claim 2, is characterized in that: the weight ratio of tiadinil and dimethomorph is 1 ︰ 20 ~ 10 ︰ 1.
4. the bactericidal composition containing tiadinil according to any one described in claims 1 to 3, is characterized in that: composition is made wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
5. the bactericidal composition containing tiadinil according to claim 4 is for preventing and treating the application of corps diseases.
6. application according to claim 5, is characterized in that: described disease is black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, brown spot, leaf blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold.
CN201210153369.7A 2012-05-17 2012-05-17 A kind of bactericidal composition containing tiadinil Expired - Fee Related CN103416416B (en)

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CN101647446A (en) * 2009-06-22 2010-02-17 陕西标正作物科学有限公司 Bactericidal composite with fluopicolide and dimethomorph
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CN102316729A (en) * 2009-02-11 2012-01-11 巴斯夫欧洲公司 Dimethomorph as safener for pesticides with phytotoxic effects

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CN102316729A (en) * 2009-02-11 2012-01-11 巴斯夫欧洲公司 Dimethomorph as safener for pesticides with phytotoxic effects
CN101647446A (en) * 2009-06-22 2010-02-17 陕西标正作物科学有限公司 Bactericidal composite with fluopicolide and dimethomorph
CN101642130A (en) * 2009-09-08 2010-02-10 深圳诺普信农化股份有限公司 Bactericidal composition containing iprovalicarb
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