CN105613520B - A kind of bactericidal composition containing tiadinil - Google Patents
A kind of bactericidal composition containing tiadinil Download PDFInfo
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- CN105613520B CN105613520B CN201610087466.9A CN201610087466A CN105613520B CN 105613520 B CN105613520 B CN 105613520B CN 201610087466 A CN201610087466 A CN 201610087466A CN 105613520 B CN105613520 B CN 105613520B
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- tiadinil
- active component
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
Abstract
The invention discloses a kind of bactericidal composition containing tiadinil, the bactericidal composition containing active components A Yu active component B, active components A is selected from tiadinil, and active component B is selected from any one following compound：Dimethomorph, metalaxyl and salt, Propamocarb and salt, cymoxanil, and active components A and active component B weight ratio are the ︰ 1 of 1 ︰ 80~60.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum, and with the characteristics of dosage is small, resistance of rainwater washing against, and synergy is obvious.
Description
The application is divisional application, and for the patent application of Shaanxi Welch Crop Protection Co., Ltd., " one kind contains for original application
The bactericidal composition of tiadinil ", the application Wei ︰ 201210153369.7 of original application, original application day 2012.05.17.
Technical field
The invention belongs to technical field of pesticide, is related to a kind of bactericidal composition containing tiadinil answering in crop disease
With.
Technical background
Tiadinil (Tiadinil), molecular formula：C11H10ClN3OS, chemical name：Chloro- 4,4'- dimethyl -1,2 of 3'-,
3- thiadiazoles -5- formailides, the medicament have good absorbability, can be by root absorption, and are transmitted to other portions rapidly
Position, used suitable for the water surface, lasting period length, have preferable prevention effect to leaf blast disease and fringe rice blast.
Dimethomorph (Dimethomorph) chemical name：(E, Z) -4- [3- (4- chlorphenyls) 3- (3,4- dimethoxy benzenes
Base) acryloyl] morpholine, molecular formula：C21H22ClNO4, this product be it is single-minded kill Oomycete fungal bactericide, its action character be destroy
The formation of cell envelope, there is effect to each stage of the oomycetes history of life, it is outstanding in the formation stages of sporangiophore and egg spore
For sensitivity, at much lower concentrations (<0.25 μ g/ml) it is suppressed.With phenylamide medicament no interactions resistance.
Metalaxyl (Metalaxyl) chemical name：D, L-N- (2,6- 3,5-dimethylphenyls)-N- (2'- methoxyl groups acetyl) third
Propylhomoserin methyl esters, molecular formula：C15H21NO4.The salt of metalaxyl refers to Metalaxyl-M (Metalaxyl-M) chemical name：N- (2,6- bis-
Tolyl)-N- (Methoxyacetyl)-D- alanine methyl esters.Metalaxyl and the absorbability of the protection of salt tool and therapeutic action are sterilized
It agent, can be absorbed by the root, stem, leaf of plant, and be operated with plant moisture in vivo and be transferred to each organ of plant, cauline leaf can be made
Processing, seed treatment and soil treatment are effective to the disease caused by downy mildew, phytophthora, pythium spp.
Propamocarb (Propamocarb) chemical name：3- (dimethylamino) propyl carbamic acid propyl ester, molecular formula：
C9H21N2O2Cl.The salt of Propamocarb refers to propamocarb (Propamocarb hydrochloride) chemical name：Propyl group-
3- (dimethylamino) propyl carbamic acid hydrochloride.Propamocarb and salt have local systemic action, also can be used as impregnation
And seed protectant.
Cymoxanil (cymoxanil) chemical name：2- cyano group-N- [(ethylamino-) carbonyl] -2- (methoxyl group imido grpup) second
Acid amides, molecular formula：C7H10N4O3.Cymoxanil have contact and local systemic action, spore germination can be suppressed, to downy mildew of garpe,
Epidemic disease etc. is effective, mixed with protective fungicide to extend the lasting period.
The content of the invention
Tiadinil, metalaxyl and salt, Propamocarb and salt, dimethomorph, the long-term use of cymoxanil single dose may bring anti-
Property occur, the problems such as drug effect declines, bactericidal composition proposed by the present invention contains active components A and active component B, and in right amount
Surfactant and carrier.
A kind of bactericidal composition containing tiadinil, contains active components A and active component B, it is characterised in that：Activity into
It is the ︰ 1 of 1 ︰ 80~60 to divide A and active component B weight ratio, and described active components A is selected from tiadinil, and active component B is selected from first
White spirit and one of salt, Propamocarb and salt, dimethomorph, cymoxanil kind.Active components A and active component B preferably weight ratios
For the ︰ 1 of 1 ︰ 60~40；More preferably the weight ratio of tiadinil and dimethomorph is the ︰ 1 of 1 ︰ 20~10, tiadinil and metalaxyl
And the weight ratio of salt is the ︰ 1 of 1 ︰ 30~5, the weight ratio of tiadinil and Propamocarb and salt be the ︰ 1 of 1 ︰ 35~5, tiadinil with it is white
The weight ratio of urea cyanogen is the ︰ 1 of 1 ︰ 20~10.
The described bactericidal composition containing tiadinil is used for the disease for preventing and treating crops, and described crops include grain
Crop, legume crop, oil crops, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby
Crop, root crop, flower crop, medicinal crop, crop, green manure pasture crop.
Described disease includes black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, epidemic disease
Mildew, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, gray mold.
The amount of application when content of active component depends on being used alone in the present composition, also depends on a kind of chemical combination
Thing and the mixed ratio and synergistic effect degree of another compound, at the same it is also relevant with target disease.In usual composition
The weight percentage of active component is the 1%~90% of gross weight, preferably 5%~80%.According to different preparation classes
Type, active component content scope are different.Generally, liquid preparation contains by weight 1%~60% active material, preferably
Ground is 5%~50%；Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of administration when active component in water
It is scattered.Surface-active contents are the 2%~30% of total formulation weight, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art：It can be selected from
One or more in dispersant, wetting agent, thickener or defoamer.According to different dosage forms, this area can also be contained in preparation
Stabilizer, antifreeze well known to technical staff etc..
The bactericidal composition of the present invention can be used by user before use through dilution or directly.Its preparation can be by ability
Prepared by the processing method well known to field technique personnel, i.e., after active component is mixed with liquid flux or solid carrier, add
One or more in surfactant such as dispersant, stabilizer, wetting agent, binding agent, defoamer.
The bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred agent
Type is wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-outstanding
Floating agent.
Composition includes following constituent content when wettable powder is made：Active components A 1%~80%, active component
B1%~60%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 1%~80%, active component B
1%~60%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~4%, more than filler
Amount.
Composition includes following constituent content when suspending agent is made：Active components A 0.1%~50%, active component B
0.1%~50%, dispersant 2%~10%, wetting agent 2%~10%, defoamer 0.01%~2%, thickener 0%~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqueous emulsion is made：Active components A 0.1%~50%, active component B
0.1%~50%, solvent 0~30%, emulsifying agent 1%~15%, antifreeze 0~8%, thickener 0%~2%, defoamer
0.01%~2%, deionized water supplies surplus.
Composition includes following constituent content when microemulsion is made：Active components A 0.1%~50%, active component B
0.1%~50%, solvent 0~30%, emulsifying agent 3%~20%, antifreeze 0~8%, defoamer 0.01%~2%, stabilizer
0~4%, deionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.1%~50%, active component B
0.1%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, solvent 0~10%, emulsifying agent 1%~
7%th, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.1%~50%, activity
Composition B 0.1%~50%, macromolecule cyst material 2%~12%, surfactant 3%~15%, solvent 1%~15%,
Emulsifying agent 1%~6%, defoamer 0.01%~2%, thickener 0.05%~2%, pH adjusting agent 0.01%~5%, deionization
Water adds to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.1%~50%, active component B
0.1%~50%, dispersant 2%~10%, defoamer 0.01%~2%, solvent 0~15%, thickener 0%~2%, emulsification
Agent 2%~12%, antifreeze 0~8%, stabilizer 0~3%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The advantage of the invention is that：
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) agriculture
Medicinal dose is reduced, and is reduced residual quantity of the agricultural chemicals on crop, is mitigated environmental pollution；(3) fungicidal spectrum is expanded, to multiple diseases
Such as black spot, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, evening
Epidemic disease, balck shank, samping off, scab, spot defoliation, rice blast, gray mold have greater activity.
Embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The invention is not limited in this.
The wettable powder of example 1~20
Tiadinil, active ingredient B, dispersant, wetting agent, filler are mixed, are well mixed in mixed cylinder, through air-flow
Pulverizer remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
The each component of 1 example of table 1~20 and content
The water dispersible granules of example 21~33
Tiadinil, active ingredient B, dispersant, wetting agent, binding agent, disintegrant, filler are obtained through air-flow crushing together
To the particle diameter of needs, materials of pelletizing are obtained.Item is quantified and is sent into fluidized bed granulating dryer after granulation and drying, system
Obtain water dispersible granules product of the present invention.Specifically it is shown in Table 2.
The each component of 2 example of table 21~33 and content
The suspending agent of example 34~45
Dispersant, wetting agent, defoamer, thickener, antifreeze are well mixed by high speed shear, add thiophene acyl bacterium
Amine, active ingredient B, surplus are supplied with deionized water, ball milling 2~3 hours in ball mill, make diameter of particle all 5 μm with
Under, oil-suspending agent product of the present invention is made.Specifically it is shown in Table 3.
The each component of 3 example of table 34~45 and content
The suspension emulsion of example 46~50
Dispersant, defoamer, thickener, antifreeze, stabilizer, solvent in above-mentioned formulation material are mixed by high speed shear
Uniformly, tiadinil is added, ball milling 2~3 hours in ball mill, makes diameter of particle all below 5 μm, tiadinil is made
Suspending agent, then active component B, emulsifying agent and various auxiliary agents are directly emulsified in suspending agent with high speed agitator, this is made
The described suspension emulsion product of invention.Specifically it is shown in Table 4.
The each component of 4 example of table 46~50 and content
The aqueous emulsion of example 51~60
Tiadinil, active ingredient B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By deionized water,
Antifreeze, thickener, defoamer mix, into homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added into oil phase, this is made
The described aqueous emulsion production of invention
Product.Specifically it is shown in Table 5.
The each component of 5 example of table 51~60 and content
The microcapsule suspending agent of example 61~64
Tiadinil, active component B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, is shearing
Under the conditions of, by oil phase be added to containing emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus deionization
Water is supplied, and two kinds of materials react in oil-water interfaces, forms high score ascus wall, and well dispersed micro- of the present composition is made
Capsule suspending agent product.Specifically it is shown in Table 6.
The each component of 6 example of table 60~63 and content
Example 65,66 microcapsule suspension-suspendinagent agents
Tiadinil, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifying agent, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Profit agent, defoamer, thickener are well mixed by high speed shear, addition active component B, ball milling 2~3 hours in ball mill,
Make diameter of particle all below 5 μm, suspending agent is made, then suspending agent is added to the aqueous phase solution of micro-capsule suspension
In, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent product of the present composition is made.Specifically it is shown in Table 7.
The example 65 of table 7,66 each components and content
Active component B dimethomorphs, Propamocarb and salt, metalaxyl and salt, cymoxanil in table 1~7 are exchanged, can be made new
Preparation.
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.First pass through indoor virulence survey
It is fixed, clear and definite two kinds of medicaments compound by a certain percentage after synergy ratio (SR), SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field test.
Test method：After prerun determines the effective inhibition concentration scope of each medicament, medicament sets 5 respectively by active constituent content
Individual dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule bactericide》Carry out, using mycelial growth speed
Rate method determines virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley methods
Two medicament different ratio synergy ratios (SR) are calculated, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 are synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active component B ratio shared in combination；
A is tiadinil；
B is selected to one of dimethomorph, Propamocarb and salt, cymoxanil, metalaxyl and salt kind.
Application Example two：
For trying disease：Cucumber downy mildew.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design：Having for tiadinil and dimethomorph active compound and the two different ratio mixture is determined by pilot study
Imitate inhibition concentration scope.
Toxicity test result
The tiadinil of table 8 compounds the toxicity test analysis of results table to cucumber downy mildew with dimethomorph
As shown in Table 8, tiadinil is matched in 1 80~60 ︰ 1 of ︰ to the synergy ratio of cucumber downy mildew with dimethomorph
SR is all higher than 1.5, illustrates that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~60, when tiadinil and alkene acyl
In 1 20~10 ︰ 1 of ︰, synergistic effect becomes apparent protruding the proportioning of quinoline, and synergy ratio is more than 2.00.Especially when thiophene acyl
Bacterium amine is 1 with dimethomorph weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most obvious.Tested through applicant and find thiophene acyl
The proportioning of bacterium amine and dimethomorph is 10：1、9：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、2：3、1：2、1：3、1：
4、1：5、1：6、1：7、1：8、1：9、1：10、1：15、1：When 20, tiadinil and dimethomorph are compounded to black spot, epidemic disease, white
Powder disease, downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, damping off
The preventing and treating of disease, scab, spot defoliation, rice blast, gray mold has an obvious synergistic effect, synergy ratio 1.50 with
On.
Application Example three：
For trying disease：Tomato late blight.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design：Tiadinil and metalaxyl and salt active compound and the two different ratio mixture are determined by pilot study
Effective inhibition concentration scope.
Toxicity test result
The tiadinil of table 9 compounds the toxicity test analysis of results table to tomato late blight with metalaxyl and salt
As shown in Table 9, tiadinil is matched in 1 80~60 ︰ 1 of ︰ to the synergic ratio of tomato late blight with metalaxyl and salt
Value SR is all higher than 1.5, illustrates that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~60, when tiadinil and first frost
For the proportioning of spirit and salt in 1 25~5 ︰ 1 of ︰, synergistic effect is more prominent, and synergy ratio is more than 2.20.Especially when thiophene acyl
Bacterium amine is 1 with metalaxyl and salt weight ratio：Synergy ratio is maximum when 5, and synergistic effect is the most obvious.Tested through applicant and find thiophene
Acyl bacterium amine is 5 with the proportioning of metalaxyl and salt：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、
1：12、1：13、1：14、1：15、1：20、1：When 25, tiadinil and metalaxyl and salt compounding to black spot, epidemic disease, powdery mildew,
It is downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, black
The preventing and treating of star disease, spot defoliation, rice blast, gray mold has obvious synergistic effect, and synergy ratio is more than 1.50.
Application Example four：
For trying disease：Cucumber downy mildew.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design：Tiadinil and Propamocarb and salt active compound and the two different ratio mixture are determined by pilot study
Effective inhibition concentration scope.
Toxicity test result
The tiadinil of table 10 compounds the toxicity test analysis of results table to cucumber downy mildew with Propamocarb and salt
As shown in Table 10, tiadinil is matched in 1 80~60 ︰ 1 of ︰ to the synergic ratio of cucumber downy mildew with Propamocarb and salt
Value SR is all higher than 1.5, illustrates that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~60, when tiadinil and downy mildew
In 1 30~5 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and synergy ratio is more than 2.20 for prestige and the proportioning of salt.Especially when
Tiadinil is 1 with Propamocarb and salt weight ratio：Synergy ratio is maximum when 6, and synergistic effect is the most obvious.Test and send out through applicant
Existing tiadinil is 5 with the proportioning of Propamocarb and salt：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：
11、1：12、1：13、1：14、1：15、1：20、1：25、1：When 30, tiadinil is with Propamocarb and salt compounding to black spot, epidemic disease
Disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, black shin
The preventing and treating of disease, samping off, scab, spot defoliation, rice blast, gray mold has an obvious synergistic effect, and synergy ratio is equal
More than 1.50.
Application Example five：
For trying disease：Downy mildew of garpe.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental design：The effective of tiadinil and cymoxanil active compound and the two different ratio mixture is determined by pilot study
Inhibition concentration scope.
Toxicity test result
The tiadinil of table 11 compounds the toxicity test analysis of results table to downy mildew of garpe with cymoxanil
As shown in Table 11, the proportioning of tiadinil and cymoxanil in 1 80~60 ︰ 1 of ︰ to the synergy ratio of downy mildew of garpe
SR is all higher than 1.5, illustrates that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~60, when tiadinil and cymoxanil
Proportioning in 1 15~10 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and synergy ratio is more than 2.10.Especially when thiophene acyl bacterium
Amine is 2 with cymoxanil weight ratio：Synergy ratio is maximum when 3, and synergistic effect is the most obvious.Tested through applicant and find tiadinil
Proportioning with cymoxanil is 10：1、9：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、2:3、1：2、1：3、1：4、1：5、
1:6、1:7、1:8、1:9、1:10、1:11、1:12、1:13、1:14、1:When 15, tiadinil and cymoxanil compound to black spot,
Epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, droop, rust, phytophthora root rot, brown spot, leaf blight, late blight, black shin
The preventing and treating of disease, samping off, scab, spot defoliation, rice blast, gray mold has an obvious synergistic effect, and synergy ratio is equal
More than 1.50.
The tiadinil of Application Example six and active component B and its compounding preventing and treating downy mildew of garpe test of pesticide effectiveness
This test arrangement in Xianyang, Shanxi province city, by Shaanxi Welch Crop Protection Co., Ltd. researched and developed, carried by test medicine
For the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% metalaxyl can
WP (purchased in market), 35% Propamocarb aqua (purchased in market), 20% cymoxanil wettable powder (autogamy).
The downy mildew of garpe state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.
7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 12 and active component B and its compounding preventing and treating downy mildew of garpe test of pesticide effectiveness
As can be seen from Table 12, tiadinil after active component B compoundings with can effectively prevent and treat downy mildew of garpe, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example seven and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
This test arrangement is ground in Xi'an City, Shanxi Province Changan District, test medicine by Shaanxi Welch Crop Protection Co., Ltd.
Hair, provide, the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% first
The clever wettable powder (purchased in market) of frost, 20% Metalaxyl-M missible oil (autogamy), 35% Propamocarb aqua (purchased in market), 20% cymoxanil can
WP (autogamy).
The cucumber downy mildew state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.
7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 13 and active component B and its compounding preventing and treating cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 13, tiadinil after active component B compoundings with can effectively prevent and treat cucumber downy mildew, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example eight and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
This test arrangement is ground in Shaanxi Province Weinan City Dali County, test medicine by Shaanxi Welch Crop Protection Co., Ltd.
Hair, provide, the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% first
The clever wettable powder (purchased in market) of frost, 20% Metalaxyl-M missible oil (autogamy), 35% Propamocarb aqua (purchased in market), 20% cymoxanil can
WP (autogamy).
The tomato blight state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.The
7 days after secondary dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 14 and active component B and its compounding preventing and treating tomato blight test of pesticide effectiveness
As can be seen from Table 14, for tiadinil with can effectively prevent and treat tomato blight after active component B compoundings, prevention effect is equal
Better than the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example nine and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
This test arrangement in Shaanxi Province's Hanzhong City, by Shaanxi Welch Crop Protection Co., Ltd. researched and developed, carried by test medicine
For the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% metalaxyl can
WP (purchased in market), 35% Propamocarb aqua (purchased in market), 20% cymoxanil wettable powder (autogamy).
The rice blast state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.
7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 15 and active component B and its compounding preventing and treating rice blast test of pesticide effectiveness
As can be seen from Table 15, tiadinil after active component B compoundings with can effectively prevent and treat rice blast, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example ten and active component B and its compounding preventing and treating late blight of potato test of pesticide effectiveness
This test arrangement in Shaanxi Province Jingyang County, by Shaanxi Welch Crop Protection Co., Ltd. researched and developed, carried by test medicine
For the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% metalaxyl can
WP (purchased in market), 20% Metalaxyl-M missible oil (autogamy), 35% Propamocarb aqua (purchased in market), 20% cymoxanil wettable powder
Agent (autogamy).
The late blight of potato state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2
It is secondary.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 16 and active component B and its compounding preventing and treating late blight of potato test of pesticide effectiveness
As can be seen from Table 16, tiadinil is with can effectively prevent and treat the late blight of potato, preventing and treating effect after active component B compoundings
Fruit is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example 11 and active component B and its compounding preventing and treating grey mould fruit rot of strawberry test of pesticide effectiveness
This test arrangement is ground in Shaanxi Province Weinan suburban area, test medicine by Shaanxi Welch Crop Protection Co., Ltd.
Hair, provide, the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% first
The clever wettable powder (purchased in market) of frost, 35% Propamocarb aqua (purchased in market), 20% cymoxanil wettable powder (autogamy).
The grey mould fruit rot of strawberry state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.
7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 17 and active component B and its compounding preventing and treating grey mould fruit rot of strawberry test of pesticide effectiveness
As can be seen from Table 17, tiadinil after active component B compoundings with can effectively prevent and treat grey mould fruit rot of strawberry, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example 12 and active component B and its compounding preventing and treating wheat leaf blight test of pesticide effectiveness
This test arrangement is ground in Xian District, Shanxi Province suburban area, test medicine by Shaanxi Welch Crop Protection Co., Ltd.
Hair, provide, the tiadinil suspending agent (autogamy) of comparison medicament 24%, 50% dimethomorph wettable powder (purchased in market), 25% first
The clever wettable powder (purchased in market) of frost, 20% Metalaxyl-M missible oil (autogamy), 35% Propamocarb aqua (purchased in market), 20% cymoxanil can
WP (autogamy).
The wheat leaf blight state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2 times.
7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 18 and active component B and its compounding preventing and treating wheat leaf blight test of pesticide effectiveness
As can be seen from Table 18, tiadinil after active component B compoundings with can effectively prevent and treat wheat leaf blight, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The tiadinil of Application Example 13 and active component B and its compounding preventing and treating rose powdery mildew test of pesticide effectiveness
This test arrangement is ground in Jinan City, Shandong Province Pingying County, test medicine by Shaanxi Welch Crop Protection Co., Ltd.
Hair, provide, the tiadinil suspending agent (autogamy) of comparison medicament 24%, 25% metalaxyl wettable powder (purchased in market), 35% downy mildew
Prestige aqua (purchased in market), 20% Metalaxyl-M missible oil (autogamy), 50% dimethomorph wettable powder (purchased in market), 20% cymoxanil can
WP (autogamy).
The rose powdery mildew state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days once, is total to dispenser 2
It is secondary.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
The tiadinil of table 19 and active component B and its compounding preventing and treating rose powdery mildew test of pesticide effectiveness
As can be seen from Table 19, tiadinil is with can effectively prevent and treat rose powdery mildew, preventing and treating effect after active component B compoundings
Fruit is superior to the preventive effect of single dose, and preventive effect phase is grown.Target crop is had no adverse effects in experiment scope of medication.
The experiment by different places throughout the country is drawn afterwards, tiadinil and dimethomorph, metalaxyl and salt, downy mildew
To the black spot in various crop, epidemic disease, powdery mildew, downy mildew, anthracnose, banded sclerotial blight, withered after prestige and salt, cymoxanil compounding
Disease, rust, phytophthora root rot, brown spot, leaf blight, late blight, balck shank, samping off, scab, spot defoliation, rice blast, ash
The preventive effect of the Common Diseases such as mildew is obvious better than single dose preventive effect, synergistic effect more than 95%.
Claims (6)
1. a kind of bactericidal composition containing tiadinil, it is characterised in that contain active components A and active component B, active components A
Be the ︰ 1 of 1 ︰ 80~60 with active component B weight ratio, described active components A is selected from tiadinil, active component B be Propamocarb and
Salt.
2. the bactericidal composition according to claim 1 containing tiadinil, it is characterised in that：Active components A with activity into
The weight ratio for dividing B is the ︰ 1 of 1 ︰ 60~40.
3. the bactericidal composition according to claim 2 containing tiadinil, it is characterised in that：Tiadinil and Propamocarb and
The weight ratio of salt is the ︰ 1 of 1 ︰ 30~5.
4. the bactericidal composition according to claim 3 containing tiadinil, it is characterised in that：Wettable powder is made in composition
Agent, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the bactericidal composition according to claim 4 containing tiadinil is used for the application for preventing and treating corps diseases.
6. application according to claim 5, it is characterised in that：Described disease includes black spot, epidemic disease, powdery mildew, frost
Mildew, anthracnose, banded sclerotial blight, droop, rust, brown spot, leaf blight, balck shank, samping off, scab, spot defoliation,
Rice blast, gray mold.
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| CN101647446A (en) * | 2009-06-22 | 2010-02-17 | 陕西标正作物科学有限公司 | Bactericidal composite with fluopicolide and dimethomorph |
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| CN102057928A (en) * | 2010-12-31 | 2011-05-18 | 河北省农林科学院植物保护研究所 | Composite bactericide for controlling fruit and vegetable oomycetes diseases |
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