CN104336027B - A kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone - Google Patents
A kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone Download PDFInfo
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- ethyl ketone
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- thiazole pyrrole
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Abstract
The invention discloses a kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone, the bactericidal composition containing active components A Yu active constituent B, active components A is selected from fluorine thiazole pyrrole ethyl ketone, and active constituent B is selected from any one following compound：Zoxamide, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium amine, pyrimorph Huo hymexazos, and active components A and the weight ratio of active constituent B are 1: 80~60: 1.The present composition has the multiple diseases in various crop a greater activity, and with apparent synergistic effect, expands fungicidal spectrum, and with the characteristics of dosage is small, resistance of rainwater washing against, and synergy is apparent.
Description
Technical field
The invention belongs to technical field of pesticide, are related to a kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone in crop disease
Application.
Technical background
Fluorine thiazole pyrrole ethyl ketone is a kind of novel fungicide, notable to downy mildew, the preventive effect of epidemic disease.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the generation of disease drug resistance.No
It is compounded with kind ingredient, is to prevent the very common method of resistance disease.Heterogeneity is compounded, and is imitated according to practical application
Fruit, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of pesticide is all to add
And effect, the compounding for really having synergistic effect is seldom, especially synergistic effect clearly, the very high compounding of synergy ratio just more
It is few.It studies, is found fluorine thiazole pyrrole ethyl ketone and zoxamide, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium by inventor
Amine, pyrimorph Huo hymexazos mutually compound, and have good synergistic effect in a certain range, and in relation to fluorine thiazole pyrrole ethyl ketone and
Zoxamide, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium amine, pyrimorph Huo hymexazos correlation compounding, at present at home and abroad still
Have no relevant report.
Invention content
There is synergistic function, the fluorine-containing thiazole pyrrole that use cost is low, preventive effect is good the purpose of the present invention is to propose to a kind of
The composition pesticide of ethyl ketone.
The present invention is to be achieved through the following technical solutions：
A kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone, containing active components A and active constituent B, active components A and work
Property ingredient B weight ratios be 1: 80~60: 1, the active components A is selected from fluorine thiazole pyrrole ethyl ketone, and active constituent B is selected from benzoyl bacterium
One kind in amine, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium amine, pyrimorph Huo hymexazos；Preferably active components A and work
Property ingredient B weight ratio be 1 ︰, 60~40 ︰ 1；More preferably the weight ratio of fluorine thiazole pyrrole ethyl ketone and zoxamide is 1: 20~10:
1, the weight ratio of fluorine thiazole pyrrole ethyl ketone and dimethomorph is 1: 20~10: 1, and fluorine thiazole pyrrole ethyl ketone and the weight ratio of pyrrole metsulfovax are
1: 20~20: 1, the weight ratio of fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine is 1: 20~10: 1, fluorine thiazole pyrrole ethyl ketone and fourth pyrrole
The weight ratio of quinoline is 1: 20~10: 1；Most preferably the weight ratio of fluorine thiazole pyrrole ethyl ketone and zoxamide is 1: 9~4: 1, fluorine thiophene
The weight ratio of azoles pyrrole ethyl ketone and dimethomorph is 1: 9~4: 1, and fluorine thiazole pyrrole ethyl ketone and the weight ratio of pyrrole metsulfovax are 1: 9~9:
1, the weight ratio of fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine is 1: 9~4: 1, and the weight ratio of fluorine thiazole pyrrole ethyl ketone and pyrimorph is
1: 9~4: 1.
Wettable powder, water dispersible granules, suspension is made in the composition pesticide of the fluorine-containing thiazole pyrrole ethyl ketone, composition
Aqua, kind can also be made in agent, oil-suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent
Clothing agent, suspension seed-coating agent.
The composition pesticide of the fluorine-containing thiazole pyrrole ethyl ketone is used to prevent the disease of crop, and the crop includes grain
Crop, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, rhizome
Class crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop；The disease include downy mildew,
It is peronospora tabacina, epidemic disease, balck shank, gray mold, brown spot, powdery mildew, rust, sclerotiniose, rice blast, damping-off, banded sclerotial blight, complete
Lose disease, head blight, snow mold, root rot, glume blight, samping off or droop.
The amount of application when content of active constituent depends on being used alone in the bactericidal composition of the present invention, also depends on one
Kind compound and another mixed ratio of compound and synergistic effect degree, at the same it is also related with target disease.Usual group
The weight percentage for closing active constituent in object is the 1%~90% of total weight, preferably 5%~80%.According to different preparations
Type, active component content range are different.In general, liquid preparation contains by weight 1%~60% active material, preferably
Ground is 5%~50%；Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
At least containing a kind of surfactant in the bactericidal composition of the present invention, so that active component is in water during application
Dispersion.Surface-active contents are the 2%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can be used through dilution or directly before use by user.Its preparation can be by ability
Prepared by the processing method well known to field technique personnel, i.e., after active constituent is mixed with liquid flux or solid carrier, add
Surfactant such as one or more of dispersant, stabilizer, wetting agent, binding agent, antifreeze, disintegrant, antifoaming agent etc..
According to different dosage forms, antifreeze known in those skilled in the art etc. can also be contained in preparation.
Comprising following component and content when wettable powder is made in composition：Active components A 0.5%~60%, active constituent
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, filler surplus.
Composition includes following component and content when water dispersible granules are made：Active components A 0.5%~60%, active constituent
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~8%, filler surplus.
Composition includes following component and content when suspending agent or oil-suspending agent is made：Active components A 0.5%~50% is lived
It is property ingredient B0.5%~50%, dispersant 1%~10%, wetting agent 1%~10%, antifoaming agent 0.01%~2%, thickener 0~2%, freeze proof
Agent 0~8%, deionized water or vegetable oil add to 100%.
Composition includes following component and content when aqueous emulsion is made：Active components A 0.5%~50%, active constituent B0.5%
~50%, solvent 1%~20%, emulsifier 1%~12%, antifreeze 0~8%, antifoaming agent 0.01%~2%, thickener 0~2%, go from
Sub- water adds to 100%.
Composition includes following component and content when microemulsion is made：Active components A 0.5%~50%, active constituent B0.5%
~50%, emulsifier 3%~25%, solvent 1%~10%, antifreeze 0~8%, antifoaming agent 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when suspension emulsion is made：Active components A 0.5%~50%, active constituent B0.5%
~50%, emulsifier 1%~10%, dispersant 1%~10%, solvent 1%~20%, antifoaming agent 0.01%~2%, thickener 0~2%, anti-
Freeze agent 0~8%, deionized water adds to 100%.
Composition includes following component and content when microcapsule suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, macromolecule cyst material 1%~10%, dispersant 2%~10%, solvent 1%~10%, emulsifier 1%~7%, pH tune
Section agent 0.01%~5%, antifoaming agent 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
Ingredient B0.5%~50%, macromolecule cyst material 1%~12%, dispersant 1%~12%, wetting agent 1%~8%, solvent 1%~15%,
Emulsifier 1%~8%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
（1）The present composition has good synergy and lasting effect in a certain range, and preventive effect is higher than single dose；（2）Agriculture
Medicinal dose is reduced, and is reduced residual quantity of the pesticide on crop, is mitigated environmental pollution；（3）Fungicidal spectrum is expanded, to multiple diseases
As downy mildew, peronospora tabacina, epidemic disease, balck shank, gray mold, brown spot, powdery mildew, rust, sclerotiniose, rice blast, damping-off,
Banded sclerotial blight, full rot, head blight, snow mold, root rot, glume blight, samping off or droop have greater activity.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~14 wettable powder of embodiment
Fluorine thiazole pyrrole ethyl ketone, active constituent B, dispersant, wetting agent, filler are mixed, are uniformly mixed in mixed cylinder, warp
Airslide disintegrating mill remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1,2,3.
1 Examples 1 to 5 each component of table and content
2 embodiment of table, 6~10 each component and content
3 embodiment of table, 11~14 each component and content
15~28 water dispersible granules of embodiment
Fluorine thiazole pyrrole ethyl ketone, active constituent B, dispersant, wetting agent, disintegrant, filler etc. are obtained together through air-flow crushing
To the grain size of needs, binding agent is added（Can add can be not added with）Etc. other auxiliary agents, granulation materials are obtained.Item is quantified into feeding stream
Change in bed granulating drier after granulation and drying, you can water dispersible granules product of the present invention is made, is specifically shown in Table
4、5、6。
4 embodiment of table, 15~19 each component and content
5 embodiment of table, 20~24 each component and content
6 embodiment of table, 25~28 each component and content
29~42 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener（Can add can be not added with）, antifreeze（Can add can be not added with）, by a high speed
Shear-mixed is uniform, adds in fluorine thiazole pyrrole ethyl ketone, active constituent B, in the ball mill ball milling 2~3 hours, makes diameter of particle whole
At 5 μm hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 7,8,9.
7 embodiment of table, 29~33 each component and content
8 embodiment of table, 34~38 each component and content
9 embodiment of table, 39~42 each component and content
43~49 aqueous emulsion of embodiment
Fluorine thiazole pyrrole ethyl ketone, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；To go from
Sub- water, antifreeze（Can add can be not added with）, thickener（Can add can be not added with）, antifoaming agent mix, into uniform water phase.At a high speed
Under stirring, water phase is added in into oil phase, aqueous emulsion product of the present invention is made.Specifically it is shown in Table 10,11.
10 embodiment of table, 43~49 each component and content
Zoxamide, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium amine, pyrimorph in table 1~10 are exchanged, can be made
Novel formulation.
50~54 microemulsion of embodiment
Fluorine thiazole pyrrole ethyl ketone, active constituent B are dissolved in the homogenizer equipped with solvent, by emulsifier, antifreeze（It can add
It can be not added with）, antifoaming agent, be added in the homogenizer equipped with above-mentioned solution, surplus mixes strongly after being supplied with deionized water
And homogenize, finally obtain the transparent microemulsion product of the present invention of clear appearance.Specifically it is shown in Table 11.
11 embodiment of table, 50~54 each component and content
55~57 suspension emulsion of embodiment
By dispersant, antifoaming agent, thickener（Can add can be not added with）, antifreeze（Can add can be not added with）It is mixed by high speed shear
Uniformly, fluorine thiazole pyrrole ethyl ketone is added in, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, fluorine thiophene is made
Then azoles pyrrole ethyl ketone suspending agent directly emulsifies active constituent B, emulsifier, solvent and various auxiliary agents with high speed agitator outstanding
In floating agent, suspension emulsion product of the present invention is made.Specifically it is shown in Table 12.
12 embodiment of table, 55~57 each component and content
58~60 microcapsule suspending agent of embodiment
Fluorine thiazole pyrrole ethyl ketone, active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase,
Under shearing condition, by oil phase be added to containing emulsifier, pH adjusting agent, dispersant, antifoaming agent aqueous phase solution in, surplus is spent
Ionized water is supplied, and two kinds of materials react in oil-water interfaces, forms high score ascus wall, it is well dispersed that the present composition is made
Microcapsule suspending agent product.Specifically it is shown in Table 13.
13 embodiment of table, 58~60 each component and content
61~63 microcapsule suspension of embodiment -- suspending agent
Active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Moisten agent, antifoaming agent, thickener（Can add can be not added with）It is uniformly mixed by high speed shear, fluorine thiazole pyrrole ethyl ketone is added in, in ball mill
Middle ball milling 2~3 hours makes diameter of particle all at 5 μm hereinafter, suspending agent is made, suspending agent then is added to microcapsules and is hanged
In the aqueous phase solution of floating agent, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent production of the present composition is made
Product.Specifically it is shown in Table 14.
14 embodiment of table, 61~63 each component and content
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
Calmly, the synergy ratio after clear and definite two kinds of medicaments compound by a certain percentage（SR）, SR ＜ 0.5 be antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 respectively by active constituent content
A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia
Rate method measures virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth（mm）=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value（y）, liquor strength（μg/mL）It is converted into logarithm（x）, with minimum
Square law acquires virulence regression equation（y=a+bx）, and thus calculate the EC of each medicament50Value.Simultaneously according to Wadley method meters
Calculate two medicament different ratio synergy ratios（SR）, SR ＜ 0.5 be antagonism, 0.5≤SR≤1.5 be summation action, SR
＞ 1.5 is synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active constituent B ratio shared in combination；
A is fluorine thiazole pyrrole ethyl ketone；
B is selected from one of zoxamide, dimethomorph, pyrrole metsulfovax, ring propionyl bacterium amine, pyrimorph Huo hymexazos kind.
Application Example two：
For trying disease：Downy mildew of garpe, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
Cross effective inhibition concentration range that pilot study determines both fluorine thiazole pyrrole ethyl ketone and zoxamides different ratio mixture.
Toxicity test result
15 fluorine thiazole pyrrole ethyl ketone of table compounds the toxicity test analysis of results table to downy mildew of garpe with zoxamide
As shown in Table 15, fluorine thiazole pyrrole ethyl ketone prevents the proportioning of downy mildew of garpe in 1 ︰, 80~60 ︰ 1 with zoxamide compounding
When, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine thiazole
The proportioning of pyrrole ethyl ketone and zoxamide is 1: 20~10: 1, and synergistic effect is more prominent, and synergy ratio works as fluorine more than 2.25
When the weight ratio of thiazole pyrrole ethyl ketone and zoxamide is 1: 9~4: 1, synergistic effect is the most prominent, synergy ratio 2.40 with
On.The proportioning that discovery fluorine thiazole pyrrole ethyl ketone and zoxamide are tested through applicant is 10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰
1st, 3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20, wherein fluorine thiazole pyrrole ethyl ketone
It is 1 with zoxamide weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
Application Example three：
For trying disease：Cucumber downy mildew, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
It crosses pilot study and determines fluorine thiazole pyrrole ethyl ketone and dimethomorph active compound and effective inhibition concentration range of the two different ratio mixture
Toxicity test result
16 fluorine thiazole pyrrole ethyl ketone of table compounds the toxicity test analysis of results table to cucumber downy mildew with dimethomorph
As shown in Table 16, fluorine thiazole pyrrole ethyl ketone prevents the proportioning of cucumber downy mildew in 1 ︰, 80~60 ︰ 1 with dimethomorph compounding
When, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine thiazole
The proportioning of pyrrole ethyl ketone and dimethomorph is in 1 ︰ 20~10: 1, and synergistic effect is more prominent, and synergy ratio works as fluorine more than 2.30
When the weight ratio of thiazole pyrrole ethyl ketone and dimethomorph is 1: 9~4: 1, synergistic effect is the most prominent, synergy ratio 2.40 with
On.The proportioning that discovery fluorine thiazole pyrrole ethyl ketone and dimethomorph are tested through applicant is 10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰
1st, 3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20, wherein fluorine thiazole pyrrole ethyl ketone
It is 2 with dimethomorph weight ratio：Synergy ratio is maximum when 5, and synergistic effect is the most apparent.
Application Example four：
For trying disease：Grape grey mould, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
It crosses pilot study and determines fluorine thiazole pyrrole ethyl ketone and pyrrole metsulfovax active compound and effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
17 fluorine thiazole pyrrole ethyl ketone of table compounds the toxicity test analysis of results table to grape grey mould with pyrrole metsulfovax
As shown in Table 17, fluorine thiazole pyrrole ethyl ketone prevents the proportioning of grape grey mould in 1 ︰, 80~60 ︰ 1 with pyrrole metsulfovax compounding
When, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine thiazole
The proportioning of pyrrole ethyl ketone and pyrrole metsulfovax is 1: 20~20: 1, and synergistic effect is more prominent, and synergy ratio is more than 2.25, fluorine thiophene
When azoles pyrrole ethyl ketone and the weight ratio of pyrrole metsulfovax are 1: 9~9: 1, synergistic effect is the most prominent, and synergy ratio is more than 2.40.
Tested through applicant find fluorine thiazole pyrrole ethyl ketone and pyrrole metsulfovax proportioning be 20 ︰ 1,15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,
5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15, wherein 1 ︰ 20, fluorine thiazole
Pyrrole ethyl ketone is 1 with pyrrole metsulfovax weight ratio：Synergy ratio is maximum when 1, and synergistic effect is the most apparent.
Application Example five：
For trying disease：Rice blast, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：Through
It crosses pilot study and determines fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine active compound and effective inhibition concentration model of the two different ratio mixture
It encloses.
Toxicity test result
18 fluorine thiazole pyrrole ethyl ketone of table compounds the toxicity test analysis of results table to rice blast with ring propionyl bacterium amine
As shown in Table 18, the proportioning of fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine compounding prevention rice blast 1 ︰ 80~
During 60 ︰ 1, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine
For the proportioning of thiazole pyrrole ethyl ketone and ring propionyl bacterium amine 1: 20~10: 1, synergistic effect is more prominent, synergy ratio 2.25 with
On, when the weight ratio of fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine is 1: 9~4: 1, synergistic effect is the most prominent, and synergy ratio is equal
More than 2.40.Tested through applicant find fluorine thiazole pyrrole ethyl ketone and ring propionyl bacterium amine proportioning be 10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,
6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15, wherein 1 ︰ 20, fluorine
Thiazole pyrrole ethyl ketone is 1 with ring propionyl bacterium amine weight ratio：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
Application Example six：
For trying disease：Tomato blight, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：By
Pilot study determines fluorine thiazole pyrrole ethyl ketone and pyrimorph active compound and effective inhibition concentration range of the two different ratio mixture.
Toxicity test result
19 fluorine thiazole pyrrole ethyl ketone of table compounds the toxicity test analysis of results table to tomato blight with pyrimorph
As shown in Table 19, fluorine thiazole pyrrole ethyl ketone prevents the proportioning of tomato blight in 1 ︰, 80~60 ︰ 1 with pyrimorph compounding
When, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine thiazole
The proportioning of pyrrole ethyl ketone and pyrimorph is 1: 20~10: 1, and synergistic effect is more prominent, and synergy ratio works as fluorine more than 2.25
When the weight ratio of thiazole pyrrole ethyl ketone and pyrimorph is 1: 9~4: 1, synergistic effect is the most prominent, synergy ratio 2.40 with
On.The proportioning that discovery fluorine thiazole pyrrole ethyl ketone and pyrimorph are tested through applicant is 10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰
1st, 3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20, wherein fluorine thiazole pyrrole ethyl ketone
It is 1 with pyrimorph weight ratio：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example seven：
For trying disease：Target, test medicine are provided by Shaanxi Meibang Pesticide Co., Ltd., experimental design：
Fluorine thiazole pyrrole ethyl ketone Yu hymexazos active compound and effective inhibition concentration range of the two different ratio mixture are determined by pilot study.
Toxicity test result
20 fluorine thiazole pyrrole ethyl ketone Yu hymexazos of table compound the toxicity test analysis of results table to target
As shown in Table 20, the proportioning of fluorine thiazole pyrrole ethyl ketone Yu hymexazos compounding prevention target is in 1 ︰, 80~60 ︰ 1
When, synergy ratio SR is all higher than 1.5, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, fluorine thiazole
The proportioning of pyrrole ethyl ketone Yu hymexazos is 1: 20~10: 1, and synergistic effect is more prominent, and synergy ratio is more than 2.25, when fluorine thiophene
When the weight ratio of azoles pyrrole ethyl ketone Yu hymexazos is 1: 9~4: 1, synergistic effect is the most prominent, and synergy ratio is more than 2.35.Through
The proportioning that applicant tests discovery fluorine thiazole pyrrole ethyl ketone Yu hymexazos is 10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰
1st, 1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20, wherein fluorine thiazole pyrrole ethyl ketone Yu hymexazos
Weight ratio is 1：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
It is found through experiment that：To downy mildew, the white phytophthora in various crop after fluorine thiazole pyrrole ethyl ketone and active constituent B compoundings
Disease, epidemic disease, balck shank, gray mold, brown spot, powdery mildew, rust, sclerotiniose, rice blast, damping-off, banded sclerotial blight, full rot,
The prevention of head blight, snow mold, root rot, glume blight, samping off or droop has apparent synergistic effect, and synergy ratio is equal
More than 1.5.
Effect experiment part：Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, 10% fluorine thiophene of comparison medicament
Azoles pyrrole ethyl ketone suspending agent（Autogamy）, 24% zoxamide suspending agent（It is purchased in market）, 50% dimethomorph water dispersion granula（It is purchased in market）、20%
Pyrrole metsulfovax suspending agent（It is purchased in market）, 22% ring propionyl bacterium amine suspending agent（It is purchased in market）, 20% pyrimorph suspending agent（Autogamy）, 20% Evil
Mould spirit suspending agent（Autogamy）.
Application Example octafluoro thiazole pyrrole ethyl ketone and active constituent B and its compounding prevention cucumber downy mildew test of pesticide effectiveness
This experiment is arranged in Shaanxi Province Jingyang County, and the cucumber downy mildew state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days is primary, altogether dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
21 fluorine thiazole pyrrole ethyl ketone of table and active constituent B and its compounding prevention cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 21, cucumber downy mildew can be effectively prevented after fluorine thiazole pyrrole ethyl ketone and active constituent B and its compounding,
Control effect is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.Simultaneously
There is good preventive effect, and preventive effect is above 96% to powdery mildew of cucumber, scab.
Nine fluorine thiazole pyrrole ethyl ketone of Application Example and active constituent B and its compounding prevention peronophythora litchi test of pesticide effectiveness
This test arrangement investigates the Peronophythora Litchii state of an illness before Guangdong Zengcheng City, medicine, in state of an illness first time at initial stage dispenser, often
Dispenser in 7 days is primary, altogether dispenser 2 times.3 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 7 days, 15 days.Experiment
As a result it is as follows：
22 fluorine thiazole pyrrole ethyl ketone of table is tested with active constituent B and its compounding prevention Peronophythora Litchii effect
As can be seen from Table 22, Peronophythora Litchii can effectively be prevented after fluorine thiazole pyrrole ethyl ketone and active constituent B and its compounding
Disease, control effect is superior to the preventive effect of single dose, and preventive effect phase is long, has no adverse effects in experiment scope of medication to target crop.
Ten fluorine thiazole pyrrole ethyl ketone of Application Example and active constituent B and its compounding prevention tomato blight test of pesticide effectiveness
This test arrangement investigates the tomato blight state of an illness before Xi'an City, Shanxi Province, medicine, in state of an illness first time at initial stage dispenser, often
Dispenser in 7 days is primary, altogether dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.It is real
It is as follows to test result：
23 fluorine thiazole pyrrole ethyl ketone of table and active constituent B and its compounding prevention tomato blight test of pesticide effectiveness
As can be seen from Table 23, fluorine thiazole pyrrole ethyl ketone and efficiency prevention tomato blight, prevention after active constituent B and its compounding
Effect is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.
11 fluorine thiazole pyrrole ethyl ketone of Application Example and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
This test arrangement investigates the rice blast state of an illness before Shaanxi Province's Hanzhong City, medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days is primary, altogether dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
24 fluorine thiazole pyrrole ethyl ketone of table and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
As can be seen from Table 24, rice blast can be effectively prevented after fluorine thiazole pyrrole ethyl ketone and active constituent B and its compounding,
Control effect is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.Simultaneously
There is good preventive effect to rice sheath blight disease, and preventive effect is above 96%.
Ten difluoro thiazole pyrrole ethyl ketone of Application Example and active constituent B and its compounding prevention grape grey mould test of pesticide effectiveness
This experiment is arranged in Shaanxi Province Dali County, and the grape grey mould state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser,
Every dispenser in 7 days is primary, altogether dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.
Experimental result is as follows：
25 fluorine thiazole pyrrole ethyl ketone of table and active constituent B and its compounding prevention grape grey mould test of pesticide effectiveness
As can be seen from Table 25, grape grey mould can be effectively prevented after fluorine thiazole pyrrole ethyl ketone and active constituent B and its compounding,
Control effect is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.
Ten trifluoro thiazole pyrrole ethyl ketone of Application Example and active constituent B and its compounding prevention wheat powdery mildew test of pesticide effectiveness
This experiment is arranged in Shaanxi Province's Weinan City, and wheat powdery mildew is investigated before medicine, in state of an illness first time at initial stage dispenser, every 7
Its dispenser is primary, altogether dispenser 2 times.7 days after second of dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experiment
As a result it is as follows：
26 fluorine thiazole pyrrole ethyl ketone of table and active constituent B and its compounding prevention wheat powdery mildew test of pesticide effectiveness
As can be seen from Table 26, wheat powdery mildew can be effectively prevented after fluorine thiazole pyrrole ethyl ketone and active constituent B and its compounding,
Control effect is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.Simultaneously
There is good preventive effect, and preventive effect is above 96% to wheat glume blotch, banded sclerotial blight, rust, head blight, full rot.
The experiment by different places throughout the country obtains afterwards, fluorine thiazole pyrrole ethyl ketone and zoxamide, dimethomorph, pyrrole
Metsulfovax, ring propionyl bacterium amine, pyrimorph compounding after in various crop downy mildew, peronospora tabacina, epidemic disease, balck shank, ash
Mildew, brown spot, powdery mildew, rust, sclerotiniose, rice blast, damping-off, banded sclerotial blight, full rot, head blight, snow mold, root-rot
The preventive effect of the Common Diseases such as disease, glume blight, samping off or droop is more than 95%, and better than single dose preventive effect, synergistic effect is bright
It is aobvious.
Claims (6)
1. a kind of composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone, it is characterised in that：Active constituent be active components A and B, activity into
It is 1: 80~60: 1 to divide A and active constituent B weight ratios, and the active components A is selected from fluorine thiazole pyrrole ethyl ketone, and active constituent B is
Pyrimorph.
2. the composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone according to claim 1, it is characterised in that：Active components A and work
Property ingredient B weight ratio be 1: 60~40: 1.
3. the composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone according to claim 2, it is characterised in that：
The weight ratio of fluorine thiazole pyrrole ethyl ketone and pyrimorph is 1: 20~10: 1.
4. the composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone described in any one of claim 1 to 3, it is characterised in that：Group
It closes object and wettable powder, water dispersible granules, suspending agent, oil-suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspension is made
Agent, microcapsule suspension-suspendinagent agent.
5. the composition pesticide of fluorine-containing thiazole pyrrole ethyl ketone according to claim 4 is used to prevent the purposes of crop disease.
6. purposes according to claim 5, it is characterised in that：The disease is downy mildew, peronospora tabacina, epidemic disease, black
Shin disease, gray mold, brown spot, powdery mildew, rust, sclerotiniose, rice blast, damping-off, banded sclerotial blight, full rot, head blight, snow are rotten
Disease, root rot, glume blight, samping off or droop.
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| CN102459256A (en) * | 2009-04-22 | 2012-05-16 | 纳幕尔杜邦公司 | Solid forms of an azocyclic amide |
| WO2014086853A1 (en) * | 2012-12-04 | 2014-06-12 | Basf Agro B.V., Arnhem (Nl) | Compositions comprising a quillay extract and a fungicidal compound |
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| CN101969781A (en) * | 2007-10-23 | 2011-02-09 | 杜邦公司 | Fungicidal compounds and mixtures |
| CN102459256A (en) * | 2009-04-22 | 2012-05-16 | 纳幕尔杜邦公司 | Solid forms of an azocyclic amide |
| WO2014086853A1 (en) * | 2012-12-04 | 2014-06-12 | Basf Agro B.V., Arnhem (Nl) | Compositions comprising a quillay extract and a fungicidal compound |
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Address after: 715500 Pucheng high tech Industrial Development Zone, Weinan, Shaanxi Patentee after: Shaanxi Mei Bang Pharmaceutical Group Limited by Share Ltd Address before: 715500 Shaanxi Pucheng Weinan County agricultural base industrial park Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |
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