CN103371153B - Bactericidal composition containing thifluzamide Yu methoxy acrylic - Google Patents
Bactericidal composition containing thifluzamide Yu methoxy acrylic Download PDFInfo
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- CN103371153B CN103371153B CN201210132060.XA CN201210132060A CN103371153B CN 103371153 B CN103371153 B CN 103371153B CN 201210132060 A CN201210132060 A CN 201210132060A CN 103371153 B CN103371153 B CN 103371153B
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- thifluzamide
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 33
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 239000005784 Fluoxastrobin Substances 0.000 claims abstract description 28
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims abstract description 27
- 239000000375 suspending agent Substances 0.000 claims description 30
- 239000004563 wettable powder Substances 0.000 claims description 18
- 235000007164 Oryza sativa Nutrition 0.000 claims description 16
- 206010039509 Scab Diseases 0.000 claims description 16
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 16
- 235000009566 rice Nutrition 0.000 claims description 16
- 239000003094 microcapsule Substances 0.000 claims description 14
- 241000233679 Peronosporaceae Species 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 12
- 241000193738 Bacillus anthracis Species 0.000 claims description 9
- 241000221785 Erysiphales Species 0.000 claims description 9
- -1 thiophene furan acyl Amine Chemical class 0.000 claims description 9
- 241001530056 Athelia rolfsii Species 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 240000007594 Oryza sativa Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 239000005800 Kresoxim-methyl Substances 0.000 abstract description 27
- 239000005762 Dimoxystrobin Substances 0.000 abstract description 26
- 239000005857 Trifloxystrobin Substances 0.000 abstract description 26
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 abstract description 26
- WXUZAHCNPWONDH-DYTRJAOYSA-N dimoxystrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1COC1=CC(C)=CC=C1C WXUZAHCNPWONDH-DYTRJAOYSA-N 0.000 abstract description 25
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 21
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 42
- 239000003814 drug Substances 0.000 description 32
- 238000013329 compounding Methods 0.000 description 31
- 230000010165 autogamy Effects 0.000 description 28
- 230000003449 preventive effect Effects 0.000 description 22
- 241000209094 Oryza Species 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 15
- 239000000575 pesticide Substances 0.000 description 15
- 239000002270 dispersing agent Substances 0.000 description 14
- 239000013530 defoamer Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000012071 phase Substances 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 231100000820 toxicity test Toxicity 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 241000510928 Erysiphe necator Species 0.000 description 7
- 235000014443 Pyrus communis Nutrition 0.000 description 7
- 241000209140 Triticum Species 0.000 description 7
- 235000021307 Triticum Nutrition 0.000 description 7
- 230000002528 anti-freeze Effects 0.000 description 7
- 206010067482 No adverse event Diseases 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 206010011732 Cyst Diseases 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 238000013401 experimental design Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 241000198596 Alternaria tomatophila Species 0.000 description 4
- 241000233622 Phytophthora infestans Species 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 3
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 3
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
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- 230000001629 suppression Effects 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
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- 229910052731 fluorine Inorganic materials 0.000 description 2
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- 230000009885 systemic effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 102000019265 Cytochrome c1 Human genes 0.000 description 1
- 108010007528 Cytochromes c1 Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
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- 239000003112 inhibitor Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
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- 150000002923 oximes Chemical class 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
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- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Abstract
The invention discloses a kind of bactericidal composition containing thifluzamide Yu methoxy acrylic, bactericidal composition containing active components A Yu active component B, active components A is selected from thifluzamide, active component B is selected from any one compound following: trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160, and the weight ratio of active components A and active component B is 1: 80～60: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious potentiation, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of potentiation.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of Bactericidal composite containing thifluzamide Yu methoxy acrylic
Application in thing disease.
Technical background
Thifluzamide (thifluzamide) is called: very heavy pellet, precious fringe, chemical name: 2,6-bis-bromo-2-methyl-4-three
Fluorine methoxyl group-4-Trifluoromethyl-1,3-thiazole-5-carbonyl acyl is for aniline.Thifluzamide has stronger systemic action, lasting period
Long.Main Function is the acidohydrogenase in suppression pathogenic fungi tricarboxylic acid cycle, causes thalline dead.
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 belong to methoxy acrylic bactericide.
The antibacterial of methoxy acrylic is the outer inhibitor of quinone, by the electron transmission of block cell pigment b Yu cytochrome c 1,
Suppression mitochondrial respiratory.Systemic fungicide, has protectiveness, therapeutic, eradicant and long residual effect, suppresses spore germination.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the generation of disease drug resistance.No
Compound with kind composition, be to prevent and treat the method that resistance disease is the most common.Heterogeneity compounds, according to reality application effect
Really, judge certain compounding be potentiation, add and or antagonism.In most cases, the compounding effect of pesticide all adds
And effect, really have potentiation compounding seldom, especially potentiation clearly, potentiation ratio the highest compounding the most more
Few.Study through inventor, find thifluzamide and trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160
Mutually compounding, have good potentiation within the specific limits, and about thifluzamide and trifloxystrobin, fluoxastrobin, dimoxystrobin,
Kresoxim-methyl, ZEN 90160 are relevant compounding, the most at home and abroad there is not yet relevant report.
Summary of the invention
The purpose of the present invention is to propose to a kind of have that synergistic function, use cost be low, preventive effect is good containing thifluzamide
Bactericidal composition with methoxy acrylic.
The present invention is to be achieved through the following technical solutions:
A kind of bactericidal composition containing thifluzamide Yu methoxy acrylic, containing active components A and active component
B, active components A and active component B weight ratio are 1: 80～60: 1, and described active components A is selected from thifluzamide, active component
B one in trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160.Active components A is with active component B's
Preferred weight ratio is 1: 60～40: 1；More preferably thifluzamide is 1: 30～15: 1 with the weight ratio of trifloxystrobin；Thifluzamide
It is 1: 30～15: 1 with the weight ratio of fluoxastrobin；Thifluzamide is 1: 30～15: 1 with the weight ratio of dimoxystrobin；Thifluzamide
It is 1: 30～15: 1 with the weight ratio of kresoxim-methyl；Thifluzamide is 1: 30～10: 1 with the weight ratio of ZEN 90160.
The described bactericidal composition containing thifluzamide Yu methoxy acrylic, can be made into wettable powder, suspension
Agent, water dispersible granules, aqueous emulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, it is also possible to make microemulsion.
The described bactericidal composition containing thifluzamide with methoxy acrylic is used for preventing and treating the disease of crop, described
Crop include fruit tree, vegetable, cereal crops, ornamental plant, fibre crops.
Described disease include banded sclerotial blight, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab,
Early blight, late blight, leaf blight, brown spot, gray mold, anthrax.
In the bactericidal composition of the present invention, the content of active component depends on amount of application when being used alone, and also depends on one
Plant compound and the mixed ratio of another kind of compound and potentiation degree, also the most relevant with target disease.Generally group
In compound, the weight percentage of active component is the 1%～90% of gross weight, is preferably 5%～80%.According to different
Preparation type, active component content scope is different.Generally, liquid preparation contains the active matter of by weight 1%～60%
Matter, preferably 5%～50%；Solid preparation contains the active substance of by weight 5%～80%, preferably 10%～
80%.
At least containing a kind of surfactant in the bactericidal composition of the present invention, when being beneficial to use, active component is in water
Dispersion.Surface-active contents is the 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art: can be selected from
One or more in dispersant, wetting agent, thickening agent or defoamer.According to different dosage form, preparation can also contain this area
Stabilizer well known to technical staff, antifreeze etc..
The bactericidal composition of invention through dilution or directly can be used before use by user.Its preparation can be by this area
Prepared by the processing method well known to technical staff, will add table after active component mixes with liquid flux or solid carrier
One or more in face activating agent such as dispersant, stabilizer, wetting agent, binding agent, defoamer etc..
Compositions comprises following component and content when making wettable powder: active components A 1%～60%, active component B
1%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
Compositions includes following component and content when making suspending agent: active components A 0.5%～50%, active component B
0.5%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickening agent 0～2%, anti-
Freeze agent 0～8%, deionized water add to 100%.
Compositions includes following component and content when making water dispersible granules: active components A 1%～60%, active component B
1%～80%, more than dispersant 1%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0～8%, filler
Amount.
Compositions includes following component and content when making aqueous emulsion: active components A 0.5%～50%, active component B
0.5%～50%, solvent 1%～20%, emulsifying agent 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, thickening
Agent 0～2%, deionized water add to 100%.
Compositions includes following component and content when making suspension emulsion: active components A 0.5%～50%, active component B
0.5%～50%, emulsifying agent 1%～10%, dispersant 1%～10%, solvent 0～20%, defoamer 0.01%～2%, increase
Thick dose 0～2%, antifreeze 0～8%, stabilizer 0～3%, deionized water add to 100%.
Compositions includes following component and content when making microemulsion: active components A 0.5%～50%, active component B
0.5%～50%, emulsifying agent 3%～25%, solvent 1%～10%, antifreeze 0～8%, stabilizer 0～3%, defoamer
0.01%～2%, deionized water adds to 100%.
Compositions includes following component and content when making microcapsule suspending agent: active components A 0.5%～50%, activity become
Divide B 0.5%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifying agent
1%～7%, pH adjusting agent 0.01%～5%, defoamer 0.01%～2%, deionized water add to 100%.
Compositions includes following component and content when making microcapsule suspension-suspendinagent agent: active components A 0.5%～50%, live
Property composition B 0.5%～50%, macromolecule cyst material 1%～12%, dispersant 1%-12%, wetting agent 1%-8%, solvent
1%～15%, emulsifying agent 1%～8%, defoamer 0.01%～2%, thickening agent 0～2%, pH adjusting agent 0.01%～5%,
Deionized water adds to 100%.
The wettable powder the key technical indexes of the present invention:
The suspending agent the key technical indexes of the present invention:
The water dispersible granules the key technical indexes of the present invention:
The aqueous emulsion the key technical indexes of the present invention:
The suspension emulsion the key technical indexes of the present invention:
The microemulsion the key technical indexes of the present invention:
The microcapsule suspending agent the key technical indexes of the present invention:
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
It is an advantage of the current invention that:
(1) present composition has good potentiation and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) agriculture
Medicinal dose reduces, and reduces pesticide residual quantity on crop, alleviates environmental pollution；(3) fungicidal spectrum is expanded, to multiple diseases
As banded sclerotial blight, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf blight,
Brown spot, gray mold, anthrax have greater activity.
Detailed description of the invention
Below in conjunction with embodiment, further instruction of the present invention, the percentage ratio in embodiment are all weight percentage, but
The invention is not limited in this.
Application Example one
Example 1～14 wettable powder
By thifluzamide, active component B, dispersant, wetting agent, filler mixing, mix homogeneously in mixed cylinder, through air-flow
Pulverizer remixes uniformly after pulverizing, and i.e. can be made into wettable powder product of the present invention.Specifically it is shown in Table 1,2.
Table 1 example 1～8 component and content
Table 2 example 9～14 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 15～28 suspending agent
By dispersant, wetting agent, defoamer, thickening agent, antifreeze, through high speed shear mix homogeneously, add thiophene furan acyl
Amine, active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, surplus deionized water is mended
Foot, can be prepared by suspending agent product of the present invention, is specifically shown in Table 3,4.
Table 3 example 15～22 each component and content
Table 4 example 23～28 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 29～42 water dispersible granules
Thifluzamide, active component B, dispersant, wetting agent, disintegrating agent, filler etc. are needed through comminution by gas stream together
The particle diameter wanted, adds other auxiliary agents such as binding agent, obtains granulation materials.Item is quantitatively sent in fluidized bed granulating dryer
Through pelletizing and dried, can be prepared by water dispersible granules product of the present invention, be specifically shown in Table 5,6.
Table 5 example 29～36 each component and content
Table 6 example 37～42 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 43～47 aqueous emulsion
Thifluzamide, active component B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By deionized water,
Antifreeze, thickening agent, defoamer mix, and become homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, prepare this
Aqueous emulsion product described in invention.Specifically it is shown in Table 7.
Table 7 example 43～49 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 50～54 suspension emulsion
Thifluzamide will add dispersant, defoamer, thickening agent, antifreeze, stabilizer, mix all through high speed shear
Even, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, prepare active component B suspending agent, then will
Active component B, emulsifying agent, solvent and the various direct emulsifying of auxiliary agent high speed agitator, in suspending agent, prepare of the present invention
Suspension emulsion product.Specifically it is shown in Table 8.
Table 8 example 50～54 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 55～59 microcapsule suspending agent
By thifluzamide, active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, shearing
Under the conditions of, oil phase is joined containing emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus deionization
Water is supplied, and bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the present composition finely disseminated micro-
Capsule suspending agent product.Specifically it is shown in Table 9.
Table 9 example 55～59 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
Example 60～64 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, by oil phase at shearing condition
Under join containing emulsifying agent, pH adjusting agent aqueous phase solution in, make finely disseminated microcapsule suspending agent.By dispersant, wet
Profit agent, defoamer, thickening agent through high speed shear mix homogeneously, add thifluzamide, ball milling 2～3 hours in ball mill, make
Diameter of particle, all below 5 μm, prepares suspending agent, is then joined by suspending agent in the aqueous phase solution of micro-capsule suspension,
Deionized water supplies surplus, makes the present composition finely disseminated microcapsule suspension-suspendinagent agent product.Specifically it is shown in Table 10.
Table 10 example 60～64 each component and content
Trifloxystrobin, fluoxastrobin, dimoxystrobin, kresoxim-methyl, ZEN 90160 in table are exchanged, novel formulation can be prepared.
The embodiment of the present invention is the method using Toxicity Determination and field test to combine.First pass through indoor virulence to survey
Fixed, after clear and definite two kinds of medicaments are compounding by a certain percentage potentiation ratio (SR), SR ＜ 0.5 is antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 is potentiation, on this basis, then carries out field test.
Test method: after prerun determines each medicament effective inhibition concentration scope, medicament is set 5 respectively by active constituent content
Individual dosage processes, if clear water comparison.Carry out with reference to " farm-chemical indoor determination test rule antibacterial ", use mycelial growth speed
Rate method measures the medicament virulence to crop pathogenic bacteria.Measure colony diameter by decussation method after 72h, calculate each process and only grow
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC50 value of every kind of medicament.Simultaneously according to Wadley method
Calculating two medicaments different ratio synergy ratio (SR), SR ＜ 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 is potentiation.Computing formula is as follows:
Wherein: a, b are respectively the ratio that active components A is shared in combination with active component B；
A is thifluzamide；
B plants selected from one of trifloxystrobin, fluoxastrobin, kresoxim-methyl, dimoxystrobin, ZEN 90160.
Application Example two:
For examination disease: rice sheath blight disease
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine that thifluzamide is dense with the effectively suppression of both trifloxystrobin different ratio mixture through pilot study
Degree scope.
Toxicity test result
Table 11 thifluzamide toxicity test analysis of results table to rice sheath blight disease compounding with trifloxystrobin
As shown in Table 11, thifluzamide and trifloxystrobin compound the proportioning preventing and treating rice sheath blight disease when 1: 80～60: 1, increase
Effect ratio SR is all higher than 1.5, illustrates that both all show potentiation, thifluzamide and oxime at mixture in the range of 1: 80～60: 1
The proportioning of bacterium ester is 1: 30～15: 1, and potentiation is the most prominent；Potentiation ratio when thifluzamide and trifloxystrobin weight ratio are 1: 2
Maximum, potentiation is the most obvious.Test through applicant and find that thifluzamide is 15: 1,10: 1,5: 1,4 with the proportioning of trifloxystrobin
: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20,1: 25,1: 30 time to stricture of vagina
Rot, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf blight, brown patch
Disease, gray mold, the preventing and treating of anthrax have obvious potentiation, and potentiation ratio is all more than 2.06.
Application Example three:
For examination disease: wheat rust
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine having of the former medicine of thifluzamide and fluoxastrobin and the two different ratio mixture through pilot study
Effect inhibition concentration scope
Toxicity test result
Table 12 thifluzamide toxicity test analysis of results table to wheat rust compounding with fluoxastrobin
As shown in Table 12, thifluzamide and fluoxastrobin compound the proportioning preventing and treating wheat rust when 1: 80～60: 1, increase
Effect ratio SR is all higher than 1.5, illustrates that both all show potentiation, thifluzamide and fluorine at mixture in the range of 1: 80～60: 1
The proportioning of Fluoxastrobin is 1: 30～15: 1, and potentiation is the most prominent；Potentiation when thifluzamide and fluoxastrobin weight ratio are 1: 2
Ratio is maximum, and potentiation is the most obvious.Test through applicant and find that thifluzamide is 15: 1,10 with the proportioning of fluoxastrobin:
1、5∶1、4∶1、3∶1、2∶1、1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9、1∶10、1∶15、1∶20、1∶25、1∶
To banded sclerotial blight, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf when 30
Rot, brown spot, gray mold, the preventing and treating of anthrax have obvious potentiation, and potentiation ratio is all more than 2.01.
Application Example four:
For examination disease: uncinula necator
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine the effective of the former medicine of thifluzamide and dimoxystrobin and the two different ratio mixture through pilot study
Inhibition concentration scope.
Toxicity test result
Table 13 thifluzamide toxicity test analysis of results table to uncinula necator compounding with dimoxystrobin
As shown in Table 13, thifluzamide and dimoxystrobin compound the proportioning of preventing and treating uncinula necator when 1: 80～60: 1, increase
Effect ratio SR is all higher than 1.5, illustrates that both all show potentiation, thifluzamide and ether at mixture in the range of 1: 80～60: 1
The proportioning of bacterium amine is 1: 30～15: 1, and potentiation is the most prominent；Potentiation ratio when thifluzamide and dimoxystrobin weight ratio are 1: 2
Maximum, potentiation is the most obvious.Test through applicant and find that thifluzamide is 15: 1,10: 1,5: 1,4 with the proportioning of dimoxystrobin
: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20,1: 25,1: 30 time to stricture of vagina
Rot, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf blight, brown patch
Disease, gray mold, the preventing and treating of anthrax have obvious potentiation, and potentiation ratio is all more than 2.01.
Application Example five:
For examination disease: pear scab
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine having of the former medicine of thifluzamide and kresoxim-methyl and the two different ratio mixture through pilot study
Effect inhibition concentration scope.
Toxicity test result
Table 14 thifluzamide toxicity test analysis of results table to pear scab compounding with kresoxim-methyl
As shown in Table 14, thifluzamide and kresoxim-methyl compound the proportioning of preventing and treating pear scab when 1: 80～60: 1,
Potentiation ratio SR is all higher than 1.5, illustrates that both all show potentiation at mixtures in the range of 1: 80～60: 1, thifluzamide with
The proportioning of kresoxim-methyl is 1: 30～15: 1, and potentiation is the most prominent；Increase when thifluzamide and kresoxim-methyl weight ratio are 1: 2
Effect ratio is maximum, and potentiation is the most obvious.Test through applicant and find that thifluzamide is 15: 1,10 with the proportioning of kresoxim-methyl
∶1、5∶1、4∶1、3∶1、2∶1、1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9、1∶10、1∶15、1∶20、1∶25、1∶
To banded sclerotial blight, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf when 30
Rot, brown spot, gray mold, the preventing and treating of anthrax have obvious potentiation, and potentiation ratio is all more than 2.02.
Application Example six:
For examination disease: Chinese cabbage downy mildew
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine having of the former medicine of thifluzamide and ZEN 90160 and the two different ratio mixture through pilot study
Effect inhibition concentration scope.
Table 15 thifluzamide toxicity test analysis of results table to Chinese cabbage downy mildew compounding with ZEN 90160
As shown in Table 15, thifluzamide and ZEN 90160 compound the proportioning of preventing and treating Chinese cabbage downy mildew when 1: 80～60: 1,
Potentiation ratio SR is all higher than 1.5, illustrates that both all show potentiation at mixtures in the range of 1: 80～60: 1, thifluzamide with
The proportioning of ZEN 90160 is 1: 30～10: 1, and potentiation is the most prominent；Increase when thifluzamide and ZEN 90160 weight ratio are 1: 3
Effect ratio is maximum, and potentiation is the most obvious.Test through applicant and find that thifluzamide is 15: 1,10 with the proportioning of ZEN 90160
∶1、5∶1、4∶1、3∶1、2∶1、1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9、1∶10、1∶15、1∶20、1∶25、1∶
To banded sclerotial blight, rust, glume blight, net blotch, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf when 30
Rot, brown spot, gray mold, the preventing and treating of anthrax have obvious potentiation, and potentiation ratio is all more than 2.05.
Application Example seven thifluzamide and active component B and compounding prevent and treat the rice sheath blight disease test of pesticide effectiveness
This experimental establishment is researched and developed at Shaanxi Province's Hanzhong City, test medicine by Shaanxi Welch Crop Protection Co., Ltd., is carried
Confession, compares 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream (certainly
Join), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 suspend
Agent (autogamy).
Investigating the rice sheath blight disease state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.
Within after dispenser 7 days, 14 days, 30 days for the third time, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 16 thifluzamide and active component B and compounding prevent and treat the rice sheath blight disease test of pesticide effectiveness
As can be seen from Table 16, thifluzamide and active component B and compounding after can effectively prevent and treat rice sheath blight disease, preventing and treating
Effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight thifluzamide and active component B and the compounding preventing and treating uncinula necator test of pesticide effectiveness thereof
This test arrangement is in Weinan City suburb, Shaanxi Province, and test medicine is ground by Shaanxi Welch Crop Protection Co., Ltd.
Send out, provide, compare 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream
(autogamy), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 are hanged
Floating agent (autogamy).
Investigating the uncinula necator state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.
Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 17 thifluzamide and active component B and the compounding preventing and treating uncinula necator test of pesticide effectiveness thereof
As can be seen from Table 17, thifluzamide and active component B and compounding after can effectively prevent and treat uncinula necator, preventing and treating
Effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine thifluzamide and active component B and the compounding preventing and treating pear scab disease test of pesticide effectiveness thereof
This test arrangement is in Xianyang, Shanxi province city, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., carried
Confession, compares 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream (certainly
Join), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 suspend
Agent (autogamy).
Investigating the pear scab state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.
Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 18 thifluzamide and active component B and the compounding preventing and treating pear scab test of pesticide effectiveness thereof
As can be seen from Table 18, thifluzamide and active component B and compounding after can effectively prevent and treat pear scab, preventing and treating
Effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten thifluzamide and active component B and compounding prevent and treat the wheat rust test of pesticide effectiveness
This test arrangement is in Weinan City suburb, Shaanxi Province, and test medicine is ground by Shaanxi Welch Crop Protection Co., Ltd.
Send out, provide, compare 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream
(autogamy), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 are hanged
Floating agent (autogamy).
The investigation wheat rust state of an illness, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.For the second time
Within after dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 19 thifluzamide and active component B and compounding prevent and treat the wheat rust test of pesticide effectiveness
As can be seen from Table 19, thifluzamide and active component B and compounding after can effectively prevent and treat wheat rust, preventing and treating effect
Fruit is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 thifluzamide and active component B and compounding prevent and treat the early blight of tomato test of pesticide effectiveness
This experimental establishment is ground by Shaanxi Welch Crop Protection Co., Ltd. at Changan District, Xi'an City, Shanxi Province, test medicine
Send out, provide, compare 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream
(autogamy), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 are hanged
Floating agent (autogamy).
Investigating the early blight of tomato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.
Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 20 thifluzamide and active component B and compounding prevent and treat the early blight of tomato test of pesticide effectiveness
As can be seen from Table 20, thifluzamide and active component B and compounding after can effectively prevent and treat early blight of tomato, preventing and treating
Effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 12 thifluzamide and active component B and compounding prevent and treat the late blight of potato test of pesticide effectiveness
This test arrangement is ground by Shaanxi Welch Crop Protection Co., Ltd. at Xian District, Shanxi Province suburban area, test medicine
Send out, provide, compare 24% thifluzamide suspending agent (commercial), 25% trifloxystrobin suspending agent (autogamy), 10% fluoxastrobin cream
(autogamy), 20% dimoxystrobin wettable powder (autogamy), 20% kresoxim-methyl wettable powder (autogamy), 25% ZEN 90160 are hanged
Floating agent (autogamy).
Investigating the late blight of potato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2
Secondary.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 21 thifluzamide and active component B and compounding prevent and treat the late blight of potato test of pesticide effectiveness
As can be seen from Table 21, thifluzamide and active component B and compounding after can effectively prevent and treat the late blight of potato, anti-
Control effect and be superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, thifluzamide and trifloxystrobin, fluoxastrobin, dimoxystrobin,
After kresoxim-methyl, ZEN 90160 are compounding to the banded sclerotial blight in various crop, rust, glume blight, net blotch, powdery mildew, downy mildew,
The preventive effect of the Common Diseases such as rice blast, scab, early blight, late blight, leaf blight, brown spot, gray mold, anthrax all exists
95% with on excellent, and in single dose preventive effect, potentiation is obvious.
Claims (4)
1. the bactericidal composition containing thifluzamide with methoxy acrylic, it is characterised in that: effective active composition is
Active components A and active component B, active components A and active component B weight ratio are 2: 1, and described active components A is thiophene furan acyl
Amine, active component B is fluoxastrobin.
Bactericidal composition containing thifluzamide Yu methoxy acrylic the most according to claim 1, it is characterised in that:
Compositions makes wettable powder, suspending agent, water dispersible granules, aqueous emulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspension
Agent.
3. the bactericidal composition containing thifluzamide Yu methoxy acrylic described in claim 1 is used for preventing and treating crop pest
Application.
Application the most according to claim 3, it is characterised in that: described disease is banded sclerotial blight, rust, glume blight, filigree
Disease, powdery mildew, downy mildew, rice blast, scab, early blight, late blight, leaf blight, brown spot, gray mold, anthrax.
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| CN102805085B (en) * | 2012-07-23 | 2015-07-08 | 广东中迅农科股份有限公司 | Sterilization composition containing dimoxystrobin and thifluzamide |
| CN103563920B (en) * | 2012-08-04 | 2015-06-03 | 南京华洲药业有限公司 | Bactericidal composition containing thifluzamide and picoxystrobin and application thereof |
| CN103563917A (en) * | 2012-08-04 | 2014-02-12 | 南京华洲药业有限公司 | Bactericidal composition containing thifluzamide and trifloxystrobin and application thereof |
| CN104604898A (en) * | 2012-09-13 | 2015-05-13 | 陕西美邦农药有限公司 | Dimoxystrobin-contained bactericidal composition |
| CN103651368A (en) * | 2013-12-13 | 2014-03-26 | 广西田园生化股份有限公司 | Ultra-low-volume liquid containing picoxystrobin and preparation method of ultra-low-volume liquid |
| CN104054730B (en) * | 2014-06-21 | 2015-11-18 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition and application thereof containing chlorine nalidixic bacterium ester and thifluzamide |
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| WO2003073852A2 (en) * | 2002-03-01 | 2003-09-12 | Basf Aktiengesellschaft | Fungicidal mixtures based on prothioconazole and a strobilurin derivative |
| CN102239852A (en) * | 2011-07-27 | 2011-11-16 | 南宁市德丰富化工有限责任公司 | Fungicide containing trifloxystrobin and thifluzamide |
| CN102273441A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Ultralow volume liquid containing azoxystronbin |
| CN102657187A (en) * | 2012-04-27 | 2012-09-12 | 杭州宇龙化工有限公司 | Bactericidal composition containing thifluzamide and trifloxystrobin |
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| DE19602095A1 (en) * | 1996-01-22 | 1997-07-24 | Bayer Ag | Halopyrimidines |
| CN101790984B (en) * | 2010-03-02 | 2012-04-11 | 杭州宇龙化工有限公司 | Disinfection composite containing thifluzamide and difenoconazole |
| CN102640758B (en) * | 2012-04-24 | 2013-11-13 | 杭州宇龙化工有限公司 | Bactericidal composition containing thifluzamide and fluoxastrobin |
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|---|---|---|---|---|
| WO2003073852A2 (en) * | 2002-03-01 | 2003-09-12 | Basf Aktiengesellschaft | Fungicidal mixtures based on prothioconazole and a strobilurin derivative |
| CN102239852A (en) * | 2011-07-27 | 2011-11-16 | 南宁市德丰富化工有限责任公司 | Fungicide containing trifloxystrobin and thifluzamide |
| CN102273441A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Ultralow volume liquid containing azoxystronbin |
| CN102657187A (en) * | 2012-04-27 | 2012-09-12 | 杭州宇龙化工有限公司 | Bactericidal composition containing thifluzamide and trifloxystrobin |
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Address after: 715500 Pucheng agricultural chemical base industrial park, Shaanxi, Weinan Patentee after: Shaanxi yitianfeng crop Technology Co.,Ltd. Address before: 715500 Pucheng agricultural chemical base industrial park, Shaanxi, Weinan Patentee before: Shaanxi Welch Crop Protection Co.,Ltd. |
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