CN103563920B - Bactericidal composition containing thifluzamide and picoxystrobin and application thereof - Google Patents
Bactericidal composition containing thifluzamide and picoxystrobin and application thereof Download PDFInfo
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- CN103563920B CN103563920B CN201210276569.1A CN201210276569A CN103563920B CN 103563920 B CN103563920 B CN 103563920B CN 201210276569 A CN201210276569 A CN 201210276569A CN 103563920 B CN103563920 B CN 103563920B
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- thifluzamide
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N Cc1nc(C(F)(F)F)c(C(Nc(c(Br)cc(OC(F)(F)F)c2)c2Br)=O)[s]1 Chemical compound Cc1nc(C(F)(F)F)c(C(Nc(c(Br)cc(OC(F)(F)F)c2)c2Br)=O)[s]1 WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 description 1
Abstract
The invention belongs to the field of pesticides, and discloses a bactericidal composition containing thifluzamide and picoxystrobin and an application thereof. The bactericidal composition takes thifluzamide and picoxystrobin as main active ingredients, wherein the weight ratio of thifluzamide to picoxystrobin is (1-70):(1-50). The bactericidal composition can be used for preventing the diseases of cereals, fruit trees and vegetables, has relatively high synergistic effect, overcomes and delays the drug resistance of germs, and realizes high bactericidal speed and long duration while the application cost is reduced and the prevention effect is obviously better than that of using a single agent.
Description
Technical field:
The invention belongs to pesticide field, relate to a kind of bactericidal composition and uses thereof, be specifically related to a kind of bactericidal composition and the application thereof that contain thifluzamide and ZEN 90160.
Background technology
Thifluzamide (Thifuzamide), chemical name: the bromo-2-methyl of 2', 6'-bis--4'-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide, structural formula is as follows:
Thifluzamide is micro-poisoning microbial inoculum of Dow AgroSciences's exploitation at present, rat acute per os LD
50>5000mg/kg, rat acute is through skin LD
50>5000mg/kg, rat acute sucks LC
50>50001.4mg/L.This medicine belongs to thiazole amide bactericide, the mechanism of action is succinate dehydrogenase inhibitor, namely in fungi tricarbonic acid cycle, suppress the synthesis of succinate dehydrogenase, there is very strong Uptake and translocation simultaneously, may be used for paddy rice, other cereal crops, lawn, peanut, potato etc., effective to the pathomycete such as Rhizoctonia, Puccinia, raw meat black point of Pseudomonas, corticium, Ustilago, especially to the disease that basidiomycetes Rhizoctonia causes, there is special efficacy.The disease that concrete controlling object causes as rice sheath blight disease, cotton seedling blight, peanut branch maize ear rot, rust, potato haulm canker and Tilletia caries and Ustilago.Because this medicine is fluorine-containing, therefore its competitiveness is very strong in biochemical pathway again, just not easily recover, and this medicine still has powerful protection effect in seed treatment once with Binding Capacity, to crop safety under recommended dose, it is a very outstanding bactericide kind.But this medicine cost is higher, when being used alone, resistance produces speed.
ZEN 90160 (Picoxystrobin), the strobilurin fungicide of Syngenta Co., Ltd's exploitation, chemical name: (E)-3-methoxyl group-2-{2-[6-(trifluoromethyl)-2-pyridine oxygen methyl] phenyl } methyl acrylate, structural formula is as follows:
ZEN 90160 low toxicity, is mitochondrial respiratory inhibitor, namely suppresses mitochondrial breathing by electro transfer between cytochrome b and C1.Prevent and treat the bacterial strain of 14-demethylation enzyme inhibitor, benzamides, tri carboxylic acid amide class and benzimidazole generation resistance effective.ZEN 90160, once be absorbed by blade, will move, flow with current in transportation system in xylem; It also flows and flows in xylem again after people's blade along with absorbing from gas phase in the gas phase of blade surface, has outstanding rain wash resistance.Just because of systemic activity and the fumigation activity of ZEN 90160, thus after dispenser, active ingredient can effectively be reallocated and fully transmit, and therefore ZEN 90160 extremely has better therapeutic activity than commercial Fluoxastrobin and oxime bacterium.Suitable for crop wheat class is as wheat, barley, oat and rye; Under recommended dose to crop safety, without poisoning.Be mainly used in preventing and treating foliage disease as leaf blight, leaf rust, glume blight, brown spot, powdery mildew etc., compared with existing strobilurin series bactericidal agent, have stronger result for the treatment of to wheat leaf blight, net blotch and moire disease.In addition, the volume increase of ZEN 90160 is also significantly better than other bactericide.But as respiration inhibitor, its mechanism of action is single, and resistance problem must draw attention ahead of time.
Rice sheath blight disease, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, damping off morbidity is serious, often causes catastrophic loss, although thifluzamide, ZEN 90160 have ideal control efficiency, but in actual applications, the difficulty of prevention and cure of phytopathogen is increasing: on the one hand, and along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
The object of the invention is the plant bactericidal composition containing thifluzamide and ZEN 90160 providing a kind of applied widely, cost low, effective for above-mentioned technical problem.
A further object of the invention is to provide the application of this bactericidal composition.
The object of the invention is to realize by following technical solution:
A kind of bactericidal composition, it is with thifluzamide and ZEN 90160 for principle active component, and wherein thifluzamide and ZEN 90160 weight ratio are 1 ~ 70:1 ~ 50, and wherein in bactericidal composition, effective ingredient is present in composition with enhancing effective amount.
Described bactericidal composition, wherein thifluzamide and ZEN 90160 weight ratio are preferably 5 ~ 50:10 ~ 50, more preferably 5 ~ 40:10 ~ 30, particularly preferably 1::01 ~ 20.
In the compositions of the present invention, total weight percent in the composition both thifluzamide and ZEN 90160 is 2 ~ 80%.Be preferably 5 ~ 50%, most preferably 8 ~ 40%.
Described bactericidal composition, wherein thifluzamide and ZEN 90160 and known auxiliary agent and excipient are re-dubbed any one formulation that agricultural chemicals allows.These known auxiliary agents, excipients have dispersant, diffusant, defoamer, wetting agent, disintegrant etc., and calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third can be adopted (as agriculture breast 33
#), castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series etc. in one or more combinations, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can be alone or and use.
Described bactericidal composition, its formulation is missible oil, wetting powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
The described compound biocide composite containing thifluzamide and ZEN 90160 is preparing the application prevented and treated in the medicine of Cereal, fruit tree, vegetable crop fungal disease.
Preferably described bactericidal composition is preparing the water prevention rice sheath blight, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, the application in the germ killing drugs of damping off.
" % " of the present invention is mass percent.
Beneficial effect of the present invention:
1, the thifluzamide that the present invention is used is thiazole amide bactericide, and ZEN 90160 is methoxy acrylic bactericide, and the mechanism of action is different, and mutual mixture can not produce low touching, and can produce obvious synergistic function, reduces dosage, reduces costs.
2, the present composition scope of application increases, be applicable to the disease of preventing and treating Cereal, fruit tree, vegetables, particularly prevent and treat paddy rice, wheat, potatoes and other crops disease, as rice sheath blight disease, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, damping off.
Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And suppress insect or fungi to the drug-fast generation of unitary agent (thifluzamide and ZEN 90160 arbitrary).
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method.
Embodiment 1:
By thifluzamide 5g, ZEN 90160 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 15% wetting powder.
Embodiment 2:
By thifluzamide 3g, ZEN 90160 12g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 15% wetting powder.
Embodiment 3:
By thifluzamide 2g, ZEN 90160 14g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 16% wetting powder.
Embodiment 4:
Take 5g thifluzamide, 50g ZEN 90160, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 55% thifluzamide-ZEN 90160 aqueous emulsion.
Embodiment 5:
Take 2g thifluzamide, 30g ZEN 90160, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 32% thifluzamide-ZEN 90160 microemulsion.
Embodiment 6:
Take 1g thifluzamide, 5g ZEN 90160, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 6% thifluzamide-ZEN 90160 aqueous emulsion.
Embodiment 7:
Take 50g thifluzamide, 20g ZEN 90160, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 70% thifluzamide-ZEN 90160 missible oil.
Embodiment 8:
Take 2g thifluzamide, 40g ZEN 90160, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 42% thifluzamide-ZEN 90160 missible oil.
Embodiment 9:
Take 5g thifluzamide, 20g ZEN 90160, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 25% thifluzamide-ZEN 90160 microemulsion.
Embodiment 10:
Take 5g thifluzamide, 0.5g ZEN 90160, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 5.5% thifluzamide-ZEN 90160 missible oil.
Embodiment 11:
Take 5g thifluzamide, 30g ZEN 90160, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 35% thifluzamide-ZEN 90160 missible oil.
Embodiment 12:
Take 10g thifluzamide, 10g ZEN 90160, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-ZEN 90160 suspending agent.
Embodiment 13:
Take 30g thifluzamide, 12g ZEN 90160, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 42% thifluzamide-ZEN 90160 suspending agent.
Embodiment 13:
Take 2g thifluzamide, 5g ZEN 90160, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 7% thifluzamide-ZEN 90160 water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 14:
Take 4g thifluzamide, 13g ZEN 90160, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% thifluzamide-ZEN 90160 water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 5g thifluzamide, 15g ZEN 90160, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-ZEN 90160 suspending agent.
Embodiment 16:
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure different agents to the EC of bacterial strain
50value, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC
50× 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When co-toxicity coefficient classification: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
Table 1: thifluzamide+ZEN 90160 different ratio is to the indoor biometrics result of Rhizoctonia solani Kuhn (Thanatephorus cucumeris (Frank) Donk)
| Medicament | Virulence regression equation | EC 50（mg/L） | Co-toxicity coefficient |
| 240g/L thifluzamide SC | Y=1.0928X+3.5746 | 20.1541 | - |
| 240g/L ZEN 90160 SC | Y=1.7899X+2.2555 | 34.1454 | - |
| Embodiment 1 | Y=1.6845X+2.8401 | 19.1514 | 144.2 |
| Embodiment 2 | Y=1.353X+3.2953 | 18.1944 | 165.3 |
| Embodiment 3 | Y=3.1608X+1.0171 | 18.2001 | 173.0 |
Field control effectiveness test:
With the pesticidal preparations water prevention rice sheath blight test that above-described embodiment is obtained.
1, test process: this test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, contrast medicament is agricultural chemicals single dose 240g/L ZEN 90160 SC and 240g/L thifluzamide SC and blank clean water experiment respectively.
2, each plot area of test method is 66.7m
2, repeat 3 times; Investigation drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point in test treatment region, checks rice sheath blight disease occurrence degree.
3, result of the test is in Table:
Table 2
Note: a represents remarkable in the level of α=0.05, and b represents variant in the level of α=0.05, and c represents not remarkable in the level of α=0.05.
Shown by indoor biometrics and field efficacy result, thifluzamide and ZEN 90160 composition have obvious synergistic function, and the control efficiency of composition is excellent, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (4)
1. a bactericidal composition, it is characterized in that thifluzamide 3g, ZEN 90160 12g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 15% wetting powder.
2. a bactericidal composition, it is characterized in that thifluzamide 2g, ZEN 90160 14g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 16% wetting powder.
3. the application of compound biocide composite in the medicine preparing the water prevention rice sheath blight containing thifluzamide and ZEN 90160 according to claim 1.
4. the application of compound biocide composite in the medicine preparing the water prevention rice sheath blight containing thifluzamide and ZEN 90160 according to claim 2.
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| CN201210276569.1A CN103563920B (en) | 2012-08-04 | 2012-08-04 | Bactericidal composition containing thifluzamide and picoxystrobin and application thereof |
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| CN103563920B true CN103563920B (en) | 2015-06-03 |
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| CN108651495A (en) * | 2017-04-01 | 2018-10-16 | 南京红太阳股份有限公司 | A kind of bactericidal composition and its application containing ZEN 90160 and carbendazim |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1980150A1 (en) * | 2007-04-13 | 2008-10-15 | Basf Se | Fungicidal mixtures based on triazolopyrimidine compounds |
| CN101400259A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
| CN103371153A (en) * | 2012-04-28 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Sterilization composition with thifluzamide and methoxy acrylics |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101400259A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
| EP1980150A1 (en) * | 2007-04-13 | 2008-10-15 | Basf Se | Fungicidal mixtures based on triazolopyrimidine compounds |
| CN103371153A (en) * | 2012-04-28 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Sterilization composition with thifluzamide and methoxy acrylics |
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