CN103563913B - A kind of bactericidal composition and application thereof containing thifluzamide and prothioconazoles - Google Patents
A kind of bactericidal composition and application thereof containing thifluzamide and prothioconazoles Download PDFInfo
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- CN103563913B CN103563913B CN201210275269.1A CN201210275269A CN103563913B CN 103563913 B CN103563913 B CN 103563913B CN 201210275269 A CN201210275269 A CN 201210275269A CN 103563913 B CN103563913 B CN 103563913B
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Abstract
The invention belongs to pesticide field, disclose a kind of bactericidal composition and the application thereof that contain thifluzamide and prothioconazoles.This bactericidal composition is with thifluzamide and prothioconazoles for principle active component, and wherein the weight ratio of thifluzamide and prothioconazoles is 1 ~ 70:1 ~ 50.This bactericidal composition can be applicable to prevent and treat Cereal, melon and fruit or vegetable crop disease, there is higher synergistic function, overcome and delayed the pesticide resistance of germ, sterilization speed is fast, the lasting period is long, reduce application cost, and control efficiency is obviously better than its single dose and uses.
Description
Technical field:
The invention belongs to agriculture field, relate to a kind of bactericidal composition and uses thereof, be specifically related to a kind of bactericidal composition and the application thereof that contain thifluzamide and prothioconazoles.
Background technology
Thifluzamide (Trifluzamide), also claims thifluzamide, chemical name: the bromo-2-methyl of 2', 6'-bis--4'-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide, molecular formula C
13h
6br
2f
6n
2o
2s, chemical structural formula is:
Thifluzamide toxicity is low: rat acute LD50 of passing through mouth >5000mg/kg, and rat acute is through skin LD50>5000mg/kg, and rat acute sucks LC50>50001.4mg/L air.There is moderate to stimulate to lagophthalmos eyeball, have minimal irritation to rabbit skin.Belong to thiazole amide bactericide, there is strong Uptake and translocation and long lasting effect.Thifluzamide is succinate dehydrogenase inhibitor, and due to fluorine-containing, its its competitiveness in biochemical pathway is very strong, just not easily recovers once be combined with substrate or enzyme.
Thifluzamide is used for paddy rice, cereal crop and lawn, effective to the pathomycete such as Rhizoctonia, Puccinia, raw meat black point of Pseudomonas, corticium, Ustilago, to the fungus-caused disease of Basidiomycetes, as damping off, banded sclerotial blight etc. have special efficacy.For paddy rice, cereal crop, lawn cauline leaf process, using dosage is 125 ~ 250g active ingredient/hm
2, for cereal crop and non-cereal crop Dressing, using dosage is 7 ~ 30g active ingredient/kg seed.Medicament has excellent preventive effect to rice banded sclerotial blight, using dosage 130 ~ 140g active ingredient/hm
2, cereal crop rust 125 ~ 250g active ingredient/hm
2.
Prothioconazoles (boscalid), chemical name: 2-(structural formula is as follows for 2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1,2,4-triazole-3-sulfo-:
Prothioconazoles is low toxicity bactericide, by the demethylation effect of the precursor of sterol in Antifungi, thus plays bactericidal action, and this kind not only has good systemic activity, excellent protection, treats and root out activity, and the lasting period is long, to crop safety.Prothioconazoles is mainly used in control cereal crop as the multiple diseases on wheat, barley, peanut, paddy rice and legume crop, almost all there is good control efficiency, as wheat powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc. to all wheat class diseases.Talented and soil-borne disease that is peanut can also be prevented and treated, as stalk break, and main leaf diseases, as gray mold, black spot, brown spot, balck shank and rust etc.Using dosage is generally per hectare about active ingredient 200g, and under this dosage, its activity is better than or equals current conventional sterilization agent kind.
The difficulty of prevention and cure of current phytopathogen is increasing, and on the one hand, along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
The object of the invention is for above-mentioned technical problem provide a kind of applied widely, cost is low, the effective plant bactericidal composition containing thifluzamide and prothioconazoles.
Another object of the present invention is to provide the application of this bactericidal composition.
The object of the invention is to be realized by following measures:
A kind of bactericidal composition, it is with thifluzamide and prothioconazoles for principle active component, and wherein thifluzamide and prothioconazoles weight ratio are 1 ~ 70:1 ~ 50, and wherein in bactericidal composition, effective ingredient is present in composition with enhancing effective amount.
Described bactericidal composition, wherein thifluzamide and prothioconazoles weight ratio are preferably 5 ~ 50:10 ~ 50, more preferably 5 ~ 40:10 ~ 30, particularly preferably 1:0.1 ~ 20.
In the compositions of the present invention, the percentage by weight accounting for composition both thifluzamide and prothioconazoles is 2 ~ 80%.Be preferably 5 ~ 50%, most preferably 8 ~ 40%.
Described bactericidal composition, wherein thifluzamide becomes with prothioconazoles any one formulation that agricultural chemicals allows with known additive compound.These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.Auxiliary agent can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33
#), one or more combinations in polyoxyethylene nonylphenol ether, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can be alone or and use.
Described bactericidal composition, its formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
The described compound biocide composite containing thifluzamide and prothioconazoles is preparing the application in the medicine preventing and treating Cereal, melon and fruit or vegetable fungi disease.
Preferably described bactericidal composition is preparing the application prevented and treated in the medicine of leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, S.scabies, brown spot, damping off, banded sclerotial blight, gray mold.
Beneficial effect of the present invention:
1, the thifluzamide that the present invention is used is thiazole amide bactericide, and prothioconazoles is New-type wide-spectrum triazolinthione series bactericidal agent, and mutual mixture can not produce low touching, and can produce higher synergistic function, reduces dosage, reduces costs.
2, the present composition scope of application increases, be applicable to the crop pest of preventing and treating Cereal, various melon and fruit, vegetables, particularly prevent and treat the crop pests such as paddy rice, wheat, capsicum, banana, mango, pineapple, cucumber, tomato, as leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, S.scabies, brown spot, damping off, banded sclerotial blight, gray mold.
Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And suppress insect or fungi to the drug-fast generation of unitary agent (thifluzamide and prothioconazoles arbitrary).
" % " of the present invention is mass percent.
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method.
Embodiment 1:
By thifluzamide 5g, prothioconazoles 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 15% wetting powder.
Embodiment 2:
By thifluzamide 10g, prothioconazoles 40g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 50% wetting powder.
Embodiment 3:
By thifluzamide 4g, prothioconazoles 32g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 36% wetting powder.
Embodiment 4:
Take 5g thifluzamide, 50g prothioconazoles, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 55% thifluzamide-prothioconazoles aqueous emulsion.
Embodiment 5:
Take 2g thifluzamide, 30g prothioconazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 32% thifluzamide-prothioconazoles microemulsion.
Embodiment 6:
Take 1g thifluzamide, 5g prothioconazoles, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 6% thifluzamide-prothioconazoles aqueous emulsion.
Embodiment 7:
Take 50g thifluzamide, 20g prothioconazoles, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 70% thifluzamide-prothioconazoles missible oil.
Embodiment 8:
Take 2g thifluzamide, 40g prothioconazoles, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 42% thifluzamide-prothioconazoles missible oil.
Embodiment 9:
Take 5g thifluzamide, 20g prothioconazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 25% thifluzamide-prothioconazoles microemulsion.
Embodiment 10:
Take 5g thifluzamide, 0.5g prothioconazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 5.5% thifluzamide-prothioconazoles missible oil.
Embodiment 11:
Take 5g thifluzamide, 30g prothioconazoles, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 35% thifluzamide-prothioconazoles missible oil.
Embodiment 12:
Take 10g thifluzamide, 10g prothioconazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-prothioconazoles suspending agent.
Embodiment 13:
Take 30g thifluzamide, 12g prothioconazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 42% thifluzamide-prothioconazoles suspending agent.
Embodiment 13:
Take 2g thifluzamide, 5g prothioconazoles, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 7% thifluzamide-prothioconazoles water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 14:
Take 4g thifluzamide, 13g prothioconazoles, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% thifluzamide-prothioconazoles water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 5g thifluzamide, 15g prothioconazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-prothioconazoles suspending agent.
Embodiment 16:
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure different agents to the EC of bacterial strain
50value, what adopt the abundant introduction of Sun Yun spends coefficient calculation method together, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture.
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC50 × 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
Table 1 thifluzamide+prothioconazoles different ratio is to Rhizoctonia solani Kuhn (Rhizoctonia solani k ü hn) indoor biometrics result
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 24% thifluzamide EC | Y=2.1231X+6.6103 | 0.1744 | - |
| 50% prothioconazoles WDG | Y=1.8904X+4.3136 | 2.3073 | - |
| Embodiment 1 | Y=1.5730X+5.8361 | 0.2941 | 154.55 |
| Embodiment 2 | Y=2.0633X+5.6484 | 0.4850 | 138.06 |
| Embodiment 3 | Y=2.7801X+5.3356 | 0.7573 | 129.16 |
Field control effectiveness test:
With the pesticidal preparations water prevention rice sheath blight test that above-described embodiment is obtained.
1, test process: this test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, contrast medicament is commercially available agricultural chemicals 50% prothioconazoles WDG and 24% thifluzamide EC and blank clean water experiment respectively.
2, each plot area of test method is 66.7m
2, repeat 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point in test treatment region, checks banded sclerotial blight occurrence degree.
3, result of the test is in table 2:
Table 2
Note: a represents remarkable in the level of α=0.05, and b represents variant in the level of α=0.05, and c represents not remarkable in the level of α=0.05.
Shown by indoor biometrics and field efficacy result, thifluzamide and prothioconazoles composition have obvious synergistic function, and the control efficiency of composition is excellent, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (8)
1., containing a bactericidal composition for thifluzamide and prothioconazoles, it is characterized in that wherein the weight ratio of thifluzamide and prothioconazoles is 1:4 or 1:8 with thifluzamide and prothioconazoles for active ingredient.
2. bactericidal composition according to claim 1, is characterized in that both thifluzamide and prothioconazoles gross weight percentage composition is in the composition 2-80%.
3. bactericidal composition according to claim 2, is characterized in that both thifluzamide and prothioconazoles gross weight percentage composition is in the composition 5-50%.
4. bactericidal composition according to claim 3, is characterized in that both thifluzamide and prothioconazoles gross weight percentage composition is in the composition 8-40%.
5. bactericidal composition according to claim 1, is characterized in that any one formulation for active ingredient and insecticides adjuvant are mixed with, agricultural chemicals allowed with thifluzamide and prothioconazoles.
6. bactericidal composition according to claim 5, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
7. the bactericidal composition containing thifluzamide and prothioconazoles according to claim 1 is preparing the application in the medicine preventing and treating Cereal, melon and fruit or vegetable fungi disease.
8. application according to claim 7, is characterized in that described bactericidal composition is preparing the application prevented and treated in the medicine of leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, shot hole, brown spot, damping off, banded sclerotial blight, gray mold.
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| US20020173529A1 (en) * | 1997-04-18 | 2002-11-21 | Stefan Dutzmann | Fungicide active substance combinations |
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101828559A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
| CN102204546A (en) * | 2011-04-16 | 2011-10-05 | 陕西汤普森生物科技有限公司 | Bactericidal composition containing thifluzamide and triazole compounds |
| CN102657186A (en) * | 2012-04-24 | 2012-09-12 | 杭州宇龙化工有限公司 | Bactericidal composition containing thifluzamide and prothioconazole |
-
2012
- 2012-08-04 CN CN201210275269.1A patent/CN103563913B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043127A (en) * | 1988-11-29 | 1990-06-20 | 孟山都公司 | Substituted thiazole and mycocide purposes thereof |
| US20020173529A1 (en) * | 1997-04-18 | 2002-11-21 | Stefan Dutzmann | Fungicide active substance combinations |
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101828559A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
| CN102204546A (en) * | 2011-04-16 | 2011-10-05 | 陕西汤普森生物科技有限公司 | Bactericidal composition containing thifluzamide and triazole compounds |
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Effective date of registration: 20180516 Address after: 211318 Dongfeng Road 8, Yalong Town, Gaochun, Nanjing, Jiangsu Co-patentee after: Nanjing Redsun Co., Ltd. Patentee after: Nanjing Huazhou Pharmaceutical Co., Ltd. Address before: 211318 Dongfeng Road 8, Yalong Town, Gaochun, Nanjing, Jiangsu Patentee before: Nanjing Huazhou Pharmaceutical Co., Ltd. |