CN103563922B - A kind of bactericidal composition and application thereof containing thifluzamide and tpn - Google Patents
A kind of bactericidal composition and application thereof containing thifluzamide and tpn Download PDFInfo
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- CN103563922B CN103563922B CN201210276970.5A CN201210276970A CN103563922B CN 103563922 B CN103563922 B CN 103563922B CN 201210276970 A CN201210276970 A CN 201210276970A CN 103563922 B CN103563922 B CN 103563922B
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Abstract
The invention belongs to agriculture field, disclose a kind of bactericidal composition and the application thereof that contain thifluzamide and tpn.This bactericidal composition is with thifluzamide and tpn for principle active component, and wherein the weight ratio of thifluzamide and tpn is 1 ~ 70: 1 ~ 50, and the two is 2-80% at described composition total weight percentage composition.This bactericidal composition can be applicable to control Cereal, fruit tree, vegetable crop disease, there is higher synergistic function, overcome and delayed the pesticide resistance of germ, sterilization speed is fast, the lasting period is long, reduce application cost, and control efficiency is obviously better than its single dose and uses.
Description
Technical field:
The invention belongs to pesticide field, relate to a kind of bactericidal composition and uses thereof, be specifically related to a kind of bactericidal composition and the application thereof that contain thifluzamide and tpn.
Background technology
Thifluzamide (Thifluzamide), chemical name: the bromo-2-methyl of 2', 6'-bis--4'-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide, structural formula is as follows:
Thifluzamide is micro-poisoning microbial inoculum of Dow AgroSciences's exploitation at present, rat acute per os LD
50>5000mg/kg, rat acute is through skin LD
50>5000mg/kg, rat acute sucks LC
50>50001.4mg/L.This medicine belongs to thiazole amide bactericide, the mechanism of action is succinate dehydrogenase inhibitor, namely in fungi tricarbonic acid cycle, suppress the synthesis of succinate dehydrogenase, there is very strong Uptake and translocation simultaneously, may be used for paddy rice, other cereal crops, lawn, peanut, potato etc., effective to the pathomycete such as Rhizoctonia, Puccinia, raw meat black point of Pseudomonas, corticium, Ustilago, especially to the disease that basidiomycetes Rhizoctonia causes, there is special efficacy.The disease that concrete controlling object causes as rice sheath blight disease, cotton seedling blight, peanut branch maize ear rot, rust, potato haulm canker and Tilletia caries and Ustilago.Because this medicine is fluorine-containing, therefore its competitiveness is very strong in biochemical pathway again, just not easily recover, and this medicine still has powerful protection effect in seed treatment once with Binding Capacity, to crop safety under recommended dose, it is a very outstanding bactericide kind.But this medicine cost is higher, when being used alone, resistance produces speed.
Tpn (Chlorothalonil), chloro-1, the 3-benzene dinitrile of chemical name: 2,4,5,6-tetra-, structural formula is as follows:
Tpn is wide spectrum, protectiveness nitrile bactericide.The mechanism of action can be had an effect with the glyceraldehyde 3-phosphate dehydrogenase in fungal cell, ties mutually entirely, thus destroy this enzymic activity, the metabolism of fungal cell is damaged and the power that loses one's life with the protein containing cysteine in this enzyme.Tpn does not have Uptake and translocation effect, but after being sprayed onto on plant corpus, can have good tackness on body surface, not easily be fallen by rain drop erosion, therefore the drug effect phase is longer.Tpn is under positive common medicine, and the general drug effect phase reaches about 10 days.Tpn is mainly used in preventing and treating various fungal disease, be applicable to the tens of kinds of crops such as wheat, paddy rice, corn, wild cabbage, oranges and tangerines, tobacco, melon, peanut, controlling object comprises a lot of fungal disease such as epidemic disease, downy mildew, brown spot, defoliation, ring spot, powdery mildew, shot hole, gray mold.
Rice sheath blight disease, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, glume blight, powdery mildew, the morbidity of rust, shot hole, gray mold, downy mildew is serious, often cause catastrophic loss, although thifluzamide, tpn have ideal control efficiency, but in actual applications, the difficulty of prevention and cure of phytopathogen is increasing: on the one hand, along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention:
The object of the invention is the bactericidal composition containing thifluzamide and tpn providing a kind of applied widely, cost low, effective for above-mentioned technical problem.
Another object of the present invention is to provide the application of this bactericidal composition.
The object of the invention is to be realized by following technical proposal:
A kind of bactericidal composition, it is with thifluzamide and tpn for principle active component, and wherein thifluzamide and tpn weight ratio are 1 ~ 70: 1 ~ 50, and wherein in bactericidal composition, effective ingredient is present in composition with enhancing effective amount.
Described bactericidal composition, wherein thifluzamide and tpn weight ratio are preferably 5 ~ 50: 10 ~ 50, and more preferably 5 ~ 40: 10 ~ 30, particularly preferably 1: 0.1 ~ 20.
In the compositions of the present invention, the gross weight percentage composition accounted in composition at composition both thifluzamide and tpn is 2 ~ 80%.Be preferably 5 ~ 50%, most preferably 10 ~ 40%.
Described bactericidal composition, wherein thifluzamide and tpn and known auxiliary agent, excipient are re-dubbed any one formulation that agricultural chemicals allows.These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant, excipients etc., and calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third can be adopted (as agriculture breast 33
#), castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series etc. in one or more combinations, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent and other auxiliary material can be alone or and use.
Described bactericidal composition, its formulation is missible oil, wetting powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
The application of described bactericidal composition in the medicine of the fungal disease of preparation control Cereal, fruit tree or vegetables.
Described bactericidal composition is preferably preparing the water prevention rice sheath blight, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, glume blight, powdery mildew, the application in the medicine of rust, shot hole, gray mold, downy mildew.
Beneficial effect of the present invention:
1, the thifluzamide that the present invention is used is thiazole amide bactericide, tpn is a kind of inhibitor of energy, the mechanism of action is different, mutual mixture can not produce low touching, compared with single dose, the two conbined usage, has obvious synergistic function, reduce dosage, reduce production cost and prevent and treat recruitment, drug cost; Thifluzamide and being used in conjunction of tpn have also overcome and have delayed pesticide resistance simultaneously, and expanding prevention is composed, and significantly improves control efficiency.
2, the present composition scope of application increases, be applicable to the crop pest of preventing and treating Cereal, fruit tree, vegetables, particularly prevent and treat the crop pests such as paddy rice, wheat, potato, fruit tree, as rice sheath blight disease, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, glume blight, powdery mildew, rust, shot hole, gray mold, downy mildew.
Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; Its successful uses higher than its single dose.
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method, and " % " of the present invention is mass percent.
Embodiment 1:
By thifluzamide 5g, tpn 25g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is the wetting powder of 30%.
Embodiment 2:
By thifluzamide 3g, tpn 10g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 13% wetting powder.
Embodiment 3:
By thifluzamide 4g, tpn 30g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 34% wetting powder.
Embodiment 4:
Take 5g thifluzamide, 50g tpn, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 55% thifluzamide-tpn aqueous emulsion.
Embodiment 5:
Take 2g thifluzamide, 30g tpn, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 32% thifluzamide-chlorothalonil microemulsion.
Embodiment 6:
Take 1g thifluzamide, 5g tpn, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making principle active component weight percentage is 6% thifluzamide-tpn aqueous emulsion.
Embodiment 7:
Take 50g thifluzamide, 20g tpn, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 70% thifluzamide-tpn missible oil.
Embodiment 8:
Take 2g thifluzamide, 40g tpn, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 42% thifluzamide-tpn missible oil.
Embodiment 9:
Take 5g thifluzamide, 20g tpn, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making principle active component weight percentage is 25% thifluzamide-chlorothalonil microemulsion.
Embodiment 10:
Take 5g thifluzamide, 0.5g tpn, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 5.5% thifluzamide-tpn missible oil.
Embodiment 11:
Take 5g thifluzamide, 30g tpn, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solubilizer oil is to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making principle active component weight percentage is 35% thifluzamide-tpn missible oil.
Embodiment 12:
Take 10g thifluzamide, 10g tpn, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-tpn suspending agent.
Embodiment 13:
Take 30g thifluzamide, 12g tpn, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 42% thifluzamide-tpn suspending agent.
Embodiment 13:
Take 2g thifluzamide, 5g tpn, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 7% thifluzamide-tpn water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 14:
Take 4g thifluzamide, 13g tpn, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% thifluzamide-tpn water dispersion granule that above raw material is made principle active component weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 5g thifluzamide, 15g tpn, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make principle active component weight percentage is 20% thifluzamide-tpn suspending agent.
Embodiment 16:
By thifluzamide 5g, tpn 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is the wetting powder of 15%.
Embodiment 17:
By thifluzamide 10g, tpn 40g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained principle active component weight percentage is 50% wetting powder.
Embodiment 18:
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure different agents to the EC of bacterial strain
50value, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC
50× 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When the classification of co-toxicity coefficient: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
Table 1: thifluzamide+tpn different ratio is to the indoor biometrics result of wheat powdery mildew (Erysiphe graminisDC.f.sp.triticlE.Marchal)
| Medicament | Virulence regression equation | EC50（mg/L） | Co-toxicity coefficient |
| 240g/L thifluzamide SC | Y=2.7957X+1.4742 | 18.2465 | - |
| 25% tpn WDG | Y=2.3409X+1.5085 | 31.0124 | - |
| Embodiment 1 | Y=2.0257X+2.5313 | 16.5454 | 167 |
| Embodiment 2 | Y=2.5415X+2.2585 | 11.9871 | 224 |
| Embodiment 3 | Y=1.3253X+3.4574 | 14.5870 | 196 |
Field control effectiveness test:
With the pesticidal preparations control wheat powdery mildew test that above-described embodiment is obtained.
1, test process: this test medicine consumption establishes three concentration for the treatment of respectively according to the difference of each composition, contrast medicament is agricultural chemicals 25% tpn WDG and 240g/L thifluzamide SC and blank clean water experiment respectively.
2, each plot area of test method is 66.7m
2, repeat 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point in test treatment region, checks Occurrence Degree of Wheat Powdery Mildew.
3, result of the test sees the following form:
Note: a represents remarkable in the level of α=0.05, and b represents variant in the level of α=0.05, and c represents not remarkable in the level of α=0.05.
Shown by indoor biometrics and field efficacy result, thifluzamide and tpn composition have obvious synergistic function, and the control efficiency of composition is excellent, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (8)
1. the bactericidal composition containing thifluzamide and tpn, is characterized in that wherein the weight ratio of thifluzamide and tpn is 1:5,3:10 or 2:15 with thifluzamide and tpn for active ingredient.
2. bactericidal composition according to claim 1, is characterized in that active ingredient thifluzamide and the tpn gross weight percentage composition in described composition is 2-80%.
3. bactericidal composition according to claim 2, is characterized in that active ingredient thifluzamide and the tpn gross weight percentage composition in described composition is 5-50%.
4. bactericidal composition according to claim 3, is characterized in that active ingredient thifluzamide and the tpn gross weight percentage composition in described composition is 10-40%.
5. bactericidal composition according to claim 1, it is characterized in that this bactericidal composition with thifluzamide with tpn for active ingredient becomes any one formulation that agricultural chemicals allows with insecticides adjuvant, excipient.
6. bactericidal composition according to claim 5, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
7. the application of the bactericidal composition containing thifluzamide and tpn according to claim 1 in the medicine of the fungal disease of preparation control Cereal, fruit tree or vegetables.
8. application according to claim 7, it is characterized in that described bactericidal composition is preparing the water prevention rice sheath blight, rice blast, false smut, wheat sharp eyespot, loose kernel smut, bunt, glume blight, powdery mildew, the application in the medicine of rust, shot hole, gray mold, downy mildew.
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| CN106889086A (en) * | 2017-03-08 | 2017-06-27 | 南京华洲药业有限公司 | A kind of bactericidal composition and its application containing Hexanaphthene flusulfamide and thifluzamide |
| CN108935495A (en) * | 2017-05-22 | 2018-12-07 | 广东广康生化科技股份有限公司 | A kind of effective component includes the Bactericidal composite of folpet and thifluzamide |
| CN111066818A (en) * | 2019-12-20 | 2020-04-28 | 利民化学有限责任公司 | Composition containing copper calcium sulfate and chlorothalonil and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012031061A2 (en) * | 2010-09-01 | 2012-03-08 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles and their mixtures |
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- 2012-08-04 CN CN201210276970.5A patent/CN103563922B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012031061A2 (en) * | 2010-09-01 | 2012-03-08 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles and their mixtures |
Non-Patent Citations (2)
| Title |
|---|
| 孙攀,孙俊清.3种杀菌剂防治水稻纹枯病药效试验.《现代农业科技》.2011,(第18期),第184页. * |
| 张从宇,等.常用杀菌剂及其复配剂对番茄灰霉病菌的毒力测定.《农药》.2003,第42卷(第8期),第28-29页. * |
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Effective date of registration: 20180516 Address after: 211318 Dongfeng Road 8, Yalong Town, Gaochun, Nanjing, Jiangsu Co-patentee after: Nanjing Redsun Co., Ltd. Patentee after: Nanjing Huazhou Pharmaceutical Co., Ltd. Address before: 211318 Dongfeng Road 8, Yalong Town, Gaochun, Nanjing, Jiangsu Patentee before: Nanjing Huazhou Pharmaceutical Co., Ltd. |
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