CN103563939A - Bactericidal composition containing pyraclostrobin and fluazinam and application thereof - Google Patents

Bactericidal composition containing pyraclostrobin and fluazinam and application thereof Download PDF

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CN103563939A
CN103563939A CN201210276566.8A CN201210276566A CN103563939A CN 103563939 A CN103563939 A CN 103563939A CN 201210276566 A CN201210276566 A CN 201210276566A CN 103563939 A CN103563939 A CN 103563939A
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fluazinam
kresoxim
pyrazol
composition according
blight
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CN201210276566.8A
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Chinese (zh)
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彭永强
刘奎涛
赵维桢
袁竹青
高瑞花
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南京华洲药业有限公司
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Abstract

The invention discloses a bactericidal composition containing pyraclostrobin and fluazinam and an application thereof. The bactericidal composition takes pyraclostrobin and fluazinam as main active ingredients, wherein the weight ratio of pyraclostrobin to fluazinam is (1-70):(1-50). The bactericidal composition can be used for preventing the diseases of cereal, melon and fruit or vegetable crops, has relatively high synergistic effect, overcomes and delays the drug resistance of germs, and realizes high bactericidal speed and long duration while the application cost is reduced and the prevention effect is obviously better than that of using a single agent. The bactericidal composition disclosed by the invention can be used for preventing fungal diseases of crops and particularly can be used for preventing the fungal diseases such as leaf blight, rust disease, powdery mildew, downy mildew, epidemic disease, anthracnose, scab, brown spot, damping off, gray mold, clubroot, late blight and the like of the cereal, melon and fruit or vegetable crops, and the effect is better than that of using a single agent.

Description

一种含吡唑醚菌酯和氟啶胺的杀菌组合物及其应用 Pyrazol-containing kresoxim fluazinam and fungicidal compositions and uses thereof

技术领域: FIELD:

[0001] 本发明涉及一种杀菌组合物及其用途,尤其是一种以吡唑醚菌酯和氟啶胺为主要活性成分的杀菌组合物及其应用。 [0001] The present invention relates to a fungicidal composition and its use, in particular a pyrazole kresoxim and fluazinam germicidal compositions and the use of the main active ingredient.

背景技术 Background technique

[0002]吡唑醚菌酯(Pyraclostrobin),又名:唑菌胺酯,化学名称为N-甲氧 [0002] pyrazol Kresoxim (pyraclostrobin), also known as: pyraclostrobin, chemical name is N- methoxy

基-N_2-[ (N-对氯苯基)-3-吡唑氧基甲基]苯基氨基甲酸酯。 Group -N_2- [(N- p-chlorophenyl) -3-methyl-pyrazol-yloxy] phenyl carbamate. 结构式如下: Structural formula:

[0003] [0003]

Figure CN103563939AD00031

[0004] 吡唑醚菌酯毒性低:大鼠经口>5000,经皮>2000,对兔眼睛无刺激性,无潜在诱变性,无致畸致癌性,对蜜蜂无害,在水中水解半衰期DT5(l>30d,pH5-7时稳定,水中光解半衰期DT5(l〈2h,大田中土壤半衰期DT5(l2-37d。该化合物不仅毒性低,对非靶标生物安全,而且对使用者和环境均安全友好,已被美国EPA列为“减小风险的候选药剂”。吡唑醚菌酯为一种线粒体呼吸抑制剂,它通过抑制线粒体内电子传递系统,与蛋白质复合体III作用而呈现抗菌活性,且吡唑醚菌酯具有显著的增产性。该药剂可阻碍病原菌生活链中的孢子发芽、芽孢生长、菌丝侵入、附着器形成和孢子形成而致效,尤其对孢子发芽有极强的抑制作用,故有卓著的预防效果。同时,它有很强的叶内渗透效果而具有很高的耐雨性,可用于小麦、花生、水稻、蔬菜、果树、烟草、茶树、观赏植物、 [0004] Kresoxim-pyrazol low toxicity: rat oral> 5000, transdermal> 2000, non-irritating to rabbit eyes potential mutagenic, non-teratogenic and carcinogenic, sound of bees, to hydrolysis in water half-DT5 (l> 30d, pH5-7 steady, water photolysis half-DT5 (l <2h, field soil half-life DT5 (l2-37d. the compounds are not only low toxicity, safe to non-target organisms, but also for users, and environmental friendly and are safe, have been listed by the US EPA "candidate agent to reduce the risk." Kresoxim pyrazole as a inhibitor of mitochondrial respiration, which is presented by inhibiting the mitochondrial electron transport system, and the role of a protein complex III antibacterial activity, and pyrazole Kresoxim significant increase of the pathogenic agent may hinder the germination of spores in chain life, spore growth, mycelium invasion, adhesion and sporulation formed effect caused, especially for a very germinate strong inhibition, it has remarkable preventive effect. At the same time, it has a strong penetration effect and inner blade has a high resistance to rain, can be used for wheat, peanuts, rice, vegetables, fruit, tobacco, tea, ornamental plants, 草坪等各种作物,防治子囊菌、担子菌、半知菌和卵菌纲真菌引起的叶枯病、锈病、白粉病、霜霉病、疫病、炭疽病、疮痴病、褐斑病、立枯病等多种病害。吡唑醚菌酯主要适用于保护和发病前期使用。 Turf and other crops, control ascomycetes, basidiomycetes, fungi imperfecti and Oomycetes cause leaf blight, rust, powdery mildew, downy mildew, blight, anthracnose, sore crazy disease, brown spot, Li blight and other diseases. kresoxim-pyrazol mainly suitable for the protection and use of early onset.

[0005] 氟啶胺(fIuazinam),化学名称:N-[3_氯_5_(三氟甲基)_2_吡啶基]_3_氯_4_( 二氟甲基)-2,6- 二硝基苯胺,结构式如下: [0005] fluazinam (fIuazinam), chemical name: N- [3_ _5_ chloro (trifluoromethyl) _2_ pyridinyl] _4_ _3_ chloro (difluoromethyl) -2,6-dinitro aniline, the following structural formula:

[0006] [0006]

Figure CN103563939AD00032

[0007] 氟啶胺属于吡啶胺衍生物,二硝基苯胺类杀菌剂。 [0007] fluazinam belonging pyridinamine derivatives, dinitroanilines fungicides. 无治疗效果和内吸活性,是广谱高效的保护性杀菌剂。 Treatment and no systemic activity, is a broad spectrum protective fungicides. 对交链孢属、疫霉属、单轴霉属、核盘菌属和黑星菌属非常有效。 On Alternaria, Phytophthora, Plasmopara viticola genus, Sclerotinia and Venturia very effective. 对于抗苯并咪唑和二羧酰亚胺类杀菌剂的灰葡萄孢也有良好的效果,对由根霉菌引起的水稻猝倒病也有很好的效果。 For Botrytis and anti-benzimidazole-dicarboximide fungicide also has a good effect on damping-off caused by Rhizopus diseases of rice is also very good results. 本品极耐雨水冲刷,残效期长。 This product is extremely resistant to rain erosion, Vinca long. 此外兼有控制植食性螨类的作用。 In addition both the control phytophagous mites effect. 由于β-三氟甲基氨吡啶部分起着输送化合物到致病菌的活性点的独特作用,能抑制感染过程中病原体孢子的萌发、渗透、菌丝的生长和孢子的形成。 Since the amino pyridine moiety β- trifluoromethyl transporting compound plays a unique role to the active site of pathogenic bacteria, can inhibit the germination of spores of the pathogen during infection, penetration, growth and spore formation of hyphae. 防治根肿病用药量为124.5~250.5g有效成分每公顷。 Control of root dosage Plasmodiophora 124.5 ~ 250.5g active ingredient per hectare.

[0008]目前植物病菌的防治难度越来越大,一方面,随着种植结构的改变,瓜果、蔬菜等经济作物种植面积逐步扩大,病害发生程度、发生数量均有所提高,在防治上难度加大;另一方面,病原菌的抗性在持续的药剂选择压力下逐年上升,单剂的防治效果大打折扣,植物病害防治面临着重大挑战。 [0008] currently difficult to control plant pathogens is increasing, on the one hand, with the change of planting structure, fruits, vegetables and other cash crops planting area gradually expanded, the degree of disease occurrence, the number of occurrences were higher in the prevention and treatment more difficult; on the other hand, resistance to pathogens increased year by year in the ongoing drug selection pressure, control effect of a single dose greatly reduced, plant disease control faces significant challenges. 发明内容: SUMMARY:

[0009] 本发明的目的是针对上述技术问题提供一种适用范围广、成本低、效果好含吡唑醚菌酯与氟啶胺的植物杀菌组合物。 [0009] The object of the present invention is to provide a wide application range, low cost, effective for the above-described technical problems kresoxim-pyrazol-containing fluazinam and plant fungicidal compositions.

[0010] 本发明还有一个目的是提供该杀菌组合物在制备防治抗性植物真菌病害上的应用。 [0010] Another object of the present invention is to provide a germicidal composition applied in controlling plant fungal diseases on preparative resistance.

[0011] 本发明的目的是通过下列措施来实现的: [0011] The object of the present invention is achieved by the following measures:

[0012] 一种杀菌组合物,它含有吡唑醚菌酯与氟啶胺,其中吡唑醚菌酯与氟啶胺重量比为广70:1飞0,其中杀菌组合物中有效成份以增效有效量存在于组合物中。 [0012] A fungicidal composition comprising the pyrazole Kresoxim fluazinam, wherein the pyrazole Kresoxim fluazinam wide weight ratio of 70: 1 0 fly, germicidal compositions wherein the active ingredients to enhance effective amount effective in the composition.

[0013] 所述的杀菌组合物,其中吡唑醚菌酯与氟啶胺重量比优选为5~50:10-50,进一步优选为5~40:10~30。 [0013] The fungicidal composition, wherein the pyrazole Kresoxim with fluazinam weight ratio is preferably from 5 to 50: 10-50, more preferably 5 to 40: 10 to 30.

[0014] 在本发明组合物中,吡唑醚菌酯和氟啶胺二者占组合物的重量百分比为2%~80%。 [0014] In the compositions of the present invention, and kresoxim-pyrazol fluazinam both weight percentage composition is 2% to 80%. 优选为5%~50%,最优选8%~40%。 Preferably from 5% to 50%, most preferably from 8% to 40%.

[0015] 所述的杀菌组合物,其中以吡唑醚菌酯和氟啶胺为主要有效成分与已知的助剂和赋形剂复配成农药上允许的任意一种剂型。 [0015] The fungicidal composition, wherein the pyrazole kresoxim and fluazinam as the main active ingredient is mixed with any of known adjuvants and excipients formulated into a dosage form pesticide allowed. 这些已知的助剂、赋形剂有分散剂、扩散剂、消泡剂、湿润剂、崩解剂等。 These known adjuvant, excipient, dispersant, spreading agents, antifoaming agents, wetting agents, disintegrating agents and the like. 助剂可以采用十二烷基苯磺酸钙、烷基酚聚氧乙烯醚、聚氧乙烯聚氧丙稀嵌段化合物(如农乳33 #)、壬基酚聚氧乙烯醚等中的一个或多个组合,赋形剂包含环己酮、二甲苯、溶剂油、水、防冻剂(如丙二醇)、去离子水等。 Additives may be used calcium dodecylbenzene sulfonate, polyoxyethylene alkylphenol ether, polyoxyethylene polyoxypropylene block compound (eg milk farmers # 33), a nonylphenol polyoxyethylene ether, and the like or more combinations, excipient comprises cyclohexanone, xylene, solvent naphtha, water, antifreeze (e.g., propylene glycol), deionized water and the like. 以上助剂、赋形剂及其它辅料可以单用或并用。 Or more adjuvants, excipients and other materials can be used alone or in combination.

[0016] 所述的杀菌组合物,其剂型是乳油、水乳剂、可湿性粉剂、悬浮剂、微乳剂或水分散粒剂。 [0016] The fungicidal composition, which dosage form is a cream, aqueous emulsions, wettable powders, suspensions, microemulsions or water-dispersible granules.

[0017] 所述的杀菌组合物在制备防治抗性植物真菌病害杀菌药物上的应用。 [0017] The fungicidal composition for preventing and treating fungal diseases of plants resistant to the bactericidal drugs application.

[0018] 所述的应用为该杀菌组合物在制备防治发生在禾谷类、瓜果或蔬菜作物上的叶枯病、锈病、白粉病、霜霉病、疫病、炭疽病、疮痴病、褐斑病、立枯病、灰霉病、根肿病、晚疫病等真菌病害杀菌药物上的应用。 [0018] The fungicidal compositions for application in the manufacture of prevention and treatment occurs on cereals, fruit or vegetable crops blight, rust, powdery mildew, downy mildew, blight, anthracnose, sore crazy disease, brown application of the fungal disease bactericidal drugs spots, blight, gray mold, clubroot, late blight.

[0019] 本发明的有益效果: [0019] Advantageous effects of the invention:

[0020] 1、本发明所用的吡唑醚菌酯是甲氧基丙烯酸酯杀菌剂,氟啶胺是吡啶类杀菌剂,作用机理不同,相互混配不会产生抵触,但可协同增效,减少用药量,降低成本。 [0020] 1, Kresoxim pyrazole used in the present invention is a strobilurin fungicide, fluazinam pyridine fungicides, different mechanisms of action, will not conflict with each other compounding, but synergistic, reduce the dosage to reduce costs.

[0021] 2、本发明组合物适用范围增加,适用于防治禾谷类、各种瓜果、蔬菜的作物病害,特别是防治水稻、小麦、辣椒、香蕉、芒果、菠萝、黄瓜、番茄等作物病害,如水稻稻瘟病、水稻纹枯病、苹果黑星病、苦瓜黑星病、草坪斑点病、黄瓜白粉病、番茄晚疫病等。 [0021] 2. The composition of the present invention is to increase the scope of application, suitable for controlling cereal, various fruits, vegetable crop diseases, in particular the control of rice, wheat, pepper, banana, mango, pineapple, cucumber, tomatoes and other crop diseases such as rice blast, rice sheath blight, apple scab, balsam pear scab, lawn scab, powdery mildew, tomato late blight.

[0022] 本发明杀菌组合物对子囊菌、担子菌、半知菌和卵菌纲真菌病害具有很好的防治效果;并抑制害虫或真菌对单一制剂(吡唑醚菌酯和氟啶胺任一)的抗药性的产生。 [0022] The fungicidal compositions of the present invention, Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes fungi diseases have a good control effect; and suppress pest or a fungus according to any of the amines single formulation (pyrazol kresoxim and fluazinam a) the development of resistance.

[0023] 本发明杀菌组合物在制备防治抗性真菌上的应用,尤其是在防治叶枯病、锈病、白粉病、霜霉病、疫病、炭疽病、疮痴病、褐斑病、立枯病、灰霉病、根肿病、晚疫病的应用均有显著的效果。 [0023] The fungicidal compositions according to the invention applied on a preparative control resistant fungi, especially in the prevention of blight, rust, powdery mildew, downy mildew, blight, anthracnose, sore crazy disease, brown spot, Rhizoctonia disease, Botrytis cinerea, clubroot, late blight application showed a significant effect. 上述杀菌组合物能产生较高的协同增效作用,并且该混合物的用量比单独活性化合物的用量大大降低,即混合物的活性大于单独组分的活性。 The sterilizing composition can produce a higher synergistic effect, and with the ratio of the amount of the individual active compound mixture is greatly reduced, i.e., the activity of the mixture is greater than the activity of the individual components.

[0024] 与现有技术相比本发明的有益效果:(1)与单剂相比,该组合物对抗性真菌病害如叶枯病、锈病、白粉病、霜霉病、疫病、炭疽病、疮痴病、褐斑病、立枯病、灰霉病、根肿病、晚疫病等真菌病害有明显协同增效作用,克服和延缓了抗药性,扩大防治谱,明显提高了防治效果;(2)减少防治用工、用药成本;(3)可替代常规和易产生抗性的农药;(4)与单剂相t匕,生产和使用成本降低;(5)抑制真菌抗药性的产生,其效果明显高于其单剂使用。 [0024] Advantageous effects of the present invention compared with the prior art: (1) Compared with the single dose, the composition antagonistic to fungal diseases such as leaf blight, rust, powdery mildew, downy mildew, blight, anthracnose, sore crazy disease, brown spot, Rhizoctonia, Botrytis, clubroot, late blight and other fungal diseases have significant synergistic effect, to overcome drug resistance and delaying, expansion control spectrum, significantly improve the control effect; ( 2) prevention of reduced labor, cost of medication; (3) can be produced and easy alternative to conventional pesticide resistance; (4) t-phase and single-agent dagger, and reduce production cost; (5) inhibits the production of resistance, which significantly higher than the effect of a single agent.

具体实施方式 Detailed ways

[0025] 以下结合实施例对本发明作进一步说明,实施例中剂型的制备方法均为常规方法。 [0025] The following embodiments in conjunction with embodiments of the present invention will be further described in the preparation of a dosage form according to a conventional method were implemented.

[0026] 两种活性化合物可以加工成允许的任意一种剂型,下面以具体的实施例说明两种有效成分加工成的制剂,但是该两种活性成分可以加工的制剂不仅限于以下所列。 [0026] The two active compounds can be processed into one dosage form of any allowed, following specific examples illustrate the two active ingredients into the formulation, but the two active ingredients can be processed is not limited to the formulation listed below.

[0027] 实施例1: [0027] Example 1:

[0028] 将吡唑醚菌酯5g、氟啶胺10g、净洗剂LS (对甲氧基脂肪酰胺基苯磺酸钠)2g、扩散剂NNO (亚甲基双萘磺酸钠)4g、白`炭黑5g,高岭土加至100g混合物进行气流粉碎,制得主要有效成分重量百分含量为15%吡唑醚菌酯.氟啶胺可湿性粉剂。 [0028] The pyrazole kresoxim 5g, fluazinam 10g, the LS detergent (p-methoxy benzene sulfonate fatty acid amide) 2g, NNO diffusing agent (methylene-bis-naphthalene sulfonate) 4g, `white carbon black 5g, 100g of kaolin was added to the mixture to jet milling to prepare the main active ingredient content of 15% by weight percent pyrazol Kresoxim. fluazinam wettable powder.

[0029] 实施例2: [0029] Example 2:

[0030] 将吡唑醚菌酯1.25g、氟啶胺13.75g、净洗剂LS 3g、扩散剂NNO 4g、白炭黑5g,高岭土加至100g混合物进行气流粉碎,制得主要有效成分重量百分含量为15%吡唑醚菌酯.氟啶胺可湿性粉剂。 [0030] The pyrazole kresoxim 1.25g, 13.75 g fluazinam, detergent LS 3g, diffusing agent NNO 4g, silica 5g, 100g of kaolin was added to the mixture to jet milling, to obtain the main weight percent active ingredient content of 15% pyrazolo kresoxim. fluazinam wettable powder.

[0031] 实施例3: [0031] Example 3:

[0032] 将吡唑醚菌酯2g、氟啶胺13g、净洗剂LS 3g、扩散剂NNO 4g、白炭黑5g,高岭土加至100g混合物进行气流粉碎,制得主要有效成分重量百分含量为15%吡唑醚菌酯.氟啶胺可湿性粉剂。 [0032] The pyrazole kresoxim 2g, 13g fluazinam, detergent LS 3g, diffusing agent NNO 4g, silica 5g, 100g of kaolin was added to the mixture to jet milling to prepare the main active ingredient Weight% 15% pyrazolo Kresoxim. fluazinam wettable powder.

[0033] 实施例4: [0033] Example 4:

[0034] 称取5g吡唑醚菌酯、50g氟啶胺、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33 # 2g、烷基酚聚氧乙烯醚lg,溶剂油13g,加水至100g。 [0034] Weigh 5g pyrazol kresoxim, 50g fluazinam, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, polyoxyethylene alkylphenol ether lg, 13g oil solvent, add water to 100g. 将以上原料按常规配制水乳剂的方法投入混合釜中高速混合,制成主要有效成分重量百分含量为55%吡唑醚菌酯.氟啶胺水乳剂。 The method of these raw materials prepared by conventional aqueous emulsion mixed at high speed into a mixing tank, made of the main active ingredient content of 55% by weight percent pyrazol Kresoxim. Fluazinam water emulsions.

[0035] 实施例5: [0035] Example 5:

[0036] 称取IOg吡唑醚菌酯、30g氟啶胺、十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33 # 2g、烷基酚聚氧乙烯醚lg,异丙醇10g,加水至100g。 [0036] pyrazol-weighed IOg kresoxim, 30g fluazinam, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, alkylphenol vinyl ethers lg, isopropanol 10g, add water to 100g. 将以上原料按常规配制微乳剂的方法投入混合釜中混合,制成主要有效成分重量百分含量为40%吡唑醚菌酯.氟啶胺微乳剂。 The above ingredients formulated into a conventional mixing kettle microemulsions prepared by mixing the main active ingredient content of 40% by weight percent pyrazol Kresoxim. Fluazinam microemulsion. [0037] 实施例6: [0037] Example 6:

[0038] 称取Ig吡唑醚菌酯、5g氟啶胺、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33 # 2g、烷基酚聚氧乙烯醚lg,溶剂油13g,加水至100g。 [0038] Weigh kresoxim-pyrazol-Ig, 5g fluazinam, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, polyoxyethylene alkylphenol ether lg, 13g oil solvent, add water to 100g. 将以上原料按常规配制水乳剂的方法投入混合釜中高速混合,制成主要有效成分重量百分含量为6%吡唑醚菌酯.氟啶胺水乳剂。 The method of these raw materials prepared by conventional aqueous emulsion mixed at high speed into a mixing tank, the main active ingredient is made 6% weight percent of pyrazole Kresoxim. Fluazinam water emulsions.

[0039] 实施例7: [0039] Example 7:

[0040] 称取50g吡唑醚菌酯、20g氟啶胺,十二烷基苯磺酸钙5g、苯乙基酚聚氧乙烯醚2g、溶剂油至100g。 [0040] pyrazol-weighed 50g kresoxim, 20g fluazinam, calcium dodecylbenzenesulfonate 5g, phenethyl phenol polyoxyethylene ether 2g, mineral spirits to 100g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成主要有效成分重量百分含量为70%吡唑醚菌酯.氟啶胺乳油。 The method of these raw materials by a conventional mixing kettle into an emulsifiable concentrate formulation was mixed to prepare a main active ingredient content of 70% by weight percent pyrazol Kresoxim. Fluazinam EC.

[0041] 实施例8: [0041] Example 8:

[0042] 称取2g吡唑醚菌酯、40g氟啶胺,十二烷基苯磺酸钙Sg、苯乙基酚聚氧乙烯醚5g、溶剂油至100g。 [0042] Weigh 2g pyrazol kresoxim, 4Og fluazinam, calcium dodecylbenzenesulfonate Sg, phenethyl phenol polyoxyethylene ether 5g, solvent to oil 100g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成主要有效成分重量百分含量为42%吡唑醚菌酯.氟啶胺乳油。 The method of these raw materials by a conventional mixing kettle into an emulsifiable concentrate formulation was mixed to prepare a main active ingredient content of 42% by weight percent pyrazol Kresoxim. Fluazinam EC.

[0043] 实施例9: [0044] 称取5g吡唑醚菌酯、20g氟啶胺、十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33 # 2g、烷基酚聚氧乙烯醚lg,异丙醇10g,加水至100g。 [0043] Example 9: [0044] Weigh 5g pyrazol kresoxim, 20g fluazinam, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier # 33 2g, polyoxyethylene alkylphenol ether lg, isopropanol 10g, add water to 100g. 将以上原料按常规配制微乳剂的方法投入混合釜中混合,制成主要有效成分重量百分含量为25%吡唑醚菌酯.氟啶胺微乳剂。 The above ingredients are mixed into a conventional mixing kettle microemulsions formulated to prepare the main active ingredient content of 25% by weight percent pyrazol Kresoxim. Fluazinam microemulsion.

[0045] 实施例10: [0045] Example 10:

[0046] 称取20g吡唑醚菌酯、IOg氟唳胺,十二烷基苯磺酸钙6g、苯乙基酹聚氧乙烯醚7g、溶剂油至100g。 [0046] Weigh 20g pyrazol kresoxim, IoG fluoro Li amines, calcium dodecylbenzenesulfonate 6g, phenethyl sprinkle polyoxyethylene 7g, mineral spirits to 100g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成主要有效成分重量百分含量为30%吡唑醚菌酯.氟啶胺乳油。 The above ingredients formulated into an emulsifiable concentrate of a conventional mixing kettle were mixed to prepare a main active ingredient content of 30% by weight percent pyrazol Kresoxim. Fluazinam EC.

[0047] 实施例11: [0047] Example 11:

[0048] 称取5g吡唑醚菌酯、30g氟啶胺,十二烷基苯磺酸钙4g、苯乙基酚聚氧乙烯醚4g、溶剂油至100g。 [0048] Weigh 5g pyrazol kresoxim, 30g fluazinam, calcium dodecylbenzenesulfonate 4g, phenethyl phenol polyoxyethylene ether 4g, solvent to oil 100g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成主要有效成分重量百分含量为35%吡唑醚菌酯.氟啶胺乳油。 The above ingredients formulated into an emulsifiable concentrate of a conventional mixing kettle were mixed to prepare a main active ingredient content of 35% by weight percent pyrazol Kresoxim. Fluazinam EC.

[0049] 实施例12: [0049] Example 12:

[0050] 称取IOg吡唑醚菌酯、IOg氟啶胺,木质素2g,烷基酚(或脂肪醇)聚氧乙烯聚氧丙烯醚及其硫酸盐4g,黄原胶0.15g,乙二醇5g,娃氧乙烧0.1Og,娃酸镁招0.5g,用水补足至100g,在砂磨机的作用下制成主要有效成分重量百分含量为20%吡唑醚菌酯.氟啶胺悬浮剂。 [0050] pyrazol-weighed IoG kresoxim, IoG fluazinam, lignin 2g, alkylphenols (or fatty alcohol) Polyoxyethylene polyoxypropylene ether sulfates and 4g, xanthan gum 0.15g, ethylenedioxy alcohol 5g, oxyacetylene burning baby 0.1Og, magnesium baby move 0.5g, made up with water to 100g, the main active ingredient is made under the action of weight percent of a sand mill is 20% pyrazolo kresoxim. fluazinam suspending agent.

[0051] 实施例13: [0051] Example 13:

[0052] 称取30g吡唑醚菌酯、12g氟啶胺,木质素2g,烷基酚(或脂肪醇)聚氧乙烯聚氧丙烯醚及其硫酸盐4g,黄原胶0.15g,乙二醇5g,娃氧乙烧0.1Og,娃酸镁招0.5g,用水补足至100g,在砂磨机的作用下制成主要有效成分重量百分含量为42%吡唑醚菌酯.氟啶胺悬浮剂。 [0052] Weigh 30g pyrazol kresoxim, 12g fluazinam, lignin 2g, alkylphenols (or fatty alcohol) Polyoxyethylene polyoxypropylene ether sulfates and 4g, xanthan gum 0.15g, ethylenedioxy alcohol 5g, oxyacetylene burning baby 0.1Og, magnesium baby move 0.5g, made up with water to 100g, the main active ingredient is made of 42% weight percent of kresoxim-pyrazol under the action of a sand mill. fluazinam suspending agent.

[0053] 实施例14: [0053] Example 14:

[0054] 称取2g批唑醚菌酯、5g氟唳胺,木质素磺酸钠8g、十二烷基硫酸钠2g、硫酸铵5g,聚乙烯醇5g,硼砂2g,硅藻土补足至100g,将以上原料按水分散粒剂方法制成主要有效成分重量百分含量为7%吡唑醚菌酯.氟啶胺水分散粒剂。 [0054] Weigh 2g batch kresoxim yl, 5g fluoro Li amine, sodium lignosulfonate 8g, 2g sodium dodecyl sulfate, ammonium sulfate 5g, polyvinyl 5g, 2g borax, diatomaceous earth made up to 100g , these raw materials by the method of water dispersible granules made of the main active ingredient content of 7% percent by weight of pyrazole kresoxim. fluazinam water dispersible granules. [0055] 实施例15: [0055] Example 15:

[0056] 称取4g吡唑醚菌酯、13g氟啶胺,木质素磺酸钠8g、十二烷基硫酸钠2g、硫酸铵5g,聚乙烯醇5g,硼砂2g,硅藻土补足至100g,将以上原料按水分散粒剂方法制成主要有效成分重量百分含量为17%吡唑醚菌酯.氟啶胺水分散粒剂。 [0056] Weigh 4g pyrazol kresoxim, 13g fluazinam, sodium lignosulfonate 8g, sodium lauryl sulfate 2g, ammonium sulfate 5g, polyvinyl 5g, borax 2g, made up to 100g Celite , these raw materials by the method of water dispersible granules made of the main active ingredient content of 17% by weight percent pyrazol kresoxim. fluazinam water dispersible granules.

[0057] 实施例16: [0057] Example 16:

[0058] 称取70g吡唑醚菌酯、2g氟啶胺,木质素2g,烷基酚(或脂肪醇)聚氧乙烯聚氧丙烯醚及其硫酸盐4g,黄原胶0.15g,乙二醇5g,娃氧乙烧0.1Og,娃酸镁招0.5g,用水补足至100g,在砂磨机的作用下制成主要有效成分重量百分含量为72%吡唑醚菌酯.氟啶胺悬浮剂。 [0058] Weigh 70g pyrazol kresoxim, 2g fluazinam, lignin 2g, alkylphenols (or fatty alcohol) Polyoxyethylene polyoxypropylene ether sulfates and 4g, xanthan gum 0.15g, ethylenedioxy alcohol 5g, oxyacetylene burning baby 0.1Og, magnesium baby move 0.5g, made up with water to 100g, the main active ingredient is made under the action of weight percent of 72% sand mill pyrazol Kresoxim. fluazinam suspending agent.

[0059] 室内生测试验: [0059] indoor bioassay test:

[0060] 在室内采用菌丝生长速率法,测定不同药剂对菌株的EC5tl值,采用孙云沛介绍的共毒系数计算方法,计算出混剂的共毒系数(CTC),确定混剂的增效性。 [0060] The mycelial growth rate in the chamber, for measuring different agents EC5tl values ​​strains, by co-toxicity coefficient Sun Yunpei described calculation method, the co-toxicity coefficient (CTC) Mixture determining synergistic mixture by .

[0061] 以混剂中某一单剂为标准药剂(通常选择EC5tl较低者),进行计算: [0061] (usually the lower EC5tl persons), to calculate a single dose in mixture of standard agents:

[0062] 单剂毒力指数=标准药剂EC5tl/某单剂EC5tlX 100 [0062] The single dose toxicity index = standard agents EC5tl / a single dose EC5tlX 100

[0063] 理论毒力指数=A单剂的毒力指数XA单剂在混剂中所占比例+ B单剂的毒力指数XB单剂在混剂中所占比例 [0063] Theoretical toxicity index = index XA single dose toxicity A single dose proportion XB + Toxicity index of a single dose of a single agent B in mixture in a proportion in the mixed agent

[0064] 实测毒力指数=标准单剂的EC5tl值/混剂的EC5tl值X 100 [0064] Found toxicity index = value of standard single agent EC5tl / agent mixture EC5tl value X 100

[0065] 共毒系数=实测毒力指数/理论毒力指数X 100 [0065] Co-toxicity coefficient = virulence index Found / Theoretical toxicity index X 100

[0066] CTC大于120时混剂具有协同增效性,CTC小于80时为拮抗,CTC在80-120之间为相加作用。 [0066] When the mixture is greater than 120 CTC agent having synergistic properties, CTC antagonistic less than 80, CTC additive effect between 80-120.

[0067] 表1:吡唑醚菌酯+氟啶胺不同配比对番茄晚疫病菌的室内生测结果 [0067] Table 1: Kresoxim-pyrazol + fluazinam different ratio bioassay results of Phytophthora infestans

[0068] [0068]

Figure CN103563939AD00071

[0069] 田间药效试验: [0069] Field Trial:

[0070] 用上述实施例制得的农药制剂防治黄瓜霜霉病试验。 [0070] Prevention of cucumber downy mildew above embodiment pesticide formulations prepared.

[0071] 1、试验处理:本试验药剂用量根据各个成分的不同分别设三个处理浓度,对照药剂分别是市售农药500g/L氟啶胺SC (悬浮剂)和24%吡唑醚菌酯EC (乳油)及空白清水试验。 [0071] 1, processing test: This test pharmaceutical dosage depending on the individual components are arranged three treatment concentration, control agents are commercially available pesticide 500g / L Fluazinam SC (suspension) and 24% pyrazolo Kresoxim EC (EC) and blank water test.

[0072] 2、试验方法每个小区面积为66.7m2,重复3次;施药前调查及防治后的检查药效方法为:在试验处理区内随机取样5点,检查黄瓜霜霉病发生程度。 [0072] 2. Test method of each cell area of ​​66.7m2, repeated three times; investigation and control method of checking efficacy before administration to after: Test treatment zone in randomly sampled 5:00, check the occurrence degree Cucumber Downy Mildew . [0073] 3、试验结果见下表: [0073] 3, the following table results:

Figure CN103563939AD00081

[0075] 注:a表示在α = 0.05水平上显著,b表示在α =0.05水平上有差异,c表示在α=0.05水平上不显著。 [0075] Note: a represents the α = 0.05 level significantly, b represents the difference in the α = 0.05 level, c denotes not significant at the α = 0.05 level.

[0076] 通过室内生测和田间药效结果表明,吡唑醚菌酯与氟啶胺组合物具有明显的协同增效作用,组合物的防治效果优良,防治效果均好于单剂品种,在农业应用中具有应用价值。 [0076] by bioassay and field efficacy results show that the pyrazole kresoxim fluazinam composition has obvious synergistic effect, an excellent prevention effect of the composition, control effect was better than single agent species, the agricultural applications have value.

Claims (10)

1.一种杀菌组合物,其特征在于含有吡唑醚菌酯与氟啶胺,其中吡唑醚菌酯与氟啶胺的重量比为I~70:1-50ο 1. A fungicidal composition characterized by containing the pyrazole Kresoxim fluazinam, wherein the weight-pyrazol Kresoxim with fluazinam ratio I ~ 70: 1-50ο
2.根据权利要求1所述的杀菌组合物,其特征在于吡唑醚菌酯与氟啶胺的重量比为5~50:10~50。 2. The germicidal composition according to claim 1, wherein the weight ratio of the pyrazole Kresoxim fluazinam is from 5 to 50: 10 to 50.
3.根据权利要求2所述的杀菌组合物,其特征在于所述的吡唑醚菌酯和氟啶胺的重量比为5~40:10~30。 3. A fungicidal composition according to claim 2, wherein the weight of the pyrazole and kresoxim fluazinam ratio of 5 to 40: 10 to 30.
4.根据权利要求1所述的杀菌组合物,其特征在于吡唑醚菌酯和氟啶胺二者占组合物的重量百分含量为2%~80%。 4. The germicidal composition according to claim 1, characterized in that both pyrazol kresoxim accounting and fluazinam weight percent of the composition is 2% to 80%.
5.根据权利要求4所述的杀菌组合物,其特征在于吡唑醚菌酯和氟啶胺二者占组合物的重量百分含量为5%~50%。 5. A fungicidal composition according to claim 4, characterized in that both pyrazol kresoxim accounting and fluazinam weight percent of the composition is 5% to 50%.
6.根据权利要求5所述的杀菌组合物,其特征在于吡唑醚菌酯和氟啶胺二者占组合物的重量百分含量为8%~40%。 6. A fungicidal composition according to claim 5, characterized in that both pyrazol kresoxim accounting and fluazinam weight percent composition of 8% to 40%.
7.根据权利要求1所述的杀菌组合物,其特征在于以吡唑醚菌酯和氟啶胺为主要有效成分和农药助剂、赋形剂配制成农药上允许的任意一种剂型。 The germicidal composition according to claim 1, characterized in that at pyrazol kresoxim and fluazinam as the main active ingredient of pesticides and adjuvants, excipients formulated into any dosage forms permit the pesticide.
8.根据权利要求7所述的杀菌组合物,其特征在于所述剂型是乳油、悬浮剂、水乳剂、可湿性粉剂、微乳剂或水分散粒剂。 8. The germicidal composition according to claim 7, wherein the dosage form is a cream, suspensions, water emulsions, wettable powders, microemulsions or water-dispersible granules.
9.权利要求1所述的杀菌组合物在制备防治抗性植物真菌病害杀菌药物上的应用。 9. The germicidal composition according to claim 1 for the preparation of resistant plant fungal diseases Control Application bactericidal medicament.
10.根据权利要求9所述的应用为该杀菌组合物在制备防治发生在禾谷类、瓜果或蔬菜作物上的叶枯病、锈病、白粉病、霜霉病、疫病、炭疽病、疮痴病、褐斑病、立枯病、灰霉病、根肿病、晚疫病等真菌病害杀菌药物上的应用。 10. The use according to claim 9 for preparing fungicidal compositions in the prevention and treatment occurs in cereals, fruit or vegetable crops blight, rust, powdery mildew, downy mildew, blight, anthracnose, sore crazy application of the fungal disease bactericidal drugs disease, brown spot, Rhizoctonia, Botrytis, clubroot, late blight.
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103271049A (en) * 2013-04-27 2013-09-04 广东中迅农科股份有限公司 Pyraclostrobin-fluazinam pesticide composition
CN103858915A (en) * 2014-03-19 2014-06-18 浙江乐吉化工股份有限公司 Fluazinam-containing soil treatment agent composition and application thereof
CN106719853A (en) * 2016-11-26 2017-05-31 防城港市林木良种繁育中心苗圃 A kind of pharmaceutical composition for preventing and treating eucalyptus gray mold
CN107361080A (en) * 2017-08-31 2017-11-21 广西沙田仙人滩农业投资有限公司 A kind of black scurf of potato bactericide containing tolelofos-methyl
CN107494569A (en) * 2017-08-25 2017-12-22 深圳诺普信农化股份有限公司 A kind of bactericidal composition is used for the purposes for preventing and treating dragon fruit canker

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216898A (en) * 1996-04-26 1999-05-19 巴斯福股份公司 Fungicidal mixtures
CN102715177A (en) * 2012-06-29 2012-10-10 青岛星牌作物科学有限公司 Sterilization combination containing pyraclostrobin and fluazinam and application thereof
WO2012161354A2 (en) * 2011-05-25 2012-11-29 Ishihara Sangyo Kaisha, Ltd. Agricultural or horticultural fungicide composition and method for controlling plant pathogen
CN103271049A (en) * 2013-04-27 2013-09-04 广东中迅农科股份有限公司 Pyraclostrobin-fluazinam pesticide composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216898A (en) * 1996-04-26 1999-05-19 巴斯福股份公司 Fungicidal mixtures
WO2012161354A2 (en) * 2011-05-25 2012-11-29 Ishihara Sangyo Kaisha, Ltd. Agricultural or horticultural fungicide composition and method for controlling plant pathogen
CN102715177A (en) * 2012-06-29 2012-10-10 青岛星牌作物科学有限公司 Sterilization combination containing pyraclostrobin and fluazinam and application thereof
CN103271049A (en) * 2013-04-27 2013-09-04 广东中迅农科股份有限公司 Pyraclostrobin-fluazinam pesticide composition

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103271049A (en) * 2013-04-27 2013-09-04 广东中迅农科股份有限公司 Pyraclostrobin-fluazinam pesticide composition
CN103858915A (en) * 2014-03-19 2014-06-18 浙江乐吉化工股份有限公司 Fluazinam-containing soil treatment agent composition and application thereof
CN106719853A (en) * 2016-11-26 2017-05-31 防城港市林木良种繁育中心苗圃 A kind of pharmaceutical composition for preventing and treating eucalyptus gray mold
CN107494569A (en) * 2017-08-25 2017-12-22 深圳诺普信农化股份有限公司 A kind of bactericidal composition is used for the purposes for preventing and treating dragon fruit canker
CN107361080A (en) * 2017-08-31 2017-11-21 广西沙田仙人滩农业投资有限公司 A kind of black scurf of potato bactericide containing tolelofos-methyl

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