CN102640758B - Bactericidal composition containing thifluzamide and fluoxastrobin - Google Patents
Bactericidal composition containing thifluzamide and fluoxastrobin Download PDFInfo
- Publication number
- CN102640758B CN102640758B CN2012101219816A CN201210121981A CN102640758B CN 102640758 B CN102640758 B CN 102640758B CN 2012101219816 A CN2012101219816 A CN 2012101219816A CN 201210121981 A CN201210121981 A CN 201210121981A CN 102640758 B CN102640758 B CN 102640758B
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- CN
- China
- Prior art keywords
- fluoxastrobin
- bactericidal composition
- thifluzamide
- rice
- bactericide
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Abstract
The invention relates to an agricultural bactericidal composition, in particular to a bactericidal composition containing thifluzamide and fluoxastrobin. The weight ratio of the thifluzamide to the fluoxastrobin is 100:1-1:100. Compared with single pesticides, the bactericidal composition has synergetic effect on rice sheath blight and rice blast, and the bactericidal effect is improved; the cost of consuming bactericides is lowered, and environment pollution and pesticide residue are reduced; and bactericidal drug resistance can be overcome and delayed. The bactericidal composition has no evident adverse influence on test crops, leaves, growth and the like of the crops are all normal, the bactericidal composition is high in safety, meets the requirement of pesticide preparations on safety, and has well control effect on rice sheath blight and rice blast.
Description
Technical field
The present invention relates to a kind of agricultural bactericidal composition, and contain the bactericide of described bactericidal composition, particularly a kind of banded sclerotial blight for the control paddy rice and the bactericidal composition of rice blast.
Background technology
Rice sheath blight disease is the important disease in paddy rice producing region, is one of China paddy rice three large diseases, in each paddy rice producing region, the whole nation, generation is arranged, and the Yangtze river basin and South Rice Region of China occur heavier, and especially the high-yield field with dense planting hybrid rice of short stem occurs the most general and serious.Mainly by Deuteromycotina Rhizoctonia Disease (Rhizoctonia solani), caused, disease is expanded from bottom to top, can arrive sword-like leave when serious, even fringe section morbidity, large stretch of lodging.The heavier field of falling ill, the general underproduction 5%～10%, seriously can reach 50%～70%.Along with the popularization of Multi spike cultivar of short stem, the raising of Planting Densities and Fertilization Level, become an outstanding problem of rice high yield stable yields.
Rice blast is commonly called as the baked wheaten cake pest, is one of important disease of paddy rice.To infect by Pyricularia oryzae Pyricularia oryzae a kind of fungal disease that causes.Can cause the significantly underproduction, the underproduction 40%～50% when serious, even No kernels or seeds are gathered, as in a year of scarcity.Each rice district, the world evenly occurs.Be distributed in each rice district, the whole nation, the blade of mainly causing harm, stem stalk, fringe section.Because harmful period, position difference are divided into seedling pest, leaf pest, joint pest, panicle blast, grain pest.Occur as manyly with leaf section, joint section, can cause the underproduction in various degree after generation, especially panicle blast or joint pest occur early and weigh, can cause dead ears so that have no harvest.
Thifluzamide (trade name: full fringe), also claim thifluzamide, English common name Trifluzamide, belong to the thiazole amide bactericide, be the new and effective systemic fungicide that Monsanto Company develops, sells, the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc. are had special efficacy.Thifluzamide is the succinate dehydrogenase inhibitor, and due to fluorine-containing, its competitiveness in biochemical pathway is very strong, in case with substrate or enzyme, be combined, just is difficult for recovering.The pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas also all there is good preventive effect.Its structural formula is:
Fluoxastrobin (Fluoxastrobin, CAS 361377-29-9) is that novel, the interior absorption cauline leaf of wide spectrum Er Qing oxazine class of Bayer Cropscience Co.,Ltd's report processed bactericide, is can buy the product of acquisition on market.Apply optimum period wide, no matter at fungal infection, grow, or at growth period of hypha, can provide extraordinary protection and therapeutic action as spore germination, germ tube in early days; Especially contaminate the most effective to spore germination and initial stage.Because of the systemic activity of its excellence that has, so it can be rapidly absorbed, and can transmit to top equably in leaf section, therefore have good resistance of rainwater washing against ability.Fluoxastrobin is mainly used in cauline leaf and processes, and can effectively prevent and treat (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease such as nearly all Mycophytes in cereal crop, potato, vegetables and coffee etc. such as epidemic disease, rice blast, rust, Ying's rot, net blotch, powdery mildew, leaf spot, downy mildew etc.
Bactericidal composition take thifluzamide and fluoxastrobin as active ingredient, be used for the control of rice sheath blight disease and rice blast, can delay the drug-fast generation of germ, improves actual preventive effect, reduces drug cost, is the important means of comprehensive control of disease.
Summary of the invention
The object of the invention is to overcome the problems such as single bactericide is single to the agricultural disease preventive and therapeutic effect, the lasting period is short, virulence is not enough, provide a kind of bactericidal effect good, delay pesticide resistance and the low bactericidal composition of drug cost.
Another object of the present invention is to provide described bactericidal composition is used for the banded sclerotial blight of paddy rice and the purposes of rice blast.
To achieve these goals, the invention provides a kind of bactericidal composition, described bactericidal composition contains thifluzamide and fluoxastrobin, and wherein the weight ratio of thifluzamide and fluoxastrobin is 100: 1～1: 100.
Preferably, the weight ratio of thifluzamide and fluoxastrobin is 15: 1～1: 15.
Above-mentioned bactericidal composition also comprises one or more the mixture in weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The present invention also provides a kind of bactericide, and wherein said bactericide contains the above-mentioned bactericidal composition of 0.1～90 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Preferably, described bactericide contains the above-mentioned bactericidal composition of 10～80 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
According to the preferred embodiment of bactericide of the present invention, its formulation is suspending agent, suspended emulsion, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.
The present invention also provides above-mentioned bactericidal composition in the application that prevents and treats rice sheath blight disease and rice blast.
The present invention also provides a kind of method of preventing and treating crop pest, before or after crops and/or fruit introduced disease, to the place of crops and/or fruit and growth or storage, uses above-mentioned bactericidal composition or above-mentioned bactericide
Below with more detailed description technical scheme of the present invention:
The invention provides a kind of bactericidal composition, described bactericidal composition contains thifluzamide and fluoxastrobin, and wherein the weight ratio of thifluzamide and fluoxastrobin is 100: 1～1: 100.
Preferably, the weight ratio of thifluzamide and fluoxastrobin is 10: 1～1: 15.
The present invention also provides a kind of bactericide, and wherein said bactericide contains the above-mentioned bactericidal composition of 0.1～90 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Preferably, described bactericide contains the above-mentioned bactericidal composition of 10～80 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Except as otherwise noted, " % " involved in the present invention is " percentage by weight ".
Above-mentioned bactericidal composition also comprises one or more the mixture in weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner.Described weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner are all can buy the product of acquisition on market.
According to method known in those skilled in the art, bactericidal composition of the present invention can be mixed with the formulation that allows on agricultural when practical application, formulation is suspending agent, suspended emulsion, aqueous emulsion, microemulsion, wetting powder or water dispersible granules preferably.
To suspending agent, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, TERSPERSE 2425 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt); Wetting agent is selected from the poly-basic ether formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500 (U.S. Huntsman Corporation product); Thickener is selected from xanthans, aluminium-magnesium silicate, bentonite; Preservative is selected from benzoic acid, Sodium Benzoate, BIT (BIT); Defoamer is silicone based defoamer; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride.
To suspension emulsion, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, TERSPERSE 2425; Wetting agent is selected from the poly-basic ether formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500; Emulsifier is selected from Nonyl pheno (EO=10) ether phosphate, triphen ethyl-phenol polyoxyethylene ether phosphate (agriculture breast 600# phosphate), Nongru-700 #, agriculture breast 2201#, Span-60#, emulsifier T-60, TX-10, agriculture breast 1601#, agriculture breast 600#, agriculture breast 400#; Solvent is selected from dimethylbenzene, toluene, cyclohexanone, solvent naphtha (trade mark: S-150, S-180, S-200); Thickener is selected from xanthans, aluminium-magnesium silicate, bentonite; Preservative is selected from benzoic acid, Sodium Benzoate, BIT (BIT); Defoamer is silicone based defoamer; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride.
To aqueous emulsion, spendable auxiliary agent has: emulsifier is selected from Nonyl pheno (EO=10) ether phosphate, triphen ethyl-phenol polyoxyethylene ether phosphate (agriculture breast 600# phosphate), Nongru-700 #, agriculture breast 2201#, Span-60#, emulsifier T-60, TX-10, agriculture breast 1601#, agriculture breast 600#, agriculture breast 400#; Solvent is selected from dimethylbenzene, toluene, cyclohexanone, solvent naphtha (trade mark: S-150, S-180, S-200); Stabilizing agent is selected from triphenyl phosphite, epoxychloropropane; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride; Thickener is selected from xanthans, bentonite, aluminium-magnesium silicate; Preservative is selected from BIT, benzoic acid, Sodium Benzoate.
To microemulsion, spendable auxiliary agent has: emulsifier is selected from calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #, agriculture breast 2201#, this dish-60#, Tween-80, TX-10, agriculture breast 1601, agriculture breast 600#, agriculture breast 400#; Cosolvent is selected from methyl alcohol, isopropyl alcohol, n-butanol, ethanol; Solvent is selected from cyclohexanone, 1-METHYLPYRROLIDONE, dimethylbenzene, toluene, solvent naphtha (trade mark: S-150, S-180, S-200); Stabilizing agent is selected from triphenyl phosphite, epoxychloropropane.
To wetting powder, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay etc.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Disintegrant is selected from ammonium sulfate, urea, sucrose, glucose, citric acid, succinic acid, sodium bicarbonate; Binding agent is selected from diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family and microcrystalline cellulose class; Filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, sepiolite, talcum powder, attapulgite, potter's clay etc.
The present invention also provides above-mentioned bactericidal composition in the application that prevents and treats rice sheath blight disease and rice blast.
The present invention also provides a kind of method of preventing and treating crop pest, before or after crops and/or fruit introduced disease, to the place of crops and/or fruit and growth or storage, uses above-mentioned bactericidal composition or above-mentioned bactericide
Bactericidal composition of the present invention can provide with the finished product preparation form, and namely in composition, each material mixes; Also can provide with the single dose preparation, directly mix in bucket (tank) before using.Concentrate of the present invention usually and water be mixed to get the concentration of required active substance.
Compared with prior art, the beneficial effect of the present invention's generation is:
(1) compare with single dose, bactericidal composition of the present invention has significant synergistic effect to disease, has improved bactericidal effect;
(2) reduce the medication number of times, reduce drug cost, environmental contamination reduction and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these embodiments.One skilled in the art would recognize that the present invention contained all alternatives, improvement project and the equivalents that may comprise in claims scope.
One, Preparation Example
In all preparation proportionings, percentage composition all is weight percentage.
1, suspending agent
Press formula rate,, take water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. are joined in high-shear emulsion machine and shear 30min, then after using the sand mill sand milling, obtain suspending agent.
Embodiment 1:40% thifluzamide fluoxastrobin suspending agent (active ingredient was than 1: 1)
Take the 20% former medicine of thifluzamide, the 20% former medicine of fluoxastrobin, 3.5%FS3000 (phosphate type anion surfactant), 1%NS-500LQ (nonionic hydroxyl polyethylene oxide block copolymer), 0.1% xanthans, 1% aluminium-magnesium silicate, 5% ethylene glycol, 0.03%BIT (1, the 2-benzisothiazole-3-ketone), 0.3% organically-modified silica alkane defoamer, deionized water adds to 100%.Make slurry, carry out sand milling, obtain product.
Embodiment 2:35% thifluzamide fluoxastrobin suspending agent (active ingredient was than 6: 1)
Take the 30% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 3%FS3000,1%NP-10,0.5%JFC (fatty alcohol-polyoxyethylene ether), 0.1% xanthans, aluminium-magnesium silicate 1%, 5% ethylene glycol, 0.3% benzoic acid, 0.5% organically-modified silica alkane defoamer, deionized water adds to 100%.Make slurry, carry out sand milling, obtain product.
Embodiment 3:30% thifluzamide fluoxastrobin suspending agent (active ingredient was than 5: 1)
Take the 25% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 2%FS3000,2%NP-10,0.5%JFC (fatty alcohol-polyoxyethylene ether), 0.1% xanthans, aluminium-magnesium silicate 1%, 4% ethylene glycol, 0.3% benzoic acid, 0.5% organically-modified silica alkane defoamer, deionized water adds to 100%.Make slurry, carry out sand milling, obtain product.
2, suspended emulsion
Press formula rate, former medicine and dispersant, wetting agent, defoamer, water etc. are mixed, through the sand mill sand milling, obtain the suspension mother liquor; Again another former medicine, solvent, emulsifier etc. are mixed, obtain the homogeneous oil phase,, according to metering proportion, under the condition of high shear, oil phase and excess water are joined in the suspension mother liquor and mix and shear evenly.Add again thickener and preservative to stir and obtain required product.
Embodiment 4:30% thifluzamide fluoxastrobin suspension emulsion (active ingredient was than 5: 1)
The 25% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 3%FS3000,1%TXC (sulfonic acid type anion surfactant), 30% solvent naphtha S150,5% agriculture breast 500,1%NS-500LQ, 0.1% xanthans, 5% ethylene glycol, 0.03%BIT, 0.3% organically-modified silica alkane defoamer, deionized water adds to 100%.
First the former medicine of thifluzamide, FS3000, TXC, ethylene glycol, defoamer, part deionized water are mixed, in the sand mill sand milling, obtain thifluzamide suspension mother liquor.Again the former medicine of fluoxastrobin, solvent naphtha, emulsifiers dissolve are mixed and obtain the homogeneous oil phase,, according to metering proportion, under the condition of high shear, oil phase and excess water are joined in the suspension mother liquor and mix and shear evenly.Add again thickener xanthans and preservative BIT to be uniformly mixed and obtain required product.
Embodiment 5:30% thifluzamide fluoxastrobin suspension emulsion (active ingredient was than 1: 2)
The 10% former medicine of thifluzamide, the 20% former medicine of fluoxastrobin, 3%FS3000,1%TXC (sulfonic acid type anion surfactant), 30% solvent naphtha S150,5% agriculture breast 500,1%NS-500LQ, 0.1% xanthans, 5% ethylene glycol, 0.03%BIT, 0.3% organically-modified silica alkane defoamer, deionized water adds to 100%.
First the former medicine of thifluzamide, FS3000, TXC, ethylene glycol, defoamer, part deionized water are mixed, in the sand mill sand milling, obtain thifluzamide suspension mother liquor.Again the former medicine of fluoxastrobin, solvent naphtha, emulsifiers dissolve are mixed and obtain the homogeneous oil phase,, according to metering proportion, under the condition of high shear, oil phase and excess water are joined in the suspension mother liquor and mix and shear evenly.Add again thickener xanthans and preservative BIT to be uniformly mixed and obtain required product.
3, water dispersible granules
Press formula rate, former medicine and dispersant, wetting agent, binding agent, filler etc. are mixed, obtain pulvis after air-flow crushing, add a certain amount of water to mix, carry out granulation in comminutor, then dry, screening namely obtains granular product.
Embodiment 6:30% thifluzamide fluoxastrobin water dispersible granules (active ingredient was than 1: 5)
Take the 5% former medicine of thifluzamide, the 25% former medicine of fluoxastrobin, 3%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 3% diatomite, 5% glucose, kaolin and add to 100%.Mix, granulate after air-flow crushing.
Embodiment 7:33% thifluzamide fluoxastrobin water dispersible granules (active ingredient was than 1: 10)
Take the 3% former medicine of thifluzamide, the 30% former medicine of fluoxastrobin, 3%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 5% diatomite, 5% glucose, kaolin and add to 100%.Mix, granulate after air-flow crushing.
Embodiment 8:30% thifluzamide fluoxastrobin water dispersible granules (active ingredient was than 5: 1)
Take the 25% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 3%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 3% diatomite, 5% glucose, kaolin and add to 100%.Mix, granulate after air-flow crushing.
4, wetting powder
, by the formula requirement, after various auxiliary agents, filler, former medicine are mixed and pulverize by Roughpulverizer, enter airslide disintegrating mill and fully be pulverized and mixed and make wetting powder.
Embodiment 9:60% thifluzamide fluoxastrobin wetting powder (active ingredient was than 1: 5)
Take the 10% former medicine of thifluzamide, the 50% former medicine of fluoxastrobin, 4% calcium lignosulfonate, 4%NNO, 1%K-12,5% white carbon, fine particle calcium carbonate and add to 100%.Mix, obtain product after pulverizing.
Embodiment 10:80% thifluzamide fluoxastrobin wetting powder (active ingredient was than 15: 1)
Take the 75% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 5% calcium lignosulfonate, 4%NNO, 2%K-12,5% white carbon, fine particle calcium carbonate and add to 100%.Mix, obtain product after pulverizing.
Embodiment 11:64% thifluzamide fluoxastrobin wetting powder (active ingredient was than 1: 15)
Take the 4% former medicine of thifluzamide, the 60% former medicine of fluoxastrobin, 5% calcium lignosulfonate, 4%NNO, 1%K-12,5% white carbon, fine particle calcium carbonate and add to 100%.Mix, obtain product after pulverizing.
5, microemulsion
Embodiment 12:20% thifluzamide fluoxastrobin microemulsion (active ingredient was than 1: 1)
Take the 10% former medicine of thifluzamide, the 10% former medicine of fluoxastrobin, 6% Nongru-700 #, 5% agriculture breast 500#, 5% agriculture breast 1601#, 15% cyclohexanone, 10%N-methyl pyrrolidone, 5% n-butanol, through dissolve complete and mix, deionized water adds to 100%.After stirring, obtain product.
Embodiment 13:22% thifluzamide fluoxastrobin microemulsion (active ingredient was than 10: 1)
Take the 20% former medicine of thifluzamide, the 2% former medicine of fluoxastrobin, 6% Nongru-700 #, 5% agriculture breast 500#, 5% agriculture breast 1601#, 20% cyclohexanone, 10%N-methyl pyrrolidone, 5% n-butanol, through dissolve complete and mix, deionized water adds to 100%.After stirring, obtain product.
6, aqueous emulsion
Embodiment 14:10% thifluzamide fluoxastrobin aqueous emulsion (active ingredient was than 1: 1)
Take the 5% former medicine of thifluzamide, the 5% former medicine of fluoxastrobin, 3% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 2% agriculture breast 600# acid phosphatide, 10% cyclohexanone, 20% solvent naphtha S150, mixed dissolution obtains oil phase.With 5% ethylene glycol, 0.3% xanthans, 0.03%BIT (BIT), deionized water adds to 100%, is made into water.Oil phase adds aqueous phase fully to mix, and after high-shear emulsifying, obtains product.
Two, biologically active embodiment
Biologically active embodiment is divided into indoor biologically active embodiment and land for growing field crops biologically active embodiment.
Active example 1: the composite Toxicity Determination to rice sheath blight disease of thifluzamide and fluoxastrobin
Experiment target is designated as rice sheath blight disease (Rhizoctonia solani), and test adopts the co-toxicity coefficient method to estimate the co-toxicity effect of complex preparation, clear and definite more rational proportioning.
Thifluzamide and fluoxastrobin are dissolved with DMF respectively, be mixed with again the liquid of series concentration with 0.1% Tween-80 aqueous solution dilution, draw respectively 6mL to sterilizing conical flask in superclean bench, the PDA+100mg/LSHAM medium 54mL that adds 50 ℃ of left and right, pour the plate of 4 diameter 9cm after shaking up into, make the toxic medium of 4 respective concentration; Use the same method the thifluzamide of different proportionings and fluoxastrobin series concentration compound solution are made toxic medium.Rice sheath blight disease pathogen with cultivating 2 days, break into the bacterium piece with the card punch of diameter 5mm at colony edge, with transfer needle, the bacterium piece moved to the toxic PDA medium that is mixed with in advance central, then is placed in 25 ℃ of incubators and cultivates, and every processing repeats 4 times.After 3 days, adopt the right-angled intersection method to measure and respectively process colony diameter cm with slide calliper rule, obtain the correction inhibition percentage.Two diameters are surveyed in each bacterium colony right-angled intersection, with its mean, represent the bacterium colony size.Obtain the colony growth inhibiting rate by following formula: colony growth inhibiting rate %=(the blank bacterium colony increases diameter-chemicals treatment bacterium colony and increases diameter) * 100/ blank bacterium colony increases diameter
On the basis of medicament bacteriostasis rate, carry out the data analysis statistics with " DPS data handling system " 3.11 professional versions, obtain regression line, EC
50, correlation coefficient.EC that each that will measure according to Sun Yunpei (Y-P Sun) method processed
50Be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical poison exponent (TTI), calculate the co-toxicity coefficient (CTC) of mixture by following formula.
The content (%) of toxicity index * B in mixed of the content (%) of toxicity index * A of theoretical mixed toxicity index (TTI)=A in mixed+B
If co-toxicity coefficient, greater than 120, shows, synergistic effect is arranged; If be starkly lower than 100, be indicated as antagonism; Between 100～120, be indicated as summation action.
The composite result of Toxicity Determination to rice sheath blight disease of table 1 thifluzamide and fluoxastrobin
Active example 2: the composite Toxicity Determination to rice blast of thifluzamide and fluoxastrobin
Experiment target is designated as rice blast (Ustilaginoidea virens), and test adopts the co-toxicity coefficient method to estimate the co-toxicity effect of complex preparation, clear and definite more rational proportioning.
Thifluzamide and fluoxastrobin are dissolved with DMF respectively, then with 0.1% Tween-80 aqueous solution dilution, be mixed with the liquid of series concentration, then thifluzamide and fluoxastrobin are made respectively default series concentration compound solution by different proportionings.Draw respectively 6mL to sterilizing conical flask in superclean bench, add the PDA medium 54mL of 50 ℃ of left and right, pour the plate of 4 diameter 9cm after shaking up into, make toxic medium.Pathogen of Rice Blast Fungus with cultivating 8 days, break into the bacterium piece with the card punch of diameter 5mm at colony edge, with transfer needle, the bacterium piece moved to the toxic PDA medium that is mixed with in advance central, then is placed in 25 ℃ of incubators and cultivates, and every processing repeats 4 times.
After 8 days, adopt the right-angled intersection method to measure and respectively process colony diameter cm with slide calliper rule, obtain the correction inhibition percentage.Two diameters are surveyed in each bacterium colony right-angled intersection, with its mean, represent the bacterium colony size.Obtain the colony growth inhibiting rate by following formula: colony growth inhibiting rate %=(the blank bacterium colony increases diameter-chemicals treatment bacterium colony and increases diameter) * 100/ blank bacterium colony increases diameter.
On the basis of medicament bacteriostasis rate, carry out the data analysis statistics with " DPS data handling system " 3.11 professional versions, obtain regression line, EC
50, correlation coefficient.EC that each that will measure according to Sun Yunpei (Y-P Sun) method processed
50Be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical poison exponent (TTI), calculate the co-toxicity coefficient (CTC) of mixture by following formula.
The content (%) of toxicity index * B in mixed of the content (%) of toxicity index * A of theoretical mixed toxicity index (TTI)=A in mixed+B
If co-toxicity coefficient, greater than 120, shows, synergistic effect is arranged; If be starkly lower than 100, be indicated as antagonism; Between 100～120, be indicated as summation action.
The composite result of Toxicity Determination to rice blast of table 2 thifluzamide and fluoxastrobin
Can find out from table 1 and table 2 result, thifluzamide and fluoxastrobin are mixed, in weight ratio is the scope of 100: 1～1: 100, banded sclerotial blight and false smut are all shown as summation action, particularly in being the scope of 15: 1～1: 15, weight ratio shows as obvious synergistic effect.Result shows, thifluzamide and fluoxastrobin are to be mixed in scope in 15: 1～1: 15 to have excellent selectivity, reasonability and feasibility in weight ratio.
Activity test 3: prevent and treat the rice sheath blight disease field control effectiveness test
Regulation according to medicine inspecting institute of the Ministry of Agriculture " GB/T 17980.20-2000 pesticide field efficacy medicine test criterion ()---bactericidal agent for preventing and treating rice sheath blight disease ", the residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, residential quarter area 15m
2, 4 repetitions, this test amounts to twice of dispenser.Be in their early stage during dispenser for the first time, execute medicine for the second time after two weeks.This test is investigated 2 times altogether, and 5 samplings of diagonal are adopted in every experimental plot, and every some investigation is connected 5 clumps, totally 25 clumps, records the disease grade.
The disease scale standard is as follows:
0 grade: complete stool is anosis;
1 grade: quaterfoil and following each leaf sheath thereof, blade morbidity (take sword-like leave as the first leaf);
3 grades: the 3rd leaf and following each leaf sheath thereof, blade morbidity;
5 grades: second leaf and following each leaf sheath thereof, blade morbidity;
7 grades: sword-like leave blade and following each leaf sheath thereof, blade morbidity;
9 grades: the complete stool morbidity, withered ahead of time.
The drug effect computational methods:
, according to investigation result, according to following (1), (2) formula, calculate disease index and preventive effect.
In formula: CK
0, CK
1Be respectively the forward and backward disease index of blank district dispenser; PT
0, PT
1Be respectively the forward and backward disease index of chemicals treatment district medicine.
Table 3 is prevented and treated rice sheath blight disease field control effectiveness test result
Activity test 4: control rice blast field control effectiveness test
Regulation according to medicine inspecting institute of the Ministry of Agriculture " GB/T 17980.19-2000 pesticide field efficacy medicine test criterion ()---bactericidal agent for preventing and treating paddy rice leaf diseases ", the residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, residential quarter area 20m
2, 4 repetitions, this test amounts to twice of dispenser.Be in their early stage during dispenser for the first time, execute medicine for the second time after 1 week.5 samplings of diagonal are adopted in every experimental plot, get 50 strains at every, and every strain investigation boot leaf and following two leaves of boot leaf, record the disease grade.
The disease scale standard is as follows:
0 grade: anosis;
1 grade: leaf spot lesion is less than 5, and length is less than 1cm;
3 grades: leaf spot lesion is less than 6～10, and part scab length is greater than 1cm;
5 grades: leaf spot lesion is less than 11～25, and the part scab is linked to be sheet, accounts for leaf area 10%～25%;
7 grades: leaf spot lesion is less than more than 26, and the part scab is linked to be sheet, accounts for leaf area 26%～50%;
9 grades: scab is linked to be sheet, and more than 50% or entirely, leaf is withered to account for leaf area.
The drug effect computational methods:
, according to investigation result, according to following (1), (2) formula, calculate disease index and preventive effect.
In formula: CK
0, CK
1Be respectively the forward and backward disease index of blank district dispenser; PT
0, PT
1Be respectively the forward and backward disease index of chemicals treatment district medicine.
Table 4 control rice blast field control effectiveness test result
Above-mentioned indoor biometrics and field control effectiveness test result show that the beneficial effect of Bactericidal composite deposits yields of the present invention is:
(1) compare with single dose, this bactericidal composition has significant synergistic effect to rice sheath blight disease and rice blast, has improved bactericidal effect;
(2) lower drug cost, environmental contamination reduction and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.The present composition is to trial crops all without obviously harmful effect, and leaf look, growing way etc. are all normal, and safety is good, meets the security requirement of pesticidal preparations.
Bactericidal composition of the present invention has good preventive effect to rice sheath blight disease and rice blast.
Claims (6)
1. bactericidal composition, the active ingredient of described bactericidal composition is thifluzamide and fluoxastrobin, the weight ratio that it is characterized in that thifluzamide and fluoxastrobin is 15:1～1:15.
2. a bactericide, is characterized in that described bactericide contains the bactericidal composition claimed in claim 1 of 0.1～90 % by weight, and surplus is acceptable auxiliary agent on agricultural chemicals.
3. bactericide according to claim 2, is characterized in that described bactericide contains the bactericidal composition of 10～80 % by weight, and surplus is acceptable auxiliary agent on agricultural chemicals.
4. according to claim 2 or 3 described bactericide, is characterized in that its formulation is suspending agent, suspended emulsion, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.
5. bactericidal composition according to claim 1 is in the application that prevents and treats rice sheath blight disease and rice blast.
6. a method of preventing and treating crop pest, before or after crops and/or fruit introduced disease, use bactericidal composition claimed in claim 1 or the described bactericide of claim 2 or 3 to the place of crops and/or fruit and growth or storage.
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| CN2012101219816A CN102640758B (en) | 2012-04-24 | 2012-04-24 | Bactericidal composition containing thifluzamide and fluoxastrobin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103371153B (en) * | 2012-04-28 | 2016-12-14 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing thifluzamide Yu methoxy acrylic |
| CN103004816B (en) * | 2012-12-21 | 2015-01-28 | 上海沪联生物药业（夏邑）股份有限公司 | Sterilizing composition containing trifluzamide and methoxyl acrylate compound |
| CN106973920A (en) * | 2017-03-07 | 2017-07-25 | 南京华洲药业有限公司 | A kind of bactericidal composition and its application containing fluoxastrobin and fenoxanil |
| CN107087623A (en) * | 2017-05-12 | 2017-08-25 | 佛山市瑞生通科技有限公司 | Composition pesticide and its application containing fluorobenzene ether amide and fluoxastrobin |
Citations (2)
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|---|---|---|---|---|
| US6103717A (en) * | 1996-01-22 | 2000-08-15 | Bayer Aktiengesellschaft | Halogen pyrimidines and its use thereof as parasite abatement means |
| CN101828564A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103717A (en) * | 1996-01-22 | 2000-08-15 | Bayer Aktiengesellschaft | Halogen pyrimidines and its use thereof as parasite abatement means |
| CN101828564A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
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| 殷锦捷.高效杀菌剂氟嘧菌酯.《农药》.2003,第42卷(第3期),第40-43页. |
| 高效杀菌剂氟嘧菌酯;殷锦捷;《农药》;20030325;第42卷(第3期);第40-43页 * |
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Address after: 311106 No. 172, Zhangjiadun Road, Tangqi Town, Linping District, Hangzhou, Zhejiang Patentee after: Zhejiang Yulong Pharmaceutical Co.,Ltd. Address before: No. 172, zhangjiadun Road, Tangqi Town, Yuhang District, Hangzhou City, Zhejiang Province, 311106 Patentee before: Hangzhou Udragon Chemical Co.,Ltd. |
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