CN102657186B - Bactericidal composition containing thifluzamide and prothioconazole - Google Patents
Bactericidal composition containing thifluzamide and prothioconazole Download PDFInfo
- Publication number
- CN102657186B CN102657186B CN201210122486.7A CN201210122486A CN102657186B CN 102657186 B CN102657186 B CN 102657186B CN 201210122486 A CN201210122486 A CN 201210122486A CN 102657186 B CN102657186 B CN 102657186B
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- bactericidal composition
- thifluzamide
- prothioconazoles
- bactericide
- bactericidal
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- 150000003852 triazoles Chemical class 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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Abstract
The invention relates to the field of agricultural bactericides, in particular to a bactericidal composition containing thifluzamide and prothioconazole, wherein the weight ratio of the thifluzamide to the prothioconazole is 100:1-1:100. Compared with a single agent, the bactericidal composition has an obvious synergistic effect on rice sheath blight disease and rice false smut, the bactericidal effect is improved, the application cost is reduced, environmental pollution and pesticide residue are reduced, and the occurrence of drug resistance of bacteria is favorably overcome and delayed. The composition has the advantages of no adverse effect on test crops, normal leaf color, growth vigor and the like, high safety, capability of meeting safety requirement of pesticide preparations and good effect on the rice sheath blight disease and the rice false smut.
Description
Technical field
The present invention relates to a kind of agricultural bactericidal composition, and the bactericide that contains described bactericidal composition, particularly a kind of for preventing and treating the bactericidal composition of rice sheath blight disease and false smut.
Background technology
Rice sheath blight disease is the important disease in paddy rice producing region, is one of China paddy rice three large diseases, in each paddy rice producing region, the whole nation, has generation, and the Yangtze river basin and South Rice Region of China occur heavier, and especially the high-yield field with dense planting hybrid rice of short stem occurs the most general and serious.Mainly by Deuteromycotina Rhizoctonia Disease (Rhizoctonia solani), caused, disease is expanded from bottom to top, when serious, can arrive sword-like leave, even fringe portion morbidity, large stretch of lodging.The heavier field of falling ill, the general underproduction 5%～10%, seriously can reach 50%～70%.Along with the popularization of Multi spike cultivar of short stem, the raising of Planting Densities and Fertilization Level, has become an outstanding problem of rice high yield stable yields.
False smut claims again pseudo-smut, and the pathogen asexual stage returns the green pyrenomycetes of Deuteromycotina to belong to (Ustilaginoidea virens); Sexual generation is returned Ascomycotina Claviceps (Claviceps virens).There is generation in most of rice district, the Ci Bing world, and China is also early on the books.Though, occurred before the sixties in 20th century sporadicly to there being generation in South China Double Cropping rice district, cause harm slight, be unnoticed.In recent years, along with cropping system changes, hybrid rice is promoted, working condition improves and the level of production improves, the generation of false smut is more and more serious, in some areas, has risen to as Major Diseases.This sick gesture that has rising year by year, greater loss is caused in many places.In addition, because its infected seed is poisonous, if as feed, content reaches 0.5% when above, can cause fowl poultry chronic poisoning, and internal organ generation pathology is death even.
Thifluzamide (trade name: full fringe), also claim thifluzamide, English common name Trifluzamide, belongs to thiazole amide bactericide, is the new and effective systemic fungicide that Monsanto Company develops, and is can buy the product of acquisition on market.The fungus-caused disease of Basidiomycetes is had to special efficacy as banded sclerotial blight, damping off etc.Thifluzamide is succinate dehydrogenase inhibitor, and due to fluorine-containing, its competitiveness in biochemical pathway is very strong, once be combined with substrate or enzyme, is just difficult for recovering.The pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas are also all had to good preventive effect.Its structural formula is:
Prothioconazoles (Prothioconazole; English trade name: Proline) be a kind of New-type wide-spectrum triazolinthione series bactericidal agent of Beyer Co., Ltd's development, sale; not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.Prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase obviously, with triazole bactericidal agent, compares, and prothioconazoles has the more sterilization of wide spectrum and lives.Be mainly used in preventing and treating cereal crop as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crops.Almost all wheat class diseases are had to good control efficiency, as the powdery mildew of Wheat and barley, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc.Can also prevent and treat the soil-borne disease of rape and peanut, as stalk break, and main foliage disease, as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.Its structural formula is:
Take the bactericidal composition that thifluzamide and prothioconazoles be active ingredient, for the control of rice sheath blight disease and false smut, can delay the drug-fast generation of germ, improve actual preventive effect, reduce drug cost, is the important means of comprehensive control of disease.
Summary of the invention
The object of the invention is to overcome the problems such as single bactericide is single to agricultural disease preventive and therapeutic effect, the lasting period is short, virulence is not enough, provide a kind of bactericidal effect good, delay pesticide resistance and the low bactericidal composition of drug cost.
Another object of the present invention is to provide described bactericidal composition for the banded sclerotial blight of paddy rice and the purposes of false smut.
To achieve these goals, the invention provides a kind of bactericidal composition, described bactericidal composition contains thifluzamide and prothioconazoles, and wherein the weight ratio of thifluzamide and prothioconazoles is 100: 1～1: 100.
Preferably, the weight ratio of thifluzamide and prothioconazoles is 20: 1～1: 20.
Above-mentioned bactericidal composition also comprises one or more the mixture in weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The present invention also provides a kind of bactericide, the above-mentioned bactericidal composition that wherein said bactericide contains 0.1～90 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Preferably, the above-mentioned bactericidal composition that described bactericide contains 10～80 % by weight, surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
According to the preferred embodiment of bactericide of the present invention, its formulation is suspended emulsion, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.
The present invention also provides above-mentioned bactericidal composition in the application that prevents and treats rice sheath blight disease and false smut.
The present invention also provides a kind of method of preventing and treating crop pest, before or after crops and/or fruit introduced disease, to the place of crops and/or fruit and growth or storage, uses above-mentioned bactericidal composition or above-mentioned bactericide.
Below by more detailed description technical scheme of the present invention:
The invention provides a kind of bactericidal composition, described bactericidal composition contains thifluzamide and prothioconazoles, and wherein the weight ratio of thifluzamide and prothioconazoles is 100: 1～1: 100.
Preferably, the weight ratio of thifluzamide and prothioconazoles is 20: 1～1: 20.
Above-mentioned bactericidal composition also comprises one or more the mixture in weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner.Described weed killer herbicide, insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner can be can buy the existing procucts of acquisition on market.
The present invention also provides a kind of bactericide, the above-mentioned bactericidal composition that wherein said bactericide contains 0.1～90 % by weight, and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Preferably, the above-mentioned bactericidal composition that described bactericide contains 10～80 % by weight, surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Except as otherwise noted, " % " involved in the present invention is " percentage by weight ".
According to method known in those skilled in the art, bactericidal composition of the present invention can be mixed with the formulation allowing in agricultural when practical application, and formulation is suspending agent, aqueous emulsion, microemulsion, wetting powder or water dispersible granules preferably.
To suspending agent, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, TERSPERSE 2425 (U.S. Huntsman Corporation produces, alkyl naphthalene sulfonic acid salt); Wetting agent is selected from the poly-base ether formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500 (U.S. Huntsman Corporation product); Thickener is selected from xanthans, aluminium-magnesium silicate, bentonite; Preservative is selected from benzoic acid, Sodium Benzoate, BIT (BIT); Defoamer is silicone based defoamer; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts as sodium chloride.
To aqueous emulsion, spendable auxiliary agent has: emulsifier is selected from Nonyl pheno (EO=10) ether phosphate, triphen ethyl-phenol polyoxyethylene ether phosphate (agriculture breast 600# phosphate), Nongru-700 #, agriculture breast 2201#, Span-60#, emulsifier T-60, TX-10, agriculture breast 1601#, agriculture breast 600#, agriculture breast 400#; Solvent is selected from dimethylbenzene, toluene, cyclohexanone, solvent naphtha (trade mark: S-150, S-180, S-200); Stabilizing agent is selected from triphenyl phosphite, epoxychloropropane; Antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea, inorganic salts as sodium chloride; Thickener is selected from xanthans, bentonite, aluminium-magnesium silicate; Preservative is selected from BIT (BIT), benzoic acid, Sodium Benzoate.
To microemulsion, spendable auxiliary agent has: emulsifier is selected from calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #, agriculture breast 2201#, this dish-60#, Tween-80, TX-10, agriculture breast 1601, agriculture breast 600#, agriculture breast 400#; Cosolvent is selected from methyl alcohol, isopropyl alcohol, n-butanol, ethanol; Solvent is selected from cyclohexanone, 1-METHYLPYRROLIDONE, dimethylbenzene, toluene, solvent naphtha (trade mark: S-150, S-180, S-200); Stabilizing agent is selected from triphenyl phosphite, epoxychloropropane.
To wetting powder, spendable auxiliary agent has: dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay etc.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate; Wetting agent is selected from polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, naphthalene sulfonate; Disintegrant is selected from ammonium sulfate, urea, sucrose, glucose, citric acid, succinic acid, sodium bicarbonate; Binding agent is selected from diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family and microcrystalline cellulose class; Filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, sepiolite, talcum powder, attapulgite, potter's clay etc.
Bactericidal composition of the present invention can provide with finished product preparation form, and in composition, each material mixes; Also can provide with single dose preparation, before using, in bucket (tank), directly mix.Concentrate of the present invention conventionally and water be mixed to get the concentration of required active substance.
The present invention also provides above-mentioned bactericidal composition in the application that prevents and treats rice sheath blight disease and false smut.
The present invention also provides a kind of method of preventing and treating crop pest, before or after crops and/or fruit introduced disease, to the place of crops and/or fruit and growth or storage, uses above-mentioned bactericidal composition or above-mentioned bactericide.
Compared with prior art, the present invention, by the use of combining of thifluzamide and prothioconazoles, has following beneficial effect:
(1) compare with single dose, bactericidal composition of the present invention has significant synergistic effect to disease, has improved bactericidal effect;
(2) reduce medication number of times, reduce drug cost, reduce environmental pollution and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these embodiments.One skilled in the art would recognize that the present invention contained all alternatives, improvement project and the equivalents that within the scope of claims, may comprise.
One, Preparation Example
In all preparation proportionings, percentage composition is all weight percentage.
1, suspending agent
Embodiment 1:40% thifluzamide prothioconazoles suspending agent (active ingredient was than 1: 1)
Take the former medicine of 20% thifluzamide, the former medicine of 20% prothioconazoles, 3.5%FS3000 (phosphate type anion surfactant), 1%TXC (sulfonic acid type anion surfactant), 0.1% xanthans, 1% aluminium-magnesium silicate, 5% ethylene glycol, 0.03%BIT (1,2-benzisothiazole-3-ketone), 0.3% organically-modified silica alkane defoamer, deionized water adds to 100%.
Press formula rate, take water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. are joined and in high-shear emulsion machine, shear 30min, then use after sand mill sand milling, obtain suspending agent.
Embodiment 2:24% thifluzamide prothioconazoles suspending agent (active ingredient was than 5: 1)
Take the former medicine of 20% thifluzamide, the former medicine of 4% prothioconazoles, 3%FS3000,1%NP-10 (polyoxyethylene nonylphenol ether), 0.2% xanthans, aluminium-magnesium silicate 1%, 5% ethylene glycol, 0.3% benzoic acid, 0.5% organically-modified silica alkane defoamer, deionized water adds to 100%.Press formula rate, take water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. are joined and in high-shear emulsion machine, shear 30min, then use after sand mill sand milling, obtain suspending agent.
2, water dispersible granules
Embodiment 3:30% thifluzamide prothioconazoles water dispersible granules (active ingredient was than 1: 1)
Take the former medicine of 15% thifluzamide, the former medicine of 15% prothioconazoles, 3.5%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2.5% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 3% diatomite, 5% glucose, kaolin and add to 100%.
Press formula rate, former medicine and dispersant, wetting agent, binding agent, filler etc. mixed, after air-flow crushing, obtain pulvis, add water to mix, in comminutor, carry out granulation, then dry, sieve and obtain granular product.
Embodiment 4:31.5% thifluzamide prothioconazoles water dispersible granules (active ingredient was than 20: 1)
Take the former medicine of 30% thifluzamide, the former medicine of 1.5% prothioconazoles, 4%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 5% diatomite, 5% glucose, kaolin and add to 100%.
Press formula rate, former medicine and dispersant, wetting agent, binding agent, filler etc. mixed, after air-flow crushing, obtain pulvis, add water to mix, in comminutor, carry out granulation, then dry, sieve and obtain granular product.
Embodiment 5:27.5% thifluzamide prothioconazoles water dispersible granules (active ingredient was than 10: 1)
Take the former medicine of 25% thifluzamide, the former medicine of 2.5% prothioconazoles, 3%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2.5% Nekal BX (nekal), 3%K-12 (lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 4% diatomite, 5% glucose, kaolin and add to 100%.
Press formula rate, former medicine and dispersant, wetting agent, binding agent, filler etc. mixed, after air-flow crushing, obtain pulvis, add water to mix, in comminutor, carry out granulation, then dry, sieve and obtain granular product.
3, wetting powder
Embodiment 6:50% thifluzamide prothioconazoles wetting powder (active ingredient was than 1: 1)
Take the former medicine of 25% thifluzamide, the former medicine of 25% prothioconazoles, 5%NNO, 2% Nekal BX, 5% white carbon, fine particle calcium carbonate and add to 100%.
By formula requirement, after various auxiliary agents, filler, former medicine are mixed and pulverized by Roughpulverizer, enter airslide disintegrating mill and be fully pulverized and mixed and make wetting powder.
Embodiment 7:48% thifluzamide prothioconazoles wetting powder (active ingredient was than 1: 5)
Take the former medicine of 8% thifluzamide, the former medicine of 40% prothioconazoles, 4%NNO, 2% Nekal BX, 6% white carbon, fine particle calcium carbonate and add to 100%.
By formula requirement, after various auxiliary agents, filler, former medicine are mixed and pulverized by Roughpulverizer, enter airslide disintegrating mill and be fully pulverized and mixed and make wetting powder.
Embodiment 8:80% thifluzamide prothioconazoles wetting powder (active ingredient was than 15: 1)
Take the former medicine of 75% thifluzamide, the former medicine of 5% prothioconazoles, 4% calcium lignosulfonate, 3%NNO, 2%K-12,5% white carbon, fine particle calcium carbonate add to 100%.Mix, after pulverizing, obtain product.
4, microemulsion
Embodiment 9:20% thifluzamide prothioconazoles microemulsion (active ingredient was than 1: 1)
Take the former medicine of 10% thifluzamide, the former medicine of 10% prothioconazoles, 5% Nongru-700 #, 5% agriculture breast 500#, 6% agriculture breast 1601#, 15% cyclohexanone, 5%N-methyl pyrrolidone, 5% n-butanol, through dissolving completely and mixing, deionized water adds to 100%.After stirring, obtain product.
Embodiment 10:30% thifluzamide prothioconazoles microemulsion (active ingredient was than 1: 2)
Take the former medicine of 10% thifluzamide, the former medicine of 20% prothioconazoles, 4% Nongru-700 #, 6% agriculture breast 500#, 6% agriculture breast 1601#, 20% cyclohexanone, 8%N-methyl pyrrolidone, 5% n-butanol, through dissolving completely and mixing, deionized water adds to 100%.After stirring, obtain product.
Embodiment 11:32% thifluzamide prothioconazoles microemulsion (active ingredient was than 1: 15)
Take the former medicine of 2% thifluzamide, the former medicine of 30% prothioconazoles, 5% Nongru-700 #, 6% agriculture breast 500#, 5% agriculture breast 1601#, 20% cyclohexanone, 10%N-methyl pyrrolidone, 5% n-butanol, through dissolving completely and mixing, deionized water adds to 100%.After stirring, obtain product.
5, aqueous emulsion
Embodiment 12:10% thifluzamide prothioconazoles aqueous emulsion (active ingredient was than 1: 1)
Take the former medicine of 5% thifluzamide, the former medicine of 5% prothioconazoles, 3% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 2% agriculture breast 600# acid phosphatide, 15% cyclohexanone, 10% solvent naphtha S150, mixed dissolution obtains oil phase.By 5% ethylene glycol, 0.3% xanthans, 0.03%BIT (BIT), deionized water adds to 100%, is made into water.Oil phase adds in water and fully mixes, and after high-shear emulsifying, obtains product.
Embodiment 13:22% thifluzamide prothioconazoles aqueous emulsion (active ingredient was than 1: 10)
Take the former medicine of 2% thifluzamide, the former medicine of 20% prothioconazoles, 3% agriculture breast 2201#, 3% Nonyl pheno (EO=10) ether phosphate, 2% agriculture breast 600# acid phosphatide, 15% cyclohexanone, 20% solvent naphtha S150, mixed dissolution obtains oil phase.By 5% ethylene glycol, 0.3% xanthans, 0.03%BIT (BIT), deionized water adds to 100%, is made into water.Oil phase adds in water and fully mixes, and after high-shear emulsifying, obtains product.
Embodiment 14:21% thifluzamide prothioconazoles aqueous emulsion (active ingredient was than 1: 20)
Take the former medicine of 1% thifluzamide, the former medicine of 20% prothioconazoles, 3% agriculture breast 2201#, 2% Nonyl pheno (EO=10) ether phosphate, 2% agriculture breast 600# acid phosphatide, 15% cyclohexanone, 20% solvent naphtha S150, mixed dissolution obtains oil phase.By 5% ethylene glycol, 0.3% xanthans, 0.03%BIT (BIT), deionized water adds to 100%, is made into water.Oil phase adds in water and fully mixes, and after high-shear emulsifying, obtains product.
Two, biologically active embodiment
Biologically active embodiment is divided into indoor biologically active embodiment and land for growing field crops biologically active embodiment.
Active example 1: the composite Toxicity Determination to rice sheath blight disease of thifluzamide and prothioconazoles
Experiment target is designated as rice sheath blight disease (Rhizoctonia solani), and test adopts co-toxicity coefficient method to evaluate the co-toxicity effect of complex preparation, clear and definite more rational proportioning.
Thifluzamide and prothioconazoles are dissolved with DMF respectively, with 0.1% Tween-80 aqueous solution dilution, be mixed with again the liquid of series concentration, in superclean bench, draw respectively 6mL to the conical flask of sterilizing, the PDA+100mg/LSHAM medium 54mL that adds 50 ℃ of left and right, after shaking up, pour the plate of 4 diameter 9cm into, make the toxic medium of 4 respective concentration; Use the same method the thifluzamide of different proportionings and prothioconazoles series concentration compound solution are made to toxic medium.Rice sheath blight disease pathogen by cultivating 2 days, breaks into bacterium piece with the card punch of diameter 5mm at colony edge, with transfer needle, bacterium piece is moved to the toxic PDA medium being mixed with in advance central, is then placed in 25 ℃ of incubators and cultivates, and every processing repeats 4 times.After 3 days, adopt right-angled intersection method to measure and respectively process colony diameter cm with slide calliper rule, obtain correction inhibition percentage.Two diameters are surveyed in each bacterium colony right-angled intersection, with its mean, represent bacterium colony size.By following formula, obtain colony growth inhibiting rate: colony growth inhibiting rate %=(blank bacterium colony increases diameter-chemicals treatment bacterium colony and increases diameter) * 100/ blank bacterium colony increases diameter
On the basis of medicament bacteriostasis rate, by " DPS data handling system " 3.11 professional versions, carry out data analysis statistics, obtain regression line, EC
50, correlation coefficient.According to Sun Yunpei (Y-P Sun) method by each EC processing measuring
50be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical poison exponent (TTI), by following formula, calculate the co-toxicity coefficient (CTC) of mixture.
The content (%) of toxicity index * B of content (the %)+B of toxicity index * A of theoretical mixed toxicity index (TTI)=A in mixed in mixed
If co-toxicity coefficient is greater than 120, showing has synergistic effect; If be starkly lower than 100, be indicated as antagonism; Between 100～120, be indicated as summation action.
The composite Toxicity Determination result to rice sheath blight disease of table 1 thifluzamide and prothioconazoles
Active example 2: the composite Toxicity Determination to rice green smut of thifluzamide and prothioconazoles
Experiment target is designated as rice green smut (Ustilaginoidea virens), and test adopts co-toxicity coefficient method to evaluate the co-toxicity effect of complex preparation, clear and definite more rational proportioning.
Thifluzamide and prothioconazoles are dissolved with DMF respectively, then be mixed with the liquid of series concentration with 0.1% Tween-80 aqueous solution dilution, then thifluzamide and prothioconazoles are made respectively to default series concentration compound solution by different proportionings.At 100mL PSB inoculation of medium, on PDA medium, cultivated 3 of the mycelia pieces (diameter 5mm) of 14d, 26 ℃ of constant temperature shake the spore mycelia suspension of training 14d, with the medical husky cloth of individual layer sterilizing, cross elimination mycelia, and spore suspension is for testing.Each single dose and compound drug, respectively by the series concentration liquid of preliminary experiment design, are joined and in PSB liquid nutrient medium, make pastille liquid nutrient medium.In the triangular flask of every 50mL, fill dilution 20mL, 4 bottles of every concentration.Establish blank simultaneously.This process is in strict accordance with sterile working.Every triangular flask adds cultivates standby spore suspension bacterial classification 2mL, and 26 ℃ of constant temperature shake training 12d (rotating speed 120r/min), static cultivation 2d.Pour out mycelia, dry for 60 ℃ and claim mycelia dry weight.Calculate the fungistatic effect of each chemicals treatment, bacteriostasis rate (%)=(blank mycelia dry weight-chemicals treatment mycelia dry weight) * 100/ blank mycelia dry weight.
On the basis of medicament bacteriostasis rate, by " DPS data handling system " 3.11 professional versions, carry out data analysis statistics, obtain regression line, EC
50, correlation coefficient.According to Sun Yunpei (Y-P Sun) method by each EC processing measuring
50be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical poison exponent (TTI), by following formula, calculate the co-toxicity coefficient (CTC) of mixture.
The content (%) of toxicity index * B of content (the %)+B of toxicity index * A of theoretical mixed toxicity index (TTI)=A in mixed in mixed
If co-toxicity coefficient is greater than 120, showing has synergistic effect; If be starkly lower than 100, be indicated as antagonism; Between 100～120, be indicated as summation action.
The composite Toxicity Determination result to rice green smut of table 2 thifluzamide and prothioconazoles
From table 1 and table 2 result, can find out, thifluzamide and prothioconazoles are mixed, in weight ratio is the scope of 100: 1～1: 100, banded sclerotial blight and false smut are all shown as to summation action, particularly in being the scope of 20: 1～1: 20, weight ratio shows as obvious synergistic effect.Result shows, thifluzamide and prothioconazoles are within 20: 1～1: 20, in scope, to be mixed to have excellent selectivity, reasonability and feasibility in weight ratio.
Field application test 1: prevent and treat rice sheath blight disease field control effectiveness test
According to the regulation of medicine inspecting institute of the Ministry of Agriculture " GB/T 17980.20-2000 pesticide field efficacy medicine test criterion ()---bactericidal agent for preventing and treating rice sheath blight disease ", the community of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, community area 15m
2, repeating for 4 times, this test amounts to twice of dispenser.During dispenser for the first time, in their early stage, after two weeks, execute medicine for the second time.This test is investigated 2 times altogether, and every experimental plot adopts 5 samplings of diagonal, and every some investigation is connected 5 clumps, totally 25 clumps, records disease grade.
Disease scale standard is as follows:
0 grade: complete stool is anosis;
1 grade: quaterfoil and following leaf sheath thereof, blade morbidity (take sword-like leave as first leaf);
3 grades: the 3rd leaf and following leaf sheath thereof, blade morbidity;
5 grades: second leaf and following leaf sheath thereof, blade morbidity;
7 grades: sword-like leave blade and following leaf sheath thereof, blade morbidity;
9 grades: complete stool morbidity, withered ahead of time.
Drug effect computational methods:
According to investigation result, according to below, (1), (2) formula calculate disease index and preventive effect.
In formula: CK
0, CK
1be respectively the forward and backward disease index of blank district dispenser; PT
0, PT
1be respectively the forward and backward disease index of chemicals treatment district medicine.
Table 3 is prevented and treated rice sheath blight disease field control effectiveness test result
Field application test 2: control rice green smut field control effectiveness test
The community of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, community area 20m
2, repeating for 4 times, this test amounts to twice of dispenser.During dispenser for the first time, in their early stage, after 1 week, execute medicine for the second time.Every experimental plot adopts 5 samplings of diagonal, and every some investigation is connected 5 clumps, and totally 25 clumps, investigate the infected seed number of each community, record disease grade.
Disease scale standard is as follows:
0 grade: anosis;
1 grade: 1 granulosis grain;
2 grades: 2～5 granulosis grains;
3 grades: 6～10 granulosis grains;
4 grades: 11～15 granulosis grains;
5 grades: 16 above infected seeds.
Drug effect computational methods:
According to investigation result, according to below, (1), (2) formula calculate disease index and preventive effect.
In formula: CK
0, CK
1be respectively the forward and backward disease index of blank district dispenser; PT
0, PT
1be respectively the forward and backward disease index of chemicals treatment district medicine.
Table 4 control rice green smut field control effectiveness test result
Above-mentioned indoor biometrics and field control effectiveness test result show that the beneficial effect of Bactericidal composite deposits yields of the present invention is:
(1) compare with single dose, this bactericidal composition has significant synergistic effect to rice sheath blight disease and false smut, has improved bactericidal effect;
(2) lower drug cost, reduce environmental pollution and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.The present composition is to trial crops all without obviously harmful effect, and leaf look, growing way etc. are all normal, and safety is good, meets the security requirement of pesticidal preparations.
Bactericidal composition of the present invention has good preventive effect to rice sheath blight disease and false smut.
Claims (7)
1. a bactericidal composition, the bactericidal active ingredient of described bactericidal composition is thifluzamide and prothioconazoles, the weight ratio that it is characterized in that thifluzamide and prothioconazoles is 20:1～1:20.
2. bactericidal composition according to claim 1, it is characterized in that described bactericidal composition also comprises other active ingredient, described other active ingredient is one or more the mixture in weed killer herbicide, insecticide, growth regulator, nutrient for plants or soil conditioner.
3. a bactericide, is characterized in that the bactericidal composition described in claim 1 or 2 that described bactericide contains 0.1～90 % by weight, and surplus is acceptable carrier on agricultural chemicals, and the auxiliary agent except carrier.
4. bactericide according to claim 3, is characterized in that the bactericidal composition described in claim 1 or 2 that described bactericide contains 10～80 % by weight, and surplus is acceptable carrier on agricultural chemicals, and the auxiliary agent except carrier.
5. according to the bactericide described in claim 3 or 4, it is characterized in that its formulation is suspending agent, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.
6. bactericidal composition according to claim 1 and 2 is being prevented and treated the application of rice sheath blight disease and false smut.
7. prevent and treat a method for crop pest, before or after crops and/or fruit introduced disease, to the place of crops and/or fruit and growth or storage, use bactericidal composition or the bactericide claimed in claim 3 described in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210122486.7A CN102657186B (en) | 2012-04-24 | 2012-04-24 | Bactericidal composition containing thifluzamide and prothioconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN103563913B (en) * | 2012-08-04 | 2015-11-04 | 南京华洲药业有限公司 | A kind of bactericidal composition and application thereof containing thifluzamide and prothioconazoles |
| CN102870794A (en) * | 2012-10-19 | 2013-01-16 | 江苏丘陵地区镇江农业科学研究所 | Sterilization composition for preventing rice sheath blight disease |
| CN104621149A (en) * | 2013-11-15 | 2015-05-20 | 南京华洲药业有限公司 | Sterilization composition containing prothioconazole and thifluzamide and application thereof |
| CN105948439A (en) * | 2016-07-11 | 2016-09-21 | 许祚员 | Glyphosate-polluted sludge treatment agent and preparation method |
| CN106007300A (en) * | 2016-07-29 | 2016-10-12 | 张凯悦 | Simazine polluted sludge treatment agent and preparation method thereof |
| CN108041047A (en) * | 2017-12-12 | 2018-05-18 | 安徽国星生物化学有限公司 | A kind of bactericidal composition and its application containing prothioconazoles and flutolanil |
| CN115152780A (en) * | 2022-06-27 | 2022-10-11 | 江西省农业科学院植物保护研究所 | Medicament for preventing and treating spike blight of plantain and preparation method thereof |
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| EP2308303B1 (en) * | 2002-03-21 | 2016-03-16 | Basf Se | Fungicidal mixtures |
| CN101828559B (en) * | 2010-06-02 | 2013-04-10 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
| CN102204546B (en) * | 2011-04-16 | 2014-02-05 | 陕西汤普森生物科技有限公司 | Bactericidal composition containing thifluzamide and triazole compounds |
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