CN104430426B - A kind of composition pesticide containing steroid enol and rosickyite azoles - Google Patents
A kind of composition pesticide containing steroid enol and rosickyite azoles Download PDFInfo
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- CN104430426B CN104430426B CN201410709606.2A CN201410709606A CN104430426B CN 104430426 B CN104430426 B CN 104430426B CN 201410709606 A CN201410709606 A CN 201410709606A CN 104430426 B CN104430426 B CN 104430426B
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Abstract
The invention discloses a kind of composition pesticide containing steroid enol Yu rosickyite azoles, including the first active ingredient steroid enol and the second active ingredient rosickyite azoles and conventional auxiliary element, the weight ratio of steroid enol and rosickyite azoles in the composition is 40:1~1:40；Show that composition pesticide of the present invention has obvious synergistic function through substantial amounts of experiment, single dose exclusive use is substantially better than to the prevention effect of crop disease viral disease；Reduce Pesticide use amount simultaneously, reduce use cost, alleviate pollution to environment, delayed the drug-fast generation of pathogen.
Description
Technical field
The present invention relates to composition pesticide and its application field, specifically using steroid enol and rosickyite azoles as active ingredient
Bactericidal composition, be mainly used in the preventing and treating of crop virosis.
Background technology
Virosis worldwide constitutes a serious threat to Crop yield and quality, according to statistics, subtracts caused by annual
Production reaches 10-30%, about 20,000,000,000 dollars of economic loss.China is a large agricultural country, every year because virosis is to grain-production, garden
The about tens billion of members of economic loss caused by skill crop, industrial crops etc., in order to efficiently control the viroses of plant
With sprawling, people take many measures, such as plant anti-disease tolerant variety, are educated from virus-free seed and seed disinfection, popularization detoxification
Seedling technology, enhancement of field management, Greenhouse, prevention and control pass virus mediator, shift of crops, adjustment crop sowing time etc., although taking
Obtained certain effect, but effect be not it is obvious that lack effectively preventing medicament be still viroses of plant wide-scale distribution,
The principal element of large area sprawling.
Steroid enol be it is a kind of be natural, efficient, safe plant antiviral agent, its mechanism of action mainly passes through change
The activity of nuclease, suppress virus synthesis, so as to direct suppressing virus replication, while it can be by changing cell generation of host
Thank, virus inoculation is not rised in value, reach induction host and produce resistance, prevent the purpose of virus infection indirectly.It is to rice, cigarette
Various virosis on the crops such as grass, wheat, cucumber, cotton, tomato have good prevention effect.
Rosickyite azoles also known as albendazole, belong to benzimidazoles derivative, and people is used as always before as disinfectant use in agriculture
Raise medication and treat various enteric bacteria and parasitic infection.With prevention ＆ protection, interior suction treatment, infiltration conduction, fungicidal spectrum
Extensively, there is good prevention effect to fungal disease, virosis, bacterial disease.
The present inventor has made intensive studies to the screening of the compounded formula of steroid enol and rosickyite azoles, surprisingly, it was found that
Steroid enol and rosickyite azoles are compounded, and are had obvious synergistic function in the range of certain compound proportion, are actually made
During, steroid enol and rosickyite azoles compounding use have excellent prevention effect to a variety of virosis on plant, through entering one
Step research, completes the present invention.
The content of the invention
Crop virosis is also easy to produce during it is an object of the invention to solve the exclusive use of prior art Pesticides single dose anti-
A kind of the problem of property of medicine and poor actual prevention effect, there is provided the tool of efficient, inexpensive, less toxic preventing and treating crop virosis
There is the composition pesticide of Synergistic.
Technical solution of the present invention：Using steroid enol and rosickyite azoles as active ingredient, the weight ratio of steroid enol and rosickyite azoles is 40:
1~1:40, the percentage by weight of steroid enol and rosickyite azoles weight summation in bactericidal composition is 1%~85%, and remaining is agriculture
Allow to use and acceptable auxiliary element in medicine.
Composition pesticide of the present invention can be prepared into by selecting suitable pesticidal preparations auxiliary element and be adapted to agriculturally make
A variety of application forms, relatively good formulation have suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, water dispersible granules,
Wettable powder and ultra low volume liquids.
Described auxiliary element is solvent, cosolvent, emulsifying agent, wetting agent, dispersant, stabilizer, antifreezing agent, thickening
Agent, binding agent, disintegrant, defoamer, bleeding agent, synergist, cyst material, pH adjusting agent and filler etc., all it is pesticidal preparations
In commonly use or allow the composition used, be not particularly limited, specific composition and dosage are according to recipe requirements by simply testing
It is determined that.
The production technology of the various application forms of described composition pesticide belongs to existing known technology, no longer superfluous herein
State.
Composition pesticide provided by the invention, early stage should occur in virosis in application or disease early period of origination uses,
The method of generally use spraying uses, and can also use technology using other agriculturally applied as needed.
Composition pesticide of the present invention can be used for preventing and treating tobacco mosaic disease, tomato virus disease, pepper virus disease, cucumber mosaic
The multiple kinds of crops virosis such as disease, stripe disease, rice stunt, black streaked dwarf virus of rice, yellow stunt of rice.
Compared with prior art, the advantage of the invention is that：
1st, two kinds of active ingredient compoundings of steroid enol and rosickyite azoles have obvious synergistic function, individually make than single dose
With, hence it is evident that improve the prevention effect to crop virosis.
2nd, two kinds of active ingredient compounding uses of steroid enol and rosickyite azoles, reduce Pesticide use amount, reduce use cost,
The pollution to environment is alleviated, delayed the generation of viral resistance, added the service life of agricultural chemicals.
Embodiment
Essence for a better understanding of the present invention, present disclosure is described further with reference to embodiment,
But limitation of the present invention can not be considered as, it is as described below to be only used for explaining the present invention, for without departing from spirit of the invention and principle
Modification, replacement or the improvement made, belong to the scope of protection of present invention.
Each component percentage composition is weight percentage in following examples.
Example of formulations 1：20% steroid enol rosickyite azoles ultra low volume liquids.
Steroid enol 19%, rosickyite azoles 1%, 1-METHYLPYRROLIDONE 10%, cyclohexanone 5%, 2- methyl naphthalenes 5%, styrene
Base phenol APEO 5%, calcium dodecyl benzene sulfonate 5%, organosilicon 2%, corn oil complements to 100%.Have above-mentioned
After effect composition is dissolved with stirring solvent, emulsifying agent, wetting agent and bleeding agent are added, is thoroughly mixed uniformly, you can be made
20% steroid enol rosickyite azoles ultra low volume liquids.
Example of formulations 2：30% steroid enol rosickyite azole suspending agent.
Steroid enol 25%, rosickyite azoles 5%, aerosol-OT salt 10%, sodium methylene bis-naphthalene sulfonate 5%,
TERSPERSE20203%, polyethylene glycol 3%, methylcellulose 1%, aqueous emulsion of dimethyl polysiloxane fluid 0.1%, formaldehyde 0.3%,
Deionized water supplies 100%.Above-mentioned active ingredient, wetting agent, dispersant, antifreezing agent, thickener, defoamer and preservative are passed through
High speed shear is scattered, is sanded in sand mill, high dispersive, the stable suspension system formed in water-medium, you can be made
30% steroid enol rosickyite azole suspending agent.
Example of formulations 3：35% steroid enol rosickyite azoles aqueous emulsion.
Steroid enol 5%, rosickyite azoles 30%, DMF 5%, cyclohexanone 15%, phenethyl phenol polyoxyethylene poly-oxygen propylene aether
10%th, aliphatic acid polyethenoxy base ester 5%, polyacrylamide 5%, triphenyl phosphite 1%, formaldehyde 0.3%, glycerine 1%,
Deionized water supplies 100%.Above-mentioned active ingredient, solvent, emulsifying agent, dispersant, stabilizer and preservative are mixed to form oil
Phase, antifreezing agent dissolves in water forms aqueous phase, slowly oil phase is added in aqueous phase under cutter effect, and continue shearing about 30
Minute, obtained 35% steroid enol rosickyite azoles aqueous emulsion.
Example of formulations 4：40% steroid enol rosickyite azoles microemulsion.
Steroid enol 35%, rosickyite azoles 5%, DMF 5%, heavy aromatics naphtha Solvesso200 15%, phenethyl phenol are gathered
Oxygen ethene polyethenoxy ether 10%, aliphatic acid polyethenoxy base ester 5%, epoxychloropropane 2%, organosilicon 1%, azone 2%, third
Triol 1%, deionized water supplies 100%.Active ingredient is completely dissolved with solvent, emulsifying agent, stabilizer is then added, oozes
Saturating agent, synergist and antifreezing agent are well mixed, and deionized water are eventually adding, after being sufficiently stirred, you can 40% steroid alkene is made
Alcohol rosickyite azoles microemulsion.
Example of formulations 5：80% steroid enol rosickyite azoles water dispersible granules.
Steroid enol 78%, rosickyite azoles 2%, Nekal BX 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polycarboxylate
2%th, succinic acid 2%, sodium carboxymethylcellulose 1%, precipitated calcium carbonate supplies 100%.By above-mentioned active ingredient, wetting agent, divide
Powder, disintegrant, binding agent and filler are well mixed, and are crushed with micro jet, through mediating, are then added fluid bed and are made
It is granulated in grain drying machine, dries, sieve, you can 80% steroid enol rosickyite azoles water dispersible granules is made.
Example of formulations 6：70% steroid enol rosickyite azoles wettable powder.
Steroid enol 5%, rosickyite azoles 65%, neopelex 10%, Nekal BX 5%, aliphatic amine polyoxyethylene
Ether 5%, clay 2%, precipitated calcium carbonate supplies 100%.Active ingredient, wetting agent, dispersant and filler are mixed by above-mentioned, machine
It is well mixed again through air-flow crushing after tool crushing, you can 70% steroid enol rosickyite azoles wettable powder is made.
Assays Example 1：To the indoor joint toxicity measuring test of tobacco mosaic virus disease.
Indoor pot tobacco susceptible variety plant is mixed isometric to the 4-5 leaf phases with the decoction of different ratio various concentrations
Viral juice frictional inoculation, often handle 3 plants, 3 leaves of often selecting good strains in the field for seed, be repeated 4 times, investigate withered spot number after 3-4 days, calculate and suppress
Rate, use EC50Value calculates co-toxicity coefficient (CTC) by the abundant methods of Sun Yun, and measurement result is shown in Table 1.
The indoor joint toxicity measuring result of table 1, steroid enol and rosickyite azoles to tobacco mosaic virus disease
| Medicament title and proportioning (weight ratio) | EC50(mg/L) | ATI | TTI | CTC |
| Steroid enol | 40.59 | 100.00 | - | - |
| Rosickyite azoles | 76.32 | 53.18 | - | - |
| Steroid enol:Rosickyite azoles (40:1) | 31.42 | 129.19 | 98.86 | 130.68 |
| Steroid enol:Rosickyite azoles (30:1) | 26.57 | 152.77 | 98.49 | 155.11 |
| Steroid enol:Rosickyite azoles (20:1) | 23.41 | 173.39 | 97.77 | 177.34 |
| Steroid enol:Rosickyite azoles (10:1) | 21.39 | 189.76 | 95.74 | 198.20 |
| Steroid enol:Rosickyite azoles (5:1) | 19.37 | 209.55 | 92.20 | 227.28 |
| Steroid enol:Rosickyite azoles (1:1) | 23.68 | 171.41 | 76.59 | 223.80 |
| Steroid enol:Rosickyite azoles (1:5) | 31.36 | 129.43 | 60.98 | 212.25 |
| Steroid enol:Rosickyite azoles (1:10) | 36.67 | 110.69 | 57.44 | 192.71 |
| Steroid enol:Rosickyite azoles (1:20) | 42.32 | 95.91 | 55.41 | 173.09 |
| Steroid enol:Rosickyite azoles (1:30) | 50.17 | 80.90 | 54.69 | 147.92 |
| Steroid enol:Rosickyite azoles (1:40) | 61.45 | 66.05 | 54.32 | 121.59 |
As shown in Table 1, steroid enol and rosickyite azoles are 40:1~1:When being compounded in the range of 40 (by weight), co-toxicity coefficient is equal
More than 120, illustrate to show synergistic function to tobacco mosaic virus disease, it is seen that it is reasonable that steroid enol has with rosickyite azoles compounding
Property and feasibility.
Assays Example 2：Prevent and treat the field control effectiveness test of tobacco mosaic virus disease.
Test medicine：30% steroid enol rosickyite azole suspending agent (steroid enol 25%：Rosickyite azoles 5%)
Comparison medicament：10% rosickyite azole suspending agent, 1% steroid enol aqua
Dispenser period：15-20d sprays for the first time after tobacco transplant, and interval 7d sprays once again, altogether dispenser 3 times.
Application method：It is watered even spraying.
Investigation method：7d, 14d, 21d are respectively investigated once after 3 dispensers.Per 5 points of samplings of cell, every singling is adjusted
10 plants of all blades of tobacco are looked into, standard grading is investigated according to related data, counts disease index, calculates preventive effect.
Result of the test is shown in Table 2；As can be seen from the test results, 30% steroid enol rosickyite azole suspending agent of the invention uses
The 150-200 grams/ha of prevention effect to tobacco mosaic virus disease of active ingredient will be significantly better than 10% rosickyite azole suspending agent and
1% steroid enol aqua is used alone, and preventive effect is not found to tobacco generation medicine up to more than 81% during pilot survey
Evil.
Table 2,30% steroid enol rosickyite azole suspending agent are to the field control effectiveness test result of tobacco mosaic virus disease
Assays Example 3：Prevent and treat the field control effectiveness test of pepper virus disease
Test medicine：40% steroid enol rosickyite azoles microemulsion (steroid enol 35%：Rosickyite azoles 5%)
Comparison medicament：10% rosickyite azole suspending agent, 1% steroid enol aqua
Dispenser period：15d sprays for the first time after capsicum transplanting, and interval 7d sprays once again, altogether dispenser 3 times.
Application method：It is watered even spraying.
Investigation method：7d, 14d, 21d are respectively investigated once after 3 dispensers.Per 5 points of samplings of cell, every singling is adjusted
10 plants of all blades of capsicum are looked into, standard grading is investigated according to related data, counts disease index, calculates preventive effect.
Result of the test is shown in Table 3；As can be seen from the test results, 40% steroid enol rosickyite azoles microemulsion of the invention uses
The 150-200 grams/ha of prevention effect to pepper virus disease of active ingredient will be significantly better than 10% rosickyite azole suspending agent and 1% steroid
Enol aqua is used alone, and preventive effect is not found to capsicum generation poisoning up to more than 80% during pilot survey.
Table 3,40% steroid enol rosickyite azoles microemulsion are to the field control effectiveness test result of pepper virus disease
In summary, the combination for the preventing and treating virosis that the present invention is compounded using two kinds of active ingredients of steroid enol and rosickyite azoles
Thing, synergistic function is obvious, and compared with existing unitary agent, preventing and treating crop virosis significant effect improves, and the lasting period
It is long, to crop safety, it is worth the popularization and application in agricultural production.
Claims (3)
- A kind of 1. composition pesticide containing steroid enol and rosickyite azoles, it is characterised in that：Active ingredient is steroid enol and rosickyite azoles, The quality parts ratio of steroid enol and rosickyite azoles is 40:1~1:40, steroid enol and rosickyite the azoles gross mass in bactericidal composition point Number percentage composition is 1%~85%, and remaining is to allow to use and receptible auxiliary element in agricultural chemicals.
- A kind of 2. composition pesticide containing steroid enol and rosickyite azoles according to claim 1, it is characterised in that：Agricultural chemicals group The formulation of compound is suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, water dispersible granules, wettable powder and ultra-low volume One kind in liquor.
- 3. a kind of composition pesticide containing steroid enol and rosickyite azoles described in claim 1 is in corps diseases are prevented and treated Using.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102838648A (en) * | 2012-08-29 | 2012-12-26 | 陕西上格之路生物科学有限公司 | Steroid enol compound as well as preparation method thereof and application thereof |
| CN103444742A (en) * | 2013-09-24 | 2013-12-18 | 南京农业大学 | Sterilization composition containing metconazole and albendazole |
| CN103563929A (en) * | 2013-10-18 | 2014-02-12 | 陕西上格之路生物科学有限公司 | Antiviral composition containing daucosterol and sitosterol and antiviral application of antiviral composition |
| CN105918336A (en) * | 2016-07-12 | 2016-09-07 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition containing prothioconazole and prothioconazole |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102838648A (en) * | 2012-08-29 | 2012-12-26 | 陕西上格之路生物科学有限公司 | Steroid enol compound as well as preparation method thereof and application thereof |
| CN103444742A (en) * | 2013-09-24 | 2013-12-18 | 南京农业大学 | Sterilization composition containing metconazole and albendazole |
| CN103563929A (en) * | 2013-10-18 | 2014-02-12 | 陕西上格之路生物科学有限公司 | Antiviral composition containing daucosterol and sitosterol and antiviral application of antiviral composition |
| CN105918336A (en) * | 2016-07-12 | 2016-09-07 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition containing prothioconazole and prothioconazole |
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