CN104770373B - A kind of containing copper 8-hydroxyquinolinate with the bactericidal composition of metconazole - Google Patents
A kind of containing copper 8-hydroxyquinolinate with the bactericidal composition of metconazole Download PDFInfo
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- CN104770373B CN104770373B CN201510183719.8A CN201510183719A CN104770373B CN 104770373 B CN104770373 B CN 104770373B CN 201510183719 A CN201510183719 A CN 201510183719A CN 104770373 B CN104770373 B CN 104770373B
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- hydroxyquinolinate
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Abstract
A kind of bactericidal composition comprising active component copper 8-hydroxyquinolinate and metconazole of the present invention, the weight ratio of the two is 1:15 15:1.Described bactericidal composition can be configured to water dispersible granules, wettable powder or suspending agent together with the most suitable auxiliary agent.The bactericidal composition component of the present invention is reasonable; treatment adds protective effect; bactericidal effect is good; drug cost is low; and its activity and bactericidal effect are not the simple superposition of each composition activity, but there is significant potentiation, good to crop safety; meeting the security requirement of pesticidal preparations, described bactericidal composition has preferable prevention effect to alternaria leaf spot of apple.
Description
Technical field
The present invention relates to pesticide field, particularly antibacterial field, in particular it relates to a kind of containing copper 8-hydroxyquinolinate and leaf
Bacterium azoles is as the bactericidal composition of active component.
Background technology
Copper 8-hydroxyquinolinate is typical organic chelated copper systemic fungicide, has extremely strong adhesion strength and resistance of rainwater washing against energy
Power, copper 8-hydroxyquinolinate is also equipped with the features such as safety is high, fungicidal spectrum is wide, the lasting period is long, low cost in addition, to preventing and treating bacterial disease tool
There is specially good effect, fungal disease preventing and treating is also had efficiently, alternative conventional Inorganic Copper series bactericidal agent, it is used for preventing and treating fruit tree, vegetable
Upper various bacillary and fungal disease.Copper 8-hydroxyquinolinate has the feature of organic quinolines and mantoquita concurrently, has double sterilization activity, root
It is that its mechanism of action is unique: organic quinolines suppression pathogenic bacteria spore metabolism, controls cell and again divide and break up, chela simultaneously
The source of disease bacterium spore that conjunction copper ion is sprouted absorbs, and directly kills spore cell inside source of disease bacterium, thus reaches the work of diseases prevention
With；Crop is all had by fungus, bacterial multiple diseases and significantly kills and inhibitory action, and in plant being stimulated
The effects such as the activity of various enzymes, has raising photosynthesis, promotes growth, purifies fruit face, increases yield, improving quality.
Metconazole (Metconazole), chemical name: 5-(4-chlorobenzyl)-2,2-dimethyl-1 (1H-1,2,4-tri-
Azoles-1-ylmethyl) cyclopentanol, it is a kind of New-type wide-spectrum systemic fungicide, has excellent protection and therapeutical effect concurrently,
Make stem and leaf process and can make again seed treatment, for C-14 demethylation enzyme inhibitor in sterol biosynthesis.Although the mechanism of action with
Other triazole bactericidal agents are the same, but activity profile then difference is relatively big, and two kinds of isomers have bactericidal activity, and wherein Cis activity is high
In trans.The antifungal of metconazole is composed widely, and activity is splendid, and compared with conventional sterilants, dosage is extremely low and prevents and treats paddy
It is the widest that class plants disease scope, is mainly used in preventing and treating cereal crop, such as Semen Tritici aestivi, Oryza sativa L., to Septoria and rust superior activity.
Vegetable, fruit tree etc. are also had preferable prevention effect.
The same with many antibacterial efficient, wide spectrum, the long-term single pesticide of substantial amounts of use, disease all can be made to produce drug resistance
Property, increase amount of application, strengthen cost accounting, the most also produce a series of environmental problem and the safety problem of food is caused one
Fixed threat.The antibacterial using the different mechanism of action compounds, and this method can not only reduce applications of pesticide amount, improve in fact
Border action effect, increasing action site, expanding prevention crop and object spectrum, moreover it is possible to delay the generation of viral resistance.
Summary of the invention
It is an object of the invention to provide a kind of component reasonable, potentiation is notable, and bactericidal effect is good, and drug cost is low,
And Drug resistance the agricultural bactericidal composition to crop safety can be delayed.
Technical scheme involved in the present invention is as follows:
A kind of bactericidal composition, it is characterised in that described compositions comprises active component copper 8-hydroxyquinolinate and metconazole, the two
Weight ratio is 1:15-15:1.
Preferably, the weight ratio of the two is 1:0-10:1；More preferably 1:5-5:1, most preferably 1:2-2:1.
A kind of antibacterial, it is characterised in that the 5～90 above-mentioned bactericidal composition of weight % and the agriculturals that described antibacterial comprises
Upper suitable auxiliary agent.It is preferably 8～75 weight %.
Described antibacterial is water-dispersible grain according to the preparation formulation that method known in those skilled in the art can be prepared
Agent, wettable powder, suspending agent.
For water dispersible granules, those skilled in the art are very familiar with using corresponding auxiliary agent to complete the present invention.Dispersion
In agent such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more；Wetting agent such as alkyl sulfate, alkyl sulphur
In hydrochlorate, naphthalene sulfonate one or more；In disintegrating agent such as ammonium sulfate, carbamide, sucrose, glucose one or more；Binding agent
Such as one or more in kieselguhr, corn starch, PVA, carboxymethyl (ethyl) cellulose family；Filler such as kieselguhr, Kaolin,
White carbon, fine particle calcium carbonate, Pulvis Talci, attapulgite, potter's clay one or more.
To wettable powder, spendable auxiliary agent has: dispersant such as polycarboxylate, lignosulfonates, alkyl naphthalene sulfonic acid
In salt one or more；In wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more；Filler such as sulphuric acid
Ammonium, carbamide, sucrose, glucose, kieselguhr, Kaolin, white carbon, fine particle calcium carbonate, Pulvis Talci, attapulgite, potter's clay are a kind of or many
Kind.
To suspending agent, spendable auxiliary agent has: dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (expand
Powder NNO), Huntsman Corporation of the TERSPERSE 2020(U.S. produce, alkyl naphthalene sulfonic acid salt) in one or more；Emulsifying
Agent such as Nongru-700 #(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60#(common name: dehydration
Sorbitan stearate), Tween-60 #(common name: polyoxyethylene sorbitan stearate), breast 1601#(is general in agriculture
Name: triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), Huntsman Corporation of the TERSPERSE 4894(U.S. produces)
In one or more；Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, alkylphenol-polyethenoxy base ether
Phosphate ester, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE
Huntsman Corporation of the 2500(U.S. produce) in one or more；Thickening agent such as xanthan gum, polyvinyl alcohol, bentonite, aluminium-magnesium silicate
In one or more；In preservative such as formaldehyde, benzoic acid, sodium benzoate one or more；Defoamer such as silicone defoamer；
In antifreezing agent such as ethylene glycol, propylene glycol, glycerol, carbamide, inorganic salts such as sodium chloride one or more；Water is deionized water.
Another object of the present invention is to provide above-mentioned bactericidal composition or antibacterial on preventing and treating alternaria leaf spot of apple
Application.
Beneficial effect: instant component is reasonable, treatment adds protective effect, and bactericidal effect is good, and drug cost is low, and its activity
It not the simple superposition of each composition activity with bactericidal effect, but have significant potentiation, good to crop safety, meet
The security requirement of pesticidal preparations.The present invention has preferable prevention effect to alternaria leaf spot of apple.
Detailed description of the invention
In order to prevent and treat the alternaria leaf spot of apple in agricultural production, inventor is compounded with copper 8-hydroxyquinolinate and metconazole
Potentiation research, method particularly includes:
Subjects is respectively alternaria leaf spot of apple (Alternaria mali), is configured to by former medicine
The test medicine needed, test method is with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T1156.2 2006 ".First
Single dose and Mixed Pharmacy first arrange 5 variable concentrations gradients (on the basis of pilot study result, combine according to different agents
Different with proportioning, Concentraton gradient arranges the most different, and bacteriostasis rate is set by geometric progression in the range of 5%～90%).If it is clear
Water compares, and is repeated 3 times.Use mycelial growth rate method, by cultured pathogen, aseptically beat with a diameter of 5 mm
Hole device, cuts bacterium cake from colony edge, is connected on the culture medium flat plate of different agents concentration by bacterium cake with Inoculating needle, put 27 DEG C,
Saturated humidity incubator is cultivated；When matched group bacterium colony covers with, measure colony diameter, calculate each chemicals treatment suppression mycelial growth
Percentage rate, by the linear regression analysis between probit value and the logarithm value of series concentration of suppression ratio, obtain each medicament
EC50 value, calculates the co-toxicity coefficient (CTC) of mixture, evaluates the reagent agent activity to pathogenic bacteria with this by the abundant method of Sun Yun.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as potentiation；CTC≤80 show as antagonism；
80 ＜ CTC ＜ 120 show as summation action.Test and result of calculation are as shown in table 1.
The Toxicity Determination of table 1 Alternaria mali
| Chemicals treatment | Virulence regression equation | Correlation coefficient (r) | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Copper 8-hydroxyquinolinate (A) | Y=-0.754+2.564X | 0.9834 | 1.969 | - |
| Metconazole (B) | Y=-0.949+1.841X | 0.9985 | 3.274 | - |
| A:B=15:1 | Y=-0.578+2.672X | 0.9925 | 1.646 | 122.7 |
| A:B=10:1 | Y=-0.481+2.850X | 0.9905 | 1.475 | 138.5 |
| A:B=5:1 | Y=-0.365+3.318X | 0.9869 | 1.288 | 163.8 |
| A:B=2:1 | Y=-0.253+3.571X | 0.9955 | 1.177 | 192.9 |
| A:B=1:1 | Y=-0.381+3.219X | 0.9965 | 1.313 | 187.3 |
| A:B=1:2 | Y=-0.525+2.783X | 0.9859 | 1.543 | 173.8 |
| A:B=1:5 | Y=-0.799+2.919X | 0.9955 | 1.878 | 157.0 |
| A:B=1:10 | Y=-0.799+2.919X | 0.9925 | 2.14 | 144.3 |
| A:B=1:15 | Y=-0.876+2.301X | 0.9889 | 2.403 | 130.8 |
Toxicity Determination result shows: copper 8-hydroxyquinolinate and metconazole are with weight ratio as 1:15～15: 1 mixed to Fructus Mali pumilae
Spot defoliation bacterium has preferable virulence, all has significant potentiation, wherein 2:1-1:2 best results.
Below in conjunction with example of formulations and biological Examples, present invention is described further.
Example of formulations 1
Weigh 30% copper 8-hydroxyquinolinate, 3% metconazole, 2% calcium lignosulfonate, 2% dispersing agent NNO, 1% Nekal BX,
1%K-12, attapulgite add to 100% weight portion.Above-mentioned raw materials is blended, prepares 33% copper 8-hydroxyquinolinate leaf after comminution by gas stream
Bacterium azoles wettable powder.
Example of formulations 2
Weigh 50% copper 8-hydroxyquinolinate, 10% metconazole, 5% calcium lignosulfonate, 2% Nekal BX, 2%K-12,5% white carbon
Black, Kaolin adds to 100% weight portion.Above-mentioned raw materials is blended, prepares 60% copper 8-hydroxyquinolinate metconazole after comminution by gas stream
Wettable powder.
Example of formulations 3
Weigh 30% copper 8-hydroxyquinolinate, 15% metconazole, 5%TERSPERSE 4894,2%TERSPERSE 2500,3%
TERSPERSE 2020,0.2% xanthan gum, 5% propylene glycol, 0.5% benzoic acid, 0.5% organic silicon defoamer, go from
Sub-water adds to 100% weight portion.Above-mentioned raw materials is blended, high speed shear dispersion 30min, prepares with after sand mill sand milling
45% copper 8-hydroxyquinolinate metconazole suspending agent.
Example of formulations 4
Weigh 10% copper 8-hydroxyquinolinate, 30% metconazole, 2%TERSPERSE 2020,2% this dish-60#, 2% tween
-60#, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthan gum, 5% ethylene glycol, 0.5% benzoic acid, 0.5% organic
Silicon defoaming agent, deionized water add to 100% weight portion.Above-mentioned raw materials is blended, high speed shear dispersion 30min, uses sand milling
40% copper 8-hydroxyquinolinate metconazole suspending agent is prepared after machine sand milling.
Example of formulations 5
Weigh 25% copper 8-hydroxyquinolinate, 25% metconazole, 4% TERSPERSE 2700,2% dispersing agent NNO, 2% pull open
Powder BX(nekal), 2%K-12,3% corn starch, 5% ammonium sulfate, attapulgite add to 100% weight
Part.The method of above-mentioned raw materials frequent regulation water intaking dispersible granule i.e. mixes, ultra micro comminution by gas stream, mixing, granulation step are produced
50% copper 8-hydroxyquinolinate metconazole water dispersible granules.
Biological Examples: preventing and treating alternaria leaf spot of apple field test
Test is located at Fushan District, Yantai City Dong Motang.Trial crops is apple tree, and kind is new Red Star, and controlling object is Herba Marsileae Quadrifoliae
Fruit tree spot defoliation (Alternaria mali).Test garden seeding row spacing 2.5 × 3m2, the cultivation condition of all experimental plots
(soil types, fertility, farming etc.) are consistent, age of tree life in 18 years, and spot defoliation over the years occurs serious and uniform.Herba Marsileae Quadrifoliae during test
Really period of duration is that autumn growth pumping initial stage ~ autumn growth stops the pumping phase.Every community 3 strain becomes fruit tree in age, if protection row, if blank,
The group arrangement of random district.The dispenser first of autumn growth premorbid, about 10 days, interval once, sprays 3 times altogether later.Use spray pesticide,
The medicine that makes Apple Leaves positive and negative uniformly, till dripping.
Investigation and statistical method
Investigation morbidity radix before medicine, dispenser terminates latter 12 days respectively drug effects of investigation.2 strains are investigated in every community.Every strain by east,
South, west, north, in 5 orientation fix 5 branches, investigate the incidence of whole blade, record the sick number of sheets at different levels, grade scale
As follows:
0 grade: without scab；
1 grade: lesion area accounts for less than the 10% of whole leaf area；
3 grades；Lesion area accounts for the 11 ~ 25% of whole leaf area；
5 grades；Lesion area accounts for the 26 ~ 40% of whole leaf area；
7 grades；Lesion area accounts for the 41 ~ 65% of whole leaf area；
9 grades；Lesion area accounts for more than the 65% of whole leaf area.
Drug effect computational methods
Alternaria leaf spot of apple field test results prevented and treated by table 2
Field test results shows: 33% copper 8-hydroxyquinolinate metconazole wettable powder 3000 times, 3200 times, 3400 times,
60% copper 8-hydroxyquinolinate metconazole wettable powder 4500 times, 4700 times, 4900 times, 45% copper 8-hydroxyquinolinate metconazole suspending agent 3200
Times, 3400 times, 3600 times, 40% copper 8-hydroxyquinolinate metconazole suspending agent 3000 times, 3200 times, 3400 times, 50% quinoline
Copper metconazole water dispersible granules 4000 times, 4200 times, 4400 times, have more significant preventing and treating to imitate to alternaria leaf spot of apple
Really, hence it is evident that be better than 33.5% copper 8-hydroxyquinolinate suspending agent 1000 times, 600 times of 60g/L metconazole water and milk, alternaria leaf spot of apple is prevented
Control effect.
The present invention, by using two kinds of active component compound schemes, creates higher synergistic function, with existing
Unitary agent is compared, and has significant bactericidal effect, has also delayed the drug-fast generation of pathogen, to crop without dirt simultaneously
Dye, safety is good, meets the security requirement of pesticidal preparations.
A kind of bactericidal composition containing copper 8-hydroxyquinolinate and metconazole of the present invention is described by concrete example,
Those skilled in the art can use for reference present invention, and the link such as suitable feed change, process conditions realizes other mesh corresponding
, its relevant change is all without departing from present disclosure, and all similar replacements and change come for those skilled in the art
Say and be apparent from, be considered as being included within the scope of the present invention.
Claims (8)
1. a bactericidal composition, it is characterised in that described compositions comprises active component copper 8-hydroxyquinolinate and metconazole, the weight of the two
Amount ratio is 1:15-15:1.
Bactericidal composition the most according to claim 1, it is characterised in that the weight ratio of the two is 1:0-10:1.
Bactericidal composition the most according to claim 1, it is characterised in that the weight ratio of the two is 1:5-5:1.
Bactericidal composition the most according to claim 1, it is characterised in that the weight ratio of the two is 1:2-2:1.
5. an antibacterial, it is characterised in that 5～90 weight % that described antibacterial comprises are according to the arbitrary institute of Claims 1-4
The bactericidal composition stated and the most suitable auxiliary agent.
Antibacterial the most according to claim 5, it is characterised in that 8～75 weight % that described antibacterial comprises are according to power
Profit requires 1 to 4 arbitrary described bactericidal composition and the most suitable auxiliary agent.
Antibacterial the most according to claim 5, it is characterised in that described antibacterial is configured to water dispersible granules, wettability
Powder or suspending agent.
8. preventing and treating Herba Marsileae Quadrifoliae according to the arbitrary described bactericidal composition of Claims 1-4 or the arbitrary described antibacterial of claim 5 to 7
The really application on spot defoliation.
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| CN106614705A (en) * | 2016-12-30 | 2017-05-10 | 陕西省蒲城美尔果农化有限责任公司 | Sterilization composition containing oxine-copper and flusilazole |
| CN108633890A (en) * | 2018-04-25 | 2018-10-12 | 浙江东风化工有限公司 | A kind of bactericidal composition containing metconazole Yu the gloomy copper of thiophene |
| CN110506747A (en) * | 2019-08-28 | 2019-11-29 | 浙江海正化工股份有限公司 | Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996001054A1 (en) * | 1994-07-01 | 1996-01-18 | Janssen Pharmaceutica N.V. | Synergistic compositions containing metconazole and another triazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0699257B2 (en) * | 1991-02-18 | 1994-12-07 | 呉羽化学工業株式会社 | Seed disinfectant |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996001054A1 (en) * | 1994-07-01 | 1996-01-18 | Janssen Pharmaceutica N.V. | Synergistic compositions containing metconazole and another triazole |
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