CN110506747A - Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application - Google Patents
Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application Download PDFInfo
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- CN110506747A CN110506747A CN201910804616.7A CN201910804616A CN110506747A CN 110506747 A CN110506747 A CN 110506747A CN 201910804616 A CN201910804616 A CN 201910804616A CN 110506747 A CN110506747 A CN 110506747A
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- copper
- hydroxyquinolinate
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention discloses using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application.The composition pesticide includes becoming active constituent and the acceptable auxiliary material of pesticidal preparations or carrier with the compounding group of cyproconazole and copper 8-hydroxyquinolinate.Invention further provides prevention and treatment plant epiphyte or various pesticidal preparations of the composition pesticide of bacterial disease, including suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, microemulsion, aqueous emulsion or oil suspending agent etc..The present invention will significantly improve the control efficiency to phytopathogen after cyproconazole and copper 8-hydroxyquinolinate mixture and extend the medicament lasting period, reduce drug cost；It effectively prevent pathogen to develop drug resistance, extends the service life of pesticide species；Good to crop safety, quick-acting is good, and the lasting period is long.
Description
Technical field
The present invention relates to a kind of prevention and treatment plant epiphyte or the composition pesticides of bacterial disease, more particularly to one kind is with ring azoles
Pure and mild copper 8-hydroxyquinolinate is the bactericidal composition and its preparation with synergistic function of active constituent, and the invention further relates to this
Application of the composition pesticide in prevention and treatment plant epiphyte or bacterial disease, belongs to bactericidal pesticide composition field.
Background technique
Cyproconazole also known as Cyproconazole belong to triazole bactericidal agent, are sterol demethylation inhibitors, have prevention and control
Treatment effect.The ingredient is to Erysiphales, Uredinales, the mould category of category spore, beak on cereal crop, coffee, beet, fruit tree and grape
Spore category, Septoria, Venturia bacterium are effective.
Copper 8-hydroxyquinolinate (oxine-copper) is novel organic chelated copper fungicide, have efficiently, it is wide spectrum, safety, low toxicity, low
The features such as residual, all has excellent control efficiency to a variety of fungies, bacterial disease.The compound has both organic quinolines and copper
The characteristics of salt, has double sterilization activity, and the mode of action is unique: forming fine and close protective film in crop surface, organic quinolines inhibit
Germ spore metabolism, while the copper ion of medicine film slow release sterilization is absorbed by germ spore, effectively inhibits germ spore
Sprouting and intrusion, thus so as to achieve the aim of preventing and treating diseases.Downy mildew and tomato to crops such as vegetables, grape, apple trees
There are good protection and therapeutic effect with the morning of potato, late blight.
With it is many efficiently, the fungicide of wide spectrum it is the same, largely use single pesticide for a long time, disease can all be made to generate anti-medicine
Property, increase amount of application, increase control cost, while also generating a series of environmental problem and one is caused to the safety problem of food
Fixed threat.It is compounded using the fungicide of different role mechanism, this method can not only reduce applications of pesticide amount, improve in fact
Border function and effect, increasing action site expand prevention and treatment crop and object spectrum, moreover it is possible to delay the generation of viral resistance.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops and field crop cultivated area gradually expand, and disease occurrence degree, generation quantity are improved, and prevent and treat upper hardly possible
Degree increases；On the other hand, the resistance of pathogen selects to rise year by year under pressure in lasting medicament, and the control efficiency of single dose is beaten greatly
Discount, control of plant disease are faced with significant challenge.It would therefore be highly desirable to need to develop it is a kind of compounded by Multiple Pesticides active constituent and
There is the composition pesticide of significant collaboration prophylactic-therapeutic effect for plant disease, is generated with delaying drug resistance, reduce amount of application, reduce prevention and treatment
Cost.
Summary of the invention
An object of the present invention is to provide the composition pesticide that a kind of pair of plant disease has significant collaboration prophylactic-therapeutic effect；
The second object of the present invention is to provide a kind of various pesticidal preparations prepared with the composition pesticide；
The third object of the present invention is that the composition pesticide is applied to prevention and treatment plant epiphyte or bacterial disease.
Above-mentioned purpose of the invention is achieved through the following technical solutions:
The present inventor is by indoor virulence test discovery, the pesticide combination that cyproconazole is obtained together with oxine-copper composite
Object all has the prevention and treatment of alternaria leaf spot of apple certain synergistic effect；On this basis, the present invention is by ring azoles
Pure and mild copper 8-hydroxyquinolinate carries out field efficacy controlling experiment according to different ratio compoundings together, and table of field test results are bright, by ring
The pure and mild copper 8-hydroxyquinolinate of azoles obtains compound preparation for the control efficiency of alternaria leaf spot of apple according to different ratio compoundings together
It is substantially better than the use of single dose.
The present invention provides the pesticide complex compositions of a kind of prevention and treatment plant epiphyte or bacterial disease as a result, comprising: has
Effect amount becomes active constituent and the acceptable auxiliary material of pesticidal preparations or carrier by the compounding group of cyproconazole and copper 8-hydroxyquinolinate.
The present invention has found that the ratio of cyproconazole and copper 8-hydroxyquinolinate imitates controlling plant diseases by further experiment
Fruit influences highly significant；Wherein, cyproconazole and copper 8-hydroxyquinolinate are according to (1-10): the mass ratio of (1-50) is compounded, for plant
Germ has certain prophylactic-therapeutic effect；Preferably, cyproconazole and copper 8-hydroxyquinolinate are according to (1-10): the mass ratio of (1-30) is answered
Match；When cyproconazole and copper 8-hydroxyquinolinate are according to (1-10): when the mass ratio of (1-5) is compounded, synergistic effect is more obvious；
When cyproconazole and copper 8-hydroxyquinolinate are according to 1:(1-5) mass ratio when being compounded, synergistic significant effect；Most preferably, ring
The pure and mild copper 8-hydroxyquinolinate of azoles is compounded according to the mass ratio of 1:1 or 1:5, and synergistic effect is the most significant.
Auxiliary material described in composition pesticide of the present invention or carrier are auxiliary material or carrier conventional in pesticidal preparations, including
But it is not limited to emulsifier, wetting dispersing agent, auxiliary agent, thickener, antifreezing agent, stabilizer, preservative, disintegrating agent, binder or disappears
Any one or more of infusion.
For example, the emulsifier can be selected from sorbitan monostearate, alkyl phenol formaldehyde resin polyoxyethylene ether, three
Phenyl ether sulfate ammonium salt, calcium dodecyl benzene sulfonate, phosphate amine salt, castor oil polyoxyethylene ether, castor oil ethylene oxide
Addition product (EL40 or EL90), triphenyl ether sulfuric ester ammonium salt, TERMUL 3016, TERSPERSE 2510, alkyl phenol polyoxy
Vinyl phosphate, aliphatic acid polyethenoxy ether, nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethyl phenol polyoxy
One of ethylene polyethenoxy ether, APES formaldehyde condensation product are a variety of；
The wetting dispersing agent can be selected from TERSPERSE 4894, TERSPERSE 2500, phosphate type anion table
Face activating agent, polyoxyethylene non-ionic surfactant, alkylphenol polyoxyethylene phosphate, aliphatic acid polyethenoxy ether,
Alkyl naphthalene sulfonic acid salt mixture, polycarboxylate, alkyl naphthalene sulfonic acid salt mixture, sodium methylene bis-naphthalene sulfonate, dodecyl sulphate
Sodium, phosphate kalium salt, calcium lignosulfonate, ammonium sulfate, polysulfide hydrochlorate, polycarboxylate, calcium dodecyl benzene sulfonate, pull open powder
One or both of BX, alkylphenol-polyethenoxy base ether, alkyl phenol formaldehyde resin polyoxyethylene ether, TERSPERSE 2280 with
On according to arbitrary proportion form mixture；
The auxiliary agent can be selected from dibutyl naphthalenesulfonic acid salt, calcium lignosulfonate, sodium methylene bis-naphthalene sulfonate, alkylsurfuric acid
Any one or more of salt, polycarboxylate, alkylnaphthalene sulfonate or alkylnaphthalene sulfonate；
The thickener can be selected from xanthan gum, carboxymethyl cellulose, Sodium Polyacrylate, aluminum magnesium silicate, gaseous state titanium dioxide
Any one or more of silicon or attapulgite；
The antifreezing agent can be double sweet selected from ethylene glycol, propylene glycol, glycerol, glycerol-ether diglycol or methyl propylene
Any one or more than one mixture formed according to arbitrary proportion in alcohol；
The stabilizer can be selected from 2,6 di tert butyl 4 methyl phenol (BHT), citric acid or butylhydroxy fennel
Any one or more in ether (BHA)；
The preservative can be sodium benzoate；
The disintegrating agent can be formed selected from any one or more in urea, bentonite, montmorillonite or sodium alginate
Mixture；
The binder can be selected from gelatin, Arabic gum, xanthan gum, sodium tripolyphosphate, phenolic resin or polyethylene
The mixture of one of pyrrolidones or a variety of compositions；
The filler can be kaolin etc.；The defoaming agent can be the defoaming agents such as organosilicon.
According to the customary preparation methods of pesticidal preparations, composition pesticide of the present invention can be prepared into various common pesticides
Preparation formulation, for example: the dosage forms such as suspending agent, wettable powder, water dispersible granules, microemulsion, aqueous emulsion, oil suspending agent；The agriculture
The preparation method of pharmaceutically dosage form is well known to the skilled person.
As reference, the present invention provides the methods that the composition pesticide is prepared into agricultural chemicals suspension agent, comprising: by ring
Azoles alcohol, copper 8-hydroxyquinolinate and wetting agent, dispersing agent, antifreeze, preservative, the thickener (50-70% of gross mass) of part, part
The uniformly mixed grinding such as defoaming agent (50-70% of gross mass) and water stops grinding when partial size is at 5 μm, adds remaining
Thickener and defoaming agent obtain suspending agent after adjusting uniformly.
As reference, the present invention provides the composition pesticide is prepared into the method that oil-suspending agent can be dispersed in pesticide,
Include: to be uniformly mixed cyproconazole, copper 8-hydroxyquinolinate and emulsifier, dispersing agent, methyl oleate etc., grinds, when partial size is at 5 μm, stop
It only grinds, is added after stabilizer is adjusted uniformly and obtains oil-suspending agent.
As reference, the present invention provides the methods that the composition pesticide is prepared into pesticide wettable, comprising:
Cyproconazole and copper 8-hydroxyquinolinate and auxiliary agent and filler etc. are sufficiently mixed, after ultra-fine pulverizer disintegrating, are uniformly mixed i.e.
Wettable powder is made.
As reference, the present invention provides the methods that the composition pesticide is prepared into pesticide water dispersible granules, comprising:
Cyproconazole, copper 8-hydroxyquinolinate and wetting dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading, is added and is granulated
It is granulated in machine, then obtains water dispersible granules through drying, screening again.
As reference, the present invention provides the methods that the composition pesticide is prepared into pesticide emulsion in water, comprising:
Cyproconazole and copper 8-hydroxyquinolinate are dissolved in solvent, in emulsifier at homogeneous oil phase；By deionized water, antifreeze, anti-corrosion
Agent, defoaming agent are mixed into uniform water phase, under high speed shear, oily phase are added in water phase, obtains aqueous emulsion.
The application method and dosage of composition pesticide of the present invention: it is diluted with water and makees even spraying；Dosage is serious according to disease
Depending on pesticide effective component content in degree and the specific formulations of pesticide.
The present invention is using cyproconazole and copper 8-hydroxyquinolinate as the pesticide synergistic composition of main active, for including apple spot
Plurality of plant diseases including defoliation has significant prophylactic-therapeutic effect.The present invention is killed after cyproconazole and copper 8-hydroxyquinolinate mixture
The active simple superposition of pathogen effect of going out not instead of each component, has significant synergistic effect, improves to phytopathogen
Control efficiency and extend the medicament lasting period, reduce drug cost；Mixed Pharmacy can prevent pathogen from developing drug resistance,
Extend the service life of pesticide species；Good to crop safety, quick-acting is good, and the lasting period is long, and application cost is low, meets pesticide system
The security requirement of agent.
Specific embodiment
Further describe the present invention below in conjunction with specific embodiment, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art
Member it should be understood that can modify without departing from the spirit and scope of the invention to details and form of the invention or
Replacement, but these modifications and replacement are fallen within the protection scope of the present invention.
The preparation of 1 31% cyproconazole copper 8-hydroxyquinolinate suspending agent of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:30)
Raw medicine, wetting agent, dispersing agent, antifreeze, preservative and part thickener, defoaming agent are weighed by above-mentioned recipe requirements
And water etc. is uniformly mixed, and is ground, and when partial size is at 5 μm, stops grinding, is added after remaining thickener and defoaming agent adjusting uniformly i.e.
Suspending agent product is made.
The preparation of 2 20% cyproconazole copper 8-hydroxyquinolinate suspending agent of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:1)
Raw medicine, wetting agent, dispersing agent, antifreeze, preservative and part thickener, defoaming agent are weighed by above-mentioned recipe requirements
And water etc. is uniformly mixed, and is ground, and when partial size is at 5 μm, stops grinding, is added after remaining thickener and defoaming agent adjusting uniformly i.e.
Suspending agent product is made.
The preparation of 3 12% cyproconazole copper 8-hydroxyquinolinate suspending agent of embodiment (cyproconazole copper 8-hydroxyquinolinate is 5:1)
Raw medicine, wetting agent, dispersing agent, antifreeze, preservative and part thickener, defoaming agent are weighed by above-mentioned recipe requirements
And water etc. is uniformly mixed, and is ground, and when partial size is at 5 μm, stops grinding, is added after remaining thickener and defoaming agent adjusting uniformly i.e.
Suspending agent product is made.
The preparation of 4 44% cyproconazole copper 8-hydroxyquinolinate suspending agent of embodiment (cyproconazole copper 8-hydroxyquinolinate is 10:1)
Raw medicine, wetting agent, dispersing agent, antifreeze, preservative and part thickener, defoaming agent are weighed by above-mentioned recipe requirements
And water etc. is uniformly mixed, and is ground, and when partial size is at 5 μm, stops grinding, is added after remaining thickener and defoaming agent adjusting uniformly i.e.
Suspending agent product is made.
The preparation of 5 31% cyproconazole copper 8-hydroxyquinolinate wettable powder of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:30)
Raw medicine, various auxiliary agents and filler etc. are weighed by above-mentioned recipe requirements to be sufficiently mixed, and after ultra-fine pulverizer disintegrating, are mixed
It closes and uniformly obtains wettable powder product.
The preparation of 6 21% cyproconazole copper 8-hydroxyquinolinate wettable powder of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:20)
Raw medicine, various auxiliary agents and filler etc. are weighed by above-mentioned recipe requirements to be sufficiently mixed, and after ultra-fine pulverizer disintegrating, are mixed
It closes and uniformly obtains wettable powder product.
The preparation of 7 10% cyproconazole copper 8-hydroxyquinolinate wettable powder of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:1)
Raw medicine, various auxiliary agents and filler etc. are weighed by above-mentioned recipe requirements to be sufficiently mixed, and after ultra-fine pulverizer disintegrating, are mixed
It closes and uniformly obtains wettable powder product.
The preparation of 8 42% cyproconazole copper 8-hydroxyquinolinate wettable powder of embodiment (cyproconazole copper 8-hydroxyquinolinate is 5:1)
Raw medicine, various auxiliary agents and filler etc. are weighed by above-mentioned recipe requirements to be sufficiently mixed, and after ultra-fine pulverizer disintegrating, are mixed
It closes and uniformly obtains wettable powder product.
The preparation of 9 55% cyproconazole copper 8-hydroxyquinolinate wettable powder of embodiment (cyproconazole copper 8-hydroxyquinolinate is 10:1)
Raw medicine, various auxiliary agents and filler etc. are weighed by above-mentioned recipe requirements to be sufficiently mixed, and after ultra-fine pulverizer disintegrating, are mixed
It closes and uniformly obtains wettable powder product.
The preparation of 10 51% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:50)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The preparation of 11 41% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:40)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The preparation of 12 33% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:10)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The preparation of 13 24% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 5:1)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The preparation of 14 12% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:5)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The preparation of 15 66% cyproconazole quinoline copper water dispersion granula of embodiment (cyproconazole copper 8-hydroxyquinolinate is 1:10)
By above-mentioned recipe requirements, raw medicine and wetting agent, dispersing agent, filler etc. are subjected to co-grinding, after adding water kneading,
It is added in pelletizer and is granulated, then obtain water dispersible granules product through drying, screening again.
The indoor toxicity determination test of the compounding of 1 cyproconazole of test example and copper 8-hydroxyquinolinate
1 test material and test method
1.1 test material
Copper 8-hydroxyquinolinate raw medicine, cyproconazole raw medicine
1.2 for trying target
Alternaria mali (Alternaria malie Roberts)
1.3 experimental condition
25 ± 1 DEG C of laboratory temperature.
1.4 test method
1.4.1 the preparation of various concentration dosing culture medium
Using mycelial growth rate method, reagent agent is made into the mother liquor for being 1000 μ g/ml containing effective component with sterile water,
The medical fluid that concentration is 1000mg/L, 500mg/L, 100mg/L, 10mg/L, 1mg/L, 0.1mg/L is configured to sterile water again.Point
Every kind of medicament various concentration medical fluid 1mL is not pipetted, after being mixed rapidly with 55 DEG C of potato dextrose agar (PDA) 9mL,
It is poured into the sterile petri dish of diameter 90mm respectively, the test plate of the uniform different pharmaceutical concentration of thickness is made, and prepare not
The culture medium flat plate of drug containing is as blank control.
1.4.2 the preparation and transplanting of bacteria cake
Typical bacterium colony is chosen from the apple peels and cores bacterium strain preservative tube inclined-plane for examination with oese, is inoculated with
Onto PDA culture medium, 72h is cultivated in 28 DEG C of biochemical cultivation cases, obtains well-grown plant epiphyte.With 5mm punch edge
Colony edge gets the bacteria cake of several same sizes.Bacteria cake is inoculated in respectively in the drug containing PDA culture medium of various concentration, bacterium
Downwards, 1 ferfas cake is put in every ware center to silk, is put into 28 DEG C of incubators and is cultivated.Each 3 ware of concentration of every kind of drug takes 3 tests
Average value, and in the identical strain of no medicine inoculation of medium as blank control.
1.4.3 the calculating of the measurement of mycelium morphology factor and inhibiting rate
For measuring and calculating after examination bacterium colony culture 72h.In the increment culture dish of mycelia the diameter of bacterium colony and just
The difference for the inoculation bacteria cake diameter that begins indicates, measures colony diameter (mm) using crossing method, each concentration of every kind of medicament takes 3
The average value of secondary measurement.Fungi growth bacteriostasis rate, calculation formula are calculated according to most result is surveyed are as follows:
Mycelial growth inhibition rate (%)=[(one initial inoculation bacteria cake diameter of colony diameter in control ware) one is (in processing ware
One initial inoculation bacteria cake diameter of colony diameter)]/(one initial inoculation bacteria cake diameter of colony diameter in control ware) × 100.
Probability value are converted by 3 duplicate average bacteriostasis rates, drug concentration is converted into logarithm, then based on Sun Yunpei's Method
Calculate the toxicity index of each medicament and the co-toxicity coefficient of mixture etc..
TTI=TIA×PA+TIB×PB
ATI: mixture surveys toxicity index
S: the EC of standard antiseptic agent50
M: the EC50 of mixture
TTI: mixtures theoretical toxicity index
TIA: A medicament toxicity index
PA: percentage composition of the A medicament in mixture
TIB: B medicament toxicity index
PB: percentage composition of the B medicament in mixture
CTC: co-toxicity coefficient
2 test results
With the logarithm (x) of drug concentration for independent variable, with the probit value (Y) of relative inhibition for dependent variable, using most
Small square law finds out the virulence regression equation and EC of each raw medicine single dose and compound drug50。
1 cyproconazole of table and copper 8-hydroxyquinolinate single dose and compounding agent evaluate alternaria leaf spot of apple synergy
According to the result of table 1 as it can be seen that single dose copper 8-hydroxyquinolinate has preferable bacteriostatic activity, EC to Alternaria mali50For
0.3211μg/mL；Single dose cyproconazole has preferable bacteriostatic activity, EC to Alternaria mali50For 0.281 μ g/mL.Ring azoles
It is each also to have preferable bacteriostatic activity, EC with comparison Alternaria mali after pure and mild oxine-copper composite50In 0.1696 μ g/
The μ g/mL of mL~0.3431, antibacterial work when wherein cyproconazole and copper 8-hydroxyquinolinate are the quality proportioning of 1:1 to Alternaria mali
Property highest.
For the CTC of cyproconazole and copper 8-hydroxyquinolinate different ratio in 93.36-176.71, different ratio composition falls apple spot
The synergy type of leaf disease is not also identical, wherein cyproconazole is (1-10) with copper 8-hydroxyquinolinate mass ratio: to apple spot when (1-30)
Point defoliation has preferable virulence, all has significant synergistic effect, wherein cyproconazole is with copper 8-hydroxyquinolinate and copper 8-hydroxyquinolinate mass ratio
(1-10): (1-5) synergistic effect is more best, imitates when cyproconazole is 1:1 with copper 8-hydroxyquinolinate mass ratio with optimal synergy
Fruit.
The field control effectiveness test of 2 cyproconazole of test example and oxine-copper composite prevention and treatment alternaria leaf spot of apple
1 test material and test method
1.1 trial crops: apple (new Red Star)
1.2 subjects: alternaria leaf spot of apple
1.3 reagent agents: the specific type of reagent agent is shown in Table 2,
The specific type of 2 reagent agent of table
1.4 application method and water consumption (liter/hectare):
Using spray method, 1000 liters of per hectare water consumption.
2 test results
Test result is shown in Table 3, from the test result of table 3 as it can be seen that compared to cyproconazole and copper 8-hydroxyquinolinate single dose, when cyproconazole with
Copper 8-hydroxyquinolinate is according to (1-10): when the mass ratio of (1-30) carries out compatibility, there is good control efficiency to alternaria leaf spot of apple, it is excellent
In the preventive effect of 40% cyproconazole suspending agent and 33.5% copper 8-hydroxyquinolinate suspending agent；When cyproconazole and copper 8-hydroxyquinolinate are according to (1-5): (1-20)
Mass ratio when carrying out compatibility, 60% 2000 times of cyproconazole copper 8-hydroxyquinolinate wettable powder, 1500 times, 1000 times to apple spot
The control efficiency of defoliation is significantly better than 1000 times of 40% cyproconazole suspending agent of control group and 33.5% copper 8-hydroxyquinolinate suspending agent
Control efficiency；Wherein, when cyproconazole and copper 8-hydroxyquinolinate carry out compatibility according to the mass ratio of 1:1 or 1:5, the promotion effect of field efficacy
Fruit is the most significant.
The field control effectiveness test result of 3 cyproconazole of table and oxine-copper composite prevention and treatment alternaria leaf spot of apple
Note: lowercase letter indication difference significance degree is P=0.05, and capitalization indicates that significant difference degree is P=
0.01。
Claims (10)
1. the composition pesticide of a kind of prevention and treatment plant epiphyte or bacterial disease, comprising: a effective amount of active constituent and pesticide
The acceptable auxiliary material of preparation or carrier；It is characterized in that, becoming active constituent with the compounding group of cyproconazole and copper 8-hydroxyquinolinate.
2. pesticide complex composition described in accordance with the claim 1, which is characterized in that cyproconazole and copper 8-hydroxyquinolinate are according to (1-10):
The mass ratio of (1-50) is compounded.
3. composition pesticide according to claim 2, which is characterized in that cyproconazole and copper 8-hydroxyquinolinate are according to (1-10): (1-
30) mass ratio is compounded.
4. composition pesticide described in accordance with the claim 3, which is characterized in that cyproconazole and copper 8-hydroxyquinolinate are according to (1-10): (1-5)
Mass ratio compounded；Preferably, cyproconazole and copper 8-hydroxyquinolinate are according to 1:(1-5) mass ratio compounded；Most preferably, ring
The pure and mild copper 8-hydroxyquinolinate of azoles is compounded according to the mass ratio of 1:1 or 1:5.
5. composition pesticide described in accordance with the claim 1, which is characterized in that the auxiliary material or carrier includes but is not limited to:
In emulsifier, wetting dispersing agent, auxiliary agent, thickener, antifreezing agent, stabilizer, preservative, disintegrating agent, binder or defoaming agent
It is any one or more of.
6. composition pesticide according to claim 5, which is characterized in that the emulsifier is selected from sorbitol anhydride monostearate
Ester, alkyl phenol formaldehyde resin polyoxyethylene ether, triphenyl ether sulfuric ester ammonium salt, calcium dodecyl benzene sulfonate, phosphate amine salt, castor
Sesame oil polyoxyethylene ether, castor oil ethylene oxide adduct, triphenyl ether sulfuric ester ammonium salt, TERMUL 3016, TERSPERSE
2510, alkylphenol polyoxyethylene phosphate, aliphatic acid polyethenoxy ether, nonylphenol polyoxyethylene ether, aliphatic alcohol polyethenoxy
One of ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, APES formaldehyde condensation product are a variety of；
The wetting dispersing agent be selected from TERSPERSE 4894, TERSPERSE 2500, phosphate type anionic surfactant,
Polyoxyethylene non-ionic surfactant, alkylphenol polyoxyethylene phosphate, aliphatic acid polyethenoxy ether, alkyl naphthalene sulfonic acid
Salt mixture, polycarboxylate, alkyl naphthalene sulfonic acid salt mixture, sodium methylene bis-naphthalene sulfonate, lauryl sodium sulfate, phosphate potassium
Salt, calcium lignosulfonate, ammonium sulfate, polysulfide hydrochlorate, polycarboxylate, calcium dodecyl benzene sulfonate, Nekal BX, alkyl phenol polyoxy
One or more of vinyl ethers, alkyl phenol formaldehyde resin polyoxyethylene ether, TERSPERSE 2280 are according to any ratio
The mixture of example composition；
The auxiliary agent is selected from dibutyl naphthalenesulfonic acid salt, calcium lignosulfonate, sodium methylene bis-naphthalene sulfonate, alkyl sulfate, gathers
Any one or more of carboxylate, alkylnaphthalene sulfonate or alkylnaphthalene sulfonate；
The thickener is selected from xanthan gum, carboxymethyl cellulose, Sodium Polyacrylate, aluminum magnesium silicate, gaseous silicon oxide or bumps
Any one or more of stick soil；
The antifreezing agent appointing in ethylene glycol, propylene glycol, glycerol, glycerol-ether diglycol or methyl propylene diglycol
The one or more kinds of mixtures formed according to arbitrary proportion of meaning；
The stabilizer is any one in 2,6 di tert butyl 4 methyl phenol, citric acid or butylated hydroxy anisole
Kind is a variety of；
The preservative is sodium benzoate；
The mixture of any one or more composition of the disintegrating agent in urea, bentonite, montmorillonite or sodium alginate；
The binder is selected from gelatin, Arabic gum, xanthan gum, sodium tripolyphosphate, phenolic resin or polyvinylpyrrolidone
One of or a variety of compositions mixture；
The filler is kaolin；The defoaming agent is organosilicon.
7. the preparation of composition pesticide described in claim 1-6 any one, which is characterized in that the preparation be suspending agent,
Dispersible oil-suspending agent, wettable powder, water dispersible granules, microemulsion, aqueous emulsion or oil suspending agent.
8. preparation according to claim 7, which is characterized in that the preparation method of the agricultural chemicals suspension agent, comprising: by ring azoles
Alcohol, copper 8-hydroxyquinolinate and wetting agent, dispersing agent, antifreeze, preservative, the thickener of gross mass 50-70%, gross mass 50-70%
Defoaming agent and water are uniformly mixed grinding, stop grinding when partial size is at 5 μm, add remaining thickener and defoaming agent adjusting is equal
Up to suspending agent after even.
The preparation method of the dispersible oil-suspending agent includes: by cyproconazole, copper 8-hydroxyquinolinate, emulsifier, dispersing agent, methyl oleate etc.
It is uniformly mixed, grinding, when partial size is at 5 μm, stops grinding, be added after stabilizer is adjusted uniformly and obtain oil-suspending agent；
The preparation method of the pesticide wettable, comprising:
Cyproconazole, copper 8-hydroxyquinolinate and auxiliary agent and filler are sufficiently mixed, after ultra-fine pulverizer disintegrating, are uniformly mixed up to wettable
Pulvis；
The preparation method of the water dispersible granules, comprising:
By cyproconazole, copper 8-hydroxyquinolinate, wetting dispersing agent, filler etc. carry out co-grinding, after adding water kneading, be added pelletizer in into
Row is granulated, and then obtains water dispersible granules through drying, screening again.
9. application of the composition pesticide described in claim 1-6 any one in prevention and treatment plant epiphyte or bacterial disease.
10. applying according to claim 9, which is characterized in that the plant epiphyte or bacterial disease includes apple
Spot defoliation bacterium.
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| CN201910804616.7A CN110506747A (en) | 2019-08-28 | 2019-08-28 | Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910804616.7A CN110506747A (en) | 2019-08-28 | 2019-08-28 | Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application |
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Cited By (1)
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|---|---|---|---|---|
| CN114938808A (en) * | 2022-06-24 | 2022-08-26 | 贵州大学 | Magnolia officinalis alkali and nuciferine medicinal composition and preparation method thereof |
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| CN102405911A (en) * | 2011-10-21 | 2012-04-11 | 海利尔药业集团股份有限公司 | Sterilizing composition comrpising cyproconazole and abietic acid copper |
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| CN114938808A (en) * | 2022-06-24 | 2022-08-26 | 贵州大学 | Magnolia officinalis alkali and nuciferine medicinal composition and preparation method thereof |
| CN114938808B (en) * | 2022-06-24 | 2023-05-26 | 贵州大学 | Magnolol and nuciferine pharmaceutical composition and preparation method thereof |
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