CN106172475A - A kind of Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham - Google Patents
A kind of Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham Download PDFInfo
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- CN106172475A CN106172475A CN201610547516.7A CN201610547516A CN106172475A CN 106172475 A CN106172475 A CN 106172475A CN 201610547516 A CN201610547516 A CN 201610547516A CN 106172475 A CN106172475 A CN 106172475A
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- silthiopham
- fluxapyroxad
- containsterilization
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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Abstract
The invention discloses the bactericidal composition of a kind of Fluxapyroxad-containsterilization and Silthiopham, the active component of described microbicide compositions is fluxapyroxad and Silthiopham, fluxapyroxad is 1:20 to 20:1 with the mass ratio of Silthiopham, and in compositions, active component weight/mass percentage composition is 5 60%.It is high that the microbicide compositions of the present invention has bactericidal activity, delays the drug-fast generation of pathogen and development simultaneously, and minimizing produces in reality and prevents and treats dosage, economical, efficient, safe and environment-friendly.The present invention is especially pronounced to rice sheath blight disease controlling effect.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of Fluxapyroxad-containsterilization and the Bactericidal composite of Silthiopham
Thing, is used for preventing and treating rice sheath blight disease.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, on Ye Shi China Oryza sativa L.
One of most important disease.Its distribution widely, has generation in China each Oryza sativa L. main producing region, especially on ground, the middle and lower reach of Yangtze River
District and South China, harm is very serious, causes yield drastically to decline.Selection-breeding and popularization disease-resistant variety, be preventing and treating rice banded sclerotial blight
One of sick important measures, in recent years, although Chinese scholars achieves a lot of progress in terms of breeding for disease resistance, but there is no at present
Select the rice varieties of immunity complete to rice sheath blight disease.Rhizoctonia solani Kuhn preventing and treating at present is also to rely on chemical control.
China is preventing and treating the medicament having been used up in rice sheath blight disease based on jingganmycin, the most i.e. at rice tillering at present
Diseased plant rate reached about 15% and started to spray medicine preventing and treating latter stage, and achieved certain effect.But have been reported display, China's part
Area rice sheath blight disease has created Drug resistance to jingganmycin, and the prevention effect of this medicament caused constantly declines.If
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique preventing and treating rice sheath blight disease, administer jingganmycin drug resistance simultaneously
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Fluxapyroxad (fluxapyroxad), chemical name: 3-(difluoro)-1-methyl-N-(3', 4', 5'-trifluoro [1,
1'-biphenyl]-2-base)-1-H-pyrazoles-4-amide, fluxapyroxad belongs to pyrazole amide series bactericidal agent, and succinate dehydrogenase suppresses
Agent, preventing and treating is had both.It can suppress the Repiration of fungus, suppresses spore-germination, and germ tube extends, mycelial growth and spore shape
Become.Can be used for the multiple fungal disease controlling and suppressing in various crop.By superior lasting effect and lasting transmission characteristic
It is integrated in one.
Fluxapyroxad molecular formula C18H12F5N3O, structural formula is:
Silthiopham (silthiopham), chemical name: N-pi-allyl-4,5-dimethyl-2-(TMS) thiophene
Fen-3-Methanamide, the concrete mechanism of action is unclear, different from the mechanism of action of triazole type, methoxy acrylic.Research
Show that it is inhibitor of energy, it may be possible to ATP inhibitor.Having good protection activity, the longevity of residure is long.
Silthiopham molecular formula C13H21NOSSi, structural formula is:
Fluxapyroxad and Silthiopham single dose life-time service, easily make disease develop immunity to drugs, cause dosage to strengthen,
The problem that preventive effect reduces, the lasting period shortens, is unfavorable for environment sustainable development.And the effective ingredient of the difference mechanism of action carries out multiple
Join, be to delay disease to develop immunity to drugs conventional method, and according to the effect in production application, judge this compounding be to increase
Effect effect or antagonism.The obvious formula of complex role, can significantly improve preventive effect, is substantially reduced the medication of pesticide
Amount, also can expand fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The invention provides the bactericidal composition of a kind of Fluxapyroxad-containsterilization and Silthiopham, there is bactericidal activity high, prolong
Slow pathogen Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection, harnesses the river anti-
Specially good effect is had on the sheath and culm blight of rice.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easy-to-use system of production
Agent, is used alone in two kinds of compositions and compares, and has biological activity high, and dosage total in unit are declines, and is substantially reduced
Dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces pathogenic fungi and kill single
Microbial inoculum produces the risk of resistance, extends the service life of each component in bactericidal composition, thus realizes economy, efficient, environmental protection
Goal of the invention.
The technical scheme is that
A kind of Fluxapyroxad-containsterilization and the microbicide compositions of Silthiopham, it is characterised in that described microbicide compositions
The mass ratio that active component is fluxapyroxad and Silthiopham, fluxapyroxad and Silthiopham be 1:20 to 20:1, group
In compound, active component weight/mass percentage composition is 5-60%.
Described Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham, it is characterised in that: described active component fluorine
The mass ratio of azoles bacterium amide and Silthiopham is 1:10 to 10:1.
Described Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham, it is characterised in that: described fluxapyroxad
It is 1:3-8 with the mass ratio of Silthiopham.
Described Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham, it is characterised in that: described fluxapyroxad
It is 1:4-6 with the mass ratio of Silthiopham.
Described Fluxapyroxad-containsterilization and the microbicide compositions of Silthiopham, it is characterised in that: described antimicrobial combination
The dosage form of thing is wettable powder, water dispersible granules, suspending agent or cream.
The microbicide compositions application of described Fluxapyroxad-containsterilization and Silthiopham, it is characterised in that: this antibacterial group
Compound various crop microbial to reaping hook disease has higher prevention effect, especially pronounced to rice sheath blight disease controlling effect.
Remarkable result and the advantage of the present invention be:
The present invention has the highest prevention effect to rice banded sclerotial blight disease, there is notable synergistic effect between two components；Can generation
For part high price pesticide species, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and wheat yield can be improved
And quality；In the present invention, fluxapyroxad and Silthiopham all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security；
The pathogenic bacteria Drug resistance to single medicament can be delayed.
First fluxapyroxad and the EC of Silthiopham two single compound (hereinafter referred to as medicament) are measured50(safety of medicine
Property index), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley potentiation system
Number C value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of Rhizoctonia solani Kuhn is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC of each medicament50,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 ＜
SR ＜ 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 fluxapyroxad and the Silthiopham compositions Wadley method measurement result to rice sheath blight disease
Note: F is fluxapyroxad, and G is Silthiopham.
Can analyze from data above, the fluxapyroxad of different proportion and Silthiopham compositions are to Rhizoctonia solani Kuhn
Fungistatic effect different, on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1, wherein
Maximum enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% fluxapyroxad Silthiopham wettable powder)
Composition of raw materials: by mass percentage
Preparation method: uniformly mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 2 (preparation method of 30% fluxapyroxad Silthiopham suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters, and suction divides
Dissipating tank high speed shear to be fully ground through sand mill after 3 minutes, control solid constituent particle diameter is within 2 microns, and grinding terminates
After stir, obtain suspending agent product.
Embodiment 3 (preparation method of 40% fluxapyroxad Silthiopham water dispersible granules)
Preparation method: by fluxapyroxad, Silthiopham, Methyl fatty amide benzene sulfonic acid sodium salt, sodium carbonate, attapulgite one
After playing mix homogeneously, it is crushed to particle diameter 5 μm through jet mill, obtains female powder, after mother's powder and sodium lignin sulfonate are sufficiently mixed
Pelletize, dry, sieve, thus prepare water-dispersible granules.
Embodiment 4 (preparation method of 20% fluxapyroxad Silthiopham suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (preparation method of 45% fluxapyroxad Silthiopham cream)
Composition of raw materials: by mass percentage
Preparation method: active component fluxapyroxad fully dissolved in dimethylbenzene reactor, makes A liquid；By activity
Component Silthiopham fully dissolves in dimethylbenzene reactor, makes B liquid；Under not stopping stirring, A liquid is mixed into B liquid, fills
Divide and stir, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.
Embodiment 6 (preparation method of 48% fluxapyroxad Silthiopham cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Prevention effect is tested:
The field efficiency test of rice sheath blight disease is carried out in suburb, Bengbu, and test area is 0.3hm2, often process repetition
Three times, carrying out latter stage spraying medicine preventing and treating at rice tillering, carry out preventive effect investigation in dispenser after 15 days, preventing and treating the results are shown in Table 2.Result table
Bright, the bactericidal composition containing fluxapyroxad and Silthiopham has good prevention effect, identical to rice sheath blight disease
Higher prevention effect can be reached under dosage or relatively low using dosage, and each process preventive effect bacterium of this bactericidal composition is more than
85%, it is significantly higher than comparison medicament.
Table 2 fluxapyroxad Silthiopham bactericidal composition prevents and treats land for growing field crops drug effect * of rice sheath blight disease
From the data of table 2, rice sheath blight disease is had by the bactericidal composition containing fluxapyroxad and Silthiopham
Good preventive effect, and the preventive effect of different ratio is different.It should be noted that the proportioning when fluxapyroxad and Silthiopham
During for 5:1, compared with other process, but rice sheath blight disease is had under relatively low consumption higher preventive effect, it is shown that preferably
Synergistic function；And indoor biometrics result also indicates that, when the proportioning of fluxapyroxad and Silthiopham is 5:1, measured
Coefficient of synergism the highest, the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. a Fluxapyroxad-containsterilization and the bactericidal composition of Silthiopham, it is characterised in that the activity of described bactericidal composition
Component be the mass ratio of fluxapyroxad and Silthiopham, fluxapyroxad and Silthiopham be 1:20 to 20:1, in compositions
Active component weight/mass percentage composition is 5-60%.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of Silthiopham, it is characterised in that: described
The mass ratio of active component fluxapyroxad and Silthiopham is 1:10 to 10:1.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of Silthiopham, it is characterised in that: described
The mass ratio of fluxapyroxad and Silthiopham is 1:3-8.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of Silthiopham, it is characterised in that: described
The mass ratio of fluxapyroxad and Silthiopham is 1:4-6.
Fluxapyroxad-containsterilization the most according to claim 1 and 2 and the bactericidal composition of Silthiopham, it is characterised in that: institute
The dosage form stating microbicide compositions is wettable powder, water dispersible granules, suspending agent or cream.
The bactericidal composition application of Fluxapyroxad-containsterilization the most according to claim 1 and 2 and Silthiopham, its feature exists
In: described bactericidal composition has the highest prevention effect to rice banded sclerotial blight disease.
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| CN105432616A (en) * | 2015-12-20 | 2016-03-30 | 广东中迅农科股份有限公司 | Sterilization composition containing fluxapyroxad and penthiopyrad |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105432616A (en) * | 2015-12-20 | 2016-03-30 | 广东中迅农科股份有限公司 | Sterilization composition containing fluxapyroxad and penthiopyrad |
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