CN101379988A - Compound bactericidal composition containing epoxiconazole - Google Patents
Compound bactericidal composition containing epoxiconazole Download PDFInfo
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- CN101379988A CN101379988A CNA2008101329824A CN200810132982A CN101379988A CN 101379988 A CN101379988 A CN 101379988A CN A2008101329824 A CNA2008101329824 A CN A2008101329824A CN 200810132982 A CN200810132982 A CN 200810132982A CN 101379988 A CN101379988 A CN 101379988A
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- carbendazim
- bactericidal composition
- ring azoles
- fluorine
- epoxiconazole
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Abstract
The invention discloses a compounded sterilization composite containing epoxiconazole, and relates to a pesticide composite; the sterilization composite contains the epoxiconazole and sanmate, wherein, the weight percentage of the epoxiconazole and the sanmate is 0.1%-50%:1%-60%. The invention is bactericide of crops, can prevent multiple plant diseases, has remarkable synergy and good safety for the crops, and effectively controls multiple fungus and some micobial disease of multiple crops such as wheat, cotton, fruit trees, vegetables and the like; in addition, the sterilization composite also has the advantages of rain drop erosion resistance, lasting drug action, etc.
Description
Technical field
The present invention relates to a kind of combination sterilization composition of fluorine-containing ring azoles, this bactericidal composition is widely used in agricultural plant chemoproection field, and said composition is for the antibiotic and bactericidal activity that shows of fungi of some harm plant growing.This microbicide compositions is different from existing other bactericide.
Background technology
Using chemical agent is the most effective means in the control plant hazard fungi.But long-term use kind of high dose ground continuously or the single chemical bactericide of the mode of action influence problems such as residual, the environmental pollution of medicament and anti-pesticide resistance fungi development easily.Rational chemical bactericide share proportioning or be mixed and have the expansion fungicidal spectrum, improve control efficiency, prolong dispenser period, reduce dosage, reduce poisoning, reduce residual, delay fungi drug resistance and positive characteristics such as drug-fast generation and development, bactericide compounded or to be mixed be one of the effective method the most that addresses the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite be mixed have small investment, research cycle is short and receive and domestic and international attention strengthen the development dynamics one after another.
Fluorine ring azoles is the efficient germicide of important economic crops foliage spray, be used for cereal crop, can prevent and treat multiple rust, powdery mildew, net blotch, root rot, gibberella zeaze petch of wheat and barley and the cercospora brown spot of peanut and zonate spot effectively and also can effectively prevent and treat grape grey mould, powdery mildew and leaf spot and tea tree tea gall.Seed treatment can thoroughly be prevented and treated loose smut of barley, black loose smut of oat, stinking smut of wheat, the bunt smut of wheat; Carbendazim is a broad-spectrum germicide, is the kind that activity is the strongest in the benzimidazole, fungicidal spectrum is the widest, has good effect.Carbendazim has prevention and protective effect to the multiple diseases on field crop, fruit, vegetables, turf and the ornamental plants.The use of carbendazim starts from the seventies, along with Prochloraz in recent years in the penetration and promotion in bactericide field, it is obvious all the more that resistance problem becomes, controlling plant diseases is that limited composition amount of application is and increases trend year by year, this just gives crop and the unexpected residual acid test that brings, but in the plant sterilization field, carbendazim has irreplaceable status.
Summary of the invention
Purpose of the present invention: use weak point separately at above-mentioned two kinds of medicaments, a kind of microbicide compositions with synergistic function is provided.Have now found that fluorine ring azoles and carbendazim are used jointly has the synergistic effect that manifests, and has enlarged fungicidal spectrum simultaneously, has reduced spraying times, and has not had cross resistance between fluorine ring azoles and the carbendazim.
Carbendazim (english common name carbendazim)
Chemical name (formula I): N-(2-benzimidazolyl) methyl carbamate
Structural formula:
This product high-efficiency low-toxicity, effective to sac fungi and imperfect fungus, invalid to oomycetes and bacterial disease, have protection and therapeutic action.The mechanism of action is the formation of imitative hammer body in the mitosis of disturbing bacterium, thereby influences cell division.
Fluorine ring azoles (english common name epoxiconazole)
Chemical name (formula I): (2RS, 3SR)-3-(2-chlorphenyl)-2-(4-fluorophenyl)-2-[(1H1,2, the 4-triazol-1-yl) methyl] oxirane.
Fluorine ring azoles is the wide spectrum triazole bactericidal agent, and consumption is low, is table angle sterol biosynthesis inhibitor.It has strong interior absorption, drug effect height, to crop safety, and characteristics such as lasting period length.Have prevention and therapeutic action.Have now found that, the present invention proposes contains fluorine ring azoles, carbendazim is the microbicide compositions that active component is formed, can be applicable to the germ harm of crops such as cereal, fruit, vegetables, economic crops, as, fusarium graminearum, sigatoka, sclerotinia rot of colza, gray mold of cucumber etc.
In the composition of the present invention, fluorine ring azoles and carbendazim weight ratio are 0.1～50:1～60, be preferably 1～30:10～50, bactericidal composition of the present invention comprises the active component of 5～86 weight portions and the auxiliary agent of accepting in agriculture field of 95～14 weight portions is formed.
Mixture of the present invention uses with the form of composition, uses with usual auxiliaries such as other carriers, surfactants usually during use.
Suitable additive and carrier can be solid or liquid, and they are material commonly used in the formulation process normally, mineral matter for example natural or regeneration, solvent, dispersant, wetting agent, adhesive, thickener, adhesive or fertilizer.
Composition of the present invention can use with constant form, perhaps preferably in preparing process normally used additive use, therefore these compounds can be configured in known manner, for example make suspending agent, aqueous emulsion, wetting powder or water dispersible granules.According to the character that these compositions had, can select as spraying, atomizing according to the purpose that will reach and ambient conditions, dust, broadcast sowing, bold and vigorous watering or the application process of seed soaking etc. and so on.The amount of application of frequency of utilization depends on the biology and the weather life condition of pathogene.
As the solid form composition, having of can mentioning is following several: (content of its active component is generally than higher for water dispersible granules, usually between the 50%-90% weight ratio), normally by comprising: wettable powder type composition carries out granulation, and its method has spray drying granulation, thermopnore drying-granulating, freeze drying granulation etc.; Or suspending agent carried out granulation, its method has rotary table granulation, extruder grain, mixed at high speed granulation, flows and create grain and compression granulation etc.
Wetting powder is generally with such method preparation, promptly so that its active component that contains the 20-85% weight ratio be as the criterion, except that solid carrier, they generally contain the wetting agent of 0-7% weight ratio, the dispersant of 3-10% weight ratio, in case of necessity, containing one or more other the additive of 0-10% weight ratio.As dyestuff, colouring agent, bleeding agent, adhesive or anti-caking agent etc.
Suspending agent can be with such method preparation, promptly the active component with the 5-80% weight ratio is as the criterion, be aided with 4-20% weight ratio emulsifier, 5-35% weight ratio solvent, all the other auxiliary agents can antifreezing agent (0.1-4%) weight ratio, stabilizing agent (0.3-5%) weight ratio, and all the other can replenish by water.
Composition active ingredient amount of application of the present invention is 65～600 gram/hectares normally, preferred 75～550 gram/hectares.
Available known method prepares various formulations: for example with active ingredient and filler, as solvent, solid carrier, can evenly mix, grind with surfactant when needing.
The solvent that is suitable for inventing is alternative to be had: aromatic hydrocarbon, preferably contain 8-12 carbon atom, as the benzene of xylene mixture or replacement, phthalate is sad as Dibutyl phthalate or phthalandione two, fat hydrocarbon, as thiacyclohexane or paraffin, pure and mild ethylene glycol and their ether and ester are as ethanol, ethylene glycol, the glycol monomethyl methyl; Ketone, as cyclohexanone, the solvent of strong polarity, as the N-N-methyl-2-2-pyrrolidone N-, dimethyl sulfoxide (DMSO) or dimethyl formamide and vegetable oil or vegetable oil are as soybean oil.
Be suitable for solid carrier of the present invention, but as be used for the normally natural minerals filler of pulvis and dispersant, for example talcum, kaolin, montmorillonite or atlapulgite.For the managing physical performance also can add polymolecularity silicic acid or polymolecularity adsorpting polymerization thing.Suitable granular skin carrier is a porous type, is coated with or bentonite as float stone, soap; Suitable non-absorption carrier is for example calcite or sand.In addition, can use being prefabricated into of a large amount of inorganic in nature or organic character granular material, particularly dolomite.
The chemical property of two active components according to the present invention, suitable surfactant is a lignin sulfuric acid, naphthalene sulfuric acid, phenol sulfuric acid, the alkali metal salt of dibutyl naphthalene sulfuric acid, alkali salt and ammonium salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, aliphatic alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether also have the condensation product of sulfonated naphthalene and naphthalene derivatives and formaldehyde, the condensation product of naphthalene or naphthalene sulfonic acids and naphthols and formaldehyde, polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, the ethylene oxide condensation product, the ethoxylation polyoxypropylene, lauric acid polyglycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Can use in the composition of the present invention, when using two components jointly, the effect of stack (equaling synergy) occur.The specific activity of this composition is used the activity expection summation of individualized compound, and the independent activity of individualized compound is more remarkable.Synergistic effect allows to show as that amount of application reduces, wideer antifungal control spectrum, action effect instant effect, more lasting control efficiency, by only once or minority use several times can better the controlling plant harmful fungoid and widened the possible administration interval time.These characteristics are special needs in the plant epiphyte control practice process.
Other characteristics that bactericidal composition of the present invention shows mainly show as: 1, composition of the present invention is widely used, and is good to crop safety, preventive effect.Through evidence, bactericide combinatorial chemistry stable in properties of the present invention, synergy is remarkable, and controlling object is shown tangible synergy and complementation; 2, fluorine ring azoles is produced the bacterial strain (as little Sclerotinia sclerotiorum) of resistance,, still show high control activity by using composition of the present invention.3, reagent combination science, medicament adhesive force, interior absorption are strong, the utilization rate of active components height.4, use cost reduces, and fluorine ring azoles cost is higher at present, uses fluorine ring azoles in practical application certain limitation to be arranged also separately, uses by the form of composition and has not only improved preventive effect, and reduced and used cost, has improved utilization rate of active components.
Following embodiment and unrestricted the present invention, and be used for just illustrating how the present invention realizes in actual applications.
Embodiment
Formulation prepares embodiment
1, water dispersible granules
Fluorine ring azoles 15.0 weight portions
Carbendazim 45.0 weight portions
Polyvinyl alcohol 3 weight portions
Sodium Laurylsulfate 4 weight portions
Wooden calcium sulfonate's 3 weight portions
Kaolin 6 weight portions
Water 9 weight portions
Above-mentioned raw materials ground in water make required particle diameter, adjust its concentration and viscosity, obtain spraying and use slurry, slurry is quantitatively sent to carried out atomized drying in the drying then, obtain this product.
The dilution emulsifying liquid of any concentration that this concentrate of dilute with water can obtain using in the plant protection.
2, suspending agent
Fluorine ring azoles 10.0 weight portions
Carbendazim 40.0 weight portions
Polyoxyethylene alcohol (75% saponification rate) 3.0 weight portions
Organic silicone 0.5 weight portion
Lignosulfonates 12.0 weight portions
Propane diols 8.0 weight portions
Water 46.5 weight portions
3, wetting powder
Fluorine ring azoles 15 weight portions
Carbendazim 55 weight portions
Alkyl polyoxy ethyl ether sulfonate 5 weight portions
Sodium lignin sulfonate 4 total amount parts
NONIN HS 240 (8-9 moles of ethylene oxide) 3 weight portions
Kaolin soil 23 weight portions
Active ingredient is thoroughly mixed with auxiliary agent, and it is thoroughly ground, mixes in suitable mill, and the wetting powder dilutable water that obtains becomes to need the suspended emulsion of concentration.
Application Example one:
Indoor biological activity determination the present invention is used as test strain to the co-toxicity coefficient of wheat rust by gather the wheat rust bacteria strain F-12 that preserves in the field, and this bacterial strain is to fluorine ring azoles, carbendazim sensitivity.The F-12 bacterial strain after 25 ℃ of half-lights are cultivated 72h down, is made the equal sheet of 5mm diameter as inoculum at colony edge after PSA (potato sucrose agar medium) goes up activation.Adopt the pastille Plating to measure the inhibition activity of medicament to wheat rust bacterium mycelia linear growth.Make the central authorities that 5mm bacterium sheet oppositely amplexiforms the pastille plate at pre-incubated wheat rust bacterium colony edge, in 25 ℃ of illumination boxs, behind the dark culturing 72h, press the diagonal angle cross and measure colony diameter (mm).Utilize the medicament of above embodiment to handle, and compare, calculate the inhibition effect (%) of each drug concentration respectively wheat rust bacterium linear growth with control treatment.Calculate the toxicity regression formula and the EC of reagent agent with the probit value method
50Value.Above-mentioned all calculating all adopt the DPS data handling system to carry out.EC with each medicament
50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient.The result shows two mixture co-toxicity coefficients all obviously greater than 100, represents that this mixture has synergistic effect.Experimental result sees Table 1.
Table 1: to wheat rust bacterium control test co-toxicity coefficient
| Pharmacopoeia | The toxicity regression formula | EC 50(ug/ml) | Co-toxicity coefficient |
| Epoxiconazole raw drug | Y＝2.36541+1.35452X | 2.983992 | |
| Carbendazim active compound | Y＝1.52142+0.30214X | 1.257525 | |
| Embodiment 1 (60% water dispersible granules) | Y＝0.76593+1.57592X | 0.463243 | 174.8214 |
As can be seen, the co-toxicity coefficient that the preparation that makes that utilizes embodiment 1 is measured wheat rust illustrates that all greater than 100 the preparation that utilizes the foregoing description to make has obvious synergistic effect to the wheat rust control efficiency from above table.
2, experimental example two: (70% wetting powder) control sclerotinia rot of colza test of pesticide effectiveness
Test is carried out Shanxi Houma arrish Tanaka, and rape variety is 67m for remittance oil-50. every sub-district areas
2, randomized arrangement, rape, triplicate (this field piece used 50% carbendazol wettable powder control sclerotinia rot of colza in continuous 3 years, and preventive effect is respectively 85%, 84%, 84%).In the rape Sheng phase dispenser of blooming.Institute an inquiry preventive effect after 40 days, diseased plant rate, relative control effect are calculated in classification.Experimental result sees Table 4.
The field control effectiveness test of 2 pairs of sclerotinia rot of colzas of table 2. embodiment
3, experimental example three:
Prevent and treat sigatoka result of the test (test site: Fujian Province's Xianyou County)
Application method: complete stool spray medicine is handled after taking to decide leaf (young leaves that does not occur scab as yet) mark, and every blade evenly sprays.Till spray value is dripped with the blade face, spray and blade back as far as possible.During pilot survey, carry out complete stool transfer poor, except three Lao Ye of lobus cardiacus that top does not launch and base portion.Account for whole area ratio according to lesion area and divide sick level, relatively calculate preventive effect with treatment region and check plot.
Table 3,50% suspending agent are prevented and treated the sigatoka test of pesticide effectiveness
Field efficacy shows that fluorine ring azoles and carbendazim composition have good control efficiency to wheat rust, sclerotinia rot of colza, sigatoka, and control efficiency all is better than single agent kind.
Claims (5)
1. the combination sterilization composition of a fluorine-containing ring azoles is characterized in that, contains fluorine ring azoles and carbendazim, and wherein the weight ratio of fluorine bacterium azoles and carbendazim is 0.1～50:1～60.
2. bactericidal composition according to claim 1 is characterized in that, the weight ratio of fluorine ring azoles and carbendazim is 1～30:10～50.
3. bactericidal composition according to claim 1 and 2 is characterized in that, fluorine ring azoles and carbendazim and known auxiliary agent and excipients are re-dubbed any one formulation that agricultural chemicals allows.
4. bactericidal composition according to claim 3 is characterized in that, formulation is suspending agent, wetting powder or water dispersible granules.
5. bactericidal composition according to claim 1 and 2 is characterized in that, imitates the multiple fungi and some bacteriosis of various crop such as control wheat, cotton, fruit tree, vegetables.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101329824A CN101379988A (en) | 2008-07-04 | 2008-07-04 | Compound bactericidal composition containing epoxiconazole |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101329824A CN101379988A (en) | 2008-07-04 | 2008-07-04 | Compound bactericidal composition containing epoxiconazole |
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| Publication Number | Publication Date |
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| CN101379988A true CN101379988A (en) | 2009-03-11 |
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| CNA2008101329824A Pending CN101379988A (en) | 2008-07-04 | 2008-07-04 | Compound bactericidal composition containing epoxiconazole |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907449A (en) * | 2012-10-26 | 2013-02-06 | 山东潍坊润丰化工有限公司 | Bactericidal composition containing epoxiconazole and carbendazim and application thereof |
| CN103598191A (en) * | 2013-11-29 | 2014-02-26 | 苏州佳辉化工有限公司 | Carbendazim-epoxiconazole compounded agent |
| CN104472504A (en) * | 2014-11-18 | 2015-04-01 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Sterilization composition containing epoxiconazole and thiabendazole and application thereof |
| CN107372620A (en) * | 2017-07-19 | 2017-11-24 | 广西南宁乐蕊生物科技有限责任公司 | One kind sterilization synergistic composition |
-
2008
- 2008-07-04 CN CNA2008101329824A patent/CN101379988A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907449A (en) * | 2012-10-26 | 2013-02-06 | 山东潍坊润丰化工有限公司 | Bactericidal composition containing epoxiconazole and carbendazim and application thereof |
| CN102907449B (en) * | 2012-10-26 | 2014-04-30 | 山东潍坊润丰化工股份有限公司 | Bactericidal composition containing epoxiconazole and carbendazim and application thereof |
| CN103598191A (en) * | 2013-11-29 | 2014-02-26 | 苏州佳辉化工有限公司 | Carbendazim-epoxiconazole compounded agent |
| CN104472504A (en) * | 2014-11-18 | 2015-04-01 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Sterilization composition containing epoxiconazole and thiabendazole and application thereof |
| CN107372620A (en) * | 2017-07-19 | 2017-11-24 | 广西南宁乐蕊生物科技有限责任公司 | One kind sterilization synergistic composition |
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Open date: 20090311 |