CN102907449B - Bactericidal composition containing epoxiconazole and carbendazim and application thereof - Google Patents
Bactericidal composition containing epoxiconazole and carbendazim and application thereof Download PDFInfo
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- CN102907449B CN102907449B CN201210416001.5A CN201210416001A CN102907449B CN 102907449 B CN102907449 B CN 102907449B CN 201210416001 A CN201210416001 A CN 201210416001A CN 102907449 B CN102907449 B CN 102907449B
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Abstract
The invention discloses bactericidal composition. Effective components of the bactericidal composition include epoxiconazole and carbendazim, and weight ratio of the epoxiconazole to the carbendazim is 1-80:1-80. The invention further discloses application of the bactericidal composition. Mixing the epoxiconazole and the carbendazim is evidently synergistic, advantages of the same are given to effective play, the obtained bactericidal composition is excellent in quality and high in efficacy, diseases of powdery mildew of cucumber, grapevine anthracnose and the like can be prevented effectively, a preparation method of the bactericidal composition is simple, convenient to operate and low in energy consumption, drug dosage is reduced by the use of the mixed composition, drug resistance to a single drug by germs is delayed, and the bactericidal composition has high social and economic benefits.
Description
Technical field
The present invention relates to a kind of composition and application thereof containing epoxiconazole and carbendazim, belong to technical field of pesticide.
Background technology
Carbendazim, English common name: carbendazim, chemical name: N-(2-benzimidazole base)-methyl carbamate, is mainly used in preventing and treating cucurbits powdery mildew, epidemic disease, shallot, leek gray mold, eggplant, stem rot of cucumber, melon, bean anthracnose, powdery mildew of pea, brassicaceous vegetable gray mold, Leucoplakia etc., long-term single use carbendazim easily makes germ develop immunity to drugs, and uses or mixes use for well with other bactericide rotations.
Epoxiconazole, English name epoxiconazole, it is a kind of interior absorption triazole bactericidal agent, its active component epoxiconazole suppresses the synthetic of germ ergosterol, hinder the formation of germ cell wall, and epoxiconazole molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), compared with current known bactericide, can more effectively suppress germ fungal pathogens.Epoxiconazole can improve all fourth matter enzymic activitys of crop, causes the contraction of fungi haustorium, suppresses germ and invades, and this is epoxiconazole unique characteristic in all triazole type products.The diseases such as the anthracnose on leaf spot, powdery mildew, rust and grape on the crops such as banana, green onion garlic, celery, Kidney bean, melon, asparagus, peanut, beet, white rot are had to good preventive effect.
In the real process of agricultural production, prevent and treat in disease process and be easy to produce the drug-fast problem of germ, if the powdery mildew in agricultural is because its spread speed is fast, host range is wide, in the melon crop growth later stage, often occurs, and especially easily produces resistance.For example in some powdery mildews, endanger serious place again, common bactericide as tpn, the spirit of methyl sulphur bacterium etc. separately use there is no what effect, triazolones etc. are because large-area application has also caused serious resistance, and easily produce poisoning.Therefore the bactericide that research is not easy to develop immunity to drugs, bactericidal effect is good is determined to win.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of bactericidal composition containing epoxiconazole and carbendazim, this bactericidal composition function admirable, bactericidal effect is good.
The present invention also provides the application of this bactericidal composition.
The present invention has higher control efficiency by the mixed of active ingredient to fungal disease, between two components, there is obvious synergistic effect, and the active ingredient dosage after mixed reduces, effectively reduce ecosystem environment and pollute, and improved crop yield and quality.In the present invention, carbendazim and epoxiconazole all belong to the toxicity such as low, and to people hold, beneficial organism, Environmental security, can delay the pesticide resistance of germ to single medicament.
Technical scheme of the present invention is as described below:
A kind of bactericidal composition, active ingredient comprises epoxiconazole and carbendazim, and wherein epoxiconazole and carbendazim weight ratio are 1～80: 1～80, and the weight ratio of preferred epoxiconazole and carbendazim is 1:1-4, and the weight ratio of preferred epoxiconazole and carbendazim is 1:2.2.According to the mixed composition medicine better effects if obtaining of preferred proportion.
Epoxiconazole and carbendazim active ingredient can add existing required auxiliary material in prior art to make dissimilar formulation, such as water dispersible granules, suspending agent or wetting powder etc., in these formulations, the content of epoxiconazole and carbendazim active ingredient is 10-90wt%, preferably 80wt%.
Further, can, by the formula of preferred various formulations and auxiliary material, obtain the formulation of better effects if.
The preferred water dispersible granules of the present invention comprises active ingredient and the auxiliary material of following percentage by weight: active ingredient 10-90%, dispersant 2～6%, wetting agent 1～4%, disintegrant 1～5%, foliage fertilizer 0.01～1%, inert filler surplus.More preferably comprise active ingredient and the auxiliary material of following percentage by weight: active ingredient 80%, dispersant 4%, wetting agent 3%, disintegrant 4%, foliage fertilizer 0.03%, inert filler surplus.The preferable amount of active ingredient recited above is still set up in water dispersible granules, and the weight ratio of epoxiconazole and carbendazim is 1:1-4, and the weight ratio of preferred epoxiconazole and carbendazim is 1:2.2, and these preferred schemes are also set up in water dispersible granules.
In above-mentioned preferred water dispersible granule, auxiliary material used is as follows:
Described dispersant is di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate (NNO), maleic acid-acrylic acid copolymer salt, polyox-yethylene-polyoxypropylene block copolymer, naphtholsulfonic acid formaldehyde condensation products sodium salt, ethylene oxide-propylene oxide block copolymer, aryl phenol APEO, two naphthalenesulfonate formaldehyde condensation compound sodium salts, polycarboxylate sodium, alkylphenol sodium sulfonate, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt, one or more in calcium lignosulfonate and alkylphenol polyoxyethylene formaldehyde condensation products sulphate.
Described wetting agent is lauryl sodium sulfate, neopelex, sodium lignin sulfonate, pull open powder, a-sulfo methyl ester, sodium tetradecyl sulfate, Negel, a-alkene sulfonic acid sodium, fatty acid amide N methyl taurine sodium salt, dialkyl group succinate sulfonate sodium, sodium sulfate of polyethenoxy ether of fatty alcohol, alkyl phenol polyethenoxy ether sodium sulfate, alkylphenol polyoxyethylene succinic acid half ester sodium sulfonate, one or more in fatty acid sulphate and fatty acid ester sulphate.
Described disintegrant is one or more in potassium sulfate, potassium chloride, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, diammonium hydrogen phosphate, urea, ammonium sulfate and ammonium nitrate, and the mass ratio of preferred nitrogen, phosphorus, potassium element is 4:1:1.
Described foliage fertilizer is one or more in ferrous sulfate, RE microbial fertilizer, zinc sulphate and sodium sulphate.
Described inert filler is one or more in kaolin, attapulgite, diatomite, organobentonite, white carbon, precipitated calcium carbonate, corn starch, glucose, sucrose, talcum powder and anhydrous sodium sulfate.
The preparation method of the water dispersible granules of epoxiconazole and carbendazim comprises the following steps:
(1) epoxiconazole, carbendazim, dispersant, wetting agent, disintegrant and inert filler are mixed, carry out ultra micro air-flow crushing, obtain 680～840 object fine powders, standby;
(2) gained fine powder is added to water and mediate, then kneading material is carried out to extruder grain, 30～70 ℃ and dry to obtain water dispersible granules.
Dispersant, wetting agent, disintegrant, foliage fertilizer and inert filler are that the auxiliary agent in water dispersible granules (is auxiliary material, lower same), wherein, dispersant, wetting agent, disintegrant and inert filler it can make water dispersible granules have excellent dispersiveness, foaming characteristic, disintegrative, suspensibility etc., disintegrant and foliage fertilizer can add plant nutrition to strengthen plant self resistance against diseases, the selection of all auxiliary agents and consumption also can have a certain impact to epoxiconazole and carbendazim medicine effect, through experimental verification, water dispersible granules performance the best when auxiliary agent adopts following consumption, drug effect optimum: dispersant 4wt%, wetting agent 3wt%, disintegrant 4wt%, foliage fertilizer 0.03wt%, inert filler surplus.Water dispersible granules performance the best when the following composition of selection of auxiliary, drug effect optimum: described dispersant by polycarboxylate sodium, alkylphenol sodium sulfonate and calcium lignosulfonate in mass ratio 2:1:1 mix; Described wetting agent by a-sulfo methyl ester, a-alkene sulfonic acid sodium and fatty acid amide N methyl taurine sodium salt in mass ratio 1:1:1 mix; Described disintegrant is that 4:1:1 mixes by potassium chloride, diammonium hydrogen phosphate and ammonium nitrate by nitrogen, phosphorus, potassium mass ratio; Described foliage fertilizer is ferrous sulfate; Described inert filler is precipitated calcium carbonate.
By selection and the cooperation of the preferred and each auxiliary agent to effective ingredient consumption, obtained the water dispersible granules of epoxiconazole and carbendazim, use foliage fertilizer as auxiliary material, can strengthen plant self resistance against diseases by adding plant nutrition, not add binding agent, cost is low simultaneously, the function admirables such as this water-dispersible granules dispersiveness, foaming characteristic, disintegrative, suspensibility, drug effect is high, and bactericidal effect is good, easy to utilize.
In the present invention, the water dispersible granules preparation method of epoxiconazole and carbendazim is simple, easy to operate, less energy consumption, environmental protection, can realize serialization and produce, adopt ultra micro air-flow crushing to pulverize medicine, gained granula particle diameter, between 680～840 orders, meets the requirement of epoxiconazole and the performance of carbendazim drug effect, utilizes extruder grain method more simple, be convenient to implement, it can carry out serialization production, and manufacturing cost is lower, product quality excellence.
The preferred suspending agent of the present invention comprises active ingredient and the auxiliary material of following percentage by weight: active ingredient 10-90%, dispersant 2～5%, thickener 0.05～1%, defoamer 0.05～1%, antifreezing agent 1～5%, water surplus, wherein the content of active ingredient carbendazim is 1-60wt%, the content of epoxiconazole is 1-80wt%.More preferably comprise active ingredient and the auxiliary material of following percentage by weight: active ingredient 80%, dispersant 2%, thickener 0.08%, defoamer 0.5%, antifreezing agent 3%, water surplus, the content of active ingredient carbendazim is 1-60wt%.The preferable amount of active ingredient recited above is still set up in suspending agent, and the weight ratio of epoxiconazole and carbendazim is 1:1-4, and the weight ratio of preferred epoxiconazole and carbendazim is 1:2.2, and these preferred schemes are also set up in suspending agent.
In above-mentioned preferred suspending agent, auxiliary material used is as follows:
Described dispersant is one or more in calcium lignosulfonate, methyl naphthalene sulfonate formaldehyde condensate, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, alkylphenol polyoxyethylene phosphate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, polyoxyethylene poly-oxygen propylene aether block copolymer, ethoxylated dodecyl alcohol sodium sulphate and polycarboxylate sodium, preferably by di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, calcium lignosulfonate and polycarboxylate sodium in mass ratio 2:1:1 mix.
Described thickener is one or more in Magnesiumaluminumsilicate, xanthans, organobentonite, sodium carboxymethylcellulose, polyvinylpyrrolidone and polyvinyl alcohol, preferably by organobentonite, polyvinylpyrrolidone and polyvinyl alcohol in mass ratio 1:2:2 mix.
Described defoamer is ester-ether type compound, organosilicon ketone and C
8-10one or more in fatty alcohol, are preferably C
8-10fatty alcohol.
Described antifreezing agent is one or more in urea, glycerine, ethylene glycol, sorbierite and propane diols, preferably by glycerine, ethylene glycol and sorbierite in mass ratio 1:1.5:3.5 mix.
The supplementary product consumption of above-mentioned suspending agent and the selection of composition thereof are mainly that the performance of suspending agent formulation is had to impact, such as suspensibility, foaming characteristic etc.Because the variation meeting of formulation performance has some impacts to drug effect.
The preparation method of the suspending agent of epoxiconazole and carbendazim comprises the following steps:
(1) water, dispersant, defoamer are mixed through high speed shear;
(2) in step (1), add active ingredient epoxiconazole and carbendazim, through sand mill sand milling, until product cut size is below 5 μ m.
(3) thickener is added in antifreezing agent and mixed, be added in the complete liquid of above-mentioned (2) sand milling, through high speed shear, mix, make the suspending agent product of the present composition.
The preferred wetting powder of the present invention, comprises active ingredient and the auxiliary material of following percentage by weight: active ingredient 10-90%, dispersant 1～10%, wetting agent 1～10%, filler surplus.More preferably comprise active ingredient and the auxiliary material of following percentage by weight: active ingredient 80%, dispersant 8%, wetting agent 6%, filler surplus.The preferable amount of active ingredient recited above is still set up in wetting powder, and the weight ratio of epoxiconazole and carbendazim is 1:1-4, and the weight ratio of preferred epoxiconazole and carbendazim is 1:2.2, and these preferred schemes are also set up in wetting powder.
In above-mentioned preferred wetting powder, auxiliary material used is as follows:
Described dispersant is one or more in lignin and derivative sulfonate, naphthalenesulfonic acid-formaldehyde condensate, methyl naphthalene sulfonate formaldehyde condensate, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate and alkylphenol polyoxyethylene phosphate, preferably by naphthalenesulfonic acid-formaldehyde condensate, methyl naphthalene sulfonate formaldehyde condensate and alkylphenol polyoxyethylene formaldehyde condensation products sulfonate in mass ratio 1:1:2 mix.
Described wetting agent is one or more that pull open in powder, sldium lauryl sulfate, lauryl sodium sulfate, dialkyl succinylsuccinate sulfonate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, petroleum sodium sulfonate, fatty alcohol-polyoxyethylene ether, alkylphenol polyoxyethylene and calcium dodecyl benzene sulfonate, preferably by pull open powder, petroleum sodium sulfonate and fatty alcohol-polyoxyethylene ether in mass ratio 1:2.5:1.5 mix.
Described filler is one or more in bentonite, diatomite, kaolin, white carbon, potter's clay, precipitated calcium carbonate and talcum powder etc., is preferably precipitated calcium carbonate.
The supplementary product consumption of above-mentioned wetting powder and the selection of composition thereof are mainly that the performance of suspending agent formulation is had to impact, such as wetting time etc.Because the variation meeting of formulation performance has some impacts to drug effect.
The preparation method of the wetting powder of epoxiconazole and carbendazim comprises the following steps: active ingredient, dispersant, wetting agent and filler are mixed in mixing kettle, after airslide disintegrating mill is pulverized, mix again, can make the wetting powder product of the present composition.
By mixed with carbendazim epoxiconazole, there is obvious synergistic effect in the present invention, effectively brought into play the two advantage, products obtained therefrom good quality, good drug efficacy, can effectively prevent and treat powdery mildew of cucumber, the diseases such as bitter rot or anthracnose of grape, and preparation method is simple, easy to operate, less energy consumption, mixed composition has reduced drug use amount, delay the pesticide resistance of germ to single medicament, there is good society and economic benefit.
Embodiment
The present invention is elaborated with following instantiation, but the present invention is limited to absolutely not these examples.
water dispersible granules
embodiment 180% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 25%, carbendazim 55%, dispersant polycarboxylate sodium 2.0%, alkylphenol sodium sulfonate 10%, calcium lignosulfonate 1.0%, wetting agent a-sulfo methyl ester 1.0%, a-alkene sulfonic acid sodium 1.0%, fatty acid amide N methyl taurine sodium salt 1.0%, disintegrant potassium chloride 1.04%, diammonium hydrogen phosphate 1.84%, ammonium nitrate 1.12%, ferrous sulfate 0.03%, precipitated calcium carbonate supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 750 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 50 ℃, dry, obtain 80% epoxiconazole carbendazim water dispersing granule.
embodiment 251.2% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 16%, carbendazim 35.2%, dispersant polycarboxylate sodium 2.0%, alkylphenol sodium sulfonate 10%, calcium lignosulfonate 1.0%, wetting agent a-sulfo methyl ester 1.0%, a-alkene sulfonic acid sodium 1.0%, fatty acid amide N methyl taurine sodium salt 1.0%, disintegrant potassium chloride 1.04%, diammonium hydrogen phosphate 1.84%, ammonium nitrate 1.12%, ferrous sulfate 0.03%, precipitated calcium carbonate supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 720 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 60 ℃, dry, obtain 51.2% epoxiconazole carbendazim water dispersing granule.
embodiment 380% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 25%; carbendazim 55%; dispersant alkylphenol polyoxyethylene formaldehyde condensation products sulphate 3.0%; wetting agent pulls open powder 1.0%, Negel 1.0%; disintegrant ammonium sulfate 1.0%; sodium sulphate 0.1%; talcum powder supplies 100%; after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 730 order fine powders; again gained fine powder is added in kneader appropriate water to mediate; through rotating disc type granulator granulation, in fluidizing fluid-bed, at 55 ℃, dry, obtain 80% epoxiconazole carbendazim water dispersing granule.
embodiment 482% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 41%, carbendazim 41%, dispersant alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt 4.5%; wetting agent sodium tetradecyl sulfate 1.5%, disintegrant dipotassium hydrogen phosphate 1.5%, zinc sulphate 0.05%; white carbon supplies 100%; after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 720 order fine powders; again gained fine powder is added in kneader appropriate water to mediate; through rotating disc type granulator granulation, in fluidizing fluid-bed, at 60 ℃, dry, obtain 82% epoxiconazole carbendazim water dispersing granule.
embodiment 580% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 16%; carbendazim 64%; dispersant NNO5.0%; wetting agent lauryl sodium sulfate 1%, neopelex 2%, sodium lignin sulfonate 1%; disintegrant potassium dihydrogen phosphate 2%, ammonium sulfate 3%; RE microbial fertilizer 0.035%; kaolin supplies 100%; after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 680 order fine powders; again gained fine powder is added in kneader appropriate water to mediate; through rotating disc type granulator granulation, in fluidizing fluid-bed, at 60 ℃, dry, obtain 80% epoxiconazole carbendazim water dispersing granule.
embodiment 681% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 80%, carbendazim 1%, dispersant maleic acid-acrylic acid copolymer salt 1.5%, alkylphenol sodium sulfonate 2.4%, wetting agent Negel 1.5%, sodium sulfate of polyethenoxy ether of fatty alcohol 1.4%, disintegrant diammonium hydrogen phosphate 2.5%, zinc sulphate 0.025%, attapulgite 5%, diatomite 4%, organobentonite supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 780 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 70 ℃, dry, obtain 81% epoxiconazole carbendazim water dispersing granule.
embodiment 781% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 1%, carbendazim 80%, dispersant ethylene oxide-propylene oxide block copolymer 1%, aryl phenol APEO 0.5%, two naphthalenesulfonate formaldehyde condensation compound sodium salts 0.5%, , wetting agent dialkyl group succinate sulfonate sodium 3.5%, disintegrant potassium dihydrogen phosphate 0.5%, urea 2.1%, potassium sulfate 1.3%, sodium sulphate 1.0%, white carbon 10%, corn starch supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 810 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 40 ℃, dry, obtain 81% epoxiconazole carbendazim water dispersing granule.
embodiment 810% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 7.5%, carbendazim 2.5%, dispersant polyox-yethylene-polyoxypropylene block copolymer 2.0%, naphtholsulfonic acid formaldehyde condensation products sodium salt 2.5%, alkyl naphthalene sulfonic acid formaldehyde condensation products sodium salt 1.5%, wetting agent alkyl phenol polyethenoxy ether sodium sulfate 0.5%, alkylphenol polyoxyethylene succinic acid half ester sodium sulfonate 0.5%, disintegrant dipotassium hydrogen phosphate 1.5%, diammonium hydrogen phosphate 1.6%, urea 1.0%, zinc sulphate 0.01%, glucose 15%, sucrose supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 840 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 30 ℃, dry, obtain % epoxiconazole carbendazim water dispersing granule.
embodiment 990% epoxiconazole carbendazim water dispersing granule
Epoxiconazole 3%, carbendazim 87%, dispersant polyox-yethylene-polyoxypropylene block copolymer 2.5%, naphtholsulfonic acid formaldehyde condensation products sodium salt 1.0%, wetting agent fatty acid sulphate 1.0%, fatty acid ester sulphate 1.5%, disintegrant dipotassium hydrogen phosphate 2.0%, diammonium hydrogen phosphate 1.0%, urea 2.0%, zinc sulphate 0.02%, sodium sulphate 0.03%, sodium sulphate supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 700 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 35 ℃, dry, obtain 90% epoxiconazole carbendazim water dispersing granule.
embodiment 1086% epoxiconazole carbendazim water dispersing granule
According to the method for embodiment 3, preparation 86% epoxiconazole carbendazim water dispersing granule, different is epoxiconazole 85% used, carbendazim 1%.
suspending agent
embodiment 1180% epoxiconazole carbendazim suspending agent
By water 14.42%, dispersant di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 1%, calcium lignosulfonate 0.5% and polycarboxylate sodium 0.5%, defoamer C
8-10fatty alcohol 0.5%, after high speed shear mixes, add epoxiconazole 25%, carbendazim 55%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener organobentonite 0.016%, polyvinylpyrrolidone 0.032% and polyvinyl alcohol 0.032%, add in antifreezing agent glycerine 0.5%, ethylene glycol 0.75% and sorbierite 1.75% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 80% epoxiconazole carbendazim suspending agent.
embodiment 1250% epoxiconazole carbendazim suspending agent
By water 44.42%, dispersant di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 1%, calcium lignosulfonate 0.5% and polycarboxylate sodium 0.5%, defoamer C
8-10fatty alcohol 0.5%, after high speed shear mixes, add epoxiconazole 25%, carbendazim 25%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener organobentonite 0.016%, polyvinylpyrrolidone 0.032% and polyvinyl alcohol 0.032%, add in antifreezing agent glycerine 0.5%, ethylene glycol 0.75% and sorbierite 1.75% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 50% epoxiconazole carbendazim suspending agent.
embodiment 1375% epoxiconazole carbendazim suspending agent
By water 19.42%, dispersant di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 1%, calcium lignosulfonate 0.5% and polycarboxylate sodium 0.5%, defoamer C
8-10fatty alcohol 0.5%, after high speed shear mixes, add epoxiconazole 15%, carbendazim 60%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener organobentonite 0.016%, polyvinylpyrrolidone 0.032% and polyvinyl alcohol 0.032%, add in antifreezing agent glycerine 0.5%, ethylene glycol 0.75% and sorbierite 1.75% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 75% epoxiconazole carbendazim suspending agent.
embodiment 1461% epoxiconazole carbendazim suspending agent
By water 34.85%, dispersant polyoxyethylene poly-oxygen propylene aether block copolymer 2.1%, defoamer organosilicon ketone 1.0%, after high speed shear mixes, add epoxiconazole 1%, carbendazim 60%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener xanthans 0.05%, add in antifreezing agent urea 1.0% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 61% epoxiconazole carbendazim suspending agent.
embodiment 1510% epoxiconazole carbendazim suspending agent
By water 84.88%, dispersant methyl naphthalene sulfonate formaldehyde condensate 3%, defoamer ester-ether type compound 0.05%, after high speed shear mixes, add epoxiconazole 9%, carbendazim 1%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener sodium carboxymethylcellulose 0.07%, add in antifreezing agent propane diols 2.0% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 10% epoxiconazole carbendazim suspending agent.
embodiment 1681% epoxiconazole carbendazim suspending agent
By water 7.4%, dispersant alkylphenol polyoxyethylene phosphate 2%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2% and ethoxylated dodecyl alcohol sodium sulphate 1%, defoamer ester-ether type compound 0.6%, after high speed shear mixes, add epoxiconazole 80%, carbendazim 1%, through sand mill sand milling, until product cut size is below 5 μ m, by thickener Magnesiumaluminumsilicate 1.0%, add in antifreezing agent propane diols 5.0% and mix, be added in the liquid of sand milling after complete, through high speed shear, mix, make 81% epoxiconazole carbendazim suspending agent.
wetting powder
example 1780% epoxiconazole carbendazol wettable powder
By epoxiconazole 25%, carbendazim 55%, dispersant naphthalenesulfonic acid-formaldehyde condensate 2%, methyl naphthalene sulfonate formaldehyde condensate 2%, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 4%, wetting agent pulls open powder 1.2%, petroleum sodium sulfonate 3.0% and fatty alcohol-polyoxyethylene ether 1.8%, filler precipitated calcium carbonate complements to 100%, in mixing kettle, mix, after airslide disintegrating mill is pulverized, mix again, can make 80% epoxiconazole carbendazol wettable powder.
example 1850% epoxiconazole carbendazol wettable powder
By epoxiconazole 25%, carbendazim 25%, dispersant naphthalenesulfonic acid-formaldehyde condensate 2%, methyl naphthalene sulfonate formaldehyde condensate 2%, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 4%, wetting agent pulls open powder 1.2%, petroleum sodium sulfonate 3.0% and fatty alcohol-polyoxyethylene ether 1.8%, filler precipitated calcium carbonate complements to 100%, in mixing kettle, mix, after airslide disintegrating mill is pulverized, mix again, can make 50% epoxiconazole carbendazol wettable powder.
example 1975% epoxiconazole carbendazol wettable powder
By epoxiconazole 15%, carbendazim 60%, dispersant naphthalenesulfonic acid-formaldehyde condensate 2%, methyl naphthalene sulfonate formaldehyde condensate 2%, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 4%, wetting agent pulls open powder 1.2%, petroleum sodium sulfonate 3.0% and fatty alcohol-polyoxyethylene ether 1.8%, filler precipitated calcium carbonate complements to 100%, in mixing kettle, mix, after airslide disintegrating mill is pulverized, mix again, can make 75% epoxiconazole carbendazol wettable powder.
example 2081% epoxiconazole carbendazol wettable powder
By epoxiconazole 1%, carbendazim 80%, dispersant lignin 1.0%, wetting agent sldium lauryl sulfate 3.0%, lauryl sodium sulfate 7.0%%, filler bentonite 3%, diatomite complement to 100%, in mixing kettle, mix, after airslide disintegrating mill is pulverized, mix again, can make 81% epoxiconazole carbendazol wettable powder.
example 2110% epoxiconazole carbendazol wettable powder
By epoxiconazole 9%, carbendazim 1%, dispersant alkylphenol polyoxyethylene phosphate 10.0%, wetting agent alkylphenol polyoxyethylene 1.0%, dialkyl succinylsuccinate sulfonate 4.0%, filler talcum powder complements to 100%, in mixing kettle, mix, after airslide disintegrating mill is pulverized, mix again, can make 10% epoxiconazole carbendazol wettable powder.
properties of product test
The water dispersible granules of embodiment 1-10 gained is carried out to performance test, the results are shown in Table 1.
Embodiment the 1, the 2nd, the optimum embodiment of active ingredient and auxiliary material, can find out by above-mentioned data, by with effective ingredient consumption preferably and selection, the combination of auxiliary agent, the epoxiconazole carbendazim water dispersing granule good quality of gained.
The suspending agent of embodiment 11-16 gained is carried out to performance test, the results are shown in Table 2.
Embodiment 11-13 is the optimum embodiment of active ingredient and auxiliary material, by above-mentioned data, can find out, by with effective ingredient consumption preferably and selection, the combination of auxiliary agent, the epoxiconazole carbendazim suspending agent good quality of gained.
The wetting powder of embodiment 17-21 gained is carried out to performance test, the results are shown in Table 3.
Embodiment 17-19 is the optimum embodiment of active ingredient and auxiliary material, by above-mentioned data, can find out, by with effective ingredient consumption preferably and selection, the combination of auxiliary agent, the epoxiconazole carbendazol wettable powder good quality of gained.
drug test
Enumerate some drugs below and test to prove the advantage of medicine of the present invention.
one, powdery mildew of cucumber control efficiency research
1 tests at local powdery mildew of cucumber their early stage, selects 16 cucumber fields to test.Application method is: at powdery mildew of cucumber their early stage, carry out spray pesticide control, during herbal sprinkling, according to 3000 times of thin ups, dispenser weather on the same day is fine, dispenser during 9-11 in the morning, 25 ℃ of the maximum air temperatures, 15 ℃ of the minimum air temperatures.
2, drug use amount
According to active ingredient dosage, be 75-95 gram/ha and carry out dispenser.
3 results
3.1 above-mentioned 16 groups of medical treatment stripe rust of wheat effects are as following table 4.
3.2 also test according to method above the medicine of all the other embodiment, result shows, the mass ratio of carbendazim and epoxiconazole is when 1-80:1-80, gained bactericidal composition preventive effect also can keep more than 85%, the mass ratio of epoxiconazole and carbendazim is when 1:1-4, to the control efficiency of powdery mildew of cucumber, more than 93%, the mass ratio of carbendazim and epoxiconazole is when 1:2.2, and gained bactericidal composition effect is more than 98%.
4 sum up
The preferred compositions of the preferred and auxiliary agent of bactericidal composition effective ingredient consumption of the present invention, microbicide compositions drug effect the best of gained.The mass ratio of carbendazim and epoxiconazole is that 1:1～4 o'clock bactericidal effect is fine, and when mass ratio is 1:2.2, effect is best, and the bactericidal composition effect that exceeds this scope decreases.By data, can learn, the combination of epoxiconazole of the present invention and kresoxim-methyl has improved cucumber sky controlling powdery mildew effect, has reduced usage amount and the access times of medicine, economical and practical, and effectively reduces ecosystem environment and pollute, and can improve crop yield and quality.
two, to the research of bitter rot or anthracnose of grape control efficiency
1 tests at local bitter rot or anthracnose of grape their early stage, selects 16 vineyaries to test.Application method is: at bitter rot or anthracnose of grape their early stage, carry out spray pesticide control, during herbal sprinkling, according to 3000 times of thin ups, dispenser weather on the same day is fine, dispenser during 9-11 in the morning, 25 ℃ of the maximum air temperatures, 15 ℃ of the minimum air temperatures.
2, formulation rate
According to active ingredient dosage, be 70-90 gram/ha and carry out dispenser.
3 results
3.1 above-mentioned 16 groups of medical treatment bitter rot or anthracnose of grape effects are as following table 5.
3.2 also test according to method above the medicine of all the other embodiment, result shows, the mass ratio of epoxiconazole and carbendazim is when 1-80:1-80, to the control efficiency of bitter rot or anthracnose of grape more than 88%, the mass ratio of carbendazim and epoxiconazole is in 1:1～4 o'clock, gained bactericidal composition effect is between 93%, and the mass ratio of carbendazim and epoxiconazole is when 1:2.2, and gained bactericidal composition effect is more than 97%.
4 sum up
The preferred compositions of the preferred and auxiliary agent of bactericidal composition effective ingredient consumption of the present invention, microbicide compositions drug effect the best of gained.The mass ratio of carbendazim and epoxiconazole is that 1:1～4 o'clock bactericidal effect is fine, and when mass ratio is 1:2.2, effect is best, and the bactericidal composition effect that exceeds this scope decreases.By data, can learn, the combination of epoxiconazole of the present invention and kresoxim-methyl has improved the sick control efficiency of bitter rot or anthracnose of grape, has reduced usage amount and the access times of medicine, economical and practical, and effectively reduces ecosystem environment and pollute, and can improve crop yield and quality.
Claims (2)
1. a bactericidal composition, it is characterized in that: formulation is water dispersible granules, comprise active ingredient and the auxiliary material of following percentage by weight: active ingredient 80%, dispersant 4%, wetting agent 3%, disintegrant 4%, foliage fertilizer 0.03%, inert filler surplus, described active ingredient comprises epoxiconazole and carbendazim, the weight ratio of epoxiconazole and carbendazim is 1:2.2;
Described dispersant by polycarboxylate sodium, alkylphenol sodium sulfonate and calcium lignosulfonate in mass ratio 2:1:1 mix; Described wetting agent by alpha-sulfo fatty acid methyl ester, alpha-olefin sodium sulfonate and fatty acid amide N methyl taurine sodium salt in mass ratio 1:1:1 mix; Described disintegrant is that 4:1:1 mixes by potassium chloride, diammonium hydrogen phosphate and ammonium nitrate by nitrogen, phosphorus, potassium mass ratio; Described foliage fertilizer is ferrous sulfate; Described inert filler is precipitated calcium carbonate.
2. an epoxiconazole carbendazim water dispersing granule, it is characterized in that: epoxiconazole 16%, carbendazim 35.2%, dispersant polycarboxylate sodium 2.0%, alkylphenol sodium sulfonate 1.0%, calcium lignosulfonate 1.0%, wetting agent alpha-sulfo fatty acid methyl ester 1.0%, alpha-olefin sodium sulfonate 1.0%, fatty acid amide N methyl taurine sodium salt 1.0%, disintegrant potassium chloride 1.04%, diammonium hydrogen phosphate 1.84%, ammonium nitrate 1.12%, ferrous sulfate 0.03%, precipitated calcium carbonate supplies 100%, after mixture fully mixes, carry out ultra micro air-flow crushing, obtain 720 order fine powders, again gained fine powder is added in kneader appropriate water to mediate, through rotating disc type granulator granulation, in fluidizing fluid-bed, at 60 ℃, dry, obtain 51.2% epoxiconazole carbendazim water dispersing granule.
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| CN103598191A (en) * | 2013-11-29 | 2014-02-26 | 苏州佳辉化工有限公司 | Carbendazim-epoxiconazole compounded agent |
| CN105622272A (en) * | 2016-02-15 | 2016-06-01 | 中国农业大学 | Suspension-type bactericide liquid medicine fertilizer and preparation method thereof |
| CN105707085B (en) * | 2016-04-21 | 2018-03-30 | 山东潍坊润丰化工股份有限公司 | A kind of Garagard water dispersible granules and preparation method thereof |
| CN106116826A (en) * | 2016-06-22 | 2016-11-16 | 固镇玉鹏生态农业文化园有限公司 | A kind of bitter rot or anthracnose of grape control agent |
| CN106116904B (en) * | 2016-07-02 | 2019-11-05 | 郑州玄弘生物科技有限责任公司 | The composite assistant for promoting crop blade face to absorb boron element |
| CN106116905B (en) * | 2016-07-02 | 2019-11-05 | 郑州大学 | The composite assistant for promoting plant leaf surface to absorb ferro element |
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