Embodiment
The invention provides a kind of microbicide compositions, it is characterized in that, the active component of described microbicide compositions comprises Fluoxastrobin and folpet.
In the present invention, described active component is Fluoxastrobin and folpet, the weight ratio of Fluoxastrobin and folpet can in very large range change, particularly, the weight ratio of Fluoxastrobin and folpet can be 1: 1000~1000: 1, in preferred situation, being 1~50: 1~50, is 1~10: 1~10 in preferred situation.
In microbicide compositions of the present invention, the content of described active component in microbicide compositions can in very large range change, and particularly, the content of this active component in composition is 0.5-95 % by weight, in preferred situation, is 5-80 % by weight.
In microbicide compositions of the present invention, except active component, microbicide compositions also contains the carrier of at least two kinds conventionally, and preferably wherein at least one is surfactant.
Above-mentioned surfactant can be the known various surfactants in bactericide field, and the present invention is preferably one or more in emulsifier, dispersant and wetting agent.
Other carriers except above-mentioned surfactant can be the known various carriers in bactericide field, particularly, for example: white carbon, kaolin, diatomite, clay, talcum, organobentonite, float stone, titanium dioxide, dextrin, cellulose powder, precipitated calcium carbonate, soluble starch, urea, amine is fertile, the mixture of urea and amine fertilizer, glucose, maltose, sucrose, Anhydrous potassium carbonate, natrium carbonicum calcinatum, Carbon Dioxide hydrogen potassium, anhydrous sodium bicarbonate, one or more in the mixture of Anhydrous potassium carbonate and Carbon Dioxide hydrogen potassium and the mixture of natrium carbonicum calcinatum and anhydrous sodium bicarbonate.
Mentioned emulsifier can be the known various emulsifier in bactericide field, and particularly, this emulsifier can be dodecyl sodium sulfonate calcium, lecithin, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene fatty acid diester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty amine, ethoxy castor oil, Crodaret, fatty acid polyethylene glycol ester, alkylphenol polyoxyethylene, polyoxyethylene alkyl phenyl ether, polyoxyethylene dialkyl phenyl organic ether, polyoxyethylene alkyl phenyl ether/formalin condensation product, polyoxyethylene/polyoxypropylene block polymer ether, alkyl polyoxyethylene/polyoxypropylene block polymer ether, alkyl phenyl polyoxyethylene/polyoxypropylene block polymer ether, polyoxyethylene diphenyl ether, polyoxyethylene benzyl phenyl ether, polyoxyethylene styryl phenyl ether, Polyoxyethylene Ether siloxanes, ester type siloxanes, polyoxyethylene aliphatic alcohol ether, one or more in fatty alcohol-polyoxyethylene ether sodium sulfosuccinate and alkyl phenol polyoxyethylene polyoxypropylene ether.
Above-mentioned dispersant can be the known various dispersants in bactericide field; particularly, this dispersant is the sodium salt of lignosulfonates, Sodium Polyacrylate, naphthalene sulfonate, alkylnaphthalene sulfonate, sodium methylene bis-naphthalene sulfonate, alkyl amide taurate, polycarboxylate, alkyl naphthalene sulfonic acid condensation polymer and one or more in alkyl naphthalene sulfonic acid yuban.
Above-mentioned wetting agent can be the known various wetting agents in bactericide field, particularly, this wetting agent can be one or more in the mixture of lauryl sodium sulfate, Teepol, neopelex, fatty alcohol polyglycol ether sulphate and alkylnaphthalene sulfonate and anion wetting agent.
Microbicide compositions of the present invention; this microbicide compositions can also contain the various preparation used additives that bactericide field is commonly used; particularly, said preparation used additives can be one or more in solvent, cosolvent, thickener, antifreezing agent, capsule material, protectant, defoamer, disintegrant and binding agent.
Above-mentioned solvent can be the known various solvents in bactericide field, and particularly, this solvent can be one or more in organic solvent, vegetable oil, mineral oil, solvent naphtha and water.
Wherein, described organic solvent comprises 1-METHYLPYRROLIDONE, oxolane, dimethyl sulfoxide (DMSO), N, one or more in N-dimethyl decyl amide, DMF, dimethylbenzene, tetrahydrofurfuryl alcohol, tributyl phosphate, Isosorbide-5-Nitrae-dioxane and cyclohexanone.
Described vegetable oil comprises one or more in epoxidized soybean oil, soybean oil, peanut oil, rapeseed oil, castor oil, corn oil and pine-seed oil.
Described mineral oil comprises one or more in liquid wax, machine oil, kerosene and lubricating oil.
Described solvent naphtha comprises one or more in No. 100 solvent naphthas, No. 150 solvent naphthas and No. 200 solvent naphthas.
Meanwhile, above-mentioned solvent also can be used as cosolvent use.
Above-mentioned antifreezing agent can be the known various antifreezing agents in bactericide field, and the present invention is preferably one or more in ethylene glycol, propane diols, glycerine and urea.
Above-mentioned thickener can be the known various thickeners in bactericide field, particularly, this thickener can be one or more in xanthans, polyvinyl alcohol, POLYPROPYLENE GLYCOL, polyethylene glycol, white carbon, diatomite, kaolin, clay, sodium alginate, Magnesiumaluminumsilicate, lagoriolite, carboxymethyl cellulose, HPMC and organobentonite.
Above-mentioned capsule material can be each known seed capsules material of bactericide field, and the present invention is preferably polyurethane, polyureas or Lauxite.
Above-mentioned protectant can be the known various protectants in bactericide field, and the present invention is preferably polyvinyl alcohol and/or polyethylene glycol.
Above-mentioned defoamer can be the known various defoamers in bactericide field, and the present invention is preferably one or more in organosiloxane, tributyl phosphate and silicone.
It is a kind of by the prepared preparation of above-mentioned microbicide compositions that the present invention also provides, and the formulation of described preparation is missible oil, aqueous emulsion, microemulsion, aqueous suspension agent, oil-suspending agent, microcapsule suspending agent, wetting powder, water-dispersible granules, soluble powder or soluble granula.
The formulation of microbicide compositions of the present invention can be the known various formulations in bactericide field, particularly, can be missible oil, aqueous emulsion, aqueous suspension agent, oil-suspending agent, microcapsule suspending agent, wetting powder, water-dispersible granules, soluble powder, soluble granula or microemulsion, above-mentioned formulation all can be prepared by the conventional method of this area.
Under preferable case, described cream preparation by weight the consist of active component 0.5~95%, cosolvent 0-20%, emulsifier 1~30%, solvent of percentage complements to 100%.
The above-mentioned preparation method who states cream preparation for example can comprise each active component, solvent, cosolvent and emulsifier are mixed, and makes its property become even oil phase, can obtain cream preparation.
Under preferable case, described aqueous emulsion or microemulsion by weight the consist of active component 0.5%~95%, emulsifier 1%~30%, cosolvent 0%~30%, solvent 1%~30%, antifreezing agent 0%~10%, thickener 0%~10%, water of percentage complement to 100%.
Under preferable case, the preparation method of described aqueous emulsion or microemulsion for example can comprise active component, emulsifier, cosolvent and solvent, becomes even oil phase; By mixing such as water, thickener, antifreezing agents, make it become homogeneous water.Under high-speed stirred, water is joined to oil phase or oil phase is joined to water, form aqueous emulsion or the microemulsion of favorable dispersibility.Wherein, microemulsion appearance transparent, aqueous emulsion is suspension.
Under preferable case, described aqueous suspension agent by weight the consist of active component 0.5%~95%, surfactant 1%~30%, antifreezing agent 1%~10%, thickener 0.1%~5%, water of percentage complements to 100%.
Under preferable case, described oil-suspending agent by weight the consist of active component 0.5%~95%, emulsifier 1%~30%, thickener 0.1%~5%, oil of percentage complements to 100%.
The preparation method of water/oil-suspending agent: take water or oil as medium, the auxiliary agents such as active component, surfactant, thickener are added in sand milling still, carry out porphyrize, make oil-suspending agent or aqueous suspension agent.
Under preferable case, described soluble granula, soluble powder, water dispersible granules or wetting powder by weight the consist of active component 0.5%~95%, surfactant 1%~30%, other carriers of percentage complement to 100%.
Wherein, the preparation method of water-dispersible granules and soluble granula is: each active component and other carriers etc. are carried out to co-grinding, spray-dried or fluidized drying and get final product; Or after co-grinding, add water and mediate, add and in comminutor, carry out granulation, and then drying, 5~60 mesh sieves divide, obtain.
The preparation method of soluble powder and wetting powder is: the fillers such as each active component, various auxiliary agent and other carriers are fully mixed, use ultra-fine pulverizer disintegrating.
Under preferable case; above-mentioned microcapsule suspending agent by weight percentage consist of active component 0.5%~95%, solvent 1%~30%, protectant 0.1%~5.0%, defoamer 0.05%~1.0%, capsule material 1%~30%, dispersant 1%~30%, wetting agent 0%~30%, antifreezing agent 0%~10%, thickener 0.1%~5%, water complement to 100%.
Preparation method: solvent, capsule material are mixed, then add active component; Added again emulsification in the mixture being formed by protectant, antifreezing agent, defoamer and water, stirred until polymerisation completes; Add again thickener, dispersant and wetting agent, obtain stable microcapsule suspending agent.
The present invention also provides the application of above-mentioned preparation aspect the fungus-caused plant disease of control.
Microbicide compositions of the present invention can provide with finished product preparation form, and in composition, each material mixes; Also can provide with independent dosage form, before using, in bucket or tank, mix voluntarily, and optionally mix and dilute with water according to the concentration of required active substance.
Microbicide compositions of the present invention is applicable to various crop, vegetables such as cucumber, pumpkin, custard squash, tomato, onion, shallot, beet, capsicum; The field crops such as wheat class, cereal, paddy rice; The economic crops such as mung bean, tobacco, flax; The fruit such as strawberry, grape, citrus; Flowers and other crops such as tree peony, chrysanthemum, Chinese rose, rose, rose.
Microbicide compositions of the present invention is compared with single dose has obvious synergistic effect, for plant diseases such as powdery mildew, downy mildew, late blight, white epidemic disease, rotten mildew, damping off, black stem, false smut, canker, early blight, scab, rust, glume blight, net blotch, leaf blight, gray molds, all there is good control efficiency, particularly very remarkable to cucumber downy mildew, powdery mildew effect.
Composition of the present invention also can be used with other compound with sterilization, desinsection or herbicidal performance, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The using method of microbicide compositions of the present invention is simple, before plant disease is sprouted or after sprouting, use according to a conventional method in place to crop and plant growth, as mix soil, spraying, injection, cast etc., its amount of application is determined according to weather conditions or crop state, generally use 10-25g for every mu, be diluted to 150-250mg/L and use.Thinner is preferably water.
Microbicide compositions of the present invention, its bactericidal effect is common with as relevant in weather with extraneous factor, but by using suitable formulation can slow down climatic influences.
By specific embodiment, the present invention is further detailed below, but the present invention is not limited in following embodiment.
Polyureas in following examples (purchased from Beijing Dongsheng Fu Tian polyurethane company), organosiloxane (purchased from DowComing company), sodium lignin sulfonate (purchased from real big gram of (China) Investment Co., Ltd of virtue dimension), polyoxyethylene styryl phenyl ether (purchased from Croda company), POLYPROPYLENE GLYCOL (purchased from Beijing sunlight Global Co., Ltd), secondary octyl phenol polyethenoxy ether (purchased from Hai'an, Jiangsu petrochemical plant), fatty alcohol-polyoxyethylene ether (purchased from Akzo Nobel N.V.), polyoxyethylene aliphatic alcohol ether (purchased from Nanjing Teva-Chem. Co., Ltd.), polyoxyethylene fatty acid fat (purchased from Rhodia), kaolin (purchased from China Kaolin Co., Ltd), paraffin oil (purchased from Hebei Ao Nite industrial oil Manufacturing Co., Ltd), calcium lignosulfonate (purchased from Beijing Hua You company), fatty alcohol polyglycol ether sulphate (purchased from Hensel Man), urea (purchased from Beijing reagent Co., Ltd), alkylphenol polyoxyethylene (purchased from Dong Bang KCC), sodium methylene bis-naphthalene sulfonate (purchased from Akzo Nobel N.V.), 1-METHYLPYRROLIDONE (purchased from Beijing chemical reagent factory), ethoxy castor oil (purchased from Croda company), sodium alginate (purchased from hundred suitable (Beijing) chemical Science and Technology Ltd.s).
In following examples, the compound method of the needed spore suspension of spray inoculation method is as follows: distilled water is sprayed on the sick leaf that covers with germ, collects bacterium liquid, furnishing spore count is 2 * 10
6the germ spore suspension of individual/mL.
Embodiment 1 is containing the emulsifiable concentrate of 0.5% active component
Fluoxastrobin 0.005g, folpet 4.995g, alkylphenol polyoxyethylene (emulsifier) 50g, fatty alcohol-polyoxyethylene ether (emulsifier) 50g, dimethylbenzene (solvent) are mended to 1kg, fully be mixed into even oil phase, obtain the emulsifiable concentrate containing 0.5% active component.Be numbered A1.
Embodiment 2 is containing the aqueous emulsion of 5% active component
Formula: Fluoxastrobin 0.125g, folpet 49.875g, No. 150 solvent naphthas (solvent) 50g, polyoxyethylene styryl phenyl ether (emulsifier) 50g, POLYPROPYLENE GLYCOL (thickener) 80g, diatomite (carrier) 20g, water complement to 1kg.
Preparation method: above-mentioned Fluoxastrobin, folpet, No. 150 solvent naphthas, polyoxyethylene styryl phenyl ethers are mixed into even oil phase; POLYPROPYLENE GLYCOL, diatomite and water are mixed into even water; Under high-speed stirred, water is joined in oil phase, form the aqueous emulsion containing 5% active component of favorable dispersibility.Be numbered A2.
Embodiment 3 is containing the microemulsion of 15% active component
Formula: Fluoxastrobin 3g, folpet 147g, 1-METHYLPYRROLIDONE (solvent) 50g, secondary octyl phenol polyethenoxy ether (emulsifier) 100g, ethoxy castor oil (emulsifier) 200g, ethylene glycol (antifreezing agent) 50g, water complement to 1kg.
Preparation method: above-mentioned Fluoxastrobin, folpet, 1-METHYLPYRROLIDONE, secondary octyl phenol polyethenoxy ether, ethoxy castor oil are mixed into even oil phase; By the even water of ethylene glycol formation soluble in water; Under high-speed stirred, water is joined in oil phase, form the microemulsion containing 15% active component.Be numbered A3.
Embodiment 4 is containing the aqueous suspension agent of 25% active component
Formula: Fluoxastrobin 25g, folpet 225g, ethoxy castor oil (emulsifier) 10g, fatty alcohol-polyoxyethylene ether (emulsifier) 30g, diatomite (thickener) 30g, propane diols (antifreezing agent) 60g, water complement to 1kg.
Preparation method: take water as medium, by above-mentioned Fluoxastrobin, folpet, ethoxy castor oil, fatty alcohol-polyoxyethylene ether, diatomite and propane diols add porphyrize in sand milling still, makes the aqueous suspension agent containing 25% active component.Be numbered A4.
Embodiment 5 is containing the oil-suspending agent of 50% active component
Formula: Fluoxastrobin 499.5g, folpet 0.5g, polyoxyethylene aliphatic alcohol ether (emulsifier) 100g, polyoxyethylene fatty acid fat (emulsifier) 50g, kaolin (thickener) 30g, paraffin oil subsidy are to 1kg.
Preparation method: take paraffin oil as medium, above-mentioned Fluoxastrobin, folpet, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty acid fat, kaolin are added to porphyrize in sand milling still, obtain the oil-suspending agent containing 50% active component.Be numbered A5.
Embodiment 6 is containing the oil-suspending agent of 60% active component
Formula: Fluoxastrobin 598.8g, folpet 1.2g, polyoxyethylene aliphatic alcohol ether (emulsifier) 100g, polyoxyethylene fatty acid fat (emulsifier) 50g, kaolin (thickener) 30g, paraffin oil subsidy are to 1kg.
Preparation method: take paraffin oil as medium, above-mentioned Fluoxastrobin, folpet, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty acid fat, kaolin are added to porphyrize in sand milling still, obtain the oil-suspending agent containing 60% active component.Be numbered A6.
Embodiment 7 is containing the microcapsule suspending agent of 70% active component
Formula: Fluoxastrobin 695g, folpet 5g, No. 150 solvent naphthas (solvent) 210g, polyureas (capsule material) 30g, polyvinyl alcohol (protectant) 10g, organosiloxane (defoamer) 0.5g, xanthans (thickener) 1.5g, sodium lignin sulfonate (dispersant) 30g, water are mended to 1Kg.
By Fluoxastrobin, folpet, mix with the mixture of No. 150 solvent naphthas and polyureas; Then this mixture is added to emulsification in the mixture being comprised of polyvinyl alcohol, organosiloxane and water.Be uniformly mixed until polymerisation completes; Add again xanthans and sodium lignin sulfonate, obtain stable microcapsule suspending agent.This capsule diameter intermediate value is 5~8 microns.Be numbered A7.
Embodiment 8 is containing the wetting powder of 80% active component
Formula: Fluoxastrobin 784g, folpet 16g, sodium lignin sulfonate (dispersant) 30g, sodium methylene bis-naphthalene sulfonate (dispersant NNO) 20g, soluble starch (carrier) 50g, kaolin (carrier) complement to 1kg
Preparation method: said components is fully mixed, through ultra-fine pulverizer disintegrating, make the wetting powder containing 80% active component.Be numbered A8.
Embodiment 9 is containing the water-dispersible granules of 90% active component
Formula: Fluoxastrobin 864g, folpet 36g, calcium lignosulfonate (dispersant) 50g, fatty alcohol polyglycol ether sulphate (wetting agent) 50g, urea (carrier) complement to 1kg.
Preparation method: by above-mentioned Fluoxastrobin, folpet, calcium lignosulfonate, fatty alcohol polyglycol ether sulphate, urea co-grinding, make the water-dispersible granules containing 90% active component through fluidized drying.Be numbered A9.
Embodiment 10 is containing the soluble powder of 95% active component
Formula: Fluoxastrobin 855g, folpet 95g, lauryl sodium sulfate 20, soluble starch complement to 1kg.
Preparation method: said components is fully mixed, through ultra-fine pulverizer disintegrating, make the soluble powder containing 95% active component.Be numbered A10.
Embodiment 11 is containing the aqueous emulsion of 50% active component
Formula: Fluoxastrobin 125g, folpet 375g, 1-METHYLPYRROLIDONE (solvent) 50g, alkylphenol polyoxyethylene (emulsifier) 30g, fatty alcohol-polyoxyethylene ether (emulsifier) 20g, ethylene glycol (antifreezing agent) 50g, sodium alginate (thickener) 10g, water complement to 1kg.
Preparation method: above-mentioned Fluoxastrobin, folpet, 1-METHYLPYRROLIDONE, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether are mixed into even oil phase; Ethylene glycol, sodium alginate and water are mixed into even water; Under high-speed stirred, oil phase is joined in water, form the aqueous emulsion containing 50% active component of favorable dispersibility.Be numbered A11.
Comparative example 1-2
Control drug Fluoxastrobin single dose and folpet single dose (purchased from Shangyu Nutrichem Co., Ltd).Fluoxastrobin single dose is numbered to C1, folpet single dose is numbered to C2.
Experimental example 1-13
Experimental example 1-13 is used for illustrating the application of above-mentioned medicament aspect the fungus-caused plant disease of control.
The disease of plant variety and infection is as being shown in Table 1.The experimental determining method of different plants is as follows:
The test method of paddy rice: test adopts pot-culture method, every group of 12 basins, are further divided into three concentration groups and one group of clear water blank in every group.When growing to 2-3 leaf, paddy rice with crops sprayer foliar spray, processes during the phase, spray respectively the medicament that is diluted to variable concentrations, spray 4mL medicine, medicament title and content are in Table 1, spraying latter 24 hours inoculation germs of processing, (adopt spray inoculation method, spore concentration is that spore concentration is 2 * 10
6individual/mL, sprays to blade face moistening), to inoculate latter 8 days and investigate, result is as shown in table 1, and its result is calculated in the following way:
Control efficiency (%)=[1-(treatment region is processed front disease index-treatment region and processed sequela index)]/(disease index before the index-check plot processing of check plot processing sequela) * 100
The experimental technique of cucumber: test adopts cucumber seedling pot-culture method, every group of 12 basins, are further divided into three concentration groups and one group of clear water blank in every group.When growing to two leaves, cucumber with crops sprayer foliar spray, processes during one heart stage, spray respectively the medicament that is diluted to variable concentrations, spray 4mL medicine, medicament title and content are in Table 1, spraying latter 24 hours inoculation germs of processing, (adopt spray inoculation method, spore concentration is that spore concentration is 2 * 10
6individual/mL, sprays to blade face moistening), to inoculate latter 7 days and investigate, result is as shown in table 1, and its result is calculated in the following way:
Control efficiency (%)=[1-(treatment region is processed front disease index-treatment region and processed sequela index)]/(disease index before the index-check plot processing of check plot processing sequela) * 100
The experimental technique of eggplant: test adopts eggplant seedling pot-culture method, every group of 12 basins, are further divided into three concentration groups and one group of clear water blank in every group.When growing to 2-3 leaf, with crops sprayer foliar spray, processes during the phase eggplant, spray respectively the medicament that is diluted to variable concentrations, spray 4mL medicine, medicament title and content are in Table 1, spraying latter 24 hours inoculation germs of processing, (adopt spray inoculation method, spore concentration is that spore concentration is 2 * 10
6individual/mL, sprays to blade face moistening), to inoculate latter 8 days and investigate, result is as shown in table 1, and its result is calculated in the following way:
Control efficiency (%)=[1-(treatment region is processed front disease index-treatment region and processed sequela index)]/(disease index before the index-check plot processing of check plot processing sequela) * 100
Table 1
Note: in table, the kind of cucumber is the close thorn in Shandong, and the kind of eggplant is Zhejiang eggplant 28, the kind of paddy rice is fragrant round-grained rice R109.
By table 1, can find out, show fabulous synergistic effect by Fluoxastrobin and folpet are composite in certain ratio range, compare the obvious bactericidal effect that improved with single dose, thereby reduced the usage amount of bactericide, when reducing peasant's drug cost, reduced the impact on environment.And, the multiple diseases of various crop is all had to good drug effect, there is the wide feature of fungicidal spectrum.