CN104434982A - Medicinal globefish oil making method - Google Patents
Medicinal globefish oil making method Download PDFInfo
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- CN104434982A CN104434982A CN201510004347.8A CN201510004347A CN104434982A CN 104434982 A CN104434982 A CN 104434982A CN 201510004347 A CN201510004347 A CN 201510004347A CN 104434982 A CN104434982 A CN 104434982A
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- globefish
- oil
- fugu ocellatus
- tetrodotoxin
- medicinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a medicinal globefish oil making method. The existential state of tetrodotoxin in vivo is not affected, and the curative effect of the tetrodotoxin can be improved. The technological difficulty of high-purity tetrodotoxin extraction is high, and technology and equipment are complex. However, according to the medicinal globefish oil preparation method, tetrodotoxin extraction and tetrodotoxin removing are not needed, the general equipment and technology for making oleum morrhuae are adopted, the technology is simple, the cost is low, and curative tetrodotoxin popularization is facilitated; the utilization value of globefish viscera is improved, the whole liver and ovary (comprising eggs) are utilized instead of utilizing only toxin in the viscera, other abundant nutrition ingredients in the whole liver and ovary are sufficiently utilized, the rich highly unsaturated fatty acids can enhance the comprehensive treatment effect and enhance the immunologic function and also has the tumor suppression effect, and the suppression rate of globefish oil to tumors can reach 59%. The globefish oil can be developed as a health care product for tumor suppression, immunity increasing and addiction removing besides detoxification, analgesia and anesthesia. Globefish breeding has no value in the tetrodotoxin related industries originally, however, by means of the medicinal globefish oil making method, bred globefish becomes indispensable raw materials, and the values besides the edible value of globefish are improved.
Description
Technical field
The present invention relates to a kind of fish oil preparation field, be specially a kind of preparation method of medicinal Fugu ocellatus fish oil.
Background technology
Fugu ocellatus internal organs contain hypertoxic Fugu ocellatus toxin, are most valuable marine pharmaceutical resources.Fugu ocellatus toxin can treat various diseases, its maximum medical value be have in treating narcotic addiction, analgesia, anesthesia efficient, have no side effect and addicted function.
The emphasis of people's research all concentrates on how from Fugu ocellatus internal organs, to extract Fugu ocellatus toxin for this reason, how to improve its purity.The general preparation method of tetrodotoxin formulation is: first extract high-purity tetrodotoxin, the preparation of tetrodotoxin formulation then generally adopts distilled water or medical oil to dilute the way of high-purity tetrodotoxin to reasonable concentration, disclose a invention and created name for " a kind of Fugu ocellatus oil formulation and preparation method thereof " in existing disclosed patent application, still be unable to do without detoxification (Fugu ocellatus toxin) technique in above-mentioned patent application scheme and dilute when adding medical oil in Fugu ocellatus oil during Fugu ocellatus toxin concentration height.
Summary of the invention
In order to overcome above-mentioned deficiency of the prior art, the invention provides a kind of medicinal Fugu ocellatus fish oil preparation method not destroying Fugu ocellatus toxin existence in vivo completely.
The object of the present invention is achieved like this:
the formation of Fugu ocellatus toxin is a bioprocess, bioprocess is different from chemical process and physical process in essence, extracting Fugu ocellatus toxin is chemical process, it is physical process that Fugu ocellatus toxin is diluted, direct use toxic Fugu ocellatus fish oil and the diluted high-purity Fugu ocellatus toxin of use are cured the disease, should have different effects, being expected the former has better curative effect;
A preparation method for medicinal Fugu ocellatus fish oil, its concrete steps are as follows:
1), not Fugu ocellatus toxin must be extracted, must detoxification yet, adopt general cod-liver oil production technology, prepare toxic Fugu ocellatus liver oil or ovary oil, measure its Fugu ocellatus toxin concentration, stored refrigerated;
2), according to cultivating globe fish is not toxic or toxic atomic, adopts general cod-liver oil production technology, prepares not toxic Fugu ocellatus liver oil or ovary oil, stored refrigerated;
3), according to Fugu ocellatus toxin concentration in medicinal Fugu ocellatus fish oil should be 0.01 ~ 15ug/ml, calculate the mixed proportion of toxic and not toxic two kinds of Fugu ocellatus fish oil, be mixed in proportion and obtain required medicinal Fugu ocellatus fish oil.
positive beneficial effect:the preparation method of a kind of medicinal Fugu ocellatus fish oil disclosed by the invention, does not affect Fugu ocellatus toxin existence in vivo, is expected the curative effect improving Fugu ocellatus toxin; Extract high-purity Fugu ocellatus toxin technical difficulty large, Processes and apparatus is complicated, and the present invention must not carry poison, detoxification, and adopt the general apparatus and process manufacturing cod-liver oil, technology is simple, and cost is low, is conducive to the popularization that Fugu ocellatus toxin is cured the disease; The present invention improves the value of globe fish internal organs, from the toxin only utilized contained by internal organs, to utilizing whole liver and ovary (comprising ovum).Other abundant nutritions contained by them are obtained for make full use of, the highly unsaturated fatty acid be rich in, can strengthen combined therapy effect and strengthen immunologic function, and having tumor killing effect, Fugu ocellatus fish oil can reach 59% to the suppression ratio of tumor.Fugu ocellatus fish oil, except treating narcotic addiction, analgesia, anesthesia, is expected to develop into a kind of tumor suppression, increases immunity, removes various addicted health product; Cultivation Fugu ocellatus was nugatory originally in Fugu ocellatus toxin industries concerned, but had had the present invention, and cultivation Fugu ocellatus becomes indispensable raw material, improved its value except edible.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described further:
The object of the present invention is achieved like this:
the formation of Fugu ocellatus toxin is a bioprocess, bioprocess is different from chemical process and physical process in essence, extracting Fugu ocellatus toxin is chemical process, it is physical process that Fugu ocellatus toxin is diluted, direct use toxic Fugu ocellatus fish oil and the diluted high-purity Fugu ocellatus toxin of use are cured the disease, should have different effects, being expected the former has better curative effect;
A preparation method for medicinal Fugu ocellatus fish oil, its concrete steps are as follows:
1), not Fugu ocellatus toxin must be extracted, must detoxification yet, adopt general cod-liver oil production technology, prepare toxic Fugu ocellatus liver oil or ovary oil, measure its Fugu ocellatus toxin concentration, stored refrigerated;
2), according to cultivating globe fish is not toxic or toxic atomic, adopts general cod-liver oil production technology, prepares not toxic Fugu ocellatus liver oil or ovary oil, stored refrigerated;
3), according to Fugu ocellatus toxin concentration in medicinal Fugu ocellatus fish oil should be 0.01 ~ 15ug/ml, calculate the mixed proportion of toxic and not toxic two kinds of Fugu ocellatus fish oil, be mixed in proportion and obtain required medicinal Fugu ocellatus fish oil.
The preparation method of a kind of medicinal Fugu ocellatus fish oil disclosed by the invention, does not affect Fugu ocellatus toxin existence in vivo, is expected the curative effect improving Fugu ocellatus toxin; Extract high-purity Fugu ocellatus toxin technical difficulty large, Processes and apparatus is complicated, and the present invention must not carry poison, detoxification, and adopt the general apparatus and process manufacturing cod-liver oil, technology is simple, and cost is low, is conducive to the popularization that Fugu ocellatus toxin is cured the disease; The present invention improves the value of globe fish internal organs, from the toxin only utilized contained by internal organs, to utilizing whole liver and ovary (comprising ovum).Other abundant nutritions contained by them are obtained for make full use of, the highly unsaturated fatty acid be rich in, can strengthen combined therapy effect and strengthen immunologic function, and having tumor killing effect, Fugu ocellatus fish oil can reach 59% to the suppression ratio of tumor.Fugu ocellatus fish oil, except treating narcotic addiction, analgesia, anesthesia, is expected to develop into a kind of tumor suppression, increases immunity, removes various addicted health product; Cultivation Fugu ocellatus was nugatory originally in Fugu ocellatus toxin industries concerned, but had had the present invention, and cultivation Fugu ocellatus becomes indispensable raw material, improved its value except edible.
The above is only for illustration of the preferred embodiment of the present invention, but the present invention is not limited to above-mentioned embodiment, and any amendment made in the ken that described field possesses, modification are all encompassed within technical protection scope of the present invention.
Claims (1)
1. a preparation method for medicinal Fugu ocellatus fish oil, its concrete steps are as follows:
1), not Fugu ocellatus toxin must be extracted, must detoxification yet, adopt general cod-liver oil production technology, prepare toxic Fugu ocellatus liver oil or ovary oil, measure its Fugu ocellatus toxin concentration, stored refrigerated;
2), according to cultivating globe fish is not toxic or toxic atomic, adopts general cod-liver oil production technology, prepares not toxic Fugu ocellatus liver oil or ovary oil, stored refrigerated;
3), according to Fugu ocellatus toxin concentration in medicinal Fugu ocellatus fish oil should be 0.01 ~ 15ug/ml, calculate the mixed proportion of toxic and not toxic two kinds of Fugu ocellatus fish oil, be mixed in proportion and obtain required medicinal Fugu ocellatus fish oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510004347.8A CN104434982A (en) | 2015-01-06 | 2015-01-06 | Medicinal globefish oil making method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510004347.8A CN104434982A (en) | 2015-01-06 | 2015-01-06 | Medicinal globefish oil making method |
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| CN104434982A true CN104434982A (en) | 2015-03-25 |
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| CN201510004347.8A Pending CN104434982A (en) | 2015-01-06 | 2015-01-06 | Medicinal globefish oil making method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477182A (en) * | 2015-12-19 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid |
| CN105497277A (en) * | 2015-12-19 | 2016-04-20 | 青岛浩大海洋保健食品有限公司 | Fugu-rubripe-oil oral solution for improving sexual hypofunction |
| CN105559060A (en) * | 2015-12-19 | 2016-05-11 | 青岛浩大海洋保健食品有限公司 | Spleen-benefiting and stomach-invigorating globefish oil health capsule |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193516A (en) * | 1997-03-13 | 1998-09-23 | 辽阳鸿宇制药有限公司 | Application of liver oil of globefish in preparation of medicines for drug dependence |
| CN1425666A (en) * | 2001-12-14 | 2003-06-25 | 上海华腾生物工程有限公司 | Method for extracting tetrodotoxin |
| CN1754539A (en) * | 2004-09-28 | 2006-04-05 | 黄致强 | Tetrodotoxin oil phase formulation preparation method |
| CN102318685A (en) * | 2011-05-25 | 2012-01-18 | 宁德市夏威食品有限公司 | Processing technic of large yellow croaker fish liver oil |
-
2015
- 2015-01-06 CN CN201510004347.8A patent/CN104434982A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193516A (en) * | 1997-03-13 | 1998-09-23 | 辽阳鸿宇制药有限公司 | Application of liver oil of globefish in preparation of medicines for drug dependence |
| CN1425666A (en) * | 2001-12-14 | 2003-06-25 | 上海华腾生物工程有限公司 | Method for extracting tetrodotoxin |
| CN1754539A (en) * | 2004-09-28 | 2006-04-05 | 黄致强 | Tetrodotoxin oil phase formulation preparation method |
| CN102318685A (en) * | 2011-05-25 | 2012-01-18 | 宁德市夏威食品有限公司 | Processing technic of large yellow croaker fish liver oil |
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国水产部科学技术委员会编: "《水产科学技术成果汇编水产品加工部分》", 30 April 1960 * |
| 王海磊，等。: ""鱼油的提取方法及精制工艺探讨"", 《湖南农业科学》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477182A (en) * | 2015-12-19 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid |
| CN105497277A (en) * | 2015-12-19 | 2016-04-20 | 青岛浩大海洋保健食品有限公司 | Fugu-rubripe-oil oral solution for improving sexual hypofunction |
| CN105559060A (en) * | 2015-12-19 | 2016-05-11 | 青岛浩大海洋保健食品有限公司 | Spleen-benefiting and stomach-invigorating globefish oil health capsule |
| CN105559060B (en) * | 2015-12-19 | 2018-03-16 | 青岛浩大海洋生物科技股份有限公司 | A kind of beneficial spleen stomach invigorating filefish fish oil health-caring capsule |
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Application publication date: 20150325 |
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| RJ01 | Rejection of invention patent application after publication |